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Global developmental delay in a child with asphyxia neonatorum: Why search for an additional explanation? 新生儿窒息的整体发育迟缓:为什么要寻找一个额外的解释?
Pub Date : 2023-06-02 DOI: 10.32677/ijch.v10i6.3868
Shreyas A Surpure, B. Rathod
Children presenting neurological problems and a history of “not cried immediately at birth” are labeled to have cerebral palsy due to birth asphyxia. Although this may be true in many situations, the presence of some additional features may help determine an alternate diagnosis. We present such a case with an alternate diagnosis. A child with a history of birth asphyxia was labeled as a case of global developmental delay or a case of cerebral palsy by the treating doctors. However, the child had certain dysmorphic features such as bulbous nose, depressed nasal bridge, low-set ears, high-arched palate, squint, and flat feet. The child was initially treated in the Neonatal Intensive Care Unit after birth. Later, she developed various neurological features, with frequent episodes of aspiration pneumonia and seizures which were managed with anticonvulsant drugs and antimicrobial agents. She also had some additional non-specific features. On detailed evaluation, the child was diagnosed to have 1q43q44 microdeletion. Search for an alternate or additional diagnosis should be carried out if a child presenting with global developmental delay has some additional syndromic features. This will help in the prognostication of child and help parents in future pregnancy.
出现神经系统问题和“出生时没有立即哭泣”病史的儿童被标记为由于出生窒息而患有脑瘫。虽然这在许多情况下可能是正确的,但一些附加特征的存在可能有助于确定替代诊断。我们以另一种诊断提出这样一个病例。一个有出生窒息史的孩子被治疗医生标记为全面发育迟缓或脑瘫病例。然而,儿童有某些畸形特征,如球根鼻,鼻梁凹陷,耳位低,上颚高弓,斜视,扁平足。该儿童出生后最初在新生儿重症监护病房接受治疗。后来,她出现了各种神经系统特征,并频繁发作吸入性肺炎和癫痫发作,并使用抗惊厥药物和抗菌药物进行治疗。她还有一些额外的非特定特征。经详细评估,该患儿被诊断为1q43q44微缺失。如果出现全面发育迟缓的儿童有一些额外的综合征特征,则应寻找替代或额外的诊断。这将有助于孩子的预测和帮助父母在未来的怀孕。
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引用次数: 0
Cord blood albumin level as a predictor of neonatal physiological jaundice in healthy term neonate 脐带血白蛋白水平作为健康足月新生儿生理性黄疸的预测因子
Pub Date : 2023-06-02 DOI: 10.32677/ijch.v10i6.3998
K S Anupriya, N Pradeep
Background: Neonatal jaundice is a very common condition worldwide, occurring in up to 60% of term and 80% of pre-term newborns in the 1st week of life and the most common cause for readmission. The present study was conducted to evaluate the predictive value of umbilical cord blood albumin level for subsequent development of neonatal jaundice in healthy term neonates. The present study is conducted to find usefulness of cord blood albumin in predicting the subsequent development of significant neonatal jaundice. Methods and Methods: This is a hospital-based prospective study conducted in 100 healthy term neonates. Cord blood albumin level estimation was done at birth. Total serum bilirubin estimation was done for all babies with clinically suspected jaundice at 72–96 h of age. The neonates were divided into three Groups A, B, and C based on the cord albumin levels of <2.8 g/dL, 2.8–3.3 g/dL, and >3.3 g/dL, respectively. The main outcome of the study was inferred in terms of serum bilirubin ≥17 mg/dL, newborn required phototherapy, and exchange transfusion. Results: Groups A, B, and C had 21, 35, and 44 newborns, respectively. In Group A, 18 (85.7%) neonates had total bilirubin of >17 mg/dL, of which 16 (76.19%) required phototherapy and 2 (9.52%) needed exchange transfusion. 23 (65.7%) neonates in Group B developed jaundice, of which 12 (34.2%) needed phototherapy and none of them required exchange transfusion. In Group C, 15 (34.09%) developed jaundice of which 1 (2.2%) required phototherapy and none of them required exchange transfusion (p<0.001). Conclusion: Cord blood albumin level ≤2.8 g/dL is a significant risk factor for developing neonatal hyperbilirubinemia that requires early intervention, while cord blood albumin >3.3 g/dL is probably safe for early discharge. Hence, this can help to identify the at-risk neonates. Hence, routine determination of cord blood albumin level can be advocated to keep a track on at-risk neonates.
