Pub Date : 2023-03-31DOI: 10.22246/jikm.2023.44.1.77
Sol Jeong, H. Jin, Ji-Hyun Hwang, J. Bak, Hye-soo Jeon, B. Moon, J. Yun
Objective: This clinical study describes the effect of Korean medicine on a post-traumatic hydrocephalus patient complaining of gait disturbance and dementia.Case presentation: A post-traumatic hydrocephalus patient complaining of gait disturbance and dementia was treated with herbal medicine, acupuncture, moxibustion, and cupping. Clinical symptoms were measured with the Korean Mini Mental Status Exam (K-MMSE), Functional Independence Measure (FIM), and Modified Barthel Index (MBI). After treatment, the patient showed improved K-MMSE, FIM, and MBI scores.Conclusion: This clinical case study provides evidence of the effect of Korean medicine on a post-traumatic hydrocephalus patient complaining of gait disturbance and dementia.
{"title":"A Case Report of Korean Medicine Treatment for a Post-traumatic Hydrocephalus Patient Complaining of Gait Disturbance and Dementia","authors":"Sol Jeong, H. Jin, Ji-Hyun Hwang, J. Bak, Hye-soo Jeon, B. Moon, J. Yun","doi":"10.22246/jikm.2023.44.1.77","DOIUrl":"https://doi.org/10.22246/jikm.2023.44.1.77","url":null,"abstract":"Objective: This clinical study describes the effect of Korean medicine on a post-traumatic hydrocephalus patient complaining of gait disturbance and dementia.Case presentation: A post-traumatic hydrocephalus patient complaining of gait disturbance and dementia was treated with herbal medicine, acupuncture, moxibustion, and cupping. Clinical symptoms were measured with the Korean Mini Mental Status Exam (K-MMSE), Functional Independence Measure (FIM), and Modified Barthel Index (MBI). After treatment, the patient showed improved K-MMSE, FIM, and MBI scores.Conclusion: This clinical case study provides evidence of the effect of Korean medicine on a post-traumatic hydrocephalus patient complaining of gait disturbance and dementia.","PeriodicalId":22826,"journal":{"name":"The Journal of Internal Korean Medicine","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89747485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.22246/jikm.2023.44.1.35
Chien-hsin Kuo, Heung Ko, S. Shin
Objective: Internal injuries and consumptive disease have different causes, yet they can affect each other. The relationship and combination of prescription drugs in the clinical practice of internal injuries and consumptive disease were analyzed for various diseases of “Donguibogam” through network analysis.Methods: The prescriptions used in consumptive disease and internal injury were established by conducting a full survey on the papers extracted from Donguibogam. The R version 4.0.3 (2020-10-10) and the igraph and arules package were used to perform network analysis and association rule relationship mining analysis in the first and second prescription compositions. Results: The herb frequently used for internal injury was Glycyrrhizae Radix, while the herb combination frequently used was Citri Pericarpium-Glycyrrhizae Radix. For centrality, the main factor was generally Glycyrrhizae Radix. In the case of consumptive disease, the herb most frequently used was Angelicae Gigantis Radix, and the combination most frequently used was Rehmanniae Radix Preparata-Angelicae Gigantis Radix. In terms of centrality, it was Angelicae Gigantis Radix. As a result of the network analysis of herbal prescription frequency, each group was divided into three.Conclusion: The interrelationship between internal injury and consumptive disease prescription drugs may reveal the differences and similarities between internal injury and consumptive disease and may serve as a basis for the development of new drugs or materials that can enhance mutual effectiveness in the treatment of internal injury and consumptive diseases.
