P. Shukla, D. Gupta, Pronati Gupta, S. Bisht, M. Pant, Seema Gupta, N. Husain, V. Joshi
Myxofibrosarcoma, is a myxoid variant of Malignant Fibrous Histiocytoma (MFH) first described by Weiss & Enzinger (1) with a better prognosis. MFH rarely occurs in the skull, with only 17 cases documented in literature (2). The tumor frequently erodes the outer table of the skull and spreads in the extracranial space. Intradural and brain invasion are very rare. We report a case of myxofibrosarcoma originating in the right fronto-temporal region with subsequent intracranial extension.
{"title":"Myxofibrosarcoma of Right Fronto-Temporal Region With Intracranial Extension: A case report","authors":"P. Shukla, D. Gupta, Pronati Gupta, S. Bisht, M. Pant, Seema Gupta, N. Husain, V. Joshi","doi":"10.5580/e5d","DOIUrl":"https://doi.org/10.5580/e5d","url":null,"abstract":"Myxofibrosarcoma, is a myxoid variant of Malignant Fibrous Histiocytoma (MFH) first described by Weiss & Enzinger (1) with a better prognosis. MFH rarely occurs in the skull, with only 17 cases documented in literature (2). The tumor frequently erodes the outer table of the skull and spreads in the extracranial space. Intradural and brain invasion are very rare. We report a case of myxofibrosarcoma originating in the right fronto-temporal region with subsequent intracranial extension.","PeriodicalId":22534,"journal":{"name":"The Internet Journal of Oncology","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86566131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Shukla, D. Gupta, Jitender Verma, S. Bisht, M. Pant, N. Husain, Deepti Mishra
We report the case of ovarian carcinoma with skin and umbilical metastasis in a thirty year old female. The CT scan abdomen showed right ovarian mass with anterior abdominal wall metastasis . The CT guided FNAC from the ovarian mass showed adenocarcinoma. FNAC from umbilical and skin metastasis also showed adenocarcinoma.Because of the unresectability of the mass, the patient was put on taxol based chemotherapy which she took for two cycles and then expired.
{"title":"Skin And Umbilical Metastasis In Carcinoma Ovary - A Rare Presentation","authors":"P. Shukla, D. Gupta, Jitender Verma, S. Bisht, M. Pant, N. Husain, Deepti Mishra","doi":"10.5580/607","DOIUrl":"https://doi.org/10.5580/607","url":null,"abstract":"We report the case of ovarian carcinoma with skin and umbilical metastasis in a thirty year old female. The CT scan abdomen showed right ovarian mass with anterior abdominal wall metastasis . The CT guided FNAC from the ovarian mass showed adenocarcinoma. FNAC from umbilical and skin metastasis also showed adenocarcinoma.Because of the unresectability of the mass, the patient was put on taxol based chemotherapy which she took for two cycles and then expired.","PeriodicalId":22534,"journal":{"name":"The Internet Journal of Oncology","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75007037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Arrangóiz, Susan Garand, C. Slomski, Travis A. Littman, J. Osuch
Background: We hypothesize that a hypocellullar FNA of a palpable breast mass provides diagnostic accuracy in the context of an otherwise negative triple diagnosis (TD).Methods: A database of 1279 patients with palpable lesions was retrospectively reviewed. Lesions <1.5cm in size, clinical breast exam (CBE) not suspicious for cancer, mammography results of BIRADS I and II, and hypocellular FNAB results were extracted from the database and correlated with final pathology on openbiopsy.Results: There were 276 patients with hypocellular results. Of those, 165 had mammograms of BIRADS I and II. After review of the clinical breast exam data, 83 patients met our study criteria. All were negative for malignancy on open biopsy - a false negative rate of 0% and negative predictive value of 100%.Conclusion: A hypocellular FNA, in the context of a benign CBE and breast imaging study is diagnostically accurate, eliminating the need for breast biopsy.