背景:新生儿黄疸在世界范围内是一种非常常见的疾病,高达60%的足月新生儿和80%的早产新生儿在出生后第一周发生,是最常见的再入院原因。本研究旨在评估脐带血白蛋白水平对健康足月新生儿黄疸后续发展的预测价值。本研究旨在发现脐带血白蛋白在预测新生儿黄疸的后续发展方面的有用性。方法和方法:这是一项以医院为基础的前瞻性研究,在100名健康足月新生儿中进行。脐带血白蛋白水平在出生时测定。所有临床怀疑为黄疸的婴儿在72-96小时进行血清总胆红素测定。根据新生儿脐带白蛋白水平3.3 g/dL分为A、B、C三组。根据血清胆红素≥17 mg/dL、新生儿需要光疗和换血来推断研究的主要结局。结果:A组21例,B组35例,C组44例。A组总胆红素>17 mg/dL 18例(85.7%),其中16例(76.19%)需要光照治疗,2例(9.52%)需要换血。B组新生儿出现黄疸23例(65.7%),其中12例(34.2%)需要光照治疗,无一例需要换血。C组15例(34.09%)出现黄疸,其中1例(2.2%)需要光疗,没有一例需要换血(p3.3 g/dL可能是早期出院安全的)。因此,这有助于识别有风险的新生儿。因此,可以提倡常规测定脐带血白蛋白水平,以跟踪高危新生儿。
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引用次数: 1
Risk factors for infant formula usage during the initial hospital stay in term and late pre-term neonates after implementation of a breastfeeding support program: A retrospective case–control study from a tertiary care hospital 实施母乳喂养支持计划后足月和晚期早产儿初次住院期间婴儿配方奶粉使用的危险因素:一项来自三级医院的回顾性病例对照研究
Pub Date : 2023-05-01 DOI: 10.32677/ijch.v10i5.3910
S. Ganapathy, S. Buddhavarapu
Background: Infant formula usage in hospitals is inevitable in certain circumstances. We explored the high-risk groups who required formula during hospital stays during the post-intervention phase of a quality improvement initiative for improving exclusive breastfeeding (EBF) rates in hospitals. Methods: A retrospective and case–control study was conducted involving 50 cases of neonates who received infant formula and 200 control who were exclusively breastfed. Data regarding maternal and neonatal details were from breastfeeding assessment forms and case record which was collected prospectively during the program. We compared common risk factors between the two groups. Results: There was a strong association between infant formula usage and cesarean sections, assisted reproductive technology (ART) conceptions, multiple gestations, neonatal intensive care unit admissions, being small for gestational age, and being an infant of a diabetic mother. First-h breastfeeding was associated with a higher likelihood of EBF in the hospital. In the final model, ART conception, multiple gestations, and delayed initiation of breastfeeding were strong predictors of the use of infant formula in the hospital. Conclusion: Initiating breastfeeding within the 1st h promotes EBF. ART conception and multiple gestations remain strong risk factors for formula usage, the social, physiological, and genetic reasons for which will need to be studied in detail.