目的:内伤与消耗性疾病病因不同，但又能相互影响。通过网络分析，分析“东桂伯干”各类疾病内伤与消耗性疾病临床实践中处方药的关系及组合。方法:通过对东桂保根提取文献的全面调查，建立治疗消耗性疾病和内伤的处方。使用R版本4.0.3(2020-10-10)和igraph and rules包对第一、第二处方成分进行网络分析和关联规则关系挖掘分析。结果:内伤常用中药为甘草，内伤常用中药组合为柠檬皮-甘草。中心性的主要因子一般为甘草。在消耗性疾病的情况下，最常使用的草药是当归，最常使用的组合是地黄-当归。在中心位置上，它是白芷。通过对中药处方频次的网络分析，将每组分为3组。结论:内伤与消耗性疾病处方药之间的相互关系可以揭示内伤与消耗性疾病之间的异同，为开发治疗内伤与消耗性疾病的新药物或新材料提供基础。
{"title":"Comparison of Herbs in Prescription Composition of Consumptive Disease and Internal Injury in Donguibogam Through Network Analysis","authors":"Chien-hsin Kuo, Heung Ko, S. Shin","doi":"10.22246/jikm.2023.44.1.35","DOIUrl":"https://doi.org/10.22246/jikm.2023.44.1.35","url":null,"abstract":"Objective: Internal injuries and consumptive disease have different causes, yet they can affect each other. The relationship and combination of prescription drugs in the clinical practice of internal injuries and consumptive disease were analyzed for various diseases of “Donguibogam” through network analysis.Methods: The prescriptions used in consumptive disease and internal injury were established by conducting a full survey on the papers extracted from Donguibogam. The R version 4.0.3 (2020-10-10) and the igraph and arules package were used to perform network analysis and association rule relationship mining analysis in the first and second prescription compositions. Results: The herb frequently used for internal injury was Glycyrrhizae Radix, while the herb combination frequently used was Citri Pericarpium-Glycyrrhizae Radix. For centrality, the main factor was generally Glycyrrhizae Radix. In the case of consumptive disease, the herb most frequently used was Angelicae Gigantis Radix, and the combination most frequently used was Rehmanniae Radix Preparata-Angelicae Gigantis Radix. In terms of centrality, it was Angelicae Gigantis Radix. As a result of the network analysis of herbal prescription frequency, each group was divided into three.Conclusion: The interrelationship between internal injury and consumptive disease prescription drugs may reveal the differences and similarities between internal injury and consumptive disease and may serve as a basis for the development of new drugs or materials that can enhance mutual effectiveness in the treatment of internal injury and consumptive diseases.","PeriodicalId":22826,"journal":{"name":"The Journal of Internal Korean Medicine","volume":"398 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79390726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.22246/jikm.2023.44.1.53
Jung-min Yang, Jaewoo Yang, Ji-hoon Oh, W. Hwang
Objective: The purpose of this study is to report two cases of breast cancer patients whose side effects after Tamoxifen were treated with traditional Korean medicine.Methods: Two breast cancer patients underwent Tamoxifen after breast-conserving surgery, and both were treated with traditional Korean medicine. Subjective discomfort symptoms were evaluated using the Numerical Rating Scale. Adverse events were assessed using the National Cancer Institute Common Terminology Criteria for Adverse Events, Version 5.0.Results: After treatment with traditional Korean medicine, the discomfort symptoms that occurred after Tamoxifen, such as osteoarthritis, hot flushes, and cold sweat, all gradually improved. In addition, no hematologic, hepatic, or renal side effects were observed from the traditional Korean medicine treatment.Conclusion: This case study suggests that traditional Korean medicine may contribute to the improvement of side effects caused by Tamoxifen and enhance the quality of life of patients.
