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The parturition-relevant hormone profile in hyper-prolific sows under different housing conditions.
IF 0.4 4区 农林科学 Q4 VETERINARY SCIENCES Pub Date : 2025-03-03 DOI: 10.1055/a-2519-7296
Desirée Lehn, Sarah Blim, Michael Oster, Winfried Otten, Klaus Failing, Theresa Scheu, Christian Koch, Georg Thaller, Jens Peter Teifke, Hartwig Bostedt

Aim was to characterize birth-relevant hormone profiles of reproductively productive hybrid sows in the peripartum period. It was examined whether there are deviations in the hormone profile depending on the birth process (eutocia:dystocia) and the type of housing (box stall BS vs. farrowing pen FP vs. group housing GH).A total of 40 healthy, heavily pregnant hybrid sows (German Landrace x Large White) with a gestation number≥ 2 were available. The distribution between the housing types was: BS n=18, FP n=15, GH n=7. All births occurred after the biologically completed gestation period. Blood samples were taken via indwelling catheters (113th day ante partum to 4th day post partum). Progesterone (P4), oestradiol (E2), prostaglandin F2α and its metabolites (PGFM), relaxin, oxytocin, cortisol, adrenaline and noradrenaline were determined.The ratio of eutocia:dystocia was 15:25. Dystocia occurred regardless of type of housing. The only reason for dystocia was a weak labor (>60 min). The litter size was 17.73± 3.85 piglets. Differences in the hormone profiles between eutocia and dystocia were as follows: P4 tended to be higher in dystocia p=0.0776; oxytocin higher in eutocia (not significant), 12.5% of sows permanently with hypoxytocinemia; cortisol p=0.0503; noradrenaline p=0.0098. The type of housing had the following influence on the hormone profile: P4 p=0.046; E2 p=0.0009; PGFM p=0.0108; relaxin p=0.0022; noradrenaline p=0.0078.The parturition-relevant hormones are related to the parturition and to the type of housing during birth. The hormone profiles obtained could be of use in the discussion about the animal welfare-oriented housing system in the peripartum phase in pigs. The proportion of sows of the hyperproliferative line studied with permanent hypoxytocinaemia in stage II of parturition is remarkable. The ratio of eutocia:dystocia is unevenly distributed. Dystocia occurred regardless of the type of housing.

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引用次数: 0
[Equine piroplasmosis: Case descriptions and overview of the epidemiological situation in Europe with focus on Germany]. [马螺旋体病:病例描述和欧洲流行病学情况概述,重点是德国]。
IF 0.4 4区 农林科学 Q4 VETERINARY SCIENCES Pub Date : 2025-02-01 Epub Date: 2024-12-04 DOI: 10.1055/a-2457-5516
Carla Wiebke Axt, Andrea Springer, Jennifer von Luckner, Torsten J Naucke, Elisabeth Müller, Christina Strube, Ingo Schäfer

Equine piroplasmosis (EP) is caused by Babesia (B.) caballi and Theileria (T.) equi and is transmitted by hard ticks. Predominantly, the Mediterranean region is known as being endemic for both pathogens in Europe. However, autochthonous infections in central European countries such as Germany can no longer be ruled out due to individual case reports in horses without any stays abroad as well as the geographical expansion of the habitats of different tick species. The case reports presented underline the risk of infection for horses travelling to endemic areas and in horses imported from such areas to non-endemic countries. Clinical signs are often unspecific and include fever, icterus, lethargy, inappetence, weight loss, and reduced performance. Mild to severe anemia is the most common hematologic abnormality, but thrombocytopenia has also been described. Direct (polymerase chain reaction, microscopical analysis of blood smears) and indirect detection methods (detection of antibodies) are available for the diagnosis of pathogen contact and/or infection. Imidocarb-dipropionate is recommended as treatment of choice against EP. Infections with B. caballi can be cleared, while infections with T. equi often result in a life-long carrier status despite treatment. Prevention is limited to controlling or avoiding tick contact. Aside from potentially severe and life-threatening clinical signs, equine piroplasmosis has a significant economic impact on the international trade of horses worldwide. EP is classified as a notifiable disease according to WOAH guidelines, which recommend serological screening for B. caballi and T. equi according to the respective national guidelines when travelling across borders. To date, EP is not classified as a notifiable nor reportable disease in Germany.

