S. Guruvare, L. Rai, P. Adiga, R. Kadavigere, Jacob Kurien Neriamparampil, Vidyasagar
Endometrial cancer is not suspected in a young woman with abnormal uterine bleeding. The disease is often advanced when diagnosed, thereby depriving the woman of the option for fertility sparing conservative approach. In young women with menstrual abnormalities and polycystic ovarian disease and/ or infertility, an endometrial evaluation should be performed.
{"title":"An Unusual Case Of Endometrial Cancer In A Young Lady","authors":"S. Guruvare, L. Rai, P. Adiga, R. Kadavigere, Jacob Kurien Neriamparampil, Vidyasagar","doi":"10.5580/26cc","DOIUrl":"https://doi.org/10.5580/26cc","url":null,"abstract":"Endometrial cancer is not suspected in a young woman with abnormal uterine bleeding. The disease is often advanced when diagnosed, thereby depriving the woman of the option for fertility sparing conservative approach. In young women with menstrual abnormalities and polycystic ovarian disease and/ or infertility, an endometrial evaluation should be performed.","PeriodicalId":22534,"journal":{"name":"The Internet Journal of Oncology","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2007-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83836260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Chadha, C. LeVea, T. Mashtare, G. Wilding, M. Javle, C. Nwogu
Thirty percent of patients undergoing neoadjuvant chemoradiation therapy (neo-CRT) for locally advanced esophageal cancer achieve a complete pathologic response (CPR) based on standard Hematoxylin and Eosin staining (CPR-HE). There is controversy regarding the prognostic value of CPR-HE. Immunohistochemical staining may be useful to detect subtle microscopic residual disease in such patients. We undertook this present study to test this hypothesis. Eighteen consecutive patients who achieved CPR-HE were identified. Seven patients had positive cytokeratin staining; three had microscopic residual disease that was not identified on original hematoxylin-eosin sections. Three of the seven patients (43%) with positive cytokeratin staining had systemic relapse (60 % of patients with systemic relapse).Cytokeratin staining could be a useful adjunct to routine hemaoxylin-eosin staining to identify residual tumor in such patients. The prognostic significance of CPR-CK, however, needs to be validated in a large cohort.
{"title":"Cytokeratin Staining to Detect Residual Disease in Patients Undergoing Neoadjuvant Chemoradiation followed by Esophagectomy for Locally Advanced Esophageal Cancer","authors":"M. Chadha, C. LeVea, T. Mashtare, G. Wilding, M. Javle, C. Nwogu","doi":"10.5580/17d1","DOIUrl":"https://doi.org/10.5580/17d1","url":null,"abstract":"Thirty percent of patients undergoing neoadjuvant chemoradiation therapy (neo-CRT) for locally advanced esophageal cancer achieve a complete pathologic response (CPR) based on standard Hematoxylin and Eosin staining (CPR-HE). There is controversy regarding the prognostic value of CPR-HE. Immunohistochemical staining may be useful to detect subtle microscopic residual disease in such patients. We undertook this present study to test this hypothesis. Eighteen consecutive patients who achieved CPR-HE were identified. Seven patients had positive cytokeratin staining; three had microscopic residual disease that was not identified on original hematoxylin-eosin sections. Three of the seven patients (43%) with positive cytokeratin staining had systemic relapse (60 % of patients with systemic relapse).Cytokeratin staining could be a useful adjunct to routine hemaoxylin-eosin staining to identify residual tumor in such patients. The prognostic significance of CPR-CK, however, needs to be validated in a large cohort.","PeriodicalId":22534,"journal":{"name":"The Internet Journal of Oncology","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2007-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74770083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Sodhi, A. Chaturvedi, S. Misra, Vijay Kumar, M. Athar, M. Srivastava, N. Husain
Merkel cell carcinoma (MCC) is a rare malignant cutaneous tumor of the elderly that is characterized by an aggressive course with regional nodal involvement, distant metastases and a high rate of recurrence. It is a very rare tumor with an annual incidence of approximately 0.42 per 100,000. We describe two patients of Merkel cell carcinoma presented to us. Both patients were treated by surgery and chemotherapy. The response to treatment was very different in both the patients. The final outcome however has been very unsatisfactory in both patients.
