Inflammatory bowel disease (IBD) is a chronic intestinal disease with no permanent cure.Holarrhena antidysenterica which has proven antinflammatory property can be tried in case of IBD.Therefore; a study was conducted to evaluate the efficacy of holarrhena antidysenterica in dextran sulphate sodium induced colitis in albino rats. 48 albino rats were randomized to four different groups (n=12).Control Group A was administered no drug, Group B sulphasalazine and prednisolone, Group C holarrhena antidysenterica, Group D sulphasalazine, prednisolone and holarrhena antidysenterica. Colitis was induced with the help of dextran sulphate sodium dissolved in drinking water of rats. All the rats were sacrificed at the end of the experiment and various parameters were assessed. The results showed that the mean large intestinal macroscopic and microscopic examination scores as well as myeloperoxidase levels were comparatively higher in Group A as compared to Group B, C & D.This confirmed the induction of experimental colitis. No statistically significant difference was noted when mean scores and levels in the Group B, C & D were compared in between the groups. But when the same scores and levels in Group B, C & D were compared with Group A indivually statistically significant values were obtained. This study concluded that holarrhena antidysenterica induced remission in acute experimental colitis in albino rats. Therefore, it is recommended that a further clinical study be carried out.
{"title":"A study to evaluate the efficacy of holarrhena antidysenterica in acute experimental colitis in albino rats","authors":"A. Hasamnis, S. Sinha, P.S.Worlikar","doi":"10.5580/24c5","DOIUrl":"https://doi.org/10.5580/24c5","url":null,"abstract":"Inflammatory bowel disease (IBD) is a chronic intestinal disease with no permanent cure.Holarrhena antidysenterica which has proven antinflammatory property can be tried in case of IBD.Therefore; a study was conducted to evaluate the efficacy of holarrhena antidysenterica in dextran sulphate sodium induced colitis in albino rats. 48 albino rats were randomized to four different groups (n=12).Control Group A was administered no drug, Group B sulphasalazine and prednisolone, Group C holarrhena antidysenterica, Group D sulphasalazine, prednisolone and holarrhena antidysenterica. Colitis was induced with the help of dextran sulphate sodium dissolved in drinking water of rats. All the rats were sacrificed at the end of the experiment and various parameters were assessed. The results showed that the mean large intestinal macroscopic and microscopic examination scores as well as myeloperoxidase levels were comparatively higher in Group A as compared to Group B, C & D.This confirmed the induction of experimental colitis. No statistically significant difference was noted when mean scores and levels in the Group B, C & D were compared in between the groups. But when the same scores and levels in Group B, C & D were compared with Group A indivually statistically significant values were obtained. This study concluded that holarrhena antidysenterica induced remission in acute experimental colitis in albino rats. Therefore, it is recommended that a further clinical study be carried out.","PeriodicalId":22523,"journal":{"name":"The Internet Journal of Pharmacology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90647542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The present study investigates the effect of combination of the antidepressant venlafaxine (serotonin/noradrenaline reuptake inhibitor, SNRI) with the angiotensin converting enzyme inhibitor perindopril on the immobility time in the forced swimming test (FST) as well as on systolic blood pressure (SBP) in uninephroctemized DOCA salt-treated rats as a model of experimental hypertension. The FST is a behavioral test used to predict the efficacy of antidepressant treatments. It has a good predictive value for antidepressant potency in humans . This is to try to provide an experimental study about the benefit of the use of perindopril as a better antihypertensive in hypertensive patients with co-morbidity like depression or anxiety.Albino rats were divided into 4 groups; Group 1 (control) uninephrectomized without DOCA injection; Group 2 was uninephrectomized and received DOCA without any treatment. Group 3 were uninephrectomized and received DOCA then venlafaxine only in a dose of 8 mg/kg i. p. 30 min. before FST; Group 4 was uninephrectomized and received DOCA then the interacting drugs before FST. SBP measurements were conducted in all groups over a period of 8 hours post-injection at 30 min. intervals. Results revealed that perindopril potentiates the anti-immobility effect of venlafaxine. Additionally, venlafaxine did not affect the anti-hypertensive effect of perindopril. Venlafaxine did not change the SBP of non-hypertensive albino rats as showed in a pilot study.These results could provide a support for the effective use of venlafaxine in association with perindopril in hypertension and depression co-morbidity.
