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Application of Metabolomics to Reveal the Biological Mechanism of Toxicological Research 应用代谢组学揭示毒理学研究的生物学机制
Pub Date : 2020-12-04 DOI: 10.31031/SBB.2020.04.000583
Xi jun Wang
Metabolomics can illustrate microscopic changes in the metabolic mechanisms of toxicity caused by frequent exposure to drugs, herbs, and environmental pollutants, and recent reports have supported the great potential and value of metabolomics in reducing the occurrence of injury reactions.
代谢组学可以说明频繁暴露于药物、草药和环境污染物引起的毒性代谢机制的微观变化,最近的报道支持代谢组学在减少损伤反应发生方面的巨大潜力和价值。
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引用次数: 0
Towards a Sustainable Green World? A Better use of OM 迈向可持续发展的绿色世界?更好地利用OM
Pub Date : 2020-11-25 DOI: 10.31031/SBB.2020.04.000581
Orange Didier
In a world in constant and rapid changes, it becomes urgent that research activities adopt new methodologies to develop technological innovations allowing rapid adaptations by the policy-makers and the smallholders in respect to the environment. Nature-based solutions (NBS) and problem-solving learning (PSL) ensure active participation from the actors. By this way ecohydrology within bioengineering, bioinspiration, ecological engineering offers new opportunities for scientific activities on organic matter (OM) management to pass achievements to policy makers and the public through more active developments in social media. Then better competencies on OM management will create opportunities for technological innovations and paradigm shifts to make possible and efficient an economic and ecological asset for green production, promoting food and health security for the populations and for a sustainable environment. As more and more well known, the stationarity is dead. The Earth is a non-linear complex system. Recent discoveries on the importance of living things and their environmental feedbacks, on the role of homeostatic processes and breakpoints confirm that global warming is only part of the current ecological crisis which is also manifested by the loss of biodiversity, the loss of soil fertility, the water pollution but also the drastic increase in diseases that affect the entire living world. The current COVID-19 pandemic is just one more dramatic example. In 2020, the management of domestic wastewater remains a major global challenge, as well as feeding the poorest populations, stopping the soil losses through the galloping urbanization and mitigating the environmental quality of our cities. 2/3 of the world’s population still does not have access to sanitation, creating recurrent health and environmental disasters. The majority of them are in tropical regions, mainly in Sub-Saharan Africa, in countries whose economy does not allow the rapid development of wastewater treatment plants. It is therefore necessary to innovate and change the wastewater management model. Like international institutions (UNESCO, USAID, AFD, FFEM, etc.) and the pursuit of the SDGs for the Horizon 2030, the Research arena is highly challenged to develop technological innovations allowing changes in concepts regarding the perception of the usefulness of wastewater for green production. Domestic wastewater represents a volume of water loaded with organic matter useful for plant production (natural and agricultural), for the rational and amplified use of water and soil (maintenance of fertility, carbon storage) and for improvement of the living conditions of the populations while fully respecting their health, their environment, the soils, the waters and the biodiversity. The innovation opportunities are numerous, from process engineering to ecological engineering and bioengineering, from biogeochemist and microbiologist to creator of IoT and AI algorithm, from architect
在一个不断和迅速变化的世界中,迫切需要研究活动采用新的方法来发展技术创新,使决策者和小农能够迅速适应环境。基于自然的解决方案(NBS)和问题解决学习(PSL)确保参与者的积极参与。通过这种方式,生物工程、生物灵感、生态工程中的生态水文学为有机物质(OM)管理的科学活动提供了新的机会,通过更积极的社交媒体发展,将成果传递给决策者和公众。然后,更好的OM管理能力将为技术创新和范式转变创造机会,使绿色生产、促进人口的粮食和健康安全以及可持续环境成为可能和有效的经济和生态资产。随着越来越多的人知道,平稳性已死。地球是一个非线性的复杂系统。最近关于生物及其环境反馈的重要性的发现,关于稳态过程和断点的作用的发现证实,全球变暖只是当前生态危机的一部分,目前的生态危机还表现为生物多样性的丧失、土壤肥力的丧失、水污染以及影响整个生物世界的疾病的急剧增加。当前的COVID-19大流行只是一个更引人注目的例子。2020年,生活污水管理仍是一项重大的全球挑战,同时还将解决最贫困人口的温饱问题、遏制快速城市化带来的土壤流失以及降低城市环境质量等问题。世界上三分之二的人口仍然无法获得卫生设施,造成经常性的健康和环境灾害。其中大多数位于热带地区,主要是撒哈拉以南非洲,这些国家的经济不允许快速发展废水处理厂。因此,有必要创新和改变废水管理模式。与国际机构(联合国教科文组织、美国国际开发署、AFD、FFEM等)和对2030年地平线可持续发展目标的追求一样,研究领域也面临着巨大的挑战,需要开发技术创新,从而改变人们对废水对绿色生产有用性的看法。生活废水是一种含有有机物的水量,对植物生产(自然和农业)、合理和扩大利用水和土壤(维持肥力、碳储存)和改善人口的生活条件有用,同时充分尊重他们的健康、环境、土壤、水和生物多样性。从工艺工程到生态工程和生物工程,从生物地球化学家和微生物学家到物联网和人工智能算法的创造者,从建筑师和城市规划师到地理学家,创新机会数不胜数。因此,更好地利用土壤、水和当地气候方面的剩余有机质,将有助于提高粮食产量,改善人类和环境健康,提高水和养分效率,缩短资源消耗周期,促进当地经济发展。
