Pub Date : 2020-01-01DOI: 10.19112/2413-6174-2020-21-4-60-65
A. Tinkov, A. P. Kuzmicheva
The objective of the present study is investigation of hair essential element content in children with different clinical forms of cerebral palsy (CP). Assessment of hair element content in children with spastic and ataxic cerebral palsy was performed using inductively-coupled plasma mass-spectrometry. The obtained data demonstrate that hair cobalt, copper, manganese, and selenium levels were 33%, 9%, 19%, and 18% lower than those in the control group. At the same time, more profound differences were observed in patients with spastic diplegia, where the level of cobalt, copper, manganese, selenium, and vanadium was 33%, 9%, 20%, 18%, and 43% lower than in controls. A strong tendency to reduced hair iron and magnesium was also observed. Patients with ataxic cerebral palsy were characterized by 33%, 5%, and 21% lower hair cobalt, copper, and selenium content, whereas chromium levels exceeded the respective control values by 63%. In regression models only hair copper (β = -0.337; p < 0.001) and chromium (β = 0.214; p < 0.023) content were significantly associated with cerebral palsy in children. The observed differences may be associated with the role of metals in pathogenetic mechanisms of different forms of cerebral palsy.
{"title":"COMPARATIVE ANALYSIS OF HAIR ESSENTIAL ELEMENT CONTENT IN CHILDREN WITH SPASTIC AND ATAXIC CEREBRAL PALSY","authors":"A. Tinkov, A. P. Kuzmicheva","doi":"10.19112/2413-6174-2020-21-4-60-65","DOIUrl":"https://doi.org/10.19112/2413-6174-2020-21-4-60-65","url":null,"abstract":"The objective of the present study is investigation of hair essential element content in children with different clinical forms of cerebral palsy (CP). Assessment of hair element content in children with spastic and ataxic cerebral palsy was performed using inductively-coupled plasma mass-spectrometry. The obtained data demonstrate that hair cobalt, copper, manganese, and selenium levels were 33%, 9%, 19%, and 18% lower than those in the control group. At the same time, more profound differences were observed in patients with spastic diplegia, where the level of cobalt, copper, manganese, selenium, and vanadium was 33%, 9%, 20%, 18%, and 43% lower than in controls. A strong tendency to reduced hair iron and magnesium was also observed. Patients with ataxic cerebral palsy were characterized by 33%, 5%, and 21% lower hair cobalt, copper, and selenium content, whereas chromium levels exceeded the respective control values by 63%. In regression models only hair copper (β = -0.337; p < 0.001) and chromium (β = 0.214; p < 0.023) content were significantly associated with cerebral palsy in children. The observed differences may be associated with the role of metals in pathogenetic mechanisms of different forms of cerebral palsy.","PeriodicalId":23176,"journal":{"name":"Trace elements in medicine","volume":"23 1","pages":"60-65"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86859825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.19112/2413-6174-2020-21-3-3-23
M. Spivak, V. Kaplunenko, M. V. Kosinov, A. Skalny, Nanotechnologies Ltd
The review article studies the role of trace elements in protecting the body from viruses and focuses on the high antiviral activity of trace elements, which they exhibit if they are in a low degree of oxidation. Trace elements in a degree of oxidation make it possible to create new generation of antiseptics safe for humans. Has been discovered the mechanism of antiviral action of trace elements in a low degree of oxidation based on the suppression of electrostatic Coulomb interaction of virus with the cell. Sanitizers of a new generation can become effective prophylactic means for protecting the body from infection COVID-19 due to the fact that a vaccine against the SARS-CoV-2 coronavirus is under development, and there are no direct drugs for it. Compositions of substances for pharmaceutical use based on antimicrobial trace elements in a low degree of oxidation, which can be used either directly or as raw materials for production of drugs against the SARS-CoV-2 coronavirus, are given. Aqueous solutions of trace element sanitizers are suitable for inhalation and intranasal application and can be used in the form of aerosol or spray for throat and nose or eye drops at the first symptoms of disease, as well as at high risks of infection.
