Pub Date : 2023-09-01DOI: 10.21608/mjcu.2023.325783
H. A. E. P. AMIRA A. MAHMOUD, M.Sc.; SILVIA
Background: Cerebral palsyis a neurodevelopmental disorder that caused by non-progressive lesion to the immature brain, this lesion causes permanent motor disability that presents with or without other associated disorders. Diplegia is a CP'S subtype where the four limbs of the body affected with more affection in both lower limbs. Balance problems are major problems faced by these children. Aim of Study: The purpose of the current study was to investigate which is more effective and has a better impact on balance in diplegic CP. Subjects and Methods: Thirty-four children with diplegic Cerebral Palsy of both genders, aged from 5 to 11 years with spasticity ranged from grade 1 or 1+ according to Modified Ashworth Scale and they were at level I or II on Gross Motor Function Classification System participated in the study. They were randomly assigned into 2 equal groups; All the included children received traditional physical therapy program while group (A) received additional vestibular training program, and group (B) received additional dual-task training program. Balance was assessed before and after the study using HUMAC balance system and pediatric balance scale. Results: There was significant increase in all variables that represent balance ( p >0.001), center of pressure, eye open firm surface, eye closed firm surfaceand pediatric balance scale in both group post treatment compared with pretreatment results, but there was no significant difference betweenall these variablesin the between groups comparison pre or post treatment ( p >0.05). Conclusion: Both vestibular training and dual task training improve balance of diplegic children mostly to the same extent, therefore, we can recommend them as basic protocols that should be included in the treatment plan for diplegic children.
{"title":"Effectiveness of Vestibular Versus Dual-Task Training on Balance in Children with Diplegic Cerebral Palsy","authors":"H. A. E. P. AMIRA A. MAHMOUD, M.Sc.; SILVIA","doi":"10.21608/mjcu.2023.325783","DOIUrl":"https://doi.org/10.21608/mjcu.2023.325783","url":null,"abstract":"Background: Cerebral palsyis a neurodevelopmental disorder that caused by non-progressive lesion to the immature brain, this lesion causes permanent motor disability that presents with or without other associated disorders. Diplegia is a CP'S subtype where the four limbs of the body affected with more affection in both lower limbs. Balance problems are major problems faced by these children. Aim of Study: The purpose of the current study was to investigate which is more effective and has a better impact on balance in diplegic CP. Subjects and Methods: Thirty-four children with diplegic Cerebral Palsy of both genders, aged from 5 to 11 years with spasticity ranged from grade 1 or 1+ according to Modified Ashworth Scale and they were at level I or II on Gross Motor Function Classification System participated in the study. They were randomly assigned into 2 equal groups; All the included children received traditional physical therapy program while group (A) received additional vestibular training program, and group (B) received additional dual-task training program. Balance was assessed before and after the study using HUMAC balance system and pediatric balance scale. Results: There was significant increase in all variables that represent balance ( p >0.001), center of pressure, eye open firm surface, eye closed firm surfaceand pediatric balance scale in both group post treatment compared with pretreatment results, but there was no significant difference betweenall these variablesin the between groups comparison pre or post treatment ( p >0.05). Conclusion: Both vestibular training and dual task training improve balance of diplegic children mostly to the same extent, therefore, we can recommend them as basic protocols that should be included in the treatment plan for diplegic children.","PeriodicalId":22964,"journal":{"name":"The Medical Journal of Cairo University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139343358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.21608/mjcu.2023.325785
D. A. G. M. AMAL RAYAN, M.D.*; ASMAA M. ZAHRAN,
.
.
{"title":"Risk of Second Malignancy in Upper Egypt in the Era of COVID-19: A Multicentric Cancer Experience","authors":"D. A. G. M. AMAL RAYAN, M.D.*; ASMAA M. ZAHRAN,","doi":"10.21608/mjcu.2023.325785","DOIUrl":"https://doi.org/10.21608/mjcu.2023.325785","url":null,"abstract":".","PeriodicalId":22964,"journal":{"name":"The Medical Journal of Cairo University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139345017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.21608/mjcu.2023.325787