{"title":"Effect Of Co-Administration Of Venlafaxine And Perindopril To Uninephrectomized DOCA-Salt-Treated Albino Rats.","authors":"S. Kamal","doi":"10.5580/50c","DOIUrl":"https://doi.org/10.5580/50c","url":null,"abstract":"The present study investigates the effect of combination of the antidepressant venlafaxine (serotonin/noradrenaline reuptake inhibitor, SNRI) with the angiotensin converting enzyme inhibitor perindopril on the immobility time in the forced swimming test (FST) as well as on systolic blood pressure (SBP) in uninephroctemized DOCA salt-treated rats as a model of experimental hypertension. The FST is a behavioral test used to predict the efficacy of antidepressant treatments. It has a good predictive value for antidepressant potency in humans . This is to try to provide an experimental study about the benefit of the use of perindopril as a better antihypertensive in hypertensive patients with co-morbidity like depression or anxiety.Albino rats were divided into 4 groups; Group 1 (control) uninephrectomized without DOCA injection; Group 2 was uninephrectomized and received DOCA without any treatment. Group 3 were uninephrectomized and received DOCA then venlafaxine only in a dose of 8 mg/kg i. p. 30 min. before FST; Group 4 was uninephrectomized and received DOCA then the interacting drugs before FST. SBP measurements were conducted in all groups over a period of 8 hours post-injection at 30 min. intervals. Results revealed that perindopril potentiates the anti-immobility effect of venlafaxine. Additionally, venlafaxine did not affect the anti-hypertensive effect of perindopril. Venlafaxine did not change the SBP of non-hypertensive albino rats as showed in a pilot study.These results could provide a support for the effective use of venlafaxine in association with perindopril in hypertension and depression co-morbidity.","PeriodicalId":22523,"journal":{"name":"The Internet Journal of Pharmacology","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86352400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Genetically modified mouse models have emerged as an excellent approach to provide insight into gene regulation, development, pathogenesis, and the treatment of disease.Transgenic models are the biological tools that aid target discovery, validation, and production of therapeutic proteins. Despite several theoretical and technical challenges in generation of knockout models, transgenic technology holds great potential in many fields including medicine, industry. This short review covers briefly the methods used to produce transgenic mice and the importance of these genetically modified animals in biomedical research.
{"title":"Genetically manipulated mice models as research tool","authors":"D. Chopra, H. Rehan","doi":"10.5580/2891","DOIUrl":"https://doi.org/10.5580/2891","url":null,"abstract":"Genetically modified mouse models have emerged as an excellent approach to provide insight into gene regulation, development, pathogenesis, and the treatment of disease.Transgenic models are the biological tools that aid target discovery, validation, and production of therapeutic proteins. Despite several theoretical and technical challenges in generation of knockout models, transgenic technology holds great potential in many fields including medicine, industry. This short review covers briefly the methods used to produce transgenic mice and the importance of these genetically modified animals in biomedical research.","PeriodicalId":22523,"journal":{"name":"The Internet Journal of Pharmacology","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89305165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Vyawahare, R. Pujari, Ajay Khsirsagar, D. Ingawale, M. Patil, V. Kagathara
Phoenix dactylifera L (Date palm) belonging to family Arecaceae, called ‘Nakhla’ and the ‘Tree of Life’ by the Arabs, is considered as one of the oldest cultivated fruit trees. It is believed to be indigenous to the countries around the Arabian Gulf. Many Middle Easterners believe that consumption of date fruits, particularly in the morning on an empty stomach, can reverse the actions of any toxic material that the subject may have been exposed to. Different parts of this plant are traditionally claimed to be used for the treatment of a broad spectrum of ailments including memory disturbances, fever, loss of consciousness and nervous disorders. There has been a tremendous interest in this plant as evidenced by the voluminous work in last few decades. Therefore, we aimed to compile an up to date and comprehensive review of Phoenix dactylifera that covers its traditional and folk medicine uses, phytochemistry and pharmacology including various preclinical and clinical studies.