{"title":"ANTIVIRAL, ANTIOXIDANT AND CATALYTIC ACTIVITY OF TRACE ELEMENTS IN A LOW DEGREE OF OXIDATION","authors":"M. Spivak, V. Kaplunenko, M. V. Kosinov, A. Skalny, Nanotechnologies Ltd","doi":"10.19112/2413-6174-2020-21-3-3-23","DOIUrl":"https://doi.org/10.19112/2413-6174-2020-21-3-3-23","url":null,"abstract":"The review article studies the role of trace elements in protecting the body from viruses and focuses on the high antiviral activity of trace elements, which they exhibit if they are in a low degree of oxidation. Trace elements in a degree of oxidation make it possible to create new generation of antiseptics safe for humans. Has been discovered the mechanism of antiviral action of trace elements in a low degree of oxidation based on the suppression of electrostatic Coulomb interaction of virus with the cell. Sanitizers of a new generation can become effective prophylactic means for protecting the body from infection COVID-19 due to the fact that a vaccine against the SARS-CoV-2 coronavirus is under development, and there are no direct drugs for it. Compositions of substances for pharmaceutical use based on antimicrobial trace elements in a low degree of oxidation, which can be used either directly or as raw materials for production of drugs against the SARS-CoV-2 coronavirus, are given. Aqueous solutions of trace element sanitizers are suitable for inhalation and intranasal application and can be used in the form of aerosol or spray for throat and nose or eye drops at the first symptoms of disease, as well as at high risks of infection.","PeriodicalId":23176,"journal":{"name":"Trace elements in medicine","volume":"34 1","pages":"3-23"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83398725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.19112/2413-6174-2020-21-1-22-26
A. K. Gulyan, L. Babayan, T. Arutyunyan, N. Gasparyan, A. K. Mikaelyan, S. G. Grigoryan
70 practically healthy subjects and 100 patients with hypertensive disease were united regimen of diet, sleep and wakefulness. Urine was collected with 4-hour portions during 3-5 days. Each specimen was analyzed for electrolytes (sodium, potassium, phosphorus, chlorine, calcium, magnesium) and trace elements (iron, copper, zinc, chromium, cadmium, vanadium). Rhythms parameters have been estimated by dispersion analysis for nonsinusoidal rhythms and by nonlinear least squares method for sinusoidal rhythms. In healthy subjects in 91% cases of 593 rhythmological investigations urinary excretion electrolytes and trace elements statistically significant rhythms were observed. Healthy subjects characterized with circadian rhythms and with definite value of mesor and amplitude within the confidence limit. Acrophases of rhythms were mostly individual. The data witness that in early stage of HD electrolytes and trace elements exeretion rhythms 22% were statistically nonsignificant. Among significant rhythms of electrolytes and trace elements excretion infradians prevail - 46%. Statistically significant rhythms of electrolytes and trace elements excretion were not revealed in most of patients in the late stage of HD. Among significant rhythms circadian prevail - 48%. The data witness that in HD the coefficient of correlation between the biorhythms and the rhythms of hydrometerological indices were statistically nonsignificant (for early stage - 37% and for late stage - 30%).
