Pub Date : 2023-07-06DOI: 10.22625/2072-6732-2023-15-2-24-34
D. R. Prilepskaya, E. Domonova
Reactivation of Betapolyomavirus hominis (BKPyV) in kidney and hematopoietic stem cell recipients can lead to serious complications such as BKPyV-associated nephropathy followed by transplant rejection and BKPyV-associated hemorrhagic cystitis. Early diagnosis of the disease is hampering by the possible combination of infection of BKPyV with other post-transplant pathologies and the absence of specific symptoms. Replication of BKPyV is currently the only reliable prognostic sign of the development of long-term consequences, so patient management is basseting on monitoring the concentration of viral DNA. However, consistency between the results of determining the viral load and the development of post-transplant complications associated with BKPyV reactivation cannot be achieving without effective means of standardizing laboratory testing. This review covers the current understanding of the epidemiology; pathogenesis and the clinical features of the disease associated with BKPyV, and also considers in detail the current methods of laboratory diagnosis infection of BKPyV.
{"title":"A systematic review. Current understanding of the infection caused by Betapolyomavirus hominis","authors":"D. R. Prilepskaya, E. Domonova","doi":"10.22625/2072-6732-2023-15-2-24-34","DOIUrl":"https://doi.org/10.22625/2072-6732-2023-15-2-24-34","url":null,"abstract":"Reactivation of Betapolyomavirus hominis (BKPyV) in kidney and hematopoietic stem cell recipients can lead to serious complications such as BKPyV-associated nephropathy followed by transplant rejection and BKPyV-associated hemorrhagic cystitis. Early diagnosis of the disease is hampering by the possible combination of infection of BKPyV with other post-transplant pathologies and the absence of specific symptoms. Replication of BKPyV is currently the only reliable prognostic sign of the development of long-term consequences, so patient management is basseting on monitoring the concentration of viral DNA. However, consistency between the results of determining the viral load and the development of post-transplant complications associated with BKPyV reactivation cannot be achieving without effective means of standardizing laboratory testing. This review covers the current understanding of the epidemiology; pathogenesis and the clinical features of the disease associated with BKPyV, and also considers in detail the current methods of laboratory diagnosis infection of BKPyV.","PeriodicalId":226950,"journal":{"name":"Journal Infectology","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114510060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-06DOI: 10.22625/2072-6732-2023-15-2-60-67
A. O. Mikhailov, S. Sokotun, N. Plekhova, A. Simakova, S. N. Beniova, S. Petukhova, E. S. Machtareva, A. S. Bedareva
Introduction. Asthenic disorders due to COVID-19 infection are generally classified under a recently introduced category in ICD-10: U09.9 Condition after COVID-19, unspecified. In this regard, it is necessary to study the clinical manifestations and systematize the asthenic syndrome after coronavirus infection in order to better understand the tactics of treatment and rehabilitation of this group of patients.Objective. To assess the prevalence of asthenic syndrome in patients who have had a coronavirus infection, to characterize and present its dynamics.Materials and methods. The study involved 200 people with a confirmed diagnosis of COVID-19, aged 51 to 83, who were undergoing inpatient treatment. After discharge from the hospital after 6 months and 12 months, these patients again underwent a physical examination, anamnesis, complaints, and a questionnaire to identify symptoms of asthenia and other psychopathological syndromes.Results. Asthenic symptoms were found in 2/3 of the examined persons. Autonomic disorders were noted with a slight decrease from 81.5% after 6 months to 74.2% after 12. Sleep disorders and increased fatigue progressed during the observed period from 70.4% to 80.6% and 63.0 to 74.2% respectively. Emotional lability of patients as a whole did not change.Conclusion. Polymorphic symptoms of asthenic syndrome were revealed, the most common phenomena were sleep disorders and symptoms of fatigue.
