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Is the human papilloma virus vaccine a good investment 人乳头瘤病毒疫苗是一项好的投资吗
Pub Date : 2008-12-31 DOI: 10.5580/28ce
O. Varsou, Paschalis Kapsomenakis
More than 100 different HPV genotypes have been recognised and classified into low and high risk. The latter are responsible for a number of anogenital malignancies in both genders. For example, persistent genital infection with HPV 16 or 18, in association with various cofactors (i.e. prolonged Pill use, multiparity, smoking, co-infection with other STIs, etc.), causes cervical cancer 20 to 30 years later. This long latency period, between exposure and disease development, allows for screening to detect precancerous abnormalities. In contrast, the low risk genotypes are mainly associated with benign conditions. For example, HPV 6 and 11 cause genital warts (Condylomata acuminata).
超过100种不同的HPV基因型已被确认并分为低风险和高风险。后者是许多男性和女性的肛门生殖器恶性肿瘤的原因。例如,持续的HPV 16或18生殖器感染与各种辅助因素(即长期服用避孕药、多胎、吸烟、与其他性传播感染等)有关,可在20至30年后导致宫颈癌。这种暴露和疾病发展之间的长潜伏期使得筛查能够发现癌前异常。相反,低风险基因型主要与良性疾病相关。例如,HPV 6和11引起生殖器疣(尖锐湿疣)。
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引用次数: 0
Determination of absorbed dose for Mantle Field with Extended FSD. 扩展FSD法测定地幔场吸收剂量。
Pub Date : 2008-12-31 DOI: 10.5580/1dbc
K. Saravanan, K. Reddy, S. Vivekanandam, V. Parthasarathy, N. Vijayaprabhu, S. Mourougan
Mantle field is used for supradiaphragmatic disease. Determination of absorbed dose for Mantle Field technique by conventional method and direct dosimetry is studied and compared in this paper. For Mantle field, a field size of about or more than 40 X 40cm is usually needed. To obtain a bigger field size it is mandatory to extend the FSD. A change of FSD results in a significant change in Percentage Depth Dose (PDD) and beam out-put. Mayneord factor is used to determine the PDD for extended FSD. The behavior of the PDD at various FSD is studied by mathematical as well as by direct dosimetry method. The absorbed dose is obtained by performing dosimetry at extended FSD using TRS-398 protocol. From the study it is concluded that direct dosimetry is one of the precise method to determine absorbed dose for Mantle Field at Extended FSD.
地幔野用于膈上疾病。本文研究了地幔场法和直接剂量法测定吸收剂量的方法,并进行了比较。对于地幔田,通常需要40 × 40cm左右或以上的田。为了获得更大的场大小,必须扩展FSD。FSD的变化会导致百分比深度剂量(PDD)和光束输出的显著变化。Mayneord因子用于确定扩展FSD的PDD。用数学和直接剂量法研究了PDD在不同FSD下的行为。吸收剂量是通过使用TRS-398方案在扩展FSD进行剂量测定获得的。研究结果表明,直接剂量法是确定扩展FSD地幔场吸收剂量的精确方法之一。
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引用次数: 0
Giant cell tumors of the child’s fibula: a case study 儿童腓骨巨细胞瘤:个案研究
Pub Date : 2008-12-31 DOI: 10.5580/137f
G. Ngom, Dakar Sénégal, A. Ndiaye, O. Ndour, M. Fall, M. Ndoye, G. Ngom, A. Ndiaye, O. Ndour, M. Fall, M. Ndoye
We report an exceptional case of Giant Cell Tumor (GCT) in child. A twelve –year-old girl which presented a tumefaction at the lower extremity of her right leg. The clinical examination revealed a good general state of health, a non inflammatory tumor at the latero-external side of his right leg. A standard X-ray photography showed a bee nest like osteolysis lesion at the lower fibula metaphyse. A biopsy was performed and confirmed the diagnosis of a GCT. The treatment consisted in a large ablation of the tumor including part of the healthy zone, followed by an autologous iliac bone graft, stabilized with a Metaizeau pin and a cruropedal plaster. The evolution was favourable after a period of two years. The case we are presenting is fairly exceptional because of its location and the age of the patient.