{"title":"Phoenix dactylifera: An update of its indegenous uses,phytochemistry and pharmacology","authors":"N. Vyawahare, R. Pujari, Ajay Khsirsagar, D. Ingawale, M. Patil, V. Kagathara","doi":"10.5580/164b","DOIUrl":"https://doi.org/10.5580/164b","url":null,"abstract":"Phoenix dactylifera L (Date palm) belonging to family Arecaceae, called ‘Nakhla’ and the ‘Tree of Life’ by the Arabs, is considered as one of the oldest cultivated fruit trees. It is believed to be indigenous to the countries around the Arabian Gulf. Many Middle Easterners believe that consumption of date fruits, particularly in the morning on an empty stomach, can reverse the actions of any toxic material that the subject may have been exposed to. Different parts of this plant are traditionally claimed to be used for the treatment of a broad spectrum of ailments including memory disturbances, fever, loss of consciousness and nervous disorders. There has been a tremendous interest in this plant as evidenced by the voluminous work in last few decades. Therefore, we aimed to compile an up to date and comprehensive review of Phoenix dactylifera that covers its traditional and folk medicine uses, phytochemistry and pharmacology including various preclinical and clinical studies.","PeriodicalId":22523,"journal":{"name":"The Internet Journal of Pharmacology","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75164134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chronic hepatitis C is caused by flavi virus (RNA virus) and is the leading cause for cirrhosis, hepatocellular carcinoma and liver transplantation. The standard therapy of chronic hepatitis C is peg interferon α weekly plus oral-ribavirin daily is not effective in all patients and is limited by adverse effect. Therefore new investigational drugs are being developed and in pipeline. This article focuses on new investigational drugs that are presently in an advance stage of development also focuses on newer interferons, ribavirin analogue and anti apoptotic drug.
{"title":"The Present And Emerging Investigational Drugs For Chronic Hepatitis C: Current Status","authors":"R. Kumar","doi":"10.5580/1a5e","DOIUrl":"https://doi.org/10.5580/1a5e","url":null,"abstract":"Chronic hepatitis C is caused by flavi virus (RNA virus) and is the leading cause for cirrhosis, hepatocellular carcinoma and liver transplantation. The standard therapy of chronic hepatitis C is peg interferon α weekly plus oral-ribavirin daily is not effective in all patients and is limited by adverse effect. Therefore new investigational drugs are being developed and in pipeline. This article focuses on new investigational drugs that are presently in an advance stage of development also focuses on newer interferons, ribavirin analogue and anti apoptotic drug.","PeriodicalId":22523,"journal":{"name":"The Internet Journal of Pharmacology","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75317164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The effects of the methanol extract (crude) and aqueous fraction of Anthocleista djalonensis on acute inflammation were examined. Oral administration of the methanol extract showed acute anti-inflammatory activity against Carrageenan induced paw edema in rats although not too significantly different (P>0.05) from the control at 250 mg/kg and 500 mg/kg. The aqueous fraction of the methanol extract significantly inhibited (P < 0.05) carrageenan induced paw edema in rats at 500 mg/kg. Significant activity against Dextran induced paw edema in rats was exhibited by both methanol extract (P< 0.01) and aqueous fractions (P< 0.05) when administered orally at 250 mg/kg and 500 mg/kg. The dry powdered leaf was found to contain alkaloids, glycosides, saponins and tannins. It is revealed from the screening model used that the methanol extract and aqueous fraction of this plant possesses acute anti-inflammatory activity.
{"title":"Anti-inflammatory evaluation of methanol extract and aqueous fraction of the leaves of Anthocleista djalonensis A. Chev (Gentianaceae).","authors":"L. Okunrobo, C. Usifoh, P. Ching, M. Bariweni","doi":"10.5580/15bd","DOIUrl":"https://doi.org/10.5580/15bd","url":null,"abstract":"The effects of the methanol extract (crude) and aqueous fraction of Anthocleista djalonensis on acute inflammation were examined. Oral administration of the methanol extract showed acute anti-inflammatory activity against Carrageenan induced paw edema in rats although not too significantly different (P>0.05) from the control at 250 mg/kg and 500 mg/kg. The aqueous fraction of the methanol extract significantly inhibited (P < 0.05) carrageenan induced paw edema in rats at 500 mg/kg. Significant activity against Dextran induced paw edema in rats was exhibited by both methanol extract (P< 0.01) and aqueous fractions (P< 0.05) when administered orally at 250 mg/kg and 500 mg/kg. The dry powdered leaf was found to contain alkaloids, glycosides, saponins and tannins. It is revealed from the screening model used that the methanol extract and aqueous fraction of this plant possesses acute anti-inflammatory activity.","PeriodicalId":22523,"journal":{"name":"The Internet Journal of Pharmacology","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72887533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Effective antiretroviral therapy is required on a long-term basis to maintain viral suppression and reduce disease progression in HIV infections. An attempt has been made to implement the principles of novel drug delivery to antiretrovirals in order to overcome the drawbacks of existing therapy. Liposomal gels of lamivudine and stavudine respectively were developed for the transdermal drug delivery. The irritation potential of drug loaded and blank formulations was investigated on shaved rabbit skin, in vivo, and compared to that of 5% sodium lauryl sulphate (SLS) solution (a known irritant) as the positive control and untreated portion of the skin as a negative control. Skin irritation was assessed by visual observations and histological evaluations. We found that the drug loaded and blank liposomal gels caused no significant epidermal irritation and erythema. Thus we conclude that these liposomal gels may be used safely as transdermal drug delivery vehicles for the selected antiretrovirals.