背景:在某些情况下,医院使用婴儿配方奶粉是不可避免的。我们探讨了为提高医院纯母乳喂养(EBF)率而实施的质量改进倡议的干预后阶段住院期间需要配方奶粉的高危人群。方法:对50例婴幼儿配方奶粉喂养组和200例纯母乳喂养组进行回顾性病例对照研究。有关产妇和新生儿细节的数据来自母乳喂养评估表和病例记录,这些数据是在项目期间前瞻性收集的。我们比较了两组的常见危险因素。结果:婴儿配方奶粉的使用与剖宫产、辅助生殖技术(ART)受孕、多胎妊娠、新生儿重症监护病房入院、胎龄小以及糖尿病母亲的婴儿之间存在很强的关联。首先,母乳喂养与医院发生EBF的可能性较高有关。在最后一个模型中,ART受孕、多胎妊娠和延迟开始母乳喂养是医院使用婴儿配方奶粉的有力预测因素。结论:1 h内开始母乳喂养可促进EBF。ART受孕和多胎妊娠仍然是配方奶粉使用的重要危险因素,社会、生理和遗传原因需要详细研究。
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引用次数: 0
Study of sensorineural hearing loss in children with type 1 diabetic mellitus and the corelation with the duration of the disease in a tertiary care center 三级保健中心1型糖尿病患儿感音神经性听力损失及其与病程的相关性研究
Pub Date : 2023-05-01 DOI: 10.32677/ijch.v10i5.3939
Mahesh Gowda, No K O, Doddabele Layout
Background: Annual type 1 diabetes cases in children under the age of 15 are estimated to be around 96,000 worldwide. The pathophysiological explanation for diabetes-related hearing loss is speculative. Usually, hearing loss is bilateral, gradual onset, affecting higher frequencies. It is a well-known entity in type 2 diabetic mellitus. This study aims at knowing the prevalence of hearing loss in children with type 1 diabetic mellitus with respect to duration of diabetic mellitus. Materials and Methods: A hospital-based comparative study was conducted involving 60 diabetic children and 60 healthy (control) children. Brainstem evoked response audiometry test was done in both groups. Reports were compared and prevalence of sensorineural hearing loss in diabetic children and the corelation with the duration of disease were analyzed. Results: The mean age among cases was 11.93±2.9 years and the mean age among controls was 9.08±1.92 years. Among diabetic group, 25 (41.7%) were male, 35 (58.3%) were female. Among non-diabetic group, 33 (55%) were male, 27 (45%) were female. Although none of the diabetic children had hearing loss, the differences in absolute latency waves I, II, III, IV, and V between diabetic group and non-diabetic group in the right ear and waves I and II and III and V between diabetic group and non-diabetic group in the left ear was found to be statistically significant (p<0.05). The difference in interpeak latency values of wave I and wave V between diabetic and non-diabetic group in right ear and between wave I–V and wave III–V in the left ear was found to be statistically strongly significant (p<0.001). This indicates prolonged absolute latency and interpeak latency among diabetics than non-diabetics. Since none of the diabetic children had hearing loss, the corelation of hearing loss with the duration of the disease was unable to obtain. Conclusion: This study stresses on the need for frequent follow-up and hearing evaluation of the type 1 diabetic children for the early detection of hearing loss.