我们报告一例儿童巨细胞瘤(GCT)。一名十二岁女孩右腿下肢出现肿胀。临床检查显示他的一般健康状况良好,右腿外侧有一个非炎性肿瘤。标准x线摄影显示下腓骨干处有蜂窝样骨质溶解病变。活检证实了GCT的诊断。治疗包括肿瘤的大面积消融,包括部分健康区,然后是自体髂骨移植物,用Metaizeau针和croropedal石膏固定。两年之后的演变是有利的。由于其位置和患者的年龄,我们所呈现的病例相当特殊。
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引用次数: 0
Atypical Teratoid/Rhabdoid Tumor: An Unusual Variant of a Rare Entity 非典型畸胎瘤/横纹肌样瘤:一种罕见实体的不寻常变体
Pub Date : 2008-12-31 DOI: 10.5580/26d7
J. Jaggon, K. Bishop, M. Pedican, W. Halliday, R. Melbourne-Chambers, J. Tapper
Atypical teratoid/rhabdoid tumors (AT/RTs) of the central nervous system (CNS) are distinctive, malignant neoplasms of uncertain histogenesis. They are thought to be embryonal and are usually composed of varying amounts of rhabdoid-type cells, small primitive neuroepithelial cells, epithelial tissue and neoplastic mesenchyme. Diagnosis may be difficult due to this morphologic variability and usually depends on demonstrating the presence of a specific mutation on chromosome 22 (the hSNF5/INI1 gene) or by visualizing ultrastructural whorled masses of intracytoplasmic intermediate filaments. The prognosis is poor with the majority of patients dying within one year of diagnosis.We describe a case of an AT/RT in an 8 year old boy who died shortly after presentation and whose tumor at autopsy showed unusual gross and histologic features. Diagnosis was only made after electron microscopy and immunohistochemical stains revealed the characteristic features.
中枢神经系统(CNS)的非典型畸胎瘤/横纹肌样瘤(AT/RTs)是一种组织发生不确定的独特恶性肿瘤。它们被认为是胚胎性的,通常由不同数量的横纹肌样细胞、小的原始神经上皮细胞、上皮组织和肿瘤间质组成。由于这种形态变异,诊断可能很困难,通常依赖于证明22号染色体上存在特定突变(hSNF5/INI1基因)或通过观察胞浆内中间丝的超微结构轮状团块。预后很差,大多数患者在诊断后一年内死亡。我们描述了一个8岁男孩的AT/RT病例,他在出现后不久死亡,他的肿瘤在尸检中显示出不寻常的大体和组织学特征。只有在电子显微镜和免疫组织化学染色显示特征后才能进行诊断。
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引用次数: 1
Role of Hyperfactionated external beam radiotherapy in stage IIB to III and postoperative cases of carcinoma cervix: an evaluation 强化外束放疗在宫颈癌IIB期至III期及术后病例中的作用:评价
Pub Date : 2008-12-31 DOI: 10.5580/211d
Shahi K.S., Pant Nirdosh, V. Gupta, Abhishek Singh
OBJECTIVE – To investigate the tolerance to and response rate with hyperfractionated external radiotherapy in stages IIB to III and postoperative cases of carcinoma uterine cervix.METHODSA prospective study of carcinoma uterine cervix FIGO stage IIB to III and postoperative cases was undertaken. A total of 22 patients were studied (12 in study group and 10 in control group).Control group was treated by conventional fractionation-60Gy/30fractions (f), 2Gy/f, 5days/week for 6 weeks.Study group was treated in hyperfractionation schedule 72Gy/60f,5days/week over 6weeks. Two fractions of 120cGy per day were given at interval of 6 hours.RESULTS – Patients enrolled in this study ,13.6% had stage IIB ,4.5% stage IIIA,22.7% stage IIIB and 59.1% postoperative cases. No severe acute toxicity was observed but moderate acute reactions were high. The commonest site of complication was small bowel where severe toxicity occurred slightly higher in study group than control group. Complete response was 80% and 91.7% in control and study group respectively.CONCLUSION Hyperfractionated radiotherapy as compared to conventional radiotherapy has produced clinically better tumor control in stages IIB to III and postoperative cases without enhancing normal tissue damage.