{"title":"In-Vivo Investigation of the Irritation potential of Lamivudine and Stavudine liposomal gels in rabbits","authors":"R. Pai, D. Kusum, D. Kshama, S. Fattepur","doi":"10.5580/2968","DOIUrl":"https://doi.org/10.5580/2968","url":null,"abstract":"Effective antiretroviral therapy is required on a long-term basis to maintain viral suppression and reduce disease progression in HIV infections. An attempt has been made to implement the principles of novel drug delivery to antiretrovirals in order to overcome the drawbacks of existing therapy. Liposomal gels of lamivudine and stavudine respectively were developed for the transdermal drug delivery. The irritation potential of drug loaded and blank formulations was investigated on shaved rabbit skin, in vivo, and compared to that of 5% sodium lauryl sulphate (SLS) solution (a known irritant) as the positive control and untreated portion of the skin as a negative control. Skin irritation was assessed by visual observations and histological evaluations. We found that the drug loaded and blank liposomal gels caused no significant epidermal irritation and erythema. Thus we conclude that these liposomal gels may be used safely as transdermal drug delivery vehicles for the selected antiretrovirals.","PeriodicalId":22523,"journal":{"name":"The Internet Journal of Pharmacology","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76088808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Adefolaju, A. Caxton-Martins, B. Enaibe, O. T. Alabi, M. Ajao
Alkaline and Acid Phosphatase (ALP and ACP) activities were compared in the small intestine of the rat (Rattus norvegicus), bat (Eidolon helvum), and pangolin (Manis tricuspis) to observe possible modifications of their small intestine to different diets. Ten animals each of both sexes were used. Portions of their small intestine were homogenized and assayed spectrophotometrically for the activities of ALP, and ACP. ALP and ACP activities were significantly (at 95% confidence interval (p<0.05) and consistently higher in the bat than in the rat and pangolin. High ALP activities in the bat explain why chyle transit time in the bat gut is short because ALP facilitates transport across intestinal mucosa. A higher ACP activity in the bat is because they help to “mop up” the phosphate ions produced as a result of ATP hydrolysis. It can be concluded that the small intestine of the rat, bat and pangolin, utilizes the phosphatases to different degrees.
{"title":"Acid and Alkaline Phosphatase activities in the small intestine of the Rat (Rattus norvegicus), Bat (Eidolon helvum) and Pangolin (Manis tricuspis)","authors":"G. Adefolaju, A. Caxton-Martins, B. Enaibe, O. T. Alabi, M. Ajao","doi":"10.5580/18b5","DOIUrl":"https://doi.org/10.5580/18b5","url":null,"abstract":"Alkaline and Acid Phosphatase (ALP and ACP) activities were compared in the small intestine of the rat (Rattus norvegicus), bat (Eidolon helvum), and pangolin (Manis tricuspis) to observe possible modifications of their small intestine to different diets. Ten animals each of both sexes were used. Portions of their small intestine were homogenized and assayed spectrophotometrically for the activities of ALP, and ACP. ALP and ACP activities were significantly (at 95% confidence interval (p<0.05) and consistently higher in the bat than in the rat and pangolin. High ALP activities in the bat explain why chyle transit time in the bat gut is short because ALP facilitates transport across intestinal mucosa. A higher ACP activity in the bat is because they help to “mop up” the phosphate ions produced as a result of ATP hydrolysis. It can be concluded that the small intestine of the rat, bat and pangolin, utilizes the phosphatases to different degrees.","PeriodicalId":22523,"journal":{"name":"The Internet Journal of Pharmacology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75618496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Plants have been one of the important sources of medicines since the beginning of human civilization. There is a growing demand for plant based medicines , health products, pharmaceuticals , food supplements, cosmetics etc.there is no evidence regarding the antimicrobial studies in petroleum ether, chloroform ,alcohol extracts and acetone extracts studied together and even the isolated compounds of Murraya koeniggii compared with the synthetic carbazole alkaloids . A review of chemical constituents present in stem bark of Murraya koenigii and their search for antimicrobial activity is given in the present article .Anti-bacterial activity and antifungal activity of Murraya koenigii were studied against Staphylococcus aureus and Candida albicans respectively. The maximum inhibitory zone of inhibition of coumarin was against (22mm) Bacillus substillus and Candida albicans (21 mm).