A. A. E. E. M. ADEL M. OSMAN, M.D.; MOHAMED B.
Background: Iron deficiency anemia is widely present in patients with heart failure (HF) with an estimated prevalence of over 50% in ambulatory patients. It is an independent predictor of worse functional capacity and survival. Aim of Study: To measure serum hepicidin in patients with chronic systolic HF, compare this with healthy subjects and correlate iron status (serum ferritin and transferrin saturation) and serum hepicidin and the stages of HF severity. Patients and Methods: Sixty patients with systolic HF diagnosed at the outpatient clinic or Cardiology Department at the Mansoura Specialized Internal Medicine Hospital, Mansoura University, Mansoura, Egypt, were included in the study. Results: The mean age of the patients was 62.33 – 7.48 years, and in the control group was 61.13 – 7.50 years. In the cases group, there was 83.3% males and 16.7% females versus 63.3% males and 36.7% females in the control group. Forty five cases (75%) presented with class II NYHA classification HF and 15 cases (25%) with class III NYHA classification heart failure. The median levels of hemoglobin concentration, mean corpuscular volume, serum iron, serum ferritin and hepcidin level were higher in NYHA class II cases as compared to class III. The best cutoff point of hepcidin to identify HF cases from the control was below 9.15ng/ml with 63.3% sensitivity and 89.3% specificity. The AUC was 0.772 with high statistically difference ( p <0.001). Conclusion: Heart
{"title":"Correlation between Iron Status and Heart Failure Severity in Patients with Chronic Heart Failure","authors":"A. A. E. E. M. ADEL M. OSMAN, M.D.; MOHAMED B.","doi":"10.21608/mjcu.2023.325787","DOIUrl":"https://doi.org/10.21608/mjcu.2023.325787","url":null,"abstract":"Background: Iron deficiency anemia is widely present in patients with heart failure (HF) with an estimated prevalence of over 50% in ambulatory patients. It is an independent predictor of worse functional capacity and survival. Aim of Study: To measure serum hepicidin in patients with chronic systolic HF, compare this with healthy subjects and correlate iron status (serum ferritin and transferrin saturation) and serum hepicidin and the stages of HF severity. Patients and Methods: Sixty patients with systolic HF diagnosed at the outpatient clinic or Cardiology Department at the Mansoura Specialized Internal Medicine Hospital, Mansoura University, Mansoura, Egypt, were included in the study. Results: The mean age of the patients was 62.33 – 7.48 years, and in the control group was 61.13 – 7.50 years. In the cases group, there was 83.3% males and 16.7% females versus 63.3% males and 36.7% females in the control group. Forty five cases (75%) presented with class II NYHA classification HF and 15 cases (25%) with class III NYHA classification heart failure. The median levels of hemoglobin concentration, mean corpuscular volume, serum iron, serum ferritin and hepcidin level were higher in NYHA class II cases as compared to class III. The best cutoff point of hepcidin to identify HF cases from the control was below 9.15ng/ml with 63.3% sensitivity and 89.3% specificity. The AUC was 0.772 with high statistically difference ( p <0.001). Conclusion: Heart","PeriodicalId":22964,"journal":{"name":"The Medical Journal of Cairo University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139345703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.21608/mjcu.2023.325791
A. F. G. F. M. AHMED A. ELBARAWY, F.R.C.S., M.D.;
.
.
{"title":"Comparative Study between Effects of Intravitreal Injection of Ranibizumab With and Without Anterior Chamber Paracentesis in Diabetic Macular Oedema","authors":"A. F. G. F. M. AHMED A. ELBARAWY, F.R.C.S., M.D.;","doi":"10.21608/mjcu.2023.325791","DOIUrl":"https://doi.org/10.21608/mjcu.2023.325791","url":null,"abstract":".","PeriodicalId":22964,"journal":{"name":"The Medical Journal of Cairo University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139345285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.21608/mjcu.2023.326225
A. A. D. P. DINA A. SHERIF, M.Sc.*; AMIRA M.
.
.