{"title":"Traditional Korean Medicine Treatment for Sequelae After Tamoxifen in Breast Cancer Patients: Two Case Reports","authors":"Jung-min Yang, Jaewoo Yang, Ji-hoon Oh, W. Hwang","doi":"10.22246/jikm.2023.44.1.53","DOIUrl":"https://doi.org/10.22246/jikm.2023.44.1.53","url":null,"abstract":"Objective: The purpose of this study is to report two cases of breast cancer patients whose side effects after Tamoxifen were treated with traditional Korean medicine.Methods: Two breast cancer patients underwent Tamoxifen after breast-conserving surgery, and both were treated with traditional Korean medicine. Subjective discomfort symptoms were evaluated using the Numerical Rating Scale. Adverse events were assessed using the National Cancer Institute Common Terminology Criteria for Adverse Events, Version 5.0.Results: After treatment with traditional Korean medicine, the discomfort symptoms that occurred after Tamoxifen, such as osteoarthritis, hot flushes, and cold sweat, all gradually improved. In addition, no hematologic, hepatic, or renal side effects were observed from the traditional Korean medicine treatment.Conclusion: This case study suggests that traditional Korean medicine may contribute to the improvement of side effects caused by Tamoxifen and enhance the quality of life of patients.","PeriodicalId":22826,"journal":{"name":"The Journal of Internal Korean Medicine","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87629522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.22246/jikm.2023.44.1.66
Jun-seok Kim, Jihong Kang, Seo-hyun Kim, Chae-Eun Kim, Na-yeon Kim, WooSeok Jang
Background: The aim of this study is to investigate the use of heart rate variability on a stroke patient with autonomic dysfunction and the effectiveness of Bunshimgi-eum.Case report: The patient showed autonomic dysfunction, including chest discomfort, 煩燥 (sweating, anxiety, insomnia, nausea, lightheadedness), and abdomen discomfort (dyspepsia, heartburn) after ischemic stroke. She was treated with a herbal medicine (Bunshimgi-eum) through complex Korean medicine treatment. The effect was evaluated using heart rate variability (HRV), Mini-Mental State Examination-DS (MMSE-DS), mean pulse rate, and subjective percentage of symptoms. After treatment, the HRV score, MMSE-DS score, and subjective percentage of symptoms improved, and the pulse rate decreased from the upper boundary value.Discussion: The results suggest that HRV may be useful in evaluating stroke patients with autonomic dysfunction and that Bunshimgi-eum is suitable for treatment.
{"title":"A Case Report on the Use of Heart Rate Variability and the Treatment Effect of Bunshimgi-eum on Autonomic Dysfunction After Cerebral Infarction","authors":"Jun-seok Kim, Jihong Kang, Seo-hyun Kim, Chae-Eun Kim, Na-yeon Kim, WooSeok Jang","doi":"10.22246/jikm.2023.44.1.66","DOIUrl":"https://doi.org/10.22246/jikm.2023.44.1.66","url":null,"abstract":"Background: The aim of this study is to investigate the use of heart rate variability on a stroke patient with autonomic dysfunction and the effectiveness of Bunshimgi-eum.Case report: The patient showed autonomic dysfunction, including chest discomfort, 煩燥 (sweating, anxiety, insomnia, nausea, lightheadedness), and abdomen discomfort (dyspepsia, heartburn) after ischemic stroke. She was treated with a herbal medicine (Bunshimgi-eum) through complex Korean medicine treatment. The effect was evaluated using heart rate variability (HRV), Mini-Mental State Examination-DS (MMSE-DS), mean pulse rate, and subjective percentage of symptoms. After treatment, the HRV score, MMSE-DS score, and subjective percentage of symptoms improved, and the pulse rate decreased from the upper boundary value.Discussion: The results suggest that HRV may be useful in evaluating stroke patients with autonomic dysfunction and that Bunshimgi-eum is suitable for treatment.","PeriodicalId":22826,"journal":{"name":"The Journal of Internal Korean Medicine","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75042284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.22246/jikm.2023.44.1.1
Miso S. Park, Chan-young Kim, In-woo Choi, In-cheol Chae, Wang-Jung Hur, Sangsoo Park, Ho-Ryoung Yoo
Objective: There are currently no disease-modifying medications or definite long-term sustainable interventions for patients with Parkinson’s disease (PD), indicating an unmet treatment need. Our goal was to create a long-term sustainable intervention for PD patients that can be used in Korean medicine clinics.Methods: The Meridian Activation Remedy System (MARS) was created to stimulate a patient’s 12 meridians and sinew channels using a combination of acupoint stimulation and exercise. The acupoints and motions used in MARS were selected through literature studies and expert advice. The methodologies were refined using observational and case studies. With slow and fast movements, the MARS intervention was intended to activate both slow- and fast-twitch muscle fibers. Intradermal acupuncture and motion that shift the center of gravity were employed to enhance the patient’s balance and proprioception. In addition, the intervention included alternating movement exercises to address the complex cognitive decline commonly occurring in PD patients.Results: The following acupoints were chosen for the MARS intervention: bilateral Hegu (LI4), Houxi (SI3), Waiguan (TE5), Neiguan (PC6), Zhongchong (PC9), Yuji (LU10), Zusanli (ST36), Yanglingquan (GB34), Taichong (LR3), Kunlun (BL60), and Taixi (KI3). We also developed actions that can stimulate the body’s 12 meridians.Conclusion: We developed the MARS intervention, which combines acupuncture and exercise, to address the unmet therapeutic needs of PD patients. We hope that with additional research, the MARS intervention can be set as an effective therapeutic program for PD patients.