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引用次数: 0
Donor Heart Assessment Model 供体心脏评估模型
Pub Date : 2020-10-23 DOI: 10.31031/SBB.2020.04.000580
Tenchurina Ea
Selection of donor heart-an important step, which affects the success of heart transplantation. Purpose- creating a model for evaluation of a donor’s heart, based on donor characteristics. Materials and Methods Data consists of 650 brain dead donors (BDD) in a period from 1st of January 2012 till 31st of December 2017. In model creation, binomial logistic regression used. The dependent variable is a rejection of donor heart and donor characteristics attributed to independent factors. The odds ratios (OR) value determined for each factor, then transformed into points, and the sum of the points is a score of the donor’s heart. The given model is validated by choosing 218 donors for the period from 1st of January 2019 till 31st of December 2019. Donors characteristics included in the model are age, cause of death (Traumatic brain injury/Stroke), history of Hypertension and Diabetes Mellitus, out (-in) hospital cardiac arrest, cardiac trauma, and HR, MAP, arterial lactate, requirements of norepinephrine before procurement of organs. Based on the average value of the sum of points, 2 groups were identified: donors of low risk (≤17 points) and donors of high risk (≥18 points). Analysis of the ROC curve showed the properties of the predictive model, AUC-0.904, sensitivity-90.2 %, specificity-90.4 %. This given model assessing donor hearts accurately reflects the probability of using the heart of the donor for transplantation and forms features for optimal distribution of cardiac transplants, especially from donors of high risk.
供心的选择是影响心脏移植成功的重要环节。目的:根据捐赠者的特点,建立一个评估捐赠者心脏的模型。材料与方法数据包括2012年1月1日至2017年12月31日650例脑死亡供体。在模型创建中,使用了二项逻辑回归。因变量是由独立因素引起的对供体心脏和供体特征的排斥。为每个因素确定的比值比(OR)值,然后转换成分数,分数的总和就是捐赠者心脏的分数。通过在2019年1月1日至2019年12月31日期间选择218名捐赠者来验证给定模型。模型中包含的供体特征包括年龄、死亡原因(外伤性脑损伤/中风)、高血压和糖尿病史、院外(院内)心脏骤停、心脏创伤、HR、MAP、动脉乳酸、器官获取前的去甲肾上腺素需求。根据积分总和的平均值分为2组:低危供者(≤17分)和高危供者(≥18分)。ROC曲线分析表明,该预测模型的auc为0.904,灵敏度为90.2%,特异度为90.4%。这个给定的评估供体心脏的模型准确地反映了使用供体心脏进行移植的概率,并形成了心脏移植的最佳分布特征,特别是来自高风险供体的心脏移植。
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引用次数: 0
Impact of Space-Dependent Thermal Conductivity on Heat Transfer in a Vertical Annulus with Asymmetric Surface Heating 空间相关导热系数对不对称表面加热垂直环空传热的影响
Pub Date : 2020-10-22 DOI: 10.31031/SBB.2020.04.000578
M. Oni
Over the past two centuries, thermal conductivity (often denoted k, λ, or κ) is the property of a material to conduct heat. It is evaluated primarily in terms of Fourier’s law for heat conduction. Materials of high thermal conductivity transfer heat faster than materials with lower thermal conductivity. Correspondingly, materials of high thermal conductivity are widely used in heat sink applications and materials of low thermal conductivity are used as thermal insulation. The thermal conductivity of a material may depend on temperature. Thermal conductivity is important in material science research, electronics, building insulation and related fields, especially where high operating temperatures are achieved. The impact of temperature dependent thermal conductivity has been studied over decades and interesting results have been obtained. Prasad et al. [1] studied the effects of variable fluid properties on the hydromagnetic flow and heat transfer over a non-linearly stretching sheet. Later, Animasaun [2] investigated the effect of thermophoresis, variable viscosity and thermal conductivity on free convective heat and mass transfer of non-darcian MHD dissipative casson fluid flow with suction and order of chemical reaction. He concluded that viscosity parameter as well as thermal conductivity parameter decreases fluid temperature. Other works on temperature dependent thermal conductivity can be found in [3-6].
