Pub Date : 2026-03-20DOI: 10.1007/s12015-026-11102-y
Fatma A Abouelnazar, Mohamed Elkewedi, Ying Chu, Fei Mao, Afaf M Amin, Ahmed S Sultan
{"title":"Combined treatment of Metformin with Frankincense Essential Oil or Manuka Honey Synergistically Inhibited Stemness Characteristics, Enhanced Sensitivity, and Induced Apoptosis in the CD44⁺/CD24<sup>⁻/Low</sup> Breast Cancer Stem Subpopulation.","authors":"Fatma A Abouelnazar, Mohamed Elkewedi, Ying Chu, Fei Mao, Afaf M Amin, Ahmed S Sultan","doi":"10.1007/s12015-026-11102-y","DOIUrl":"https://doi.org/10.1007/s12015-026-11102-y","url":null,"abstract":"","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147491721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-20DOI: 10.1007/s12015-026-11105-9
Joachim Hansen, Amanda-Louise Fenger Carlander, Kathrine Kronberg Jakobsen, Josephine Skjoldbirk, Christian Grønhøj, Christian von Buchwald
{"title":"Treatment of Xerostomia with Mesenchymal Stem Cells - A Systematic Review and Meta-Analysis of Clinical Trials.","authors":"Joachim Hansen, Amanda-Louise Fenger Carlander, Kathrine Kronberg Jakobsen, Josephine Skjoldbirk, Christian Grønhøj, Christian von Buchwald","doi":"10.1007/s12015-026-11105-9","DOIUrl":"https://doi.org/10.1007/s12015-026-11105-9","url":null,"abstract":"","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147487239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-12DOI: 10.1007/s12015-026-11088-7
José Luis Sanz, Leopoldo Forner, Sergio López-García, Francisco Javier Rodríguez-Lozano, João Miguel Santos, Sofía Folguera, Concha López-Ginés, Daniel Monleón
{"title":"The Role of MicroRNA in the Behaviour of Periodontal Ligament Stem Cells and Stem Cells from the Apical Papilla: A Systematic Review.","authors":"José Luis Sanz, Leopoldo Forner, Sergio López-García, Francisco Javier Rodríguez-Lozano, João Miguel Santos, Sofía Folguera, Concha López-Ginés, Daniel Monleón","doi":"10.1007/s12015-026-11088-7","DOIUrl":"https://doi.org/10.1007/s12015-026-11088-7","url":null,"abstract":"","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-07DOI: 10.1007/s12015-026-11080-1
Nawaz Khan, Zeynab Ahmadova, Bin Zeng, Waqas Ahmed, Tayyab Shafiq, Zihao Zhang, Aiyuan Su, Nazim Muhammad, Sajid Khan, Yujie Liang, Li Duan
{"title":"Stem Cells and their Key Derivatives in Degenerative Musculoskeletal Diseases.","authors":"Nawaz Khan, Zeynab Ahmadova, Bin Zeng, Waqas Ahmed, Tayyab Shafiq, Zihao Zhang, Aiyuan Su, Nazim Muhammad, Sajid Khan, Yujie Liang, Li Duan","doi":"10.1007/s12015-026-11080-1","DOIUrl":"https://doi.org/10.1007/s12015-026-11080-1","url":null,"abstract":"","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147373199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-06DOI: 10.1007/s12015-026-11085-w
Asma Ismail Mahmod, Kayatri Govindaraju, Yogeswaran Lokanathan, Nur Akmarina, B M Said, Baharudin Ibrahim
{"title":"Metabolomics-guided Mechanisms of Mesenchymal Stromal Cell and Exosome Therapies in Chronic Diseases.","authors":"Asma Ismail Mahmod, Kayatri Govindaraju, Yogeswaran Lokanathan, Nur Akmarina, B M Said, Baharudin Ibrahim","doi":"10.1007/s12015-026-11085-w","DOIUrl":"https://doi.org/10.1007/s12015-026-11085-w","url":null,"abstract":"","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147366742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Androgenetic alopecia(AGA) is the most common form of hair loss worldwide. By middle age, approximately two-thirds of men and 40% of women are affected. The pathophysiology of AGA involves complex interactions among genetic predisposition, androgen sensitivity, and dysregulation of the hair follicles (HFs) cycle. Among the key regulatory pathways, the Wnt/β-catenin signaling pathway plays a central role in maintaining homeostasis of hair follicle stem cell (HFSCs) and dermal papilla cells (DPCs), as well as in promoting the transition to the anagen phase. Endogenous Wnt inhibitors, such as dickkopfs (DKKs) and secreted frizzled-related proteins (sFRPs), are upregulated under the influence of dihydrotestosterone and can modulate canonical Wnt signaling in DPCs and HFSCs via paracrine mechanisms, potentially contributing to the development of AGA. Targeted inhibition of these endogenous negative regulators may therefore represent a promising therapeutic strategy for AGA. This review summarizes current insights into the role of Wnt signaling in hair follicle biology, the characteristics and functions of DKKs and sFRPs in AGA, and their potential as therapeutic targets.
{"title":"Targeting Endogenous Wnt Antagonists for Therapy Development in AGA: a Focus on DKKs and sFRPs.","authors":"Zhao Wang, Hui Bai, Siqi Wang, Sili Wang, Chunrong Yuan, Zonghuang Ding","doi":"10.1007/s12015-026-11095-8","DOIUrl":"https://doi.org/10.1007/s12015-026-11095-8","url":null,"abstract":"<p><p>Androgenetic alopecia(AGA) is the most common form of hair loss worldwide. By middle age, approximately two-thirds of men and 40% of women are affected. The pathophysiology of AGA involves complex interactions among genetic predisposition, androgen sensitivity, and dysregulation of the hair follicles (HFs) cycle. Among the key regulatory pathways, the Wnt/β-catenin signaling pathway plays a central role in maintaining homeostasis of hair follicle stem cell (HFSCs) and dermal papilla cells (DPCs), as well as in promoting the transition to the anagen phase. Endogenous Wnt inhibitors, such as dickkopfs (DKKs) and secreted frizzled-related proteins (sFRPs), are upregulated under the influence of dihydrotestosterone and can modulate canonical Wnt signaling in DPCs and HFSCs via paracrine mechanisms, potentially contributing to the development of AGA. Targeted inhibition of these endogenous negative regulators may therefore represent a promising therapeutic strategy for AGA. This review summarizes current insights into the role of Wnt signaling in hair follicle biology, the characteristics and functions of DKKs and sFRPs in AGA, and their potential as therapeutic targets.</p>","PeriodicalId":21955,"journal":{"name":"Stem Cell Reviews and Reports","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147356575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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