{"title":"Merkel cell carcinoma: Report Of Two Patients","authors":"K. Sodhi, A. Chaturvedi, S. Misra, Vijay Kumar, M. Athar, M. Srivastava, N. Husain","doi":"10.5580/2833","DOIUrl":"https://doi.org/10.5580/2833","url":null,"abstract":"Merkel cell carcinoma (MCC) is a rare malignant cutaneous tumor of the elderly that is characterized by an aggressive course with regional nodal involvement, distant metastases and a high rate of recurrence. It is a very rare tumor with an annual incidence of approximately 0.42 per 100,000. We describe two patients of Merkel cell carcinoma presented to us. Both patients were treated by surgery and chemotherapy. The response to treatment was very different in both the patients. The final outcome however has been very unsatisfactory in both patients.","PeriodicalId":22534,"journal":{"name":"The Internet Journal of Oncology","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2007-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74957155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Verschraegen, H. Raftopoulos, K. Feit, R. Jager, Sang-Joon Lee, C. Sweeney
Background: TZT-1027 is a dolastatin 10 analog interfering with microtubule assembly, with increased antitumor activity when combined with gemcitabine in animal models. Patients and Methods: Eligible patients with refractory solid tumors received gemcitabine followed by TZT-1027 on Days 1 and 8 every 21 days, with pharmacokinetic sampling during the first 24 hours.
{"title":"A Phase I Study Of The Combination Of TZT-1027 (Soblidotin) And Gemcitabine Administered On Day 1 And 8 Every Three Weeks To Patients With Advanced Or Metastatic Solid Tumors","authors":"C. Verschraegen, H. Raftopoulos, K. Feit, R. Jager, Sang-Joon Lee, C. Sweeney","doi":"10.5580/15d9","DOIUrl":"https://doi.org/10.5580/15d9","url":null,"abstract":"Background: TZT-1027 is a dolastatin 10 analog interfering with microtubule assembly, with increased antitumor activity when combined with gemcitabine in animal models. Patients and Methods: Eligible patients with refractory solid tumors received gemcitabine followed by TZT-1027 on Days 1 and 8 every 21 days, with pharmacokinetic sampling during the first 24 hours.","PeriodicalId":22534,"journal":{"name":"The Internet Journal of Oncology","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2007-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74895512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Ehsani, P. Hashemi, Z. Naraghi, M. Farivar, A. Rashidi
Vulvar and salivary gland involvement are rare in Langerhans cell histiocytosis (LCH), for which less than 60 and 5 cases have been reported in the literature, respectively. We report a 22-year old woman with LCH and multisystem disease including involvement of the brain (diabetes insipidus), lungs (pneumothorax), salivary glands and vulva (skin lesion). Vulvar lesion included a 3×2 cm erythematous and ulcerated plaque on the fourchette and a 1×1 cm similar lesion on the right labia major. The lesions were slightly infiltrated and without any discharge. The diagnosis was confirmed by skin biopsies positive by immunohistochemistry for S100 and CD68. The skin lesion and the neck mass regressed completely with systemic chemotherapy. This case provides further support for using a combination of vinblastine and prednisolone in multisystem LCH.
{"title":"Langerhans Cell Histiocytosis Involving The Brain, Lungs, Salivary Glands And Vulva: Report Of A Rare Case And Review Of Literature","authors":"A. Ehsani, P. Hashemi, Z. Naraghi, M. Farivar, A. Rashidi","doi":"10.5580/4e0","DOIUrl":"https://doi.org/10.5580/4e0","url":null,"abstract":"Vulvar and salivary gland involvement are rare in Langerhans cell histiocytosis (LCH), for which less than 60 and 5 cases have been reported in the literature, respectively. We report a 22-year old woman with LCH and multisystem disease including involvement of the brain (diabetes insipidus), lungs (pneumothorax), salivary glands and vulva (skin lesion). Vulvar lesion included a 3×2 cm erythematous and ulcerated plaque on the fourchette and a 1×1 cm similar lesion on the right labia major. The lesions were slightly infiltrated and without any discharge. The diagnosis was confirmed by skin biopsies positive by immunohistochemistry for S100 and CD68. The skin lesion and the neck mass regressed completely with systemic chemotherapy. This case provides further support for using a combination of vinblastine and prednisolone in multisystem LCH.","PeriodicalId":22534,"journal":{"name":"The Internet Journal of Oncology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2007-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80791981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We present a rare case of bilateral primary lymphoma of the breast in a young multiparous woman followed by a brief review of the literature.