在过去的两个世纪里,热导率(通常表示为k, λ或κ)是材料导热的特性。它主要是根据傅立叶热传导定律来计算的。导热系数高的材料比导热系数低的材料传热快。相应地,热导率高的材料被广泛用于散热器应用,而热导率低的材料被用作隔热材料。材料的导热性可能取决于温度。导热系数在材料科学研究,电子,建筑绝缘和相关领域,特别是在实现高工作温度的领域是重要的。温度相关导热系数的影响已经研究了几十年,并获得了有趣的结果。Prasad等人[1]研究了变流体性质对非线性拉伸薄板上的磁流体流动和传热的影响。后来Animasaun[2]研究了热驱、变粘度和导热系数对非达西MHD耗散卡森流体流动随吸力和化学反应顺序的自由对流传热传质的影响。他得出结论,粘度参数和导热系数参数降低了流体温度。其他关于温度相关导热系数的研究见于[3-6]。
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引用次数: 0
Environmental Stupidity 环境的愚蠢
Pub Date : 2020-03-20 DOI: 10.31031/sbb.2020.04.000577
James F. Welles
The relationship of America to its natural environment is parasitic if not suicidal. However, we have surprisingly few illusions about ourselves being anything but exploiters, as we simultaneously rape, strangle and poison our life support system. Eventually, such behavior will limit our development, and we are actually has-tening that day in that we have elevated exploitation to something of a cultural virtue.
美国与其自然环境的关系即使不是自杀式的,也是寄生式的。然而,令人惊讶的是,我们很少幻想自己不是剥削者,因为我们同时强奸、扼杀和毒害我们的生命维持系统。最终,这样的行为会限制我们的发展,而我们实际上已经把这一天升华为一种文化美德。
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引用次数: 0
Learning Stupidity 学习愚蠢
Pub Date : 2020-01-23 DOI: 10.31031/sbb.2020.04.000576
James F. Welles
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引用次数: 0
The Role of Hba1c in Severity and Mortality Rate of ST Segment Elevation Myocardial Infarction for Hospitalized Libyan Non-Diabetic Patients 糖化血红蛋白在利比亚非糖尿病住院患者ST段抬高型心肌梗死严重程度和死亡率中的作用
Pub Date : 2019-11-27 DOI: 10.20431/2455-2550.0502003
Altalhi Kgh
Background:The severity of coronary artery disease (CAD) is directly related to the quality of glucose controlindiabetic patient. Additionally diabetes is associated with increased mortality following acute myocardial infarction compared to general population.Objectives:To evaluate the association of HbA1c level and severity of CAD, and outcome of non-diabetic patient with STEMI In our hospital.Patients and methods:60 consecutive non diabetic patient with acute ST elevationmyocardial infarction were treated with thrombolytic therapy included in the present prospective study. Blood glucose and HbA1c level of all patients were measured within 3 hours ofadmission. Patient were divided in to 3 groups according to HbA1c level: with cut-off 6.5% as diagnostic criteria of diabetes mellitus according to (American diabetes association) group (1) 6.5% , group (2) 6.5 to 8.5% , group (3) 8.5% and above.In hospital .mortality and morbidities of acute STEMI were compared between groups.Result :The mean age was 63±15 year and mean body mass index was 26. 6±6 kg/m² , 24 patients (40%) had history of hypertension , 27 patients (45%) of dyslipidemia, 36 patients (60%) were smoker.We found 45 patients with HbA1c ≤ 6 5%, 5 patients with HbA1c 6.5 -8.5 %, 10 patients with HbA1c ≥ 8.5%.There was strong correlation between admission of HbA1c and admission glucose level (P< 0.001). Infarct size as measured by peak creatinin kinase, was not correlated with HbA1c level.Conclusion:HbA1c is an important risk marker in the absence of history of diabetes mellitus in patients with AMI . The optimal management in these patients may contribute in decrease hospital mortality.