{"title":"THE INFLUENCE OF RHYTHMS OF THE HYDROMETEOROLOGICAL INDICES ON THE WATER-MINERAL HOMEOSTASIS IN HYPERTENSIVE DISEASE (HD)","authors":"A. K. Gulyan, L. Babayan, T. Arutyunyan, N. Gasparyan, A. K. Mikaelyan, S. G. Grigoryan","doi":"10.19112/2413-6174-2020-21-1-22-26","DOIUrl":"https://doi.org/10.19112/2413-6174-2020-21-1-22-26","url":null,"abstract":"70 practically healthy subjects and 100 patients with hypertensive disease were united regimen of diet, sleep and wakefulness. Urine was collected with 4-hour portions during 3-5 days. Each specimen was analyzed for electrolytes (sodium, potassium, phosphorus, chlorine, calcium, magnesium) and trace elements (iron, copper, zinc, chromium, cadmium, vanadium). Rhythms parameters have been estimated by dispersion analysis for nonsinusoidal rhythms and by nonlinear least squares method for sinusoidal rhythms. In healthy subjects in 91% cases of 593 rhythmological investigations urinary excretion electrolytes and trace elements statistically significant rhythms were observed. Healthy subjects characterized with circadian rhythms and with definite value of mesor and amplitude within the confidence limit. Acrophases of rhythms were mostly individual. The data witness that in early stage of HD electrolytes and trace elements exeretion rhythms 22% were statistically nonsignificant. Among significant rhythms of electrolytes and trace elements excretion infradians prevail - 46%. Statistically significant rhythms of electrolytes and trace elements excretion were not revealed in most of patients in the late stage of HD. Among significant rhythms circadian prevail - 48%. The data witness that in HD the coefficient of correlation between the biorhythms and the rhythms of hydrometerological indices were statistically nonsignificant (for early stage - 37% and for late stage - 30%).","PeriodicalId":23176,"journal":{"name":"Trace elements in medicine","volume":"13 1","pages":"22-26"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91388260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.19112/2413-6174-2020-21-1-5-13
V. M. Kodentsova, O.A. Vrhesinskaya, N. A. Beketova, O. Kosheleva, L. V. Shevyakova, S. Soto, A. A. Sokolnikov, S. Leonenko
Multiple alimentary deficiency of micronutrients (all vitamins, calcium, magnesium and iodine) in growing rats (51.4±0.5 g) was caused by a 2-fold decrease in the content of calcium, magnesium and iodine in the mineral mixture and 5-fold of all vitamins in the vitamin mixture in the semi-synthetic diet. It was accompanied by a decrease of the brain content of magnesium (25,2%, p=0.003) and copper (8-fold, p<0.001) with simultaneous accumulation of liver level of zinc, iron and manganese by 12.0%, 19.5% and 23.4%, (p<0.05) accordingly. Despite the equal content of these trace elements in the diet of rats from both groups (12 animals in each) they were redistributed among organs in animals with multiple micronutrient deficiency. Blood plasma concentration of calcium increased by 3.6% (p=0.001) while its urinary excretion decreased by 1.5 fold (p=0.033) and brain content increased by 16.0% (p=0.012). Phosphorus reabsorption decreased by 7.8% (p<0.001), whereas its urinary excretion 1,7-fold increased (p<0.001). Against the background of deterioration of vitamin status indicators, the ratio of γ- and α-tocopherols in blood plasma increased 2.7 times (p=0.024). A number of diagnostically significant blood parameters had been changed. The concentration of glucose increased by 13.3% (p=0.001), urea – by 43.9% (p=0.020), direct bilirubin – by 2.1 fold (p=0.052), and a slight increase in protein by 5.4% was observed (p=0.028). Multiple alimentary deficiency of micronutrients can contribute to the progression of many diseases or complicate their diagnosis.