我们提出一个罕见的病例双侧原发性淋巴瘤的乳房在一个年轻的多产妇女随后简要回顾了文献。
{"title":"Bilateral primary breast lymphoma: A Case Report With Review Of Literature","authors":"S. Pankaj, S. Shalini","doi":"10.5580/dee","DOIUrl":"https://doi.org/10.5580/dee","url":null,"abstract":"We present a rare case of bilateral primary lymphoma of the breast in a young multiparous woman followed by a brief review of the literature.","PeriodicalId":22534,"journal":{"name":"The Internet Journal of Oncology","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2007-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85083540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gastrointestinal metastases from breast cancers usually derive from invasive lobular carcinomas. This is a case report of an anorectal metastasis, which presented as a digitally palpable anorectal mass, originating from an invasive ductal carcinoma of the breast. A vigorous diagnostic approach prior to planning treatment permits prolonged survival without surgical intervention if the proper diagnosis of metastatic breast cancer can be made.
{"title":"Anorectal Metastasis from Breast Carcinoma: A case report with literature review","authors":"M. Nair, O. Fafemi","doi":"10.5580/c85","DOIUrl":"https://doi.org/10.5580/c85","url":null,"abstract":"Gastrointestinal metastases from breast cancers usually derive from invasive lobular carcinomas. This is a case report of an anorectal metastasis, which presented as a digitally palpable anorectal mass, originating from an invasive ductal carcinoma of the breast. A vigorous diagnostic approach prior to planning treatment permits prolonged survival without surgical intervention if the proper diagnosis of metastatic breast cancer can be made.","PeriodicalId":22534,"journal":{"name":"The Internet Journal of Oncology","volume":"45 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2007-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80002705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gastric carcinoma is the most common gastrointestinal malignancies worldwide, but is extremely rare in teenagers. We report a case gastric adenocarcinoma in a 13-year male who presented with anemia. He also found to have multiple hepatic metastases and ascites. A review of the literature was done.
{"title":"Extensive metastases from Gastric Adenocarcinoma In a teen male presenting as anemia","authors":"P. Sridhar, M. Rajan, S. Jha","doi":"10.5580/19e6","DOIUrl":"https://doi.org/10.5580/19e6","url":null,"abstract":"Gastric carcinoma is the most common gastrointestinal malignancies worldwide, but is extremely rare in teenagers. We report a case gastric adenocarcinoma in a 13-year male who presented with anemia. He also found to have multiple hepatic metastases and ascites. A review of the literature was done.","PeriodicalId":22534,"journal":{"name":"The Internet Journal of Oncology","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2007-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74090321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Mbuagbaw, C. Pisoh, L. Mbuagbaw, C. Bengondo, Blaise Kegoum, G. Bengono, M. Nkam, K. B. Ngu
Skin manifestations are frequently associated with the Human Immunodeficiency Virus (HIV) infection. Kaposi's Sarcoma (KS) is one of the most common cancers seen in people with HIV, and is an AIDS defining illness. The incidence of HIV associated Kaposi's Sarcoma has decreased since the advent of antiretroviral drugs in developed countries. This is not the case with Cameroon people present with generalized and aggressive KS. This study reviews the characteristics and prevalence of KS and the impact of antiretroviral drugs in a treatment center in YaoundE, Cameroon. The prevalence of KS among HIV infected patients was found to be 10.0%. Both sexes were equally affected unlike in endemic KS which is more common in males. Most patients had generalized disease, and death occurred within six months of diagnosis. These cases were associated with low CD4 cell count, anemia and low platelet counts. Patients with less extensive lesions, had tumor regression ranging from partial to total when Highly Active Antiretroviral Therapy was administered. Early diagnosis and antiretroviral therapy will decrease morbidity, mortality and severe Immune Reconstitution Inflammatory syndrome (IRIS) common in patients with aggressive HIV associated KS.