背景:全球15岁以下儿童每年1型糖尿病病例估计约为96,000例。糖尿病相关听力损失的病理生理学解释是推测性的。通常,听力损失是双侧的,逐渐发生的,影响较高的频率。它是2型糖尿病中一种众所周知的实体。本研究旨在了解1型糖尿病儿童听力损失的患病率与糖尿病病程的关系。材料与方法:以医院为基础,对60例糖尿病患儿与60例健康(对照)患儿进行比较研究。两组均行脑干诱发反应测听试验。比较报告,并分析糖尿病儿童感音神经性听力损失的患病率及其与病程的关系。结果:病例平均年龄11.93±2.9岁,对照组平均年龄9.08±1.92岁。糖尿病组男性25例(41.7%),女性35例(58.3%)。非糖尿病组男性33例(55%),女性27例(45%)。虽然糖尿病患儿均无听力损失,但糖尿病组与非糖尿病组的右耳I、II、III、IV、V波,以及糖尿病组与非糖尿病组的左耳I、II、III、V波的差异均有统计学意义(p<0.05)。糖尿病组与非糖尿病组右耳I波和V波峰间潜伏期值、左耳I - V波与III-V波峰间潜伏期值差异有统计学意义(p<0.001)。这表明糖尿病患者的绝对潜伏期和峰间潜伏期比非糖尿病患者长。由于没有糖尿病儿童有听力损失,听力损失与疾病持续时间的相关性无法获得。结论:本研究强调对1型糖尿病患儿进行频繁的随访和听力评估是早期发现听力损失的必要条件。
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引用次数: 0
Aeromonas salmonicida: A very rare but potential threat to human 沙门氏菌气单胞菌:一种非常罕见但对人类有潜在威胁的细菌
Pub Date : 2023-05-01 DOI: 10.32677/ijch.v10i5.3914
Nishant Tawari, Rajesh Agrawal, Keshav Kala
Aeromonas salmonicida is a ubiquitous Gram-negative bacterium. It mainly found in aquatic ecosystem. It is most common pathogen in salmonids. Reported infections due to A. salmonicida in humans are very rare. A 5-year-old child admitted with fever since more than a week and loose motions. The blood culture showed growth of A. salmonicida. The child responded well to intravenous antibiotics and discharged after 5 days of admission. A. salmonicida is a rare but potential pathogen for human infections. Modern diagnostic methods are being effective in diagnosing it and empirical antibiotics (Cephalosporin) are helpful in treating it.
沙门氏菌气单胞菌是一种普遍存在的革兰氏阴性细菌。主要分布于水生生态系统中。它是鲑鱼中最常见的病原体。报告的人类沙门氏菌感染是非常罕见的。一名五岁儿童因发烧一周多及活动不全入院。血培养显示沙门氏菌生长。患儿对静脉注射抗生素反应良好,入院5天后出院。沙门氏菌是一种罕见但潜在的人类感染病原体。现代诊断方法对该病的诊断是有效的,经验性抗生素(头孢菌素)对该病的治疗有帮助。
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引用次数: 0
Comparison of efficacy of paracetamol and ibuprofen for treatment of hemodynamically significant patent ductus arteriosus in preterm infants 对乙酰氨基酚与布洛芬治疗早产儿血流动力学意义显著的动脉导管未闭的疗效比较
Pub Date : 2023-05-01 DOI: 10.32677/ijch.v10i5.3942
Swathi R, Maulik Shah, Agnes Puthussery
Background: Indomethacin and ibuprofen (IBU) have been approved for the pharmacological closure of hemodynamically significant patent ductus arteriosus (hsPDA) in preterm infants. Recent works have demonstrated that paracetamol (PCM) can also be used but more research is required regarding efficacy and safety. Objectives: The objective is to compare the efficacy and safety of PCM and IBU for the treatment of hsPDA in preterm infants. Methodology: An observational study was designed with ethical clearance and parental consent. Patients were evaluated for hsPDA by clinical and 2 D echo findings. After inclusion and exclusion criteria, consecutive 100 patients were assigned between PCM and IBU and were given a 3-day course. After echocardiographic and clinical evaluation, if required, a second course with same drug was given. The outcome measures were the rate of ductal closure, the safety of drugs, and adverse events. Results: The PCM group had a closure rate of 76.25% and the IBU group had 75%. IBU had a significantly higher rate of closure in the first course (45% vs. 16.25%). The mean closure time observed was 4.54 days and 4 days for PCM and IBU, respectively. PCM gave a higher closure rate in the low-birth-weight group and where platelet counts were below normal. Regarding the safety aspect also no significant difference between groups was observed. Conclusion: PCM can be advised as a first-line treatment for hsPDA cases in preterm infants and is a better choice in cases of comorbidities and patients with low platelet count.