{"title":"Phytochemistry And Antimicrobial Screening Of Stem Bark Of Murraya Koenigii(Linn) Spreng","authors":"S. Zachariah, P. Muthumani, K. V. Ramaseshu","doi":"10.5580/12c2","DOIUrl":"https://doi.org/10.5580/12c2","url":null,"abstract":"Plants have been one of the important sources of medicines since the beginning of human civilization. There is a growing demand for plant based medicines , health products, pharmaceuticals , food supplements, cosmetics etc.there is no evidence regarding the antimicrobial studies in petroleum ether, chloroform ,alcohol extracts and acetone extracts studied together and even the isolated compounds of Murraya koeniggii compared with the synthetic carbazole alkaloids . A review of chemical constituents present in stem bark of Murraya koenigii and their search for antimicrobial activity is given in the present article .Anti-bacterial activity and antifungal activity of Murraya koenigii were studied against Staphylococcus aureus and Candida albicans respectively. The maximum inhibitory zone of inhibition of coumarin was against (22mm) Bacillus substillus and Candida albicans (21 mm).","PeriodicalId":22523,"journal":{"name":"The Internet Journal of Pharmacology","volume":"39 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82832722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Sharma, T. Katyal, G. Grewal, D. Behera, R. D. Budhiraja
A study was undertaken to evaluate the effect of antioxidants such as β-carotene, vitamin C and vitamin E on oxidative stress, thermal hyperalgesia and cold allodynia in streptozotocin induced diabetic rats. The hyperalgesia and allodynia was assessed by estimating tail withdrawal latency in warm and cold water immersion method. Furthermore, serum TBARS and plasma GSH levels were estimated to assess the oxidative stress. Treatment with β-carotene (10 mg/kg/day i.p.), vitamin C (10 mg/kg/day i.p.) and vitamin E (40 mg/kg/day i.p.) showed significant ameliorative effects on thermal hyperalgesia and cold allodynia in streptozotocin induced diabetic rats. Moreover, treatment with β-carotene markedly prevented thermal hyperalgesia and cold allodynia in streptozotocin induced diabetic rats. ADDRESS OF RESEARCH WORK Department of Pharmacology, I.S.F. College of Pharmacy, Moga, Punjab-142 001, India
{"title":"Effect of antioxidants such as β-carotene, vitamin C and vitamin E on oxidative stress, thermal hyperalgesia and cold allodynia in streptozotocin induced diabetic rats","authors":"M. Sharma, T. Katyal, G. Grewal, D. Behera, R. D. Budhiraja","doi":"10.5580/343","DOIUrl":"https://doi.org/10.5580/343","url":null,"abstract":"A study was undertaken to evaluate the effect of antioxidants such as β-carotene, vitamin C and vitamin E on oxidative stress, thermal hyperalgesia and cold allodynia in streptozotocin induced diabetic rats. The hyperalgesia and allodynia was assessed by estimating tail withdrawal latency in warm and cold water immersion method. Furthermore, serum TBARS and plasma GSH levels were estimated to assess the oxidative stress. Treatment with β-carotene (10 mg/kg/day i.p.), vitamin C (10 mg/kg/day i.p.) and vitamin E (40 mg/kg/day i.p.) showed significant ameliorative effects on thermal hyperalgesia and cold allodynia in streptozotocin induced diabetic rats. Moreover, treatment with β-carotene markedly prevented thermal hyperalgesia and cold allodynia in streptozotocin induced diabetic rats. ADDRESS OF RESEARCH WORK Department of Pharmacology, I.S.F. College of Pharmacy, Moga, Punjab-142 001, India","PeriodicalId":22523,"journal":{"name":"The Internet Journal of Pharmacology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89896514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：