{"title":"MARS-PD: Meridian Activation Remedy System for Parkinson’s Disease","authors":"Miso S. Park, Chan-young Kim, In-woo Choi, In-cheol Chae, Wang-Jung Hur, Sangsoo Park, Ho-Ryoung Yoo","doi":"10.22246/jikm.2023.44.1.1","DOIUrl":"https://doi.org/10.22246/jikm.2023.44.1.1","url":null,"abstract":"Objective: There are currently no disease-modifying medications or definite long-term sustainable interventions for patients with Parkinson’s disease (PD), indicating an unmet treatment need. Our goal was to create a long-term sustainable intervention for PD patients that can be used in Korean medicine clinics.Methods: The Meridian Activation Remedy System (MARS) was created to stimulate a patient’s 12 meridians and sinew channels using a combination of acupoint stimulation and exercise. The acupoints and motions used in MARS were selected through literature studies and expert advice. The methodologies were refined using observational and case studies. With slow and fast movements, the MARS intervention was intended to activate both slow- and fast-twitch muscle fibers. Intradermal acupuncture and motion that shift the center of gravity were employed to enhance the patient’s balance and proprioception. In addition, the intervention included alternating movement exercises to address the complex cognitive decline commonly occurring in PD patients.Results: The following acupoints were chosen for the MARS intervention: bilateral Hegu (LI4), Houxi (SI3), Waiguan (TE5), Neiguan (PC6), Zhongchong (PC9), Yuji (LU10), Zusanli (ST36), Yanglingquan (GB34), Taichong (LR3), Kunlun (BL60), and Taixi (KI3). We also developed actions that can stimulate the body’s 12 meridians.Conclusion: We developed the MARS intervention, which combines acupuncture and exercise, to address the unmet therapeutic needs of PD patients. We hope that with additional research, the MARS intervention can be set as an effective therapeutic program for PD patients.","PeriodicalId":22826,"journal":{"name":"The Journal of Internal Korean Medicine","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85090139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-30DOI: 10.22246/jikm.2022.43.6.1301
Ji-Yoon Lee, Onadipe Jo, Sang-min Park, Sae-rom Choi, J. Shin, Jee-hoon Baek
Objective: The purpose of this case study was to report the effects of Korean medicine treatment on a patient diagnosed with postgastrectomy syndrome (PGS).Methods: The patient was treated with herbal medicine, acupuncture, and moxibustion in combination with Western medicine for 3 months.Results: Though abdominal tenderness was maintained at a similar level, other clinical symptoms (epigastric pain, globus pharyngis, and epigastric pain) were improved after Korean medicine treatment.Conclusions: These results suggest that the need to promote practical research on PGS, should receive greater attention in the Korean medical community.