马体浆虫病(EP)由卡巴贝斯虫和马伊勒氏菌引起,并通过硬蜱传播。众所周知,地中海地区是欧洲这两种病原体的主要流行地区。然而,由于没有在国外停留过的马的个案报告以及不同蜱虫物种栖息地的地理扩展,中欧国家(如德国)的本地感染不能再排除。所提出的病例报告强调了前往流行地区的马匹以及从这些地区进口到非流行国家的马匹的感染风险。临床症状通常不明确,包括发热、黄疸、嗜睡、食欲不振、体重减轻和工作能力下降。轻度至重度贫血是最常见的血液学异常,但血小板减少症也有描述。直接检测方法(聚合酶链反应、血液涂片显微分析)和间接检测方法(抗体检测)可用于诊断病原体接触和/或感染。吡虫威二丙酸推荐作为治疗EP的选择。caballi B.感染可以被清除,而T. equi感染通常导致终生携带者状态,尽管治疗。预防仅限于控制或避免蜱虫接触。除了潜在的严重和危及生命的临床症状外,马螺形体病对全世界马匹的国际贸易具有重大的经济影响。根据世界卫生组织的指导方针,EP被列为一种法定疾病,该指导方针建议在跨境旅行时根据各自的国家指导方针对卡巴利白杆菌和马杆菌进行血清学筛查。迄今为止,在德国,EP未被列为必须通报或报告的疾病。
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引用次数: 0
[Guidelines for the vaccination of horses - 5th edition].
IF 0.4 4区 农林科学 Q4 VETERINARY SCIENCES Pub Date : 2025-02-01 Epub Date: 2025-02-18 DOI: 10.1055/a-2517-4204

Vaccination is one of the most important measures for preventing infectious diseases. Vaccinations against tetanus and West-Nile-Virus are essential to protect the individual horse. These infections are not contagious and are not transmitted from animal to animal. By contrast, Equine Influenza and Equine-Herpes-Virus infections are highly contagious, transmissible diseases. In addition to protecting the vaccinated individual, vaccinating as many horses as possible aims at inducing a broad herd immunity, which interrupts infection chains and thus additionally protects the individual. Vaccination against tetanus, Equine Influenza and Equine-Herpes-Virus infections are core vaccinations for horses. The immunization against West-Nile-Virus is currently considered non-core and only recommended in the outbreak areas in eastern parts of Germany and, since 2024, in the entire lowlands of Northern Germany. Prospectively, depending on the future development of the epidemic, vaccination against West-Nile-Virus is likely to become core-component. It will then be recommended for the entire country. In addition to those already mentioned, there are marketing authorizations for vaccines against dermatomycosis, strangles, rotavirus infections, equine viral arteritis and rabies. Depending on the risk of exposure, the use of these vaccines can be highly advisable for individual cases.

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引用次数: 0
[Dyspnea in a llama resulting from hyperkeratotic crusts in the area of the nasal openings].
IF 0.4 4区 农林科学 Q4 VETERINARY SCIENCES Pub Date : 2025-02-01 Epub Date: 2025-02-18 DOI: 10.1055/a-2505-4241
Sonja Franz, Pauline Petring, Katharina Schlegel, Agnes Dadak, Kathleen Wittek, Thomas Wittek

This case report describes the clinical findings, diagnostic procedures, therapeutic options, and the outcome in a llama suffering from idiopathic, necrolytic, neutrophilic hyperkeratosis (INNH) around the nares. The exact pathogenesis and etiology of this disease remains unknown up to now . To date, only a few reports on this condition are available in the scientific literature. Information regarding prevalence of this disease among South American camelids is lacking.The multimodal therapeutic measures (surgically, medically, physically) and the course of the disease are presented. A lasting clinical improvement was achieved, although complete healing did not occur.