{"title":"Clinical manifestations of asthenic syndrome after coronavirus infection caused by SARS-CoV-2","authors":"A. O. Mikhailov, S. Sokotun, N. Plekhova, A. Simakova, S. N. Beniova, S. Petukhova, E. S. Machtareva, A. S. Bedareva","doi":"10.22625/2072-6732-2023-15-2-60-67","DOIUrl":"https://doi.org/10.22625/2072-6732-2023-15-2-60-67","url":null,"abstract":"Introduction. Asthenic disorders due to COVID-19 infection are generally classified under a recently introduced category in ICD-10: U09.9 Condition after COVID-19, unspecified. In this regard, it is necessary to study the clinical manifestations and systematize the asthenic syndrome after coronavirus infection in order to better understand the tactics of treatment and rehabilitation of this group of patients.Objective. To assess the prevalence of asthenic syndrome in patients who have had a coronavirus infection, to characterize and present its dynamics.Materials and methods. The study involved 200 people with a confirmed diagnosis of COVID-19, aged 51 to 83, who were undergoing inpatient treatment. After discharge from the hospital after 6 months and 12 months, these patients again underwent a physical examination, anamnesis, complaints, and a questionnaire to identify symptoms of asthenia and other psychopathological syndromes.Results. Asthenic symptoms were found in 2/3 of the examined persons. Autonomic disorders were noted with a slight decrease from 81.5% after 6 months to 74.2% after 12. Sleep disorders and increased fatigue progressed during the observed period from 70.4% to 80.6% and 63.0 to 74.2% respectively. Emotional lability of patients as a whole did not change.Conclusion. Polymorphic symptoms of asthenic syndrome were revealed, the most common phenomena were sleep disorders and symptoms of fatigue.","PeriodicalId":226950,"journal":{"name":"Journal Infectology","volume":"91 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115017432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-06DOI: 10.22625/2072-6732-2023-15-2-14-23
A. Taraskina, E. Frolova, O. Shadrivova, O. V. Sekretareva, N. Vasilyeva
Recently, more attention has been paid to the role of indolamine-2,3-dioxygenase and aryl hydrocarbon receptor in maintaining a balance between immune reactivity and tolerance in various infectious diseases. It is known that the hallmark of COVID-19 is the activation of immuno-inflammatory pathways that induce indoleamine-2,3-dioxygenase, a key enzyme that catalyzes the metabolism of tryptophan along the kynurenine pathway, thereby changing the ratio of kynurenine/tryptophan in the blood serum of patients. An important property of SARS-CoV-2 is its ability to bind to aryl hydrocarbon receptor, which leads to an increase in intracellular expression of indolamine-2,3-dioxygenase and production of kynurenine at the initial stage of infection. Long-term activation of the aryl hydrocarbon receptor increases the production of interleukin-6, enhancing the inflammatory state and counteracting immune tolerance in the later stages of COVID-19. In aggregate, these data point to an important role of indolamine 2,3-dioxygenase and the aryl hydrocarbon receptor in controlling inflammation in patients with COVID-19. Dysregulation of the immune response not only threaten the host’s ability to cope with SARS-CoV-2, but can also predispose a person to secondary bacterial and fungal infections. Among the secondary infections that occur in patients with new coronavirus infection, COVID-19-associated invasive pulmonary aspergillosis is an important cause of death, although many aspects of the disease still remain unresolved. This review presents the current understanding of the importance of tryptophan metabolites and immunological factors in the pathogenesis of COVID-19 and invasive pulmonary aspergillosis.
{"title":"The role of immune homeostasis in patients with new coronavirus infection (COVID-19) in the development of invasive pulmonary aspergillosis","authors":"A. Taraskina, E. Frolova, O. Shadrivova, O. V. Sekretareva, N. Vasilyeva","doi":"10.22625/2072-6732-2023-15-2-14-23","DOIUrl":"https://doi.org/10.22625/2072-6732-2023-15-2-14-23","url":null,"abstract":"Recently, more attention has been paid to the role of indolamine-2,3-dioxygenase and aryl hydrocarbon receptor in maintaining a balance between immune reactivity and tolerance in various infectious diseases. It is known that the hallmark of COVID-19 is the activation of immuno-inflammatory pathways that induce indoleamine-2,3-dioxygenase, a key enzyme that catalyzes the metabolism of tryptophan along the kynurenine pathway, thereby changing the ratio of kynurenine/tryptophan in the blood serum of patients. An important property of SARS-CoV-2 is its ability to bind to aryl hydrocarbon receptor, which leads to an increase in intracellular expression of indolamine-2,3-dioxygenase and production of kynurenine at the initial stage of infection. Long-term activation of the aryl hydrocarbon receptor increases the production of interleukin-6, enhancing the inflammatory state and counteracting immune tolerance in the