{"title":"A Case Study of Korean Medical Treatment for Epigastric Pain and Insomnia after Gastrectomy","authors":"Ji-Yoon Lee, Onadipe Jo, Sang-min Park, Sae-rom Choi, J. Shin, Jee-hoon Baek","doi":"10.22246/jikm.2022.43.6.1301","DOIUrl":"https://doi.org/10.22246/jikm.2022.43.6.1301","url":null,"abstract":"Objective: The purpose of this case study was to report the effects of Korean medicine treatment on a patient diagnosed with postgastrectomy syndrome (PGS).Methods: The patient was treated with herbal medicine, acupuncture, and moxibustion in combination with Western medicine for 3 months.Results: Though abdominal tenderness was maintained at a similar level, other clinical symptoms (epigastric pain, globus pharyngis, and epigastric pain) were improved after Korean medicine treatment.Conclusions: These results suggest that the need to promote practical research on PGS, should receive greater attention in the Korean medical community.","PeriodicalId":22826,"journal":{"name":"The Journal of Internal Korean Medicine","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86619537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-30DOI: 10.22246/jikm.2022.43.6.1239
Do-yeon Park, Hyangra Moon, S. Jeon, Sang-yoon Jeon
Objectives: The purpose of this study was to report the effectiveness of Korean medicine in the treatment of reflux esophagitis.Methods: A 62-year-old male patient had reflux esophagitis that occurred one year after a proximal gastrectomy for gastric ulcer in 2020. The patient underwent drug treatment in 2021 and inpatient treatment in 2022 at Mokpo Hankook Hospital, but he did not improve. We treated him with Korean medical treatments, including herbal medicines (Pyungjingunbi-tang-gami), acupuncture, and moxibustion. His symptom severity was assessed with a daily visual analog scale (VAS) for heartburn, upper abdomen pain, and acid reflux.Results: After treatment, the patient's symptoms were improved. The severity of heartburn and acid reflux was reduced from VAS 7 to VAS 1, and his upper abdomen pain was improved from VAS 6 to VAS 1. The symptom frequency was also reduced.Conclusion: Korean medicine treatment could be an effective and quick treatment for reflux esophagitis.
{"title":"A Case Report of Reflux Esophagitis After Gastrectomy due to Gastric Ulcer","authors":"Do-yeon Park, Hyangra Moon, S. Jeon, Sang-yoon Jeon","doi":"10.22246/jikm.2022.43.6.1239","DOIUrl":"https://doi.org/10.22246/jikm.2022.43.6.1239","url":null,"abstract":"Objectives: The purpose of this study was to report the effectiveness of Korean medicine in the treatment of reflux esophagitis.Methods: A 62-year-old male patient had reflux esophagitis that occurred one year after a proximal gastrectomy for gastric ulcer in 2020. The patient underwent drug treatment in 2021 and inpatient treatment in 2022 at Mokpo Hankook Hospital, but he did not improve. We treated him with Korean medical treatments, including herbal medicines (Pyungjingunbi-tang-gami), acupuncture, and moxibustion. His symptom severity was assessed with a daily visual analog scale (VAS) for heartburn, upper abdomen pain, and acid reflux.Results: After treatment, the patient's symptoms were improved. The severity of heartburn and acid reflux was reduced from VAS 7 to VAS 1, and his upper abdomen pain was improved from VAS 6 to VAS 1. The symptom frequency was also reduced.Conclusion: Korean medicine treatment could be an effective and quick treatment for reflux esophagitis.","PeriodicalId":22826,"journal":{"name":"The Journal of Internal Korean Medicine","volume":"82 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83918146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-30DOI: 10.22246/jikm.2022.43.6.1149
K. Park, Heekyung Kang, Changwoo Han
Purpose: This systematic review was conducted to evaluate the clinical effects of Injinho-tang on hyperbilirubinemia in hepatobiliary disorders.Methods: We searched for randomized controlled clinical trials that had administered Injinho-tang as an intervention in the following medical databases: Public/Publisher MEDLINE (PubMed), Excerpta Medica dataBASE (EMBASE), Cochrane library, Research Information Sharing Service (RISS), ScienceON, Oriental Medicine Advanced Searching Integrated System (OASIS), and China National Knowledge Infrastructure (CNKI). Among the retrieved studies, only trials that met the inclusion criteria were selected, and serum total bilirubin values were extracted and analyzed from the finally selected trials.Results: The serum total bilirubin values of 1,302 patients with various hepatobiliary diseases were synthesized through a meta-analysis, which confirmed a decrease in serum total bilirubin of 21.03 µmol/L (95% CI -29.58~-12.49, p<0.01) in the group administered with Injinho-tang compared with the control group.Conclusions: Injinho-tang is effective in alleviating hyperbilirubinemia in hepatobiliary diseases when administered with conventional treatment. However, the potential risk of bias, high heterogeneity among the included trials, and differences in herbal composition are limitations of the results of this meta-analysis.