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引用次数: 0
[Validation of a decision tree for selective dry cow therapy of dairy for a digital expert system].
IF 0.4 4区 农林科学 Q4 VETERINARY SCIENCES Pub Date : 2025-02-01 Epub Date: 2025-02-18 DOI: 10.1055/a-2510-3874
Anna Stoll, Alicia Pichlmeier, Holm Zerbe, Folkert Onken, Julia Sophia Gerke, Florian Grandl, Leonid Ziegler, Rainer Martin

In this study, a decision tree derived from scientific literature on selective dry cow therapy (ST), which was developed as a knowledge base for a digital expert system, was evaluated. The decision tree merges algorithmic (based on cell count results) and cultural (based on milk sample findings) approaches.During a two-year project period (August 2021-September 2023), ST was carried out on 19 dairy farms in southern Germany according to the decision tree, without specific requirements being placed on the herd's udder health before the start. A total of 1,369 dry-off observations were recorded. The dry-off cases were evaluated regarding implementation of the recommendations, cell count at the first milk recording after calving, proportion of new infections and cures during the dry period depending on the implementation of the dry-off recommendation and the udder health status of the herd.Across all farms, 38.4% of cows were dried off without the use of an antibiotic. The potential for saving antibiotics varied greatly between farms (range: 2.4-71.3%). In 75.9% of cases, a dry-off recommendation could be made based on the available udder health data; only in around 25% of cows did the dry-off recommendation require a microbiological examination of quarter milk samples. On average, the milk cell count after the dry period was less than 100,000 cells/ml in animals that were dried off with and without an antibiotic dry-off preparation. The proportions of new infections and cures during the dry period did not differ significantly between animals with and without an antibiotic dry-off preparation.The results show that with the help of the developed decision tree, ST can be carried out safely in dairy farms without endangering udder health. This decision tree can therefore serve as a reliable knowledge base for a digital expert system to optimize dry-off management in dairy farms.

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引用次数: 0
[Statement on the efficacy and immunological safety of EHV vaccines in horses].
IF 0.4 4区 农林科学 Q4 VETERINARY SCIENCES Pub Date : 2025-02-01 Epub Date: 2025-02-18 DOI: 10.1055/a-2518-1976
<p><p>In February 2021, a serious EHV-1 outbreak occurred at an international jumping competition in Valencia, with several subsequent outbreaks in various European countries. As a consequence, several equestrian associations introduced compulsory vaccination against EHV-1, and in the immediate aftermath of the outbreak, demand for EHV vaccinations increased sharply. The initial concern has now dissipated. One equestrian association has abolished the compulsory vaccination that had only been introduced a year before, and a general debate began questioning the efficacy and safety of EHV-vaccines. This discussion has been fueled by international meta-studies that systematically re-evaluated published efficacy studies on EHV-vaccines. The meta-studies applied evidence criteria that were originally designed for preclinical studies in human medicine. It was concluded that the quality of the published data was not sufficient to prove the efficacy of EHV vaccines. Naturally, lack of evidence does not prove the opposite! Hence, one of the two author teams of these meta-studies upholds the notion that vaccination is a centerpiece of comprehensive EHV management strategies.StIKo Vet has carefully followed the discussions and the meta-studies. It cannot be expected that other infection studies on horses meeting the evidence criteria will be conducted in the near future, as EHV infection studies on horses pose considerable ethical, logistical and economic challenges. Therefore, StIKo Vet has undertaken an own re-evaluation of the existing efficacy studies. In addition, outbreak investigations were reviewed with regard to the role of EHV vaccination as a risk factor for the development of severe clinical courses.StIKo Vet concludes that, even if vaccination against EHV-1 does not confer absolute protection to the vaccinated individual, the re-evaluated studies show highly significant differences between vaccinated and unvaccinated animals: Vaccination reduces the severity of clinical symptoms and the duration and level of virus excretion. Herd vaccination can reduce overall viral loads and thus interrupt infection chains. There is ample reason to assume vaccine efficacy, but no compelling evidence was found for a correlation between EHV vaccination and severe EHV symptoms. By contrast, a comprehensive analysis of several different outbreaks shows that a herd immunity over 40 % is able to significantly reduce the risk for neurological symptoms. In addition, it has to be emphasized that the safety and efficacy of EHV-vaccines is stringently evaluated during the marketing authorization process. Only facts that have appropriately been proven in licensing studies are documented in the summary of product characteristics, e.g. the packaging leaflet. StIKo Vet therefore upholds EHV as a core-vaccination for horses. Every horse should be vaccinated and protected against EHV-1 at all times. It is likewise clear that with high viral loads and additional predisposing fac
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引用次数: 0
Occurrence of antibody titers against Borna disease virus in alpacas in Bavaria, Germany.
IF 0.4 4区 农林科学 Q4 VETERINARY SCIENCES Pub Date : 2025-02-01 Epub Date: 2025-02-18 DOI: 10.1055/a-2512-6445
Leonie Isabelle Kirmayer, Christine Lendl, Thomas Wittek