背景:吲哚美辛和布洛芬(IBU)已被批准用于早产儿血流动力学显著性动脉导管未闭(hsPDA)的药理学封闭。最近的研究表明,扑热息痛(PCM)也可以使用,但还需要更多的研究来确定其有效性和安全性。目的:目的是比较PCM和IBU治疗早产儿hsPDA的疗效和安全性。方法:一项观察性研究是在伦理许可和家长同意的情况下设计的。通过临床和二维超声检查评估患者是否患有hsPDA。按照纳入和排除标准,连续100例患者被分配到PCM和IBU之间,并给予3天疗程。在超声心动图和临床评估后,如果需要,给予相同药物的第二个疗程。结局指标为导管闭合率、药物安全性和不良事件。结果:PCM组闭合率为76.25%,IBU组闭合率为75%。IBU在第一个疗程的愈合率明显更高(45% vs. 16.25%)。PCM和IBU的平均封闭时间分别为4.54天和4天。在低出生体重组和血小板计数低于正常的组中,PCM的闭合率更高。在安全性方面,两组之间也没有观察到显著差异。结论:PCM可作为早产儿hsPDA的一线治疗方案,对于合并症和血小板计数低的患者是较好的选择。
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引用次数: 0
How well are we prescribing medications to our children? 我们给孩子开的药有多好?
Pub Date : 2023-04-04 DOI: 10.32677/ijch.v10i4.3892
Manu Rajeev, V. Bhaskar
Introduction: Prescription errors are common and every step in the process of writing a prescription has the potential for error. These errors can be broadly attributed to the lack of knowledge or lack of skill. Poor legibility, inaccuracy in writing, incomplete prescriptions, omissions, and use of abbreviations are the most common type of errors.Objectives: The primary objective of our study was to assess the completeness and legibility of the prescriptions. This is to estimate the rates of skill-based errors. Secondary objective of this study was to assess the appropriateness of the prescriptions using the pediatrics: Omission of Prescriptions and Inappropriate prescriptions (POPI) tool.Methods: This was a cross-sectional study, conducted in the pediatric outpatient department of a tertiary teaching hospital in New Delhi, India. Prescriptions received by outpatients attending both the general and special pediatric clinics were collected and evaluated using the World Health Organization Guide to Good Prescribing and the Medical Council of India guidelines.Results: A total of 343 prescriptions were assessed, in which 753 drugs were prescribed. A total of 1709 errors were uncovered pertaining to the completeness of the prescription. A majority of the prescriptions were written by postgraduates trainees (206), followed by senior residents (61), consultants (42), and junior residents (20). Abbreviations were used while mentioning the drug names in 53.64% prescriptions. The mean legibility score of all prescriptions was 3.35. Forty (11.66%) prescriptions were found inappropriate as per the International POPI tool.Conclusion: The legibility and completeness are largely overlooked yet crucial to the “Art of Prescription Writing.” They deserve as much awareness and education as the appropriateness of the drugs prescribed. The international POPI tool is a promising tool to analyze the appropriateness of pediatric prescriptions.