{"title":"What is the Diagnostic Accuracy of Hypocellular Fine Needle Aspiration of the Breast in the Context of an Otherwise Negative Triple Screen","authors":"R. Arrangóiz, Susan Garand, C. Slomski, Travis A. Littman, J. Osuch","doi":"10.5580/5eb","DOIUrl":"https://doi.org/10.5580/5eb","url":null,"abstract":"Background: We hypothesize that a hypocellullar FNA of a palpable breast mass provides diagnostic accuracy in the context of an otherwise negative triple diagnosis (TD).Methods: A database of 1279 patients with palpable lesions was retrospectively reviewed. Lesions <1.5cm in size, clinical breast exam (CBE) not suspicious for cancer, mammography results of BIRADS I and II, and hypocellular FNAB results were extracted from the database and correlated with final pathology on openbiopsy.Results: There were 276 patients with hypocellular results. Of those, 165 had mammograms of BIRADS I and II. After review of the clinical breast exam data, 83 patients met our study criteria. All were negative for malignancy on open biopsy - a false negative rate of 0% and negative predictive value of 100%.Conclusion: A hypocellular FNA, in the context of a benign CBE and breast imaging study is diagnostically accurate, eliminating the need for breast biopsy.","PeriodicalId":22534,"journal":{"name":"The Internet Journal of Oncology","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72552514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
One of the oldest molecular target approaches in breast cancer is the targeting of the estrogen receptor with tamoxifen which is responsible for improvement in outcome, reduced the risk of new primary breast cancer and improves survival. Targeted therapies are now a component of treatment for many including colorectal, lung, and pancreatic cancers, as well as lymphoma, leukemia, and multiple myeloma.Recent identification of specific molecular target in cancer cells, leads to development of new targeted therapeutic approach, signal transduction, angiogenesis, and more recent approaches are induction of apoptosis or inhibition of antiapoptosis which offer the possibility of improving outcome for patient with early as well as metastatic breast cancer. This review discusses target therapies for HER family, angiogenesis and signal transduction. Abbreviations: HER -human epidermal growth factor receptor, VEGFvascular growth factor receptor, TKItyrosine kinase inhibitor, EGFRepidermal growth factor receptor, mTOR mammalian target of rapamycin, PSTprimary systemic chemotherapy, ER – oestrogen receptor, CDKcyclin-dependent kinase,PI3K-phosphatidyl-inositol3kinase.
{"title":"Targeting Therapies in the Management of Breast Carcinoma","authors":"P. Kaur, A. Chauhan, Gajender Singh, S. Kataria","doi":"10.5580/745","DOIUrl":"https://doi.org/10.5580/745","url":null,"abstract":"One of the oldest molecular target approaches in breast cancer is the targeting of the estrogen receptor with tamoxifen which is responsible for improvement in outcome, reduced the risk of new primary breast cancer and improves survival. Targeted therapies are now a component of treatment for many including colorectal, lung, and pancreatic cancers, as well as lymphoma, leukemia, and multiple myeloma.Recent identification of specific molecular target in cancer cells, leads to development of new targeted therapeutic approach, signal transduction, angiogenesis, and more recent approaches are induction of apoptosis or inhibition of antiapoptosis which offer the possibility of improving outcome for patient with early as well as metastatic breast cancer. This review discusses target therapies for HER family, angiogenesis and signal transduction. Abbreviations: HER -human epidermal growth factor receptor, VEGFvascular growth factor receptor, TKItyrosine kinase inhibitor, EGFRepidermal growth factor receptor, mTOR mammalian target of rapamycin, PSTprimary systemic chemotherapy, ER – oestrogen receptor, CDKcyclin-dependent kinase,PI3K-phosphatidyl-inositol3kinase.","PeriodicalId":22534,"journal":{"name":"The Internet Journal of Oncology","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90204125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
U. Yetkin, Aykut Şahin, B. Ozcem, M. Bademci, I. Yurekli, A. Gürbüz
Radiation-induced heart disease is a well-known complication but rare entity.In this study we present our surgical approach to the high risk left main coronary artery stenosis in a case who received irradiation due to malignancies of two separate systems.Surgical revascularization of the coronary lesions has good long-term results.