{"title":"Effect of High-Power Laser Therapy on Pain and Electrophysiological Study in Cervical Radiculopathy Patients: A Randomized Controlled Trial","authors":"A. A. D. P. DINA A. SHERIF, M.Sc.*; AMIRA M.","doi":"10.21608/mjcu.2023.326225","DOIUrl":"https://doi.org/10.21608/mjcu.2023.326225","url":null,"abstract":".","PeriodicalId":22964,"journal":{"name":"The Medical Journal of Cairo University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139345770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.21608/mjcu.2023.325793
D. E. A. K. M. ABDELRAHMAN ELSAYED ATTIA, M.D.;, O. R. M. SAMEH SAMIR RAAFAT NAGUIB, M.D.;
Background: Percutaneous mitral commissurotomy now has emerged as the treatment of choice for severe pliable rheumatic mitral stenosis with good immediate hemodynamic outcome, low complication rates, and clinical improvement. P-wave dispersion (PWD) is a noninvasive (ECG) marker for atrial remodeling and predictor for atrial fibrillation. Effect of PMC on risk of atrial fibrillation is not well studied. Aim of Study: To evaluate the effect of percutaneous mitral commissurotomy on P wave dispersion to assess the risk of atrial fibrillation. Patients and Methods: This study is a prospective study which was on 36 patients with significant mitral stenosis (MV Area less than 1.5cm 2 ) presenting to Cardiology Department at Ain Shams University Hospital at 2022, all patients underwent PMC and ECG before PMC, 24 hours after PMC and two months after PMC. Results: The comparison of MVA, PWD and LA volume before, 24 hours postoperatively and at two months follow-up after PMC, showed that there was significant increase in MVA at 24 hours postoperatively from (0.87 – 0.2cm 2 ) to (2.01 – 0.21cm 2 ) p -value <0.001. P wave dispersion (PWD) showed significant decrease 24 hours after PMC from (63.33 – 11.71ms) to (51.39 – 9.23ms) after 24 hours and to (39.31 – 11.03ms) two months after PMC p -value <0.001. Also, left atrial volume (LA volume) showed significant decrease from (113.19 – 21.6ml) to (102.22 – 21.87ml) 24 hours after PMC and to (88.75 – 21.04ml) two months after PMC p -value <0.001. P wave dispersion (PWD) decreased in 27 patients (75%) 24 hours after PMC and in 33 patients (91.7%) after two months after PMC among suited patients. Conclusion: Percutaneous mitral commissurotomy was safe and effective in the treatment of mitral stenosis, it was associated with significant reduction in P-wave dispersion and left atrial volume and increase in mitral valve area as well as reduced risk of atrial fibrillation.
{"title":"Short Term Effect of Percutaneous Mitral Commissurotomy on P Wave Dispersion in Patients with Mitral Stenosis","authors":"D. E. A. K. M. ABDELRAHMAN ELSAYED ATTIA, M.D.;, O. R. M. SAMEH SAMIR RAAFAT NAGUIB, M.D.;","doi":"10.21608/mjcu.2023.325793","DOIUrl":"https://doi.org/10.21608/mjcu.2023.325793","url":null,"abstract":"Background: Percutaneous mitral commissurotomy now has emerged as the treatment of choice for severe pliable rheumatic mitral stenosis with good immediate hemodynamic outcome, low complication rates, and clinical improvement. P-wave dispersion (PWD) is a noninvasive (ECG) marker for atrial remodeling and predictor for atrial fibrillation. Effect of PMC on risk of atrial fibrillation is not well studied. Aim of Study: To evaluate the effect of percutaneous mitral commissurotomy on P wave dispersion to assess the risk of atrial fibrillation. Patients and Methods: This study is a prospective study which was on 36 patients with significant mitral stenosis (MV Area less than 1.5cm 2 ) presenting to Cardiology Department at Ain Shams University Hospital at 2022, all patients underwent PMC and ECG before PMC, 24 hours after PMC and two months after PMC. Results: The comparison of MVA, PWD and LA volume before, 24 hours postoperatively and at two months follow-up after PMC, showed that there was significant increase in MVA at 24 hours postoperatively from (0.87 – 0.2cm 2 ) to (2.01 – 0.21cm 2 ) p -value <0.001. P wave dispersion (PWD) showed significant decrease 24 hours after PMC from (63.33 – 11.71ms) to (51.39 – 9.23ms) after 24 hours and to (39.31 – 11.03ms) two months after PMC p -value <0.001. Also, left atrial volume (LA volume) showed significant decrease from (113.19 – 21.6ml) to (102.22 – 21.87ml) 24 hours after PMC and to (88.75 – 21.04ml) two months after PMC p -value <0.001. P wave dispersion (PWD) decreased in 27 patients (75%) 24 hours after PMC and in 33 patients (91.7%) after two months after PMC among suited patients. Conclusion: Percutaneous mitral commissurotomy was safe and effective in the treatment of mitral stenosis, it was associated with significant reduction in P-wave dispersion and left atrial volume and increase in mitral valve area as well as reduced risk of atrial fibrillation.","PeriodicalId":22964,"journal":{"name":"The Medical Journal of Cairo University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139344950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.21608/mjcu.2023.325788
E. E. S. P. MOSHIRA M. METWALLY, M.Sc.*; AMANY
.