{"title":"INFLUENCE OF MULTIPLE MICRONUTRIENT INSUFFICIENCY ON VITAMIN AND MINERAL STATUS OF RATS","authors":"V. M. Kodentsova, O.A. Vrhesinskaya, N. A. Beketova, O. Kosheleva, L. V. Shevyakova, S. Soto, A. A. Sokolnikov, S. Leonenko","doi":"10.19112/2413-6174-2020-21-1-5-13","DOIUrl":"https://doi.org/10.19112/2413-6174-2020-21-1-5-13","url":null,"abstract":"Multiple alimentary deficiency of micronutrients (all vitamins, calcium, magnesium and iodine) in growing rats (51.4±0.5 g) was caused by a 2-fold decrease in the content of calcium, magnesium and iodine in the mineral mixture and 5-fold of all vitamins in the vitamin mixture in the semi-synthetic diet. It was accompanied by a decrease of the brain content of magnesium (25,2%, p=0.003) and copper (8-fold, p<0.001) with simultaneous accumulation of liver level of zinc, iron and manganese by 12.0%, 19.5% and 23.4%, (p<0.05) accordingly. Despite the equal content of these trace elements in the diet of rats from both groups (12 animals in each) they were redistributed among organs in animals with multiple micronutrient deficiency. Blood plasma concentration of calcium increased by 3.6% (p=0.001) while its urinary excretion decreased by 1.5 fold (p=0.033) and brain content increased by 16.0% (p=0.012). Phosphorus reabsorption decreased by 7.8% (p<0.001), whereas its urinary excretion 1,7-fold increased (p<0.001). Against the background of deterioration of vitamin status indicators, the ratio of γ- and α-tocopherols in blood plasma increased 2.7 times (p=0.024). A number of diagnostically significant blood parameters had been changed. The concentration of glucose increased by 13.3% (p=0.001), urea – by 43.9% (p=0.020), direct bilirubin – by 2.1 fold (p=0.052), and a slight increase in protein by 5.4% was observed (p=0.028). Multiple alimentary deficiency of micronutrients can contribute to the progression of many diseases or complicate their diagnosis.","PeriodicalId":23176,"journal":{"name":"Trace elements in medicine","volume":"27 1","pages":"5-13"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79139394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.19112/2413-6174-2020-21-1-27-36
N. A. Tarmaeva, V. Haptanova, O. G. Bogdanovа
When studying the elemental status in patients with working-age arterial hypertension living in the city of Irkutsk, dyslementosis was observed, which manifested itself in a decrease in the level of Ca in the blood by 4.3% of the norm, which is 2.01 ± 0.05 mmol / l, in hair - by 20% (482 ± 31.2 mg / kg). In the hair, a decrease in Zn level by 9% from the norm was noted, which is 164 ± 12 mg / kg, a decrease in Mg in the hair (154 ± 3.3 mg / kg) and blood (0.64 ± 0.04 mmol / l). An increase in the Na content in the blood (149 ± 1.06 mmol / L) and hair (553 ± 156 mg / kg), and the Cl content in the blood (119.4 ± 2.8 mmol / L) was also noted. The content of toxic and conditionally toxic elements (Al, As, B, Cd, Hg, Li, Ni, Pb, Sn, Sr, V) was closer to the lower limit of the norm: Al - 5.60 ± 0.80 mg / kg; As - 0.053 ± 0.009 mg / kg; B - 1.31 ± 0.05 mg / kg; Cd - 0.049 ± 0.024 mg / kg; Hg - 0.38 ± 0.06 mg / kg; Li - 0.018 ± 0.004 mg / kg; Ni - 0.29 ± 0.06 mg / kg; Pb - 1.00 ± 0.37 mg / kg; Sn - 1.16 ± 0.73 mg / kg; Sr - 8.28 ± 1.74 mg / kg; V - 0.18 ± 0.01 mg / kg, which indicates a reduced anthropogenic load on the human body.
{"title":"ELEMENTAL STATUS OF PATIENTS OF LABOR POPULATION WITH ARTERIAL HYPERTENSION","authors":"N. A. Tarmaeva, V. Haptanova, O. G. Bogdanovа","doi":"10.19112/2413-6174-2020-21-1-27-36","DOIUrl":"https://doi.org/10.19112/2413-6174-2020-21-1-27-36","url":null,"abstract":"When studying the elemental status in patients with working-age arterial hypertension living in the city of Irkutsk, dyslementosis was observed, which manifested itself in a decrease in the level of Ca in the blood by 4.3% of the norm, which is 2.01 ± 0.05 mmol / l, in hair - by 20% (482 ± 31.2 mg / kg). In the hair, a decrease in Zn level by 9% from the norm was noted, which is 164 ± 12 mg / kg, a decrease in Mg in the hair (154 ± 3.3 mg / kg) and blood (0.64 ± 0.04 mmol / l). An increase in the Na content in the blood (149 ± 1.06 mmol / L) and hair (553 ± 156 mg / kg), and the Cl content in the blood (119.4 ± 2.8 mmol / L) was also noted. The content of toxic and conditionally toxic elements (Al, As, B, Cd, Hg, Li, Ni, Pb, Sn, Sr, V) was closer to the lower limit of the norm: Al - 5.60 ± 0.80 mg / kg; As - 0.053 ± 0.009 mg / kg; B - 1.31 ± 0.05 mg / kg; Cd - 0.049 ± 0.024 mg / kg; Hg - 0.38 ± 0.06 mg / kg; Li - 0.018 ± 0.004 mg / kg; Ni - 0.29 ± 0.06 mg / kg; Pb - 1.00 ± 0.37 mg / kg; Sn - 1.16 ± 0.73 mg / kg; Sr - 8.28 ± 1.74 mg / kg; V - 0.18 ± 0.01 mg / kg, which indicates a reduced anthropogenic load on the human body.","PeriodicalId":23176,"journal":{"name":"Trace elements in medicine","volume":"70 1","pages":"27-36"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80294114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.19112/2413-6174-2020-21-3-33-42