later stages of COVID-19. In aggregate, these data point to an important role of indolamine 2,3-dioxygenase and the aryl hydrocarbon receptor in controlling inflammation in patients with COVID-19. Dysregulation of the immune response not only threaten the host’s ability to cope with SARS-CoV-2, but can also predispose a person to secondary bacterial and fungal infections. Among the secondary infections that occur in patients with new coronavirus infection, COVID-19-associated invasive pulmonary aspergillosis is an important cause of death, although many aspects of the disease still remain unresolved. This review presents the current understanding of the importance of tryptophan metabolites and immunological factors in the pathogenesis of COVID-19 and invasive pulmonary aspergillosis.","PeriodicalId":226950,"journal":{"name":"Journal Infectology","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133858421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.22625/2072-6732-2023-15-2-68-73
Erika Martining Wardani, Riezky Faisal Nugroho, Difran Nobel Bistara, L. Wijayanti, Siti Nurhasina, Fety Susanti Cahyaningsih
Background: The disease that is endemic and has become a global pandemic is COVID-19 due to reports of thousands of cases. The pandemic is weighing on intensive care units with an influx of COVID-19 patients. The clinical manifestations of COVID-19 vary, diagnostic examinations and treatment are also experiencing dynamic developments. This study aims to provide an overview of the characteristics, clinical manifestations, length of treatment and nutritional status of COVID-19 patients who are hospitalized in the Isolation Room of Dr Soetomo Hospital Surabaya.Methods: this study used a descriptive analytic cross-sectional method with inclusion criteria that were positive for COVID-19. The research data was obtained from 130 hospital medical records for the period June to August 2021. The collected data was then analyzed using SPSS version 25.Results: The study found that men were more exposed to COVID-19 (71.5%) and 70% of patients worked as medical personnel. The age range of the majority of patients was more than 40 years (78.5%). Clinical manifestations of COVID-19 patients were cough (44.6%), fever (40%), flu-like symptoms (32.3%), painful swallowing (26.2%), anosmia (16.2%), shortness of breath (15.4%), nausea (14.6%), vomiting (13.8%), and diarrhea (0.9%). The average length of stay is 7-14 days (9.2%) with adequate nutritional status (14.6%).Conclusion: The majority of COVID-19 sufferers are male, over 40 years old, with cough symptoms, and the most comorbid hypertension, as well as deaths from hypertension and the elderly. Better treatment is needed for people with COVID-19.
{"title":"Characteristics, Clinical Manifestations, Length of Hospitalization and Nutritional Status of COVID-19 patients","authors":"Erika Martining Wardani, Riezky Faisal Nugroho, Difran Nobel Bistara, L. Wijayanti, Siti Nurhasina, Fety Susanti Cahyaningsih","doi":"10.22625/2072-6732-2023-15-2-68-73","DOIUrl":"https://doi.org/10.22625/2072-6732-2023-15-2-68-73","url":null,"abstract":"Background: The disease that is endemic and has become a global pandemic is COVID-19 due to reports of thousands of cases. The pandemic is weighing on intensive care units with an influx of COVID-19 patients. The clinical manifestations of COVID-19 vary, diagnostic examinations and treatment are also experiencing dynamic developments. This study aims to provide an overview of the characteristics, clinical manifestations, length of treatment and nutritional status of COVID-19 patients who are hospitalized in the Isolation Room of Dr Soetomo Hospital Surabaya.Methods: this study used a descriptive analytic cross-sectional method with inclusion criteria that were positive for COVID-19. The research data was obtained from 130 hospital medical records for the period June to August 2021. The collected data was then analyzed using SPSS version 25.Results: The study found that men were more exposed to COVID-19 (71.5%) and 70% of patients worked as medical personnel. The age range of the majority of patients was more than 40 years (78.5%). Clinical manifestations of COVID-19 patients were cough (44.6%), fever (40%), flu-like symptoms (32.3%), painful swallowing (26.2%), anosmia (16.2%), shortness of breath (15.4%), nausea (14.6%), vomiting (13.8%), and diarrhea (0.9%). The average length of stay is 7-14 days (9.2%) with adequate nutritional status (14.6%).Conclusion: The majority of COVID-19 sufferers are male, over 40 years old, with cough symptoms, and the most comorbid hypertension, as well as deaths from hypertension and the elderly. Better treatment is needed for people with COVID-19.","PeriodicalId":226950,"journal":{"name":"Journal Infectology","volume":"32 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121003758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-21DOI: 10.22625/2072-6732-2023-15-1-126-133
O. N. Nikishov, A. A. Kuzin, A. Y. Antipova, I. Lavrentieva, O. Maltsev, K. Kozlov, E. A. Antoniсhev, S. N. Nikishov, A. S. Sigidaev