背景:冠心病(CAD)的严重程度直接关系到糖尿病患者的血糖控制质量。此外,与一般人群相比,糖尿病与急性心肌梗死后死亡率增加有关。目的:探讨我院非糖尿病STEMI患者HbA1c水平与冠心病严重程度及预后的关系。患者和方法:本前瞻性研究对60例连续非糖尿病急性ST段抬高型心肌梗死患者进行溶栓治疗。所有患者均在入院3小时内测量血糖和HbA1c水平。根据HbA1c水平将患者分为3组:根据美国糖尿病协会(American diabetes association)的标准,以6.5%作为糖尿病的诊断标准(cut-off 6.5%)组(1)6.5%,组(2)6.5 ~ 8.5%,组(3)8.5%及以上。比较两组急性STEMI的住院死亡率和发病率。结果:患者平均年龄63±15岁,平均体重指数26。6±6 kg/m²,有高血压史24例(40%),血脂异常27例(45%),吸烟36例(60%)。HbA1c≤6.5%的患者45例,HbA1c 6.5 - 8.5%的患者5例,HbA1c≥8.5%的患者10例。入院时HbA1c与入院时血糖水平有很强的相关性(P< 0.001)。通过峰值肌凝素激酶测量的梗死面积与HbA1c水平无关。结论:在无糖尿病史的AMI患者中,HbA1c是一个重要的危险指标。对这些患者的最佳管理可能有助于降低住院死亡率。
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引用次数: 0
How Schizophrenia Could be Caused by Cholera & Ferric Chloride Disease 霍乱和氯化铁病是如何引起精神分裂症的
Pub Date : 2019-10-09 DOI: 10.31031/sbb.2019.03.000571
Cusack Paul Te
Bioengineering & Biosciences Abstract I n this brief paper, we build upon other papers by this author that had two causes for schizophrenia. We combine the findings that point to Ferric Chloride and Cholera as the culprits as the underlying
在这篇简短的论文中,我们建立在这位作者的其他论文的基础上,这些论文有两个导致精神分裂症的原因。我们将这些发现结合起来,指出氯化铁和霍乱是罪魁祸首
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引用次数: 0
Association between Maternal Dietary Diversity and Neonatal Birth Size 母亲饮食多样性与新生儿体型的关系
Pub Date : 2019-10-09 DOI: 10.31031/sbb.2019.03.000572
Sana Noreen, A. Sá, Muhammad Imran, Syed Amir Gilani, Fasiha Ahsan, S. Sikander, A. Raza, Jawad Af
Around 16% of all newborn babies of the world which make a scientific number of 22 million were underweight. South Asia has the highest prevalence of underweight babies in the world, with one in four newborns weighing less than 2,500 grams [1]. Whereas, 12-25% of newborn babies are underweight in Pakistan [2,3]. Low birth weight is a significant predictor of prenatal mortality as well as morbidity [4]. Low birth weight increases the risk of diabetes, heart diseases and cancer [5]. Weight of the baby at birth is the outcome of maternal health and nutrition. Undernourishment within womb increases the chances of early death [6]. The survivors tend to have weak immune system and increased risk of disease. They have the probability to remain undernourished resulting in weak muscles and low mental abilities [7]. Therefore, it is inferred that maternal nutrition plays a major role in affecting the growth of fetus and birth outcomes. Studies have shown that insufficient consumption of important nutrients and less intake of energy during pregnancy will have detrimental health effects on adulthood [8]. Studies indicate that food taken during pregnancy has impending effects on Crimson Publishers Wings to the Research Research Article
世界上所有新生儿中约有16%体重不足,科学数字为2200万。南亚是世界上体重不足婴儿发生率最高的地区,四分之一的新生儿体重低于2500克[1]。然而,在巴基斯坦,12-25%的新生儿体重不足[2,3]。低出生体重是产前死亡率和发病率的重要预测因子[4]。低出生体重会增加患糖尿病、心脏病和癌症的风险[5]。婴儿出生时的体重是母亲健康和营养的结果。子宫内营养不良会增加早死的几率[6]。幸存者往往免疫系统较弱,患病风险较高。他们有可能继续营养不良,导致肌肉无力和智力低下[7]。由此推断,母体营养在影响胎儿生长发育和分娩结局中起着重要作用。研究表明,孕期重要营养素摄入不足,能量摄入不足,会对成年期的健康产生不利影响[8]。研究表明,怀孕期间所吃的食物对《深红出版社》的研究文章有迫在眉睫的影响
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引用次数: 0
Stupidity as Normal 愚蠢是正常的
Pub Date : 2019-08-24 DOI: 10.31031/sbb.2019.03.000570
James F. Welles
{"title":"Stupidity as Normal","authors":"James F. Welles","doi":"10.31031/sbb.2019.03.000570","DOIUrl":"https://doi.org/10.31031/sbb.2019.03.000570","url":null,"abstract":"","PeriodicalId":21951,"journal":{"name":"Significances of Bioengineering & Biosciences","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91091152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Significances of Bioengineering & Biosciences
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