The increasing population of alpacas in Germany requires comprehensive studies on potential disease. Borna Disease, an infection believed to be primarily transmitted by the bicolored, white-toothed- shrew (Crocidura leucodon) to animals and humans, poses significant concerns. This study aimed to assess the occurrence of Borna Disease virus (BoDV) antibodies in alpacas in Bavaria, Germany, and explore associated epidemiological factors.A total of 424 serum samples were collected from 65 alpaca farms in Bavaria, which were selected voluntarily. In addition, questionnaires were filled out by the animal owners gathering information on husbandry and disease awareness of the owners.The results revealed an occurrence rate of nearly 9%, with one in every fourth farm housing at least one antibody-positive animal. While no significant differences were observed in breed, age, or gender, regional endemic areas were identified, coinciding with the presence of the shrew.This study underscores the widespread occurrence of BoDV antibodies in alpacas in Bavaria, emphasizing the importance of hygiene management and increased awareness of the disease among animal owners and veterinarians.

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引用次数: 0
Microbiological pathogens in fecal samples of foals during the first year of life. 马驹第一年粪便样本中的微生物病原体。
IF 0.4 4区 农林科学 Q4 VETERINARY SCIENCES Pub Date : 2024-12-01 Epub Date: 2024-12-05 DOI: 10.1055/a-2450-9531
Clarissa Jung, Michaela Gentil, Elisabeth Müller

Objective: The objective of the study was to investigate the age dependent occurrence of different infectious agents in foals with diarrhea.

Material and methods: Fecal samples, which were submitted to a commercial laboratory for a PCR-profile "Foal Diarrhea Pathogens" from 01.01.2021 up to 31.12.2022 (n=144), were examined for Equine Coronavirus (ECoV), Lawsonia (L.) intracellularis, Rhodococcus (R.) hoagii (=R. equi), Clostridium (Cl.) perfringens toxin-encoding genes cpa, cpe, cpb, etx and netF, Clostridioides (C.) difficile toxin-encoding genes tcdA and tcdB, as well as Rotavirus A via PCR.

Results: Pathogens could be detected in a high proportion (42.9%) of the samples. Rotavirus A was the most prevalent pathogen in the current study, followed by clostridial species. Especially in foals younger than one month, netF-producing Cl. perfringens was detected frequently. In this age group, netF-producing Cl. perfringens was as prevalent as Rotavirus A. In comparison, R. hoagii, L. intracellularis and ECoV were detected rarely. Cl. perfringens toxin-encoding genes cpb and etx were not present in the examined samples. In general, the previously known age dependency of the investigated pathogens could be confirmed. Nevertheless, Rotavirus A and netF-positive Cl. perfringens could also be detected outside of the most susceptible age group. Coinfections with the examined pathogens had a low prevalence in the current study.

Conclusions: In general, the examined pathogens showed an age dependent occurrence, but infections in foals outside of the common age group could not be ruled out with certainty due to small sample numbers in some of the age groups. Although Rotavirus A was the most prevalent pathogen in this study, netF-producing Cl. perfringens is an important differential diagnosis, especially in newborn foals. The diagnostic approach in diarrheic foals should contain a broad spectrum of pathogens. This is not only important to detect coinfections, but also to detect shedders, in order to protect other horses in the stable.