{"title":"Atypical course of parvovirus B19 infection with combined infection (clinical observation)","authors":"O. N. Nikishov, A. A. Kuzin, A. Y. Antipova, I. Lavrentieva, O. Maltsev, K. Kozlov, E. A. Antoniсhev, S. N. Nikishov, A. S. Sigidaev","doi":"10.22625/2072-6732-2023-15-1-126-133","DOIUrl":"https://doi.org/10.22625/2072-6732-2023-15-1-126-133","url":null,"abstract":"","PeriodicalId":226950,"journal":{"name":"Journal Infectology","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127401434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-21DOI: 10.22625/2072-6732-2023-15-1-121-125
N. Pshenichnaya, G. Gopatsa, T. Sergeeva
Brucellosis is the most common and severe infectious disease in the group of zoonotic infections. This disease is characterized by a multisysitemic lesion. The difficulties in diagnosing this disease are associated with the pathogenetic features of the development of brucellosis, namely prolonged bacteremia, which causes the development of secondary foci of infection in various organs and tissues, manifested by a variety of clinical manifestations, the erasure of symptoms of the disease, as well as the appearance of rare clinical forms of brucellosis.One of the rare clinical manifestations of chronic brucellosis is the defeat of the cardiovascular system and the defeat of the nervous system. According to the latest literature data, cardiovascular complications of brucellosis in humans account for only 3%, but are the main cause of death in 80%. Damage to the nervous system is rare, with a registered frequency of 3% to 13%.Clinical manifestations of neurobrucellosis are diverse and can mimic many other neurological diseases. The most common manifestations of brucellosis may be meningitis, meningoencephalitis. Despite the rare occurrence, these forms of the disease are severe, lead to disability and mortality with late diagnosis. The article presents clinical cases of brucellosis with lesions of the heart and central nervous system.
{"title":"Rare clinical forms of chronic brucellosis","authors":"N. Pshenichnaya, G. Gopatsa, T. Sergeeva","doi":"10.22625/2072-6732-2023-15-1-121-125","DOIUrl":"https://doi.org/10.22625/2072-6732-2023-15-1-121-125","url":null,"abstract":"Brucellosis is the most common and severe infectious disease in the group of zoonotic infections. This disease is characterized by a multisysitemic lesion. The difficulties in diagnosing this disease are associated with the pathogenetic features of the development of brucellosis, namely prolonged bacteremia, which causes the development of secondary foci of infection in various organs and tissues, manifested by a variety of clinical manifestations, the erasure of symptoms of the disease, as well as the appearance of rare clinical forms of brucellosis.One of the rare clinical manifestations of chronic brucellosis is the defeat of the cardiovascular system and the defeat of the nervous system. According to the latest literature data, cardiovascular complications of brucellosis in humans account for only 3%, but are the main cause of death in 80%. Damage to the nervous system is rare, with a registered frequency of 3% to 13%.Clinical manifestations of neurobrucellosis are diverse and can mimic many other neurological diseases. The most common manifestations of brucellosis may be meningitis, meningoencephalitis. Despite the rare occurrence, these forms of the disease are severe, lead to disability and mortality with late diagnosis. The article presents clinical cases of brucellosis with lesions of the heart and central nervous system.","PeriodicalId":226950,"journal":{"name":"Journal Infectology","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130085505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-20DOI: 10.22625/2072-6732-2023-15-1-93-100
T. A. Skirda, O. Borisova, A. Borisova, S. Kombarova, A. S. Pimenova, N. Gadua, I. Chagina, M. Petrova, L. Kafarskaya
{"title":"Determination of anti-pertussis antibodies in schoolchildren with long-term cough","authors":"T. A. Skirda, O. Borisova, A. Borisova, S. Kombarova, A. S. Pimenova, N. Gadua, I. Chagina, M. Petrova, L. Kafarskaya","doi":"10.22625/2072-6732-2023-15-1-93-100","DOIUrl":"https://doi.org/10.22625/2072-6732-2023-15-1-93-100","url":null,"abstract":"","PeriodicalId":226950,"journal":{"name":"Journal Infectology","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116194162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-20DOI: 10.22625/2072-6732-2023-15-1-108-114
V. T. Hoang, A. A. Kuzin, A. Zobov, A. A. Zobovа
{"title":"Features of the system of epidemiological surveillance of infectious diseases in the Socialist Republic of Vietnam","authors":"V. T. Hoang, A. A. Kuzin, A. Zobov, A. A. Zobovа","doi":"10.22625/2072-6732-2023-15-1-108-114","DOIUrl":"https://doi.org/10.22625/2072-6732-2023-15-1-108-114","url":null,"abstract":"","PeriodicalId":226950,"journal":{"name":"Journal Infectology","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127605749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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