{"title":"Prevalence And Characteristics Of Human Immunodeficiency Virus Associated Kaposi Sarcoma","authors":"J. Mbuagbaw, C. Pisoh, L. Mbuagbaw, C. Bengondo, Blaise Kegoum, G. Bengono, M. Nkam, K. B. Ngu","doi":"10.5580/17bf","DOIUrl":"https://doi.org/10.5580/17bf","url":null,"abstract":"Skin manifestations are frequently associated with the Human Immunodeficiency Virus (HIV) infection. Kaposi's Sarcoma (KS) is one of the most common cancers seen in people with HIV, and is an AIDS defining illness. The incidence of HIV associated Kaposi's Sarcoma has decreased since the advent of antiretroviral drugs in developed countries. This is not the case with Cameroon people present with generalized and aggressive KS. This study reviews the characteristics and prevalence of KS and the impact of antiretroviral drugs in a treatment center in YaoundE, Cameroon. The prevalence of KS among HIV infected patients was found to be 10.0%. Both sexes were equally affected unlike in endemic KS which is more common in males. Most patients had generalized disease, and death occurred within six months of diagnosis. These cases were associated with low CD4 cell count, anemia and low platelet counts. Patients with less extensive lesions, had tumor regression ranging from partial to total when Highly Active Antiretroviral Therapy was administered. Early diagnosis and antiretroviral therapy will decrease morbidity, mortality and severe Immune Reconstitution Inflammatory syndrome (IRIS) common in patients with aggressive HIV associated KS.","PeriodicalId":22534,"journal":{"name":"The Internet Journal of Oncology","volume":"84 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2007-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77858276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gastric cancer is one of the most common cancers and most frequent causes of cancer related deaths in the world. The overall survival rate is 15-20%. Although incidence is declining, its prognosis remains poor. The etiological factors and pathogenesis of gastric cancer are not yet fully understood. The integrated research in molecular pathology clarified the details of genetic and epigenetic abnormalities of cancer-related genes in the course of development and progression of gastric cancer. Although epidemiological evidences indicate that environmental factors play a major role in the carcinogenesis, the role of immunological, genetic and immunogenetic factors are thought to contribute to etiopathogenesis of gastric carcinoma. In addition to better understanding of pathogenesis of gastric cancer, the incidence, diagnostic studies and the therapeutic options have also undergone important changes in the last decade. There is ongoing debate regarding the role of adjuvant treatment. In advanced disease, palliation of symptoms, rather than cure, is the primary goal of patient management. Several combination therapies have been developed and have been examined in phase III trials; however, in most cases, they have failed to demonstrate a survival advantage over the reference arm. This review provides an appraisal of the published data related to concepts of molecular biology on gastric carcinogenesis and the new important recommendations for the management of patient with gastric carcinoma.
{"title":"Pathogenesis and treatment of Gastric Carcinoma: “An up-date with brief review”","authors":"Khan Aziz, Shukla Aditya Nath, Sivaselvam","doi":"10.5580/490","DOIUrl":"https://doi.org/10.5580/490","url":null,"abstract":"Gastric cancer is one of the most common cancers and most frequent causes of cancer related deaths in the world. The overall survival rate is 15-20%. Although incidence is declining, its prognosis remains poor. The etiological factors and pathogenesis of gastric cancer are not yet fully understood. The integrated research in molecular pathology clarified the details of genetic and epigenetic abnormalities of cancer-related genes in the course of development and progression of gastric cancer. Although epidemiological evidences indicate that environmental factors play a major role in the carcinogenesis, the role of immunological, genetic and immunogenetic factors are thought to contribute to etiopathogenesis of gastric carcinoma. In addition to better understanding of pathogenesis of gastric cancer, the incidence, diagnostic studies and the therapeutic options have also undergone important changes in the last decade. There is ongoing debate regarding the role of adjuvant treatment. In advanced disease, palliation of symptoms, rather than cure, is the primary goal of patient management. Several combination therapies have been developed and have been examined in phase III trials; however, in most cases, they have failed to demonstrate a survival advantage over the reference arm. This review provides an appraisal of the published data related to concepts of molecular biology on gastric carcinogenesis and the new important recommendations for the management of patient with gastric carcinoma.","PeriodicalId":22534,"journal":{"name":"The Internet Journal of Oncology","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2006-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79968591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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