处方错误是常见的,在写处方的过程中的每一步都有可能出错。这些错误可以广泛地归结为缺乏知识或缺乏技能。易读性差、书写不准确、处方不完整、遗漏和使用缩写是最常见的错误类型。目的:本研究的主要目的是评估处方的完整性和易读性。这是为了估计基于技能的错误率。本研究的次要目的是使用儿科:处方遗漏和不适当处方(POPI)工具评估处方的适宜性。方法:这是一项横断面研究,在印度新德里一家三级教学医院的儿科门诊部进行。根据世界卫生组织《良好处方指南》和印度医学委员会的准则,收集和评估了在普通和特殊儿科诊所就诊的门诊病人收到的处方。结果:共评估处方343张,其中开药753种。总共发现了1709个与处方完整性有关的错误。处方以研究生实习生(206张)居多,其次为老年住院医师(61张)、咨询医师(42张)和初级住院医师(20张)。53.64%的处方在提及药品名称时使用缩略语。所有处方的平均易读评分为3.35分。根据国际POPI工具,发现40张(11.66%)处方不合适。结论:易读性和完整性在很大程度上被忽视,但对“处方写作艺术”至关重要。他们应该像处方药物的适当性一样得到更多的认识和教育。国际POPI工具是一种很有前途的工具来分析儿科处方的适当性。
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引用次数: 0
A rare case report of ambiguous genitalia 阴部模糊的罕见病例报告
Pub Date : 2023-04-04 DOI: 10.32677/ijch.v10i4.3953
Dr Chirag L U, Lohit Kumbar, C. Selvan, Manjunath Pr
An ambiguous genitalia is a commonly referred clinical scenario to endocrinology outpatient department. Accurate diagnosis is paramount to prevent associated salt-wasting crisis, direct the gender of rearing in the short-term, and monitoring for the development of malignancy in the gonads in the long-term. 17 beta-hydroxysteroid dehydrogenase 3 deficiency (17 β HSD 3) is one of the causes of defective testosterone biosynthesis. 17β-HSD3 deficiency should be suspected in children with female external genitalia with inguinal hernias or mild clitoromegaly; as well as males with ambiguous genitalia who develop virilization and gynecomastia at puberty. A hormonal evaluation may not always be diagnostic which makes genetic confirmation essential.
一个模糊的生殖器是一个常见的参考临床情景内分泌门诊。准确的诊断对于预防相关的盐耗危机,短期内指导饲养性别,长期监测性腺恶性肿瘤的发展至关重要。17 β -羟基类固醇脱氢酶3缺乏症(17 β HSD 3)是导致睾酮生物合成缺陷的原因之一。女性外生殖器伴腹股沟疝或轻度阴蒂肿大的患儿应怀疑17β-HSD3缺乏;以及在青春期出现男性化和男性乳房发育的生殖器模糊的男性。激素评估可能并不总是诊断,这使得基因确认必不可少。
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引用次数: 0
Study of serum ferritin levels in various phases of dengue in pediatric dengue patients admitted in a tertiary hospital 某三级医院收治的小儿登革热患者登革热各阶段血清铁蛋白水平的研究
Pub Date : 2023-04-01 DOI: 10.32677/ijch.v10i4.3900
Meghana N, Pradeep N
Background: Dengue is a cause of public health concern with case fatality rate of 1%. Ferritin is an acute-phase reactant which is produced in response to infection and inflammation. The aim of this study is to evaluate serum ferritin levels in various phases of dengue in pediatric dengue patients.Methods: A hospital-based, prospective, and observational study was done involving 30 dengue cases diagnosed by positive NS1 antigen or dengue specific serology (capture enzyme-linked immunosorbent assay). Serum ferritin was estimated by electrochemiluminescence in all three phases of dengue. Clinical and platelet count monitoring was done daily; respectively. All children classified as dengue with or without warning signs and severe dengue according to the World Health Organization guidelines on diagnosis treatment, prevention, and control of dengue, 2009.Results: Out of total of 30 children with mean age of the children were 7 years, and 61% were male who were majority. High serum ferritin levels were noted during critical phase. Eight children with dengue shock syndrome and one with acute respiratory distress syndrome were managed in intensive care unit as compared to non-severe dengue with statistically significant difference as p<0.05. Increase in serum ferritin is associated with severe thrombocytopenia. The mean hospital stay duration was found to be 5±3 days (mean±standard deviation).Conclusion: Serum ferritin levels taken on admission can serve as a reliable and cost-effective biomarker in the assessment and in predicting the severity of dengue fever. Serum ferritin levels may help in identifying an uncomplicated dengue illness, from that of patients who may require inpatient admission/intensive critical care.