{"title":"Our surgical approach to the high risk left main coronary artery stenosis in a case who received irradiation due to malignancies of two separate systems","authors":"U. Yetkin, Aykut Şahin, B. Ozcem, M. Bademci, I. Yurekli, A. Gürbüz","doi":"10.5580/1bb4","DOIUrl":"https://doi.org/10.5580/1bb4","url":null,"abstract":"Radiation-induced heart disease is a well-known complication but rare entity.In this study we present our surgical approach to the high risk left main coronary artery stenosis in a case who received irradiation due to malignancies of two separate systems.Surgical revascularization of the coronary lesions has good long-term results.","PeriodicalId":22534,"journal":{"name":"The Internet Journal of Oncology","volume":"65 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79394309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Das, V. Dassi, S. Swain, M. Andankar, H. Pathak
Fatty adrenal tumors are of rare occurrence and have been increasingly reported due to advanced imaging techniques. Although asymptomatic in majority of cases they should be excised to avoid complications like rupture or malignant transformation
{"title":"Large Adrenal Myelolipoma- an unusual occurrence","authors":"K. Das, V. Dassi, S. Swain, M. Andankar, H. Pathak","doi":"10.5580/e11","DOIUrl":"https://doi.org/10.5580/e11","url":null,"abstract":"Fatty adrenal tumors are of rare occurrence and have been increasingly reported due to advanced imaging techniques. Although asymptomatic in majority of cases they should be excised to avoid complications like rupture or malignant transformation","PeriodicalId":22534,"journal":{"name":"The Internet Journal of Oncology","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84658926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Primary osteogenic sarcoma of skull is a rare entity constituting 2% of all osteogenic sarcomas. These tumors develop most often in bones of the arms, legs, or pelvis. . It is rare during middle age, and is more common in males than females. We here present a rare case of skull bone osteogenic sarcoma. 19 year male presented with swelling left parietal region .Biopsy revealed osteogenic sarcoma. He underwent wide local excision and then received adjuvant chemotherapy,but had recurrence at same site. Patient was reoperated ,wide excision of temporoparietal bony mass and cranioplasty with methylacrylate was done.Post operatively he received adjuvant External beam Radiotherapy.
{"title":"Primary Osteogenic Sarcoma of Skull Bone-A rare clinical presentation","authors":"Sweety Gupta, S. Chitra, Dinesh Singh","doi":"10.5580/1955","DOIUrl":"https://doi.org/10.5580/1955","url":null,"abstract":"Primary osteogenic sarcoma of skull is a rare entity constituting 2% of all osteogenic sarcomas. These tumors develop most often in bones of the arms, legs, or pelvis. . It is rare during middle age, and is more common in males than females. We here present a rare case of skull bone osteogenic sarcoma. 19 year male presented with swelling left parietal region .Biopsy revealed osteogenic sarcoma. He underwent wide local excision and then received adjuvant chemotherapy,but had recurrence at same site. Patient was reoperated ,wide excision of temporoparietal bony mass and cranioplasty with methylacrylate was done.Post operatively he received adjuvant External beam Radiotherapy.","PeriodicalId":22534,"journal":{"name":"The Internet Journal of Oncology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87937054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Taj, Mehvish Muzaffar, R. Sheikh, R. Qadir, S. Ratnam
Malignancies are common after renal transplant because of immunosuppression. Renal cell carcinoma is common but occurs in the native kidney. Carcinoma in the transplant kidney is less common but has been reported with an average interval of 3 to 4 years after transplant. We report a case of renal cell carcinoma occurring in transplant kidney 11 years after renal transplant and it was treated with partial nephrectomy. The patient responded well to this conservative approach.