A. Kirichuk
The aim of the study was to study the relationship between the level of essential trace elements and the functional state of the cardiovascular system (CVS) in freshmen from foreign countries compared with freshmen from Russia (control group). The CVS study was conducted by the AngioScan-01 hardware-software complex (AIC). The level of essential elements in the analyzed biosubstrates was determined by inductively coupled plasma mass spectrometry (ICP-MS). It was found that foreign students have significantly higher values of the stress index (IS) and vascular wall stiffness (SI) compared to freshmen from Russia. At the same time, the value of the reflection index (RI is a marker of peripheral vascular tone) and the integral indicator indicating aortic elasticity (dTpp) in foreign students were significantly lower than those of freshmen from Russia. Analysis of hair trace element content revealed significantly lower hair Co, Cr, Cu, Fe, I, Mg, Mn, and V levels in international students as compared to controls. Urinary trace element levels were more stable. Particularly, Co and Mn levels were found to be lower, whereas Cu and Zn concentration was higher than those in students from Russia. Correlation analysis revealed inverse association between stress index and hair Fe content. Mg and Mn levels in hair were also inversely associated with stiffness index. Urinary Cu, Se, and Zn concentration directly correlated with arterial stiffness, being inversely associated with dTpp values. Oppositely, urinary V levels were inversely and directly correlated with these parameters, respectively. Therefore, the results of analysis demonstrated the potential relationship between patterns of trace element status and cardiovascular reactivity in international students.
{"title":"THE RELATIONSHIP OF THE EXCHANGE OF ESSENTIAL TRACE ELEMENTS AND THE FUNCTIONAL STATE OF THE CARDIOVASCULAR SYSTEM IN INTERNATIONAL STUDENTS","authors":"A. Kirichuk","doi":"10.19112/2413-6174-2020-21-3-33-42","DOIUrl":"https://doi.org/10.19112/2413-6174-2020-21-3-33-42","url":null,"abstract":"The aim of the study was to study the relationship between the level of essential trace elements and the functional state of the cardiovascular system (CVS) in freshmen from foreign countries compared with freshmen from Russia (control group). The CVS study was conducted by the AngioScan-01 hardware-software complex (AIC). The level of essential elements in the analyzed biosubstrates was determined by inductively coupled plasma mass spectrometry (ICP-MS). It was found that foreign students have significantly higher values of the stress index (IS) and vascular wall stiffness (SI) compared to freshmen from Russia. At the same time, the value of the reflection index (RI is a marker of peripheral vascular tone) and the integral indicator indicating aortic elasticity (dTpp) in foreign students were significantly lower than those of freshmen from Russia. Analysis of hair trace element content revealed significantly lower hair Co, Cr, Cu, Fe, I, Mg, Mn, and V levels in international students as compared to controls. Urinary trace element levels were more stable. Particularly, Co and Mn levels were found to be lower, whereas Cu and Zn concentration was higher than those in students from Russia. Correlation analysis revealed inverse association between stress index and hair Fe content. Mg and Mn levels in hair were also inversely associated with stiffness index. Urinary Cu, Se, and Zn concentration directly correlated with arterial stiffness, being inversely associated with dTpp values. Oppositely, urinary V levels were inversely and directly correlated with these parameters, respectively. Therefore, the results of analysis demonstrated the potential relationship between patterns of trace element status and cardiovascular reactivity in international students.","PeriodicalId":23176,"journal":{"name":"Trace elements in medicine","volume":"121 1","pages":"33-42"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85258362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.19112/2413-6174-2020-21-2-54-63
O. Ajsuvakova, C. A. Gómez, O. A. Skalnaya
The method of inductive coupled plasma mass spectrometry (ICP-MS) was used for elemental analysis of alpaca hair. Various methods impact of hair sampling for analysis was evaluated with using deionized water and acetone. Sodium content decrease in the in hair samples washed with deionized water and Mg, Li, V, Ag, Cd, Ba level decrease in samples treated with acetone were found. The results can be explained by sodium attendance in the hair in the form of simple cations that are not bound to any organic compounds by strong bonds, while the results obtained for Mg, Li, V, Ag, Cd, Ba, suggest that the ions of these elements are connected with structural hair formations. Significant differences in the content of other macro- and microelements in alpaca hair treated with deionized water and acetone were not found.