.
{"title":"Effect of Prolonged Slow Expiration Technique on Oxygen Saturation and Blood Pressure Among Neonates with Pneumonia","authors":"E. E. S. P. MOSHIRA M. METWALLY, M.Sc.*; AMANY","doi":"10.21608/mjcu.2023.325788","DOIUrl":"https://doi.org/10.21608/mjcu.2023.325788","url":null,"abstract":".","PeriodicalId":22964,"journal":{"name":"The Medical Journal of Cairo University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139345598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.21608/mjcu.2023.326244
ABOBAKR, M.D. OSAMA M.
Background: Myocardial infarction MI is the leading cause of death all over the world. One of the most important risk factors for MI is diabetes mellitus especially if presented with other risk factors as smoking, hypercholesterolemia and hypertension. The higher level of HgA1c is associated with increasing complications of MI. Aim of Study: This study aimed to study the prevalence of MI in young diabetic patients (20-39 years) living in North Sinai governorate. Patients and Methods: This study was carried-out on 100 patients aged 20-39 years, patients suffering from diabetes mellitus either Type 1 or type 2 or, recently diagnosed DM or long time diabetic patients, on oral hypoglycemic medications or insulin treatment. All patients were subjected to standard 12 lead electrocardiogram (ECG), full echocardiography and full laboratory investigations. Excluded from the study were patients with ischemic heart disease diagnosed by history, cardiac enzymes, ECG and/or echocardiography. All patients underwent the following, full history, Chest pain analysis, ECG, echocardiographic, evidence of gross segmental wall motion abnormality. Results: The study indicated that diabetes increase the prevalences of myocardial infarction. Also, the results indicated that dyslipidemia, hypertension, and smoking were risk factors for myocardial infarction, The main symptoms of cardiac infarction includes chest pain. The best methods of diagnosis includes clinical presentation of TCP, ECG, and increasing level of cardiac troponin with increasing level of HgA1C, with increasing complications of MI. Conclusion: The prevalence of myocardial infarction in young diabetic patients (20-39 years) was 17% and the main symptoms of cardiac infarction was typical chest pain. The higher level of HgA1c was associated with increasing complications of MI as HF.
{"title":"Prevalence of Myocardial Infarction in Young Diabetic Patients (20-39 Years) Living in North Sinai Governorate","authors":"ABOBAKR, M.D. OSAMA M.","doi":"10.21608/mjcu.2023.326244","DOIUrl":"https://doi.org/10.21608/mjcu.2023.326244","url":null,"abstract":"Background: Myocardial infarction MI is the leading cause of death all over the world. One of the most important risk factors for MI is diabetes mellitus especially if presented with other risk factors as smoking, hypercholesterolemia and hypertension. The higher level of HgA1c is associated with increasing complications of MI. Aim of Study: This study aimed to study the prevalence of MI in young diabetic patients (20-39 years) living in North Sinai governorate. Patients and Methods: This study was carried-out on 100 patients aged 20-39 years, patients suffering from diabetes mellitus either Type 1 or type 2 or, recently diagnosed DM or long time diabetic patients, on oral hypoglycemic medications or insulin treatment. All patients were subjected to standard 12 lead electrocardiogram (ECG), full echocardiography and full laboratory investigations. Excluded from the study were patients with ischemic heart disease diagnosed by history, cardiac enzymes, ECG and/or echocardiography. All patients underwent the following, full history, Chest pain analysis, ECG, echocardiographic, evidence of gross segmental wall motion abnormality. Results: The study indicated that diabetes increase the prevalences of myocardial infarction. Also, the results indicated that dyslipidemia, hypertension, and smoking were risk factors for myocardial infarction, The main symptoms of cardiac infarction includes chest pain. The best methods of diagnosis includes clinical presentation of TCP, ECG, and increasing level of cardiac troponin with increasing level of HgA1C, with increasing complications of MI. Conclusion: The prevalence of myocardial infarction in young diabetic patients (20-39 years) was 17% and the main symptoms of cardiac infarction was typical chest pain. The higher level of HgA1c was associated with increasing complications of MI as HF.","PeriodicalId":22964,"journal":{"name":"The Medical Journal of Cairo University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139346709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.21608/mjcu.2023.326234
A. H. E. M. A. MOHAMED A. EISSA, M.D.; BASIM M.
.