目的:探讨宫颈癌IIB ~ III期及术后患者对高分割外放疗的耐受性及有效率。方法对FIGO期ⅱb ~ⅲ期及术后病例进行前瞻性研究。共研究22例患者(研究组12例,对照组10例)。对照组采用常规分剂治疗,60gy / 30gy (f)、2Gy/f, 5天/周,连用6周。实验组采用72Gy/60f高分割治疗方案,5天/周,持续治疗6周。每隔6小时给药120cGy /天两份。结果:本研究纳入的患者中,13.6%为IIB期,4.5%为IIIA期,22.7%为IIIB期,59.1%为术后病例。没有观察到严重的急性毒性,但中度急性反应很高。并发症最常见的部位是小肠,研究组的严重毒性发生率略高于对照组。对照组和研究组的完全缓解率分别为80%和91.7%。结论与常规放疗相比,超分割放疗在临床上对IIB ~ III期及术后病例的肿瘤控制效果更好,且未加重正常组织损伤。
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引用次数: 0
Right Inguinal Bowel Fistula On The Course Of Melanoma Disease 右腹股沟肠瘘在黑色素瘤病程中的作用
Pub Date : 2008-12-31 DOI: 10.5580/1a1
F. Casanova, Jesús R.C. Lizazo, S. Shezi, F. Oliver
Melanoma is the most dangerous type of skin cancer. It is the leading cause of death from skin disease. It involves cells called melanocytes, which produce a skin pigment called melanin. Melanin is responsible for skin and hair colour.Melanoma can also involve the colour part of the eye. Although it is less common than other types of skin cancer, the rate of melanoma is steadily increasing. Melanoma may appear on normal skin, or it may begin at a mole or other area that has changed in appearance. The development of melanoma is related to sun exposure, particularly to sunburns during childhood, and is most common among people with fair skin, blue or green eyes, and red or blond hair. Unlike these previous facts, the authors have been treated during the last 3year seven patients all of them from Zulu ethnic. Here the authors present a 61 years old female patient who
黑色素瘤是最危险的一种皮肤癌。它是皮肤病死亡的主要原因。它涉及一种叫做黑素细胞的细胞,这种细胞产生一种叫做黑色素的皮肤色素。黑色素负责皮肤和头发的颜色。黑色素瘤也会累及眼睛的颜色部分。虽然它不像其他类型的皮肤癌那样常见,但黑色素瘤的发病率正在稳步上升。黑色素瘤可能出现在正常皮肤上,也可能开始于痣或其他外观发生变化的区域。黑色素瘤的发展与日晒有关,特别是儿童时期的晒伤,在皮肤白皙、蓝色或绿色眼睛、红色或金色头发的人群中最常见。与之前的事实不同,作者在过去3年中治疗了7名患者,他们都来自祖鲁族。在这里,作者提出了一个61岁的女性患者谁
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引用次数: 1
A Pilot Phase Ii Study Of Capecitabine With Carboplatin In Patients With Advanced Nonsmall Cell Lung Cancer 卡培他滨联合卡铂治疗晚期非小细胞肺癌的Ii期临床试验
Pub Date : 2008-12-31 DOI: 10.5580/1d6e
Bhuvana Sagar, Fadi Estaphan, D. W. Spell, F. Klementich, Dennie V. Jones
Carboplatin forms the backbone of many regimens for nonsmall cell lung cancer (NSCLC). 5-fluorouracil (5-FU) is modestly active in NSCLC and is synergistic with platinum analogs. This trial evaluated the activity and toxicity of capecitabine, an oral 5FU prodrug, with carboplatin in patients with unresectable NSCLC. Eligibility criteria included untreated measurable stage IIIB/IV NSCLC, ECOG performance status < 2, and adequate organ function. Carboplatin, AUC=5, was administered on day one, with capecitabine, 4000 mg days 1-14, every 28 days. Tumor assessments were obtained every other cycle. Fifteen patients (median age = 64; median performance status = 0) were enrolled and received 46 cycles of protocol therapy; 13 were evaluable for response, with 5 partial responses (38.5%). Five withdrew due to toxicity; four possibly related to study therapy. Median survival was 8 months. Capecitabine and carboplatin are active in NSCLC. Further investigation is not warranted, as this current regimen is too toxic.
卡铂是许多非小细胞肺癌(NSCLC)治疗方案的支柱。5-氟尿嘧啶(5-FU)在NSCLC中具有适度活性,并与铂类似物协同作用。该试验评估了卡培他滨(一种口服5FU前药)与卡铂在不可切除的非小细胞肺癌患者中的活性和毒性。入选标准包括未治疗的可测量的IIIB/IV期NSCLC, ECOG表现状态< 2,器官功能充足。第1天给予卡铂,AUC=5,第1-14天给予卡培他滨4000mg,每28天给予一次。每隔一个周期进行肿瘤评估。15例患者(中位年龄= 64;中位表现状态= 0)入组并接受46个疗程的方案治疗;13例可评价缓解,5例部分缓解(38.5%)。5例因毒性退出;四个可能与学习治疗有关。中位生存期为8个月。卡培他滨和卡铂在非小细胞肺癌中有活性。由于目前的治疗方案毒性太大,因此不需要进一步的研究。
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引用次数: 1
Oral Leiomyosarcoma With Bilateral Renal Metastases In A Pregnant Female: A Case Report 孕妇口腔平滑肌肉瘤合并双侧肾转移1例报告
Pub Date : 2008-12-31 DOI: 10.5580/17ba
P. Shukla, Pronati Gupta, D. Gupta, M. Pant, N. Husain, S. Bisht
Leiomyosarcoma account for 5-10% of soft tissue sarcomas1. They are principally tumors of adult life and are more common in women than in men. Primary oral leiomyosarcoma is a rare entity with unusual bone location because of paucity of smooth muscle in that site2. We report a histologically proven case of leiomyosarcoma of maxilla with bilateral renal metastasis, which were visualized in CT and diagnosed by CT guided fine needle aspiration cytology (FNA).