背景:登革热是引起公共卫生关注的一种疾病,病死率为1%。铁蛋白是一种急性期反应物,是在感染和炎症反应中产生的。本研究的目的是评估小儿登革热患者不同阶段的血清铁蛋白水平。方法:一项以医院为基础的前瞻性观察性研究,涉及30例通过NS1抗原阳性或登革热特异性血清学(捕获酶联免疫吸附测定)诊断的登革热病例。用电化学发光法测定登革热三期患者血清铁蛋白。每日监测临床及血小板计数;分别。根据世界卫生组织2009年关于登革热诊断、治疗、预防和控制的指南,所有儿童均被归类为有或无警告迹象的登革热和严重登革热。结果:30例患儿中,平均年龄7岁,男性占61%,占多数。危急期血清铁蛋白水平升高。重症监护室治疗登革休克综合征患儿8例,急性呼吸窘迫综合征患儿1例,与非重症登革患儿比较,p<0.05,差异有统计学意义。血清铁蛋白升高与严重的血小板减少症有关。平均住院时间为5±3天(平均值±标准差)。结论:入院时血清铁蛋白水平可作为评估和预测登革热严重程度的可靠和经济的生物标志物。血清铁蛋白水平可能有助于从可能需要住院/重症监护的患者中识别无并发症的登革热疾病。
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引用次数: 1
Changes in biochemical profiles of children with severe acute malnutrition on admission and after nutritional rehabilitation 严重急性营养不良患儿入院时及营养康复后生化特征的变化
Pub Date : 2023-04-01 DOI: 10.32677/ijch.v10i4.3828
Mithu Barman, Jolly Rabha, S. Rohman
Purpose: The given study was done to find out the changes in biochemical profiles before and after nutritional rehabilitation of the children admitted at the Department of Paediatrics, Assam Medical College with severe acute malnutrition (SAM).Materials and Methods: A hospital based observational study was conducted from May 2020 to April 2021 with 55 consecutive cases of SAM. Vitros System 5600 was used for analysis of 13 biochemical parameters.Results: The mean values of serum sodium, potassium, and chloride at admission were 134.59±19.37 mEq/L, 4.22±0.80 mEq/L, and 101.12±16.36 mEq/L and that after rehabilitation were 136.66±19.95 mEq/L, 4.42±0.68 mEq/L, and 103.97±4.83 mEq/L. While that for magnesium, calcium, and phosphorous on admission were 2.11±0.38 mg/dL, 8.70±1.00 mg/dL, and 4.33±1.23 mg/dL and that after rehabilitation were 2.10±0.29 mg/dL, 9.45±0.65 mg/dL, and 4.76±0.84 mg/dL, respectively. The mean values of serum total protein, albumin, globulin, and A: G on admission were 6.53±1.44 g/dL, 3.30±0.88 g/dL, 3.23±0.87 g/dL, and 1.06±0.33, respectively, and that after rehabilitation were 6.84±0.98 g/dL, 3.86±0.57 g/dL, 2.98±0.69 g/dL, and 1.34±0.28, respectively. The mean of urea and creatinine on admission were found to be 26.25±19.30 mg/dL and 0.34±0.24 mg/dL, respectively, and that after rehabilitation were 23.91±11.76 mg/dL and 0.31±0.15 mg/dL respectively. Random blood sugar (RBS) on admission was 85.20±17.88 mg/dL and that after rehabilitation was 94.18±14.82 mg/dL. After rehabilitation, the mean value of calcium, phosphorous, albumin, A: G, and RBS were significantly raised. The minimum duration required for rehabilitation was 12 days with prevalence being maximum among the Tea-tribes (80.00%).Conclusion: The biochemical derangements in a patient with SAM are associated with significant morbidity and get improved after nutritional rehabilitation.