目的:评价金鸡汤治疗肝胆疾病患者高胆红素血症的临床疗效。方法:我们在以下医学数据库中检索使用金针和汤作为干预措施的随机对照临床试验:公共/出版商MEDLINE (PubMed)、医学摘录数据库(EMBASE)、Cochrane图书馆、研究信息共享服务(RISS)、ScienceON、东方医学高级检索集成系统(OASIS)和中国知网(CNKI)。在检索到的研究中，只选取符合纳入标准的试验，从最终选取的试验中提取血清总胆红素值并进行分析。结果:综合1302例各种肝胆疾病患者的血清总胆红素值，经荟萃分析证实，与对照组相比，注射金鸡汤组血清总胆红素降低21.03µmol/L (95% CI -29.58~-12.49, p<0.01)。结论:金鸡汤在常规治疗的基础上，可有效缓解肝胆疾病患者的高胆红素血症。然而，潜在的偏倚风险、纳入试验之间的高度异质性以及草药成分的差异是本荟萃分析结果的局限性。
{"title":"Clinical Effect of Injinho-tang on Hyperbilirubinemia in Hepatobiliary Disorders: A Systematic Review","authors":"K. Park, Heekyung Kang, Changwoo Han","doi":"10.22246/jikm.2022.43.6.1149","DOIUrl":"https://doi.org/10.22246/jikm.2022.43.6.1149","url":null,"abstract":"Purpose: This systematic review was conducted to evaluate the clinical effects of Injinho-tang on hyperbilirubinemia in hepatobiliary disorders.Methods: We searched for randomized controlled clinical trials that had administered Injinho-tang as an intervention in the following medical databases: Public/Publisher MEDLINE (PubMed), Excerpta Medica dataBASE (EMBASE), Cochrane library, Research Information Sharing Service (RISS), ScienceON, Oriental Medicine Advanced Searching Integrated System (OASIS), and China National Knowledge Infrastructure (CNKI). Among the retrieved studies, only trials that met the inclusion criteria were selected, and serum total bilirubin values were extracted and analyzed from the finally selected trials.Results: The serum total bilirubin values of 1,302 patients with various hepatobiliary diseases were synthesized through a meta-analysis, which confirmed a decrease in serum total bilirubin of 21.03 µmol/L (95% CI -29.58~-12.49, p<0.01) in the group administered with Injinho-tang compared with the control group.Conclusions: Injinho-tang is effective in alleviating hyperbilirubinemia in hepatobiliary diseases when administered with conventional treatment. However, the potential risk of bias, high heterogeneity among the included trials, and differences in herbal composition are limitations of the results of this meta-analysis.","PeriodicalId":22826,"journal":{"name":"The Journal of Internal Korean Medicine","volume":"05 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86482874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-30DOI: 10.22246/jikm.2022.43.6.1162
J. Kwon, S. An, K. Kong
Purpose: We examined the effects of Dansam (Salvia miltiorrhiza Bunge, SM) and Dansam-eum (DSE) on gastroesophageal reflux disease (GERD) and reflux esophagitis by comparing the inhibitory effects of SM and DSE with the representative treatment of PPI Omeprazole to determine if the effects of the prescription DSE based on Korean medicine are better than those of a single-use of SM.Methods: We performed experiments using both animal models and cancer cells.Results: Comparison of SM and DSE with PPI in the animal model tests revealed that the effects were superior for SM and DSE than for PPI in all categories (8-OHdG, p-IκB, PAR2, COX-1, cathelicidin, p-JNK, Caspase 3, ATP6V1B1, GRPR, serotonin, and NPY). In three categories (COX-1, serotonin, and NPY), SM and DSE showed superior results over the Controls. In the animal model tests, DSE was superior to SM in all categories except for serotonin. The anti-cancer effects observed in cancer cell tests revealed that SM and DSE had meaningful results in terms of cytotoxicity and cell movement rate, as well as in cancer cell apoptosis.Conclusions: We confirmed that SM and DSE can have effects on reflux esophagitis through the regulation of oxidative stress, inflammation, mucosal protection, apoptosis, proton pumping, and the enteroendocrine system in the stomach and esophagus. We also confirmed that SM and DSE have superior effects to those of PPI on all aspects, especially gastric mucosa protection and enteroendocrine system control. We also confirmed that SM and DSE have anti-cancer effects. Above all, we confirmed that DSE has superior effects on almost all aspects compared to using SM alone.