目的:研究不同感染因子在马驹腹泻发病中的年龄依赖性。材料和方法:将从2021年1月1日至2022年12月31日提交给商业实验室的粪便样本(n=144)进行PCR-profile“马驹腹泻病原体”检测,检测马冠状病毒(ECoV)、胞内Lawsonia (L.)、hoagii红球菌(R.)。产气荚膜梭菌(Cl.)毒素编码基因cpa、cpe、cpb、etx和netF,艰难梭菌(C.)毒素编码基因tcdA和tcdB,以及轮状病毒A。结果:病原菌检出率高(42.9%)。轮状病毒A是目前研究中最常见的病原体,其次是梭状芽孢杆菌。特别是在一个月以下的马驹中,净产氟的氯。产气荚膜经常被检测到。在这个年龄组中,净产f的Cl。产气荚膜原病毒与a轮状病毒一样普遍,而hoagii、胞内乳杆菌和ECoV则很少检出。Cl。产气荚膜毒素编码基因CPB和etx在检测样品中不存在。总的来说,可以证实先前已知的所调查病原体的年龄依赖性。然而,轮状病毒A和净f阳性Cl。产气荚膜菌也可以在最易感年龄组以外的人群中检测到。在目前的研究中,与所检查的病原体共感染的发生率较低。结论:一般来说,检查的病原体显示出年龄依赖性,但由于某些年龄组的样本量小,不能确定排除普通年龄组以外马驹的感染。虽然轮状病毒A是本研究中最普遍的病原体,但产净f的Cl。产气荚膜菌是重要的鉴别诊断,特别是在新生马驹中。腹泻马驹的诊断方法应包含广泛的病原体。这不仅对发现共感染很重要,而且对发现脱毛者也很重要,以保护马厩里的其他马。
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引用次数: 0
Danksagung an die Gutachter / Acknowledgement for Reviewers. Danksagung and die Gutachter /审稿人致谢。
IF 0.4 4区 农林科学 Q4 VETERINARY SCIENCES Pub Date : 2024-12-01 Epub Date: 2024-12-05 DOI: 10.1055/a-2462-7136
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引用次数: 0
[Traumatic subluxation of the cervical spine in an 1-year-old alpaca mare]. [1岁羊驼母马外伤性颈椎半脱位]。
IF 0.4 4区 农林科学 Q4 VETERINARY SCIENCES Pub Date : 2024-12-01 Epub Date: 2024-12-05 DOI: 10.1055/a-2450-9478
Hannah Hümmelchen, Jana Petzold, Henrik Wagner

A 1-year-old alpaca mare was presented due to lateral deviation of the cervical spine which had been present for a period of 2 weeks. Based on the previous report, a traumatic event was assumed. Feed and water intake were unremarkable, the gait was altered due to slight ataxic movements in all 4 limbs. The animal showed no further neurological deficits on initial presentation. Radiographs revealed a displacement of the cervical vertebrae to the left as part of a subluxation of the articular processes of the cervical vertebrae C4 and C5. During the course of conservative treatment with pain medication, neurologic signs including ataxia and I: mpaired balance developed in spite of unremarkable food intake. Subsequently, the animal died at a time when it was not under observation.Pathologic examination revealed degenerative and inflammatory alterations as well as hemorrhages in the cervical medulla at the level of the axial deviation of the cervical spine. Under consideration of the patient's history, the findings may most likely be seen as the result of blunt trauma and represent the cause of the neurologic signs.This is the first case description of a subluxation of the cervical vertebral column in an alpaca in Germany that has been evaluated in detail.

一匹1岁的羊驼母马由于颈椎侧偏已经出现了2周。根据之前的报告,假设发生了创伤性事件。摄食和饮水量无显著差异,步态因四肢轻微共济失调而改变。动物在初次出现时没有进一步的神经功能缺陷。x线片显示颈椎左侧移位,为颈椎C4和C5关节突半脱位的一部分。在止痛药保守治疗过程中,尽管食物摄入不显著,但神经系统症状包括共济失调和平衡受损。随后,这只动物在没有被观察的时候死亡。病理检查显示退行性和炎性改变以及颈椎轴向偏移水平的颈髓出血。考虑到患者的病史,这些发现很可能被视为钝性创伤的结果,并代表神经系统体征的原因。这是德国羊驼颈椎半脱位的第一例详细评估。
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引用次数: 0
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Tieraerztliche Praxis Ausgabe Grosstiere Nutztiere
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