目的:本研究旨在了解阿萨姆邦医学院儿科收治的患有严重急性营养不良(SAM)的儿童在营养康复前后的生化特征变化。材料与方法:2020年5月至2021年4月,在医院进行了一项观察性研究,连续55例SAM。采用Vitros System 5600对13项生化指标进行分析。结果:入院时血清钠、钾、氯均值分别为134.59±19.37 mEq/L、4.22±0.80 mEq/L、101.12±16.36 mEq/L,康复后分别为136.66±19.95 mEq/L、4.42±0.68 mEq/L、103.97±4.83 mEq/L。入院时镁、钙、磷含量分别为2.11±0.38 mg/dL、8.70±1.00 mg/dL、4.33±1.23 mg/dL,康复后分别为2.10±0.29 mg/dL、9.45±0.65 mg/dL、4.76±0.84 mg/dL。入院时血清总蛋白、白蛋白、球蛋白、A: G均值分别为6.53±1.44 G /dL、3.30±0.88 G /dL、3.23±0.87 G /dL、1.06±0.33;康复后血清总蛋白、白蛋白、球蛋白、A: G均值分别为6.84±0.98 G /dL、3.86±0.57 G /dL、2.98±0.69 G /dL、1.34±0.28。入院时尿素和肌酐平均值分别为26.25±19.30 mg/dL和0.34±0.24 mg/dL,康复后尿素和肌酐平均值分别为23.91±11.76 mg/dL和0.31±0.15 mg/dL。入院时随机血糖(RBS)为85.20±17.88 mg/dL,康复后为94.18±14.82 mg/dL。康复后,钙、磷、白蛋白、A: G、RBS均值均显著升高。康复所需的最短时间为12天,茶部落的患病率最高(80.00%)。结论:急性脑脊髓炎患者的生化紊乱与发病率显著相关,经营养康复后得到改善。
{"title":"Changes in biochemical profiles of children with severe acute malnutrition on admission and after nutritional rehabilitation","authors":"Mithu Barman, Jolly Rabha, S. Rohman","doi":"10.32677/ijch.v10i4.3828","DOIUrl":"https://doi.org/10.32677/ijch.v10i4.3828","url":null,"abstract":"Purpose: The given study was done to find out the changes in biochemical profiles before and after nutritional rehabilitation of the children admitted at the Department of Paediatrics, Assam Medical College with severe acute malnutrition (SAM).\u0000Materials and Methods: A hospital based observational study was conducted from May 2020 to April 2021 with 55 consecutive cases of SAM. Vitros System 5600 was used for analysis of 13 biochemical parameters.\u0000Results: The mean values of serum sodium, potassium, and chloride at admission were 134.59±19.37 mEq/L, 4.22±0.80 mEq/L, and 101.12±16.36 mEq/L and that after rehabilitation were 136.66±19.95 mEq/L, 4.42±0.68 mEq/L, and 103.97±4.83 mEq/L. While that for magnesium, calcium, and phosphorous on admission were 2.11±0.38 mg/dL, 8.70±1.00 mg/dL, and 4.33±1.23 mg/dL and that after rehabilitation were 2.10±0.29 mg/dL, 9.45±0.65 mg/dL, and 4.76±0.84 mg/dL, respectively. The mean values of serum total protein, albumin, globulin, and A: G on admission were 6.53±1.44 g/dL, 3.30±0.88 g/dL, 3.23±0.87 g/dL, and 1.06±0.33, respectively, and that after rehabilitation were 6.84±0.98 g/dL, 3.86±0.57 g/dL, 2.98±0.69 g/dL, and 1.34±0.28, respectively. The mean of urea and creatinine on admission were found to be 26.25±19.30 mg/dL and 0.34±0.24 mg/dL, respectively, and that after rehabilitation were 23.91±11.76 mg/dL and 0.31±0.15 mg/dL respectively. Random blood sugar (RBS) on admission was 85.20±17.88 mg/dL and that after rehabilitation was 94.18±14.82 mg/dL. After rehabilitation, the mean value of calcium, phosphorous, albumin, A: G, and RBS were significantly raised. The minimum duration required for rehabilitation was 12 days with prevalence being maximum among the Tea-tribes (80.00%).\u0000Conclusion: The biochemical derangements in a patient with SAM are associated with significant morbidity and get improved after nutritional rehabilitation.","PeriodicalId":22476,"journal":{"name":"The Indian journal of child health","volume":"142 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89008923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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The Indian journal of child health
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