平滑肌肉瘤占软组织肉瘤的5-10% 1。它们主要是成年人的肿瘤,在女性中比在男性中更常见。原发性口腔平滑肌肉瘤是一种罕见的肿瘤,其骨位置异常,因为该部位缺乏平滑肌2。我们报告一例经组织学证实的上颌骨平滑肌肉瘤合并双侧肾转移的病例,并采用CT引导下细针穿刺细胞学(FNA)诊断。
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引用次数: 1
Clear cell sarcoma arising from the iliac wing: case report 髂翼透明细胞肉瘤1例
Pub Date : 2008-12-31 DOI: 10.5580/24a4
H. Tran, V. Asfour, P. ChangChin-Yung, Osman Ahmedfiqi
Clear cell sarcoma (CCS) is aggressive, slow growing tumor, arising from tendons, aponeuroses, and fascial structures. CCS compromises only 1% of soft tissue sarcomas. CCS is characterized by a high rate of local recurrence and distant metastasis. CCS is commonly located in extremities, and less likely to arise in the trunk with only rare cases found in pelvis or abdomen. Here we describe a case of clear cell sarcoma, in which it develops from the iliac wing with distant pulmonary and liver metastasis. We discuss and review the clinicopathologic features of CCS include: structural and microscopic characteristics, prognosis factors, management, and outcome.
透明细胞肉瘤(CCS)是侵袭性的,生长缓慢的肿瘤,起源于肌腱膜和筋膜结构。CCS只危害了1%的软组织肉瘤。CCS的特点是局部复发和远处转移率高。CCS通常位于四肢,很少发生在躯干,只有罕见的病例发生在骨盆或腹部。我们在此报告一例透明细胞肉瘤,它起源于髂翼,并有远处肺和肝脏转移。我们讨论和回顾了CCS的临床病理特征,包括:结构和显微特征,预后因素,管理和结果。
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引用次数: 2
Bilateral Leiomyosarcoma Of The Kidney With Family History Of Bilateral Kidney Cancer: Case Report And Review Of The Literature 双侧肾脏平滑肌肉瘤伴双侧肾癌家族史:病例报告及文献复习
Pub Date : 2008-12-31 DOI: 10.5580/187f
H. Kadikoy, W. Haque, V. Topkara, A. Frome, T. Hayes
We describe an unusual case of bilateral renal leiomyosarcoma in a 61-year-old white man in a patient who presented with a pulmonary emoblism. The patient also had an uncle with bilateral kidney cancer. The patient did not undergo surgery, as the tumor had invaded the surrounding vasculature and was felt to be unresectable by the consulting surgeons. He was treated with gemcitabine and docetaxel chemotherapy, with stabilization of disease. Patient is now stable 10 months after beginning therapy. Sarcomas make up 1–2% of all malignant renal tumors in adult. Bilateral renal leiomyosarcomas are exceedingly rare, with only 17 being reported in the literature. To the best of our knowledge, this is the first reported case of bilateral renal leiomyosarcoma with a family history of bilateral renal cancer.
我们描述了一个不寻常的情况下,双侧肾脏平滑肌肉瘤在一个61岁的白人男性患者谁提出了肺栓塞。患者的叔叔也患有双侧肾癌。患者没有接受手术,因为肿瘤已经侵入周围的血管系统,咨询医生认为无法切除。患者接受吉西他滨和多西他赛化疗,病情稳定。患者在开始治疗10个月后病情稳定。肉瘤占成人肾恶性肿瘤的1-2%。双侧肾脏平滑肌肉瘤极为罕见,文献中仅报道了17例。据我们所知,这是第一例有双侧肾癌家族史的双侧肾脏平滑肌肉瘤。
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引用次数: 0
期刊
The Internet Journal of Oncology
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