目的:研究丹参(丹参，SM)和丹参-eum (DSE)对胃食管反流病(GERD)和反流性食管炎的疗效，通过比较丹参和丹参- ese与PPI奥美拉唑代表性治疗的抑制效果，确定韩医处方丹参- ese是否优于单用丹参。方法:采用动物模型和肿瘤细胞进行实验。结果:SM和DSE与PPI在动物模型试验中比较，SM和DSE在所有类别(8-OHdG、p- i - κ b、PAR2、COX-1、cathelicidin、p-JNK、Caspase 3、ATP6V1B1、GRPR、5 -羟色胺、NPY)的作用均优于PPI。在三个类别(COX-1、血清素和NPY)中，SM和DSE表现出优于对照组的结果。在动物模型试验中，除血清素外，DSE在所有类别中均优于SM。在肿瘤细胞试验中观察到的抗癌作用表明，SM和DSE在细胞毒性、细胞运动速率以及癌细胞凋亡方面都有显著的结果。结论:我们证实SM和DSE可能通过调节胃和食管的氧化应激、炎症、粘膜保护、细胞凋亡、质子泵送和肠内分泌系统对反流性食管炎有影响。我们也证实了SM和DSE在各方面的作用都优于PPI，特别是对胃粘膜的保护和对肠内分泌系统的控制。我们也证实了SM和DSE具有抗癌作用。综上所述，我们证实了与单独使用SM相比，DSE在几乎所有方面都具有优越的效果。
{"title":"Inhibitory Effects of Dansam and Dansam-eum on Reflux Esophagitis and Migration of Cancer Cells","authors":"J. Kwon, S. An, K. Kong","doi":"10.22246/jikm.2022.43.6.1162","DOIUrl":"https://doi.org/10.22246/jikm.2022.43.6.1162","url":null,"abstract":"Purpose: We examined the effects of Dansam (Salvia miltiorrhiza Bunge, SM) and Dansam-eum (DSE) on gastroesophageal reflux disease (GERD) and reflux esophagitis by comparing the inhibitory effects of SM and DSE with the representative treatment of PPI Omeprazole to determine if the effects of the prescription DSE based on Korean medicine are better than those of a single-use of SM.Methods: We performed experiments using both animal models and cancer cells.Results: Comparison of SM and DSE with PPI in the animal model tests revealed that the effects were superior for SM and DSE than for PPI in all categories (8-OHdG, p-IκB, PAR2, COX-1, cathelicidin, p-JNK, Caspase 3, ATP6V1B1, GRPR, serotonin, and NPY). In three categories (COX-1, serotonin, and NPY), SM and DSE showed superior results over the Controls. In the animal model tests, DSE was superior to SM in all categories except for serotonin. The anti-cancer effects observed in cancer cell tests revealed that SM and DSE had meaningful results in terms of cytotoxicity and cell movement rate, as well as in cancer cell apoptosis.Conclusions: We confirmed that SM and DSE can have effects on reflux esophagitis through the regulation of oxidative stress, inflammation, mucosal protection, apoptosis, proton pumping, and the enteroendocrine system in the stomach and esophagus. We also confirmed that SM and DSE have superior effects to those of PPI on all aspects, especially gastric mucosa protection and enteroendocrine system control. We also confirmed that SM and DSE have anti-cancer effects. Above all, we confirmed that DSE has superior effects on almost all aspects compared to using SM alone.","PeriodicalId":22826,"journal":{"name":"The Journal of Internal Korean Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90241979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-30DOI: 10.22246/jikm.2022.43.6.1063
Ki-Hyun Park, Sang-Hyuk Kim, Siwoo Lee, K. Bae
Objectives: The aim of this study was to investigate the differences in the prevalence of metabolic syndrome (MetS) according to the Sasang constitution (SC) and cold and heat pattern identification (CHPI).Methods: SC, CHPI, MetS, and component data were obtained from 2,561 participants in 26 Korean medical clinics from 2007 to 2013. SC, diagnosed by Korean medicine doctors, was confirmed by positive responses to herbal medicines administered according to that constitution. The CHPI was verified by a questionnaire about thermal sensitivity