.
{"title":"Factors Affecting Visual Outcomes after Transsphenoidal Pituitary Adenectomy","authors":"A. H. E. M. A. MOHAMED A. EISSA, M.D.; BASIM M.","doi":"10.21608/mjcu.2023.326234","DOIUrl":"https://doi.org/10.21608/mjcu.2023.326234","url":null,"abstract":".","PeriodicalId":22964,"journal":{"name":"The Medical Journal of Cairo University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139344287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.21608/mjcu.2023.326247
N. M. E. M. M. W. AMIRA A. ELGAMMAL, M.D.*; MOHAMED
Background: Neonatal sepsis is still a significant cause of morbidity and mortality. Aim of Study: Was to determine the typical pathogens that cause neonatal sepsis in neonates admitted to the neonatal intensive care unit, to determine the impact of neonatal sepsis on blood results, and to determine the significance of mean platelet volume, uric acid levels and neutrophil lymphocyte ratio in the early diagnosis of neonatal sepsis. Patients and Methods: The study involved seventy cases and 70 matched healthy neonates that were recruited. All newborns had been examined with emphasis on the perinatal history, maternal history and focus on newborn risk factors. Sepsis screen was done in addition to mean platelets volume and uric acid serum levels. Results: MPV was used as a predictor for sepsis diagnosis: at the cutoff value of 9.15 fL had a sensitivity of 88% and specificity of 70% with a positive predictive value (PPV) of 50%, negative predictive value (NPV) of 94.9% and accuracy of 75%. Used as a predictor of sepsis diagnosis, serum uric acid had a PPV of 60.5%, NPV of 88.2%, and accuracy of 20%. It also had a sensitivity of 65.7% and specificity of 85.7%. Conclusions: Mean platelets volume, uric acid and neutrophil: Lymphocyte ratio serve as early indicators of neonatal sepsis as compared to the blood culture in diagnosis of neonatal sepsis diagnosis.
{"title":"Neutrophil: Lymphocyte Ratio, Mean Platelet Volume and Serum Uric Acid as a Diagnostic and Prognostic Marker of Neonatal Sepsis","authors":"N. M. E. M. M. W. AMIRA A. ELGAMMAL, M.D.*; MOHAMED","doi":"10.21608/mjcu.2023.326247","DOIUrl":"https://doi.org/10.21608/mjcu.2023.326247","url":null,"abstract":"Background: Neonatal sepsis is still a significant cause of morbidity and mortality. Aim of Study: Was to determine the typical pathogens that cause neonatal sepsis in neonates admitted to the neonatal intensive care unit, to determine the impact of neonatal sepsis on blood results, and to determine the significance of mean platelet volume, uric acid levels and neutrophil lymphocyte ratio in the early diagnosis of neonatal sepsis. Patients and Methods: The study involved seventy cases and 70 matched healthy neonates that were recruited. All newborns had been examined with emphasis on the perinatal history, maternal history and focus on newborn risk factors. Sepsis screen was done in addition to mean platelets volume and uric acid serum levels. Results: MPV was used as a predictor for sepsis diagnosis: at the cutoff value of 9.15 fL had a sensitivity of 88% and specificity of 70% with a positive predictive value (PPV) of 50%, negative predictive value (NPV) of 94.9% and accuracy of 75%. Used as a predictor of sepsis diagnosis, serum uric acid had a PPV of 60.5%, NPV of 88.2%, and accuracy of 20%. It also had a sensitivity of 65.7% and specificity of 85.7%. Conclusions: Mean platelets volume, uric acid and neutrophil: Lymphocyte ratio serve as early indicators of neonatal sepsis as compared to the blood culture in diagnosis of neonatal sepsis diagnosis.","PeriodicalId":22964,"journal":{"name":"The Medical Journal of Cairo University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139346301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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