The aim of this case series was to describe how the selective dry-off therapy affected the udder health of Bavarian dairy farms under field conditions as well as to record whether a long-term reduction in antibiotic dry-off therapy was feasible. Between 2016 and 2021, 90 herds participated. A subset of dairy herds participated over a period of several years. Quarter milking samples were taken annually from all lactating cows in the herds, and treatment and test day results were evaluated. Major pathogens were detected during the initial whole herd testing (e. g., Streptococcus agalactiae, Streptococcus canis) and the treatment regimen needed to be adjusted. Even though the median treatment risk decreased, at least numerically, from 63% to 50%, the treatment rate in individual herds could vary greatly between years (-60% to+40%). Selective dry-off therapy can be implemented without endangering the udder health of the herd.