and drinking habits. The diagnosis criteria for MetS were: 1) waist circumference (WC) ≥90 cm (male) and ≥80 cm (female); 2) triglycerides ≥150 mg/dL; 3) high density lipoprotein cholesterol (HDL) <40 mg/dL (male) and <50 mg/dL (female); 4) blood pressure ≧130/85 mmHg; and 5) fasting blood glucose ≥100 mg/dL. Odds ratios (ORs) and differences in MetS and its components were compared using logistic regression and ANCOVA.Results: The MetS prevalence rates were 54.1%, 22.0%, and 33.3% for Taeeumin (TE), Soeumin (SE), and Soyangin (SY), respectively, and 30.5% and 44.5% for the cold and heat patterns, respectively. ANCOVA for MetS components showed significantly higher WC in TE than in SE or SY, and all components except HDL were higher in the heat pattern group than in the cold pattern group. Logistic regression for MetS prevalence showed a significant association between TE and the heat pattern group (OR=1.653) but not for non-TE and the cold pattern group.Conclusions: Considering SC and CHPI together may be more effective in managing MetS than considering SC alone.
{"title":"Analysis of the Difference in the Prevalence of Metabolic Syndrome According to Sasang Constitution and Cold and Heat Pattern Identification","authors":"Ki-Hyun Park, Sang-Hyuk Kim, Siwoo Lee, K. Bae","doi":"10.22246/jikm.2022.43.6.1063","DOIUrl":"https://doi.org/10.22246/jikm.2022.43.6.1063","url":null,"abstract":"Objectives: The aim of this study was to investigate the differences in the prevalence of metabolic syndrome (MetS) according to the Sasang constitution (SC) and cold and heat pattern identification (CHPI).Methods: SC, CHPI, MetS, and component data were obtained from 2,561 participants in 26 Korean medical clinics from 2007 to 2013. SC, diagnosed by Korean medicine doctors, was confirmed by positive responses to herbal medicines administered according to that constitution. The CHPI was verified by a questionnaire about thermal sensitivity and drinking habits. The diagnosis criteria for MetS were: 1) waist circumference (WC) ≥90 cm (male) and ≥80 cm (female); 2) triglycerides ≥150 mg/dL; 3) high density lipoprotein cholesterol (HDL) <40 mg/dL (male) and <50 mg/dL (female); 4) blood pressure ≧130/85 mmHg; and 5) fasting blood glucose ≥100 mg/dL. Odds ratios (ORs) and differences in MetS and its components were compared using logistic regression and ANCOVA.Results: The MetS prevalence rates were 54.1%, 22.0%, and 33.3% for Taeeumin (TE), Soeumin (SE), and Soyangin (SY), respectively, and 30.5% and 44.5% for the cold and heat patterns, respectively. ANCOVA for MetS components showed significantly higher WC in TE than in SE or SY, and all components except HDL were higher in the heat pattern group than in the cold pattern group. Logistic regression for MetS prevalence showed a significant association between TE and the heat pattern group (OR=1.653) but not for non-TE and the cold pattern group.Conclusions: Considering SC and CHPI together may be more effective in managing MetS than considering SC alone.","PeriodicalId":22826,"journal":{"name":"The Journal of Internal Korean Medicine","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83672510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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