{"title":"Renal Cell Carcinoma in a kidney allograft 11 years after renal transplant","authors":"A. Taj, Mehvish Muzaffar, R. Sheikh, R. Qadir, S. Ratnam","doi":"10.5580/2522","DOIUrl":"https://doi.org/10.5580/2522","url":null,"abstract":"Malignancies are common after renal transplant because of immunosuppression. Renal cell carcinoma is common but occurs in the native kidney. Carcinoma in the transplant kidney is less common but has been reported with an average interval of 3 to 4 years after transplant. We report a case of renal cell carcinoma occurring in transplant kidney 11 years after renal transplant and it was treated with partial nephrectomy. The patient responded well to this conservative approach.","PeriodicalId":22534,"journal":{"name":"The Internet Journal of Oncology","volume":"353 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72869754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is a very rare malignancy (less than 5% of all cervical malignancies) that is highly aggressive and usually results in unfavorable outcomes1,2. These tumors have been classified into four categories: small cell, large cell, classic carcinoid, and atypical carcinoid. Most patients with early stage disease develop metastatic disease. Frequent metastatic sites include the central nervous system, lung, and bone3. Despite aggressive surgical therapy, even in early-stage patients, mortality is high. This propensity for rapid, local and distant spread in early-stage disease emphasizes the need for systemic treatment2. In some cases, the initial diagnosis may be confused with either poorly differentiated squamousor adeno-carcinomas3.
{"title":"Large Cell Neuroendocrine Cancer (LCNEC) of uterine cervix: A case study and review of literature","authors":"G. Baral, Reetu Sharma","doi":"10.5580/21ef","DOIUrl":"https://doi.org/10.5580/21ef","url":null,"abstract":"Large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is a very rare malignancy (less than 5% of all cervical malignancies) that is highly aggressive and usually results in unfavorable outcomes1,2. These tumors have been classified into four categories: small cell, large cell, classic carcinoid, and atypical carcinoid. Most patients with early stage disease develop metastatic disease. Frequent metastatic sites include the central nervous system, lung, and bone3. Despite aggressive surgical therapy, even in early-stage patients, mortality is high. This propensity for rapid, local and distant spread in early-stage disease emphasizes the need for systemic treatment2. In some cases, the initial diagnosis may be confused with either poorly differentiated squamousor adeno-carcinomas3.","PeriodicalId":22534,"journal":{"name":"The Internet Journal of Oncology","volume":"86 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80916668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
John D. Bibb, E. Fischer, Sang-Joon Lee, E. Libby, I. Rabinowitz
The role of Positron Emission Tomography (PET) in suspected non Hodgkin’s lymphoma (NHL) relapse is not well established. An illustrative case report of a patient with a positive PET scan and suspected recurrence is presented and analyzed using Bayes’ theorem. We find that the positive predictive value (PPV) of the PET scan significantly depends on the patient’s initial prognosis and time from diagnosis. The greater the elapsed time and the better the initial prognosis, the lower the PPV of a positive PET scan. We have developed a reference table to estimate the PPV of a positive PET scan for treated NHL patients with suspected relapse. From this analysis we strongly recommend repeating a biopsy in the vast majority of suspected relapsed NHL patients with a positive PET scan to confirm the diagnosis.
{"title":"The Utility of Bayes’ theorem in positron emission tomography positive suspected cases of relapsed non-Hodgkin’s lymphoma","authors":"John D. Bibb, E. Fischer, Sang-Joon Lee, E. Libby, I. Rabinowitz","doi":"10.5580/5f7","DOIUrl":"https://doi.org/10.5580/5f7","url":null,"abstract":"The role of Positron Emission Tomography (PET) in suspected non Hodgkin’s lymphoma (NHL) relapse is not well established. An illustrative case report of a patient with a positive PET scan and suspected recurrence is presented and analyzed using Bayes’ theorem. We find that the positive predictive value (PPV) of the PET scan significantly depends on the patient’s initial prognosis and time from diagnosis. The greater the elapsed time and the better the initial prognosis, the lower the PPV of a positive PET scan. We have developed a reference table to estimate the PPV of a positive PET scan for treated NHL patients with suspected relapse. From this analysis we strongly recommend repeating a biopsy in the vast majority of suspected relapsed NHL patients with a positive PET scan to confirm the diagnosis.","PeriodicalId":22534,"journal":{"name":"The Internet Journal of Oncology","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81971669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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