{"title":"DETERMINATION OF TOXIC, ESSENTIAL AND RELATIVELY ESSENTIAL ELEMENTS LEVEL IN ALPACA HAIR WITH USING OF DIFFERENT SAMPLING TYPES","authors":"O. Ajsuvakova, C. A. Gómez, O. A. Skalnaya","doi":"10.19112/2413-6174-2020-21-2-54-63","DOIUrl":"https://doi.org/10.19112/2413-6174-2020-21-2-54-63","url":null,"abstract":"The method of inductive coupled plasma mass spectrometry (ICP-MS) was used for elemental analysis of alpaca hair. Various methods impact of hair sampling for analysis was evaluated with using deionized water and acetone. Sodium content decrease in the in hair samples washed with deionized water and Mg, Li, V, Ag, Cd, Ba level decrease in samples treated with acetone were found. The results can be explained by sodium attendance in the hair in the form of simple cations that are not bound to any organic compounds by strong bonds, while the results obtained for Mg, Li, V, Ag, Cd, Ba, suggest that the ions of these elements are connected with structural hair formations. Significant differences in the content of other macro- and microelements in alpaca hair treated with deionized water and acetone were not found.","PeriodicalId":23176,"journal":{"name":"Trace elements in medicine","volume":"53 1","pages":"54-63"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77254918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.19112/2413-6174-2020-21-2-64-70
L. L. Parnaykova, Н.G. Kekina, A. V. Dubovskoy, J. S. Aseeva, I. L. Shedlovskaya
Drinking mineral water is often used for therapeutic purposes, especially for treatment of the stomach, intestines, pancreas, liver, bile and urinary tract disorders. Mineral healing water is used for external (mineral baths) or internal use (inhalation, irrigation, douching, enema, drinking). At resorts, patients drink mineral water directly from springs. Bottling water ensures the preservation of the original composition and medicinal properties of samples. The authors evaluated the quality of mineral water from hard-to-reach areas of the Shumak Reserve, the Republic of Buryatia. Total water mineralization of samples was in the range 1.1 - 1.3 g/dm3, which indicates that Buriatia spring water belongs to natural-mineral table water group; It was established that the studied mineral water belongs to the hydro-carbonate-magnesium-calcium siliceous hydrochemical group (НСО3 85, Ca2+ 50-60, Mg2+ 30-50 equiv.%) with pH from 6.4 to 8.8. Among the balneologically active components of all water samples, silicon was in the range of 51.7 - 124.0 mg/dm3. The highest value was noted in spring No. 4 (“diabetes”) 124.0 ± 5.0 mg/dm3. Besides elevated levels of Si, all sprigs contained radioactive gas radon in concentrations between 33 to 1003 Bq/dm3. The highest radon content was found in spring No. 2: 1003 ± 119 Bq/dm3. This is higher than the threshold value of the content of a balneologically significant factor - 185 Bq/dm3 (5 nCi/dm3). Accordingly, water of spring No. 2, should be classified as low radon water and designed for external use.
{"title":"WATER QUALITY INDICATORS IN MINERAL SPRINGS OF THE REPUBLIC OF BURYATIA","authors":"L. L. Parnaykova, Н.G. Kekina, A. V. Dubovskoy, J. S. Aseeva, I. L. Shedlovskaya","doi":"10.19112/2413-6174-2020-21-2-64-70","DOIUrl":"https://doi.org/10.19112/2413-6174-2020-21-2-64-70","url":null,"abstract":"Drinking mineral water is often used for therapeutic purposes, especially for treatment of the stomach, intestines, pancreas, liver, bile and urinary tract disorders. Mineral healing water is used for external (mineral baths) or internal use (inhalation, irrigation, douching, enema, drinking). At resorts, patients drink mineral water directly from springs. Bottling water ensures the preservation of the original composition and medicinal properties of samples. The authors evaluated the quality of mineral water from hard-to-reach areas of the Shumak Reserve, the Republic of Buryatia. Total water mineralization of samples was in the range 1.1 - 1.3 g/dm3, which indicates that Buriatia spring water belongs to natural-mineral table water group; It was established that the studied mineral water belongs to the hydro-carbonate-magnesium-calcium siliceous hydrochemical group (НСО3 85, Ca2+ 50-60, Mg2+ 30-50 equiv.%) with pH from 6.4 to 8.8. Among the balneologically active components of all water samples, silicon was in the range of 51.7 - 124.0 mg/dm3. The highest value was noted in spring No. 4 (“diabetes”) 124.0 ± 5.0 mg/dm3. Besides elevated levels of Si, all sprigs contained radioactive gas radon in concentrations between 33 to 1003 Bq/dm3. The highest radon content was found in spring No. 2: 1003 ± 119 Bq/dm3. This is higher than the threshold value of the content of a balneologically significant factor - 185 Bq/dm3 (5 nCi/dm3). Accordingly, water of spring No. 2, should be classified as low radon water and designed for external use.","PeriodicalId":23176,"journal":{"name":"Trace elements in medicine","volume":"41 1","pages":"64-70"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77519988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.19112/2413-6174-2020-21-2-34-40
A. Yakimovskii
Chronic experiments were performed on rats to study the influence of prolonged acetic zinc alimentary treatment on normal (spontaneous movement in “open field and condition active avoidance reflex in “shuttle box”) and abnormal (choreomyoclonic hyperkinesia, produced by intrastriatal microinjections GABA-A receptors antagonist picrotoxin 2 mcg) motor behavior. 4 mg acetic zinc is used by rats with food ball once a day. 12 mg zinc сonsumption by rats per week did not affected on normal behavior. While 24 mg is produced smaller negative effects on rats reflex performance to 6570% correct responses (of total present during the experiment) but to improved condition avoidance behavior, violated by picrotoxinin rats and reduce the reproducibility of picrotoxin-induced choreo-mioclonic hyperkinesis (human Huntington disease hyperkinesis analog). The influence of zinc on motor behavior depending on its dose and mode of administration is discussed.
{"title":"INFLUENCE OF ZINC ALIMENTARY TREATMENT ON NORMAL AND PATHOLOGICAL MOTOR BEHAVIOR OF RATS","authors":"A. Yakimovskii","doi":"10.19112/2413-6174-2020-21-2-34-40","DOIUrl":"https://doi.org/10.19112/2413-6174-2020-21-2-34-40","url":null,"abstract":"Chronic experiments were performed on rats to study the influence of prolonged acetic zinc alimentary treatment on normal (spontaneous movement in “open field and condition active avoidance reflex in “shuttle box”) and abnormal (choreomyoclonic hyperkinesia, produced by intrastriatal microinjections GABA-A receptors antagonist picrotoxin 2 mcg) motor behavior. 4 mg acetic zinc is used by rats with food ball once a day. 12 mg zinc сonsumption by rats per week did not affected on normal behavior. While 24 mg is produced smaller negative effects on rats reflex performance to 6570% correct responses (of total present during the experiment) but to improved condition avoidance behavior, violated by picrotoxinin rats and reduce the reproducibility of picrotoxin-induced choreo-mioclonic hyperkinesis (human Huntington disease hyperkinesis analog). The influence of zinc on motor behavior depending on its dose and mode of administration is discussed.","PeriodicalId":23176,"journal":{"name":"Trace elements in medicine","volume":"2012 1","pages":"34-40"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87715632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.19112/2413-6174-2020-21-1-55-63
M. A. Deriglazova, L. Rikhvanov
The number of studies of ashed biosubstrates in terms of elemental composition is sharply increasing due to the growing interest of living matter. Thus, it is extremely important to know, is the composition of the ashed material reflects the composition of the original object and how elements behave during the process of combustion. To answer these questions, an experiment on the samples of biological material was made. The purpose of the study is to analyze the behavior of elements in the process of high-temperature combustion of bone tissue. During the experiment, the following methods of analysis were used: instrumental neutron activation and mass spectrometry with inductively coupled plasma. The study shows that most of the elements are concentrated in bone ash during combustion (Li, Na, Mg, P, Ca, Ti, Cu, Zn, Ga, U, Al, Sc, Cr, Mn, Fe, As, Y,, Zr , Nb, Mo, Cd, Sb, La, Ce, Pr, Sm, Gd, Au, W, Bi), while volatilization is observed only for Br, Hg and Sn. The exclusive role of the chemichal compound of the element is shown for the analysis of its behavior. The experiment is aslo shows the role of combustion temperature to predict the behavior of element: it was found that lower temperature of ashing (500 °C) leads to more intensive volatilization of elements. In addition, an algorithm is propesed to convert the content of the element in ash of the bone to dry matter. At the same time, the dependence of the content of elements in the ash on their content in dry tissue were established using mathematical functions with high accuracy of approximation (for Fe, Mg, Zn, As, Pr, Ce, W, Zr, Cd, Cr, Sb, Mn, Ga, Nb, Pb, and U).
{"title":"BEHAVIOR OF ELEMENTS DURING HIGH-TEMPERATURE BONE COMBUSTION","authors":"M. A. Deriglazova, L. Rikhvanov","doi":"10.19112/2413-6174-2020-21-1-55-63","DOIUrl":"https://doi.org/10.19112/2413-6174-2020-21-1-55-63","url":null,"abstract":"The number of studies of ashed biosubstrates in terms of elemental composition is sharply increasing due to the growing interest of living matter. Thus, it is extremely important to know, is the composition of the ashed material reflects the composition of the original object and how elements behave during the process of combustion. To answer these questions, an experiment on the samples of biological material was made. The purpose of the study is to analyze the behavior of elements in the process of high-temperature combustion of bone tissue. During the experiment, the following methods of analysis were used: instrumental neutron activation and mass spectrometry with inductively coupled plasma. The study shows that most of the elements are concentrated in bone ash during combustion (Li, Na, Mg, P, Ca, Ti, Cu, Zn, Ga, U, Al, Sc, Cr, Mn, Fe, As, Y,, Zr , Nb, Mo, Cd, Sb, La, Ce, Pr, Sm, Gd, Au, W, Bi), while volatilization is observed only for Br, Hg and Sn. The exclusive role of the chemichal compound of the element is shown for the analysis of its behavior. The experiment is aslo shows the role of combustion temperature to predict the behavior of element: it was found that lower temperature of ashing (500 °C) leads to more intensive volatilization of elements. In addition, an algorithm is propesed to convert the content of the element in ash of the bone to dry matter. At the same time, the dependence of the content of elements in the ash on their content in dry tissue were established using mathematical functions with high accuracy of approximation (for Fe, Mg, Zn, As, Pr, Ce, W, Zr, Cd, Cr, Sb, Mn, Ga, Nb, Pb, and U).","PeriodicalId":23176,"journal":{"name":"Trace elements in medicine","volume":"35 1","pages":"55-63"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78927032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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