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Current Developments in Soil Ecotoxicology. 土壤生态毒理学的最新发展。
IF 3.9 3区 环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2024-10-11 DOI: 10.3390/toxics12100734
Maria Luisa Fernández-Marcos

Ecotoxicology focuses on how chemicals affect organisms in the environment, with the ultimate goal of safeguarding the structure and function of ecosystems [...].

生态毒理学侧重于研究化学品如何影响环境中的生物,其最终目标是保护生态系统的结构和功能 [...] 。
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引用次数: 0
Presence of N, N'-Substituted p-Phenylenediamine-Derived Quinones in Human Urine. 人体尿液中存在 N,N'-取代对苯二胺衍生的醌类物质
IF 3.9 3区 环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2024-10-11 DOI: 10.3390/toxics12100733
Juxiu Huang, Hangbiao Jin, Yingying Zhu, Ruyue Guo, Lisha Zhou, Xiaoyu Wu

Human exposure to various N,N'-substituted p-phenylenediamine-derived quinones (PPDQs) has been of increasing concern. Recent studies have examined N-phenyl-N'-(1,3-dimethylbutyl)-p-phenylenediamine-derived quinone (6PPDQ) in human urine to evaluate human exposure. However, other PPDQs in human urine have not been thoroughly investigated. This study analyzed six PPDQs in urine collected from 149 healthy individuals in Taizhou, China. All target PPDQs were detected, with 6PPDQ (mean 2.4 ng/mL, p = 0.013) and 2,5-bis(o-tolylamino)cyclohexa-2,5-diene-1,4-dione (mean 1.1 vs. 0.62 ng/mL; p = 0.027) were significantly higher in females compared to males. For CPPDQ (p < 0.01) and 6PPDQ (p < 0.01), a decrease was observed in urinary concentrations as participants aged. The daily excretion (DE) of PPDQs through urine was estimated for Chinese adults. The highest average DE was recorded for 6PPDQ at 81 ng/kg-bw/day, with a range from <0.5 to 475 ng/kg-bw/day. Following this, CPPDQ had a mean DE of 68 ng/kg-bw/day (range <0.5-516 ng/kg-bw/day), and 77PDQ had a mean DE of 30 ng/kg-bw/day (<0.5-481 ng/kg-bw/day). This study is the first to explore the presence of various PPDQs in human urinary samples, which is essential for assessing the potential health risks associated with these substances.

人类暴露于各种 N,N'-取代对苯二胺衍生醌(PPDQ)的情况日益受到关注。最近的研究对人体尿液中的 N-苯基-N'-(1,3-二甲基丁基)-对苯二胺衍生醌(6PPDQ)进行了检测,以评估人体接触情况。然而,尚未对人体尿液中的其他 PPDQ 进行深入研究。本研究分析了中国台州 149 名健康人尿液中的六种 PPDQ。所有目标 PPDQ 均被检测到,其中女性尿液中的 6PPDQ(平均值为 2.4 ng/mL,p = 0.013)和 2,5-双(邻甲苯氨基)环己-2,5-二烯-1,4-二酮(平均值为 1.1 与 0.62 ng/mL;p = 0.027)明显高于男性。对于 CPPDQ(p < 0.01)和 6PPDQ(p < 0.01),随着参与者年龄的增长,尿液中的浓度会有所下降。对中国成年人每天通过尿液排出的 PPDQ 进行了估算。6PPDQ的平均排泄量最高,为81纳克/千克体重/天,范围从
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引用次数: 0
Effects of Perfluorinated Alkyl Substances (PFAS) on Amphibian Body and Liver Conditions: Is Lipid Metabolism Being Perturbed throughout Metamorphosis? 全氟烷基物质 (PFAS) 对两栖动物身体和肝脏状况的影响:脂质代谢是否在整个变态过程中受到干扰?
IF 3.9 3区 环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2024-10-10 DOI: 10.3390/toxics12100732
Anna Bushong, Maria Sepúlveda, Meredith Scherer, Abigail C Valachovic, C Melman Neill, Sophia Horn, Youn Choi, Linda S Lee, Priyanka Baloni, Tyler Hoskins

Per- and polyfluoroalkyl substances (PFAS) may interact with peroxisome proliferator activated receptors (PPARs) and alter lipid homeostasis. Using Xenopus laevis, we investigated the effect of PFAS on (a) lipid homeostasis and whether this correlated to changes in body and hepatic condition; (b) the expression of hepatic genes regulated by PPAR; and (c) the hepatic lipidome. We chronically exposed tadpoles to 0.5 µg/L of either PFOS, PFHxS, PFOA, PFHxA, a binary mixture of PFOS and PFHxS (0.5 µg/L of each), or a control, from NF stage 52 through metamorphic climax. Growth, development, and survival were not affected, but we detected a sex-specific decrease in body condition at NF 66 (6.8%) and in hepatic condition (16.6%) across metamorphic climax for male tadpoles exposed to PFOS. We observed weak evidence for the transient downregulation of apolipoprotein-V (apoa5) at NF 62 in tadpoles exposed to PFHxA. Acyl-CoA oxidase 1 (acox1) was downregulated only in males exposed to PFHxS (Ln(Fold Change) = -0.54). We detected PFAS-specific downregulation of structural glycerophospholipids, while semi-quantitative profiling detected the upregulation in numerous glycerophospholipids, sphingomyelins, and diglycerides. Overall, our findings indicate that PFAS can induce sex-specific effects that change across larval development and metamorphosis. We demonstrate that PFAS alter lipid metabolism at environmentally relevant concentrations through divergent mechanisms that may not be related to PPARs, with an absence of effects on body condition, demonstrating the need for more molecular studies to elucidate mechanisms of PFAS-induced lipid dysregulation in amphibians and in other taxa.

全氟和多氟烷基物质(PFAS)可能会与过氧化物酶体增殖物激活受体(PPARs)相互作用并改变脂质稳态。我们利用爪蟾研究了 PFAS 对以下方面的影响:(a) 脂质稳态,以及这是否与身体和肝脏状况的变化相关;(b) 受 PPAR 调节的肝脏基因的表达;以及 (c) 肝脏脂质体。我们将蝌蚪长期暴露于 0.5 µg/L 的 PFOS、PFHxS、PFOA、PFHxA、PFOS 和 PFHxS 的二元混合物(每种均为 0.5 µg/L)或对照组中,从 NF 阶段 52 开始,直至变态高潮。雄性蝌蚪的生长、发育和存活率均未受到影响,但我们检测到,暴露于全氟辛烷磺酸的雄性蝌蚪在NF 66期的身体状况(6.8%)和肝脏状况(16.6%)在整个变态高潮期均出现了性别特异性下降。我们观察到暴露于全氟辛烷磺酸的蝌蚪在 NF 62 处脂蛋白-V(apoa5)短暂下调的微弱证据。酰基-CoA 氧化酶 1(acox1)仅在暴露于 PFHxS 的雄性蝌蚪中出现下调(折线变化率 Ln(Fold Change) = -0.54)。我们检测到结构性甘油磷脂的 PFAS 特异性下调,而半定量分析检测到许多甘油磷脂、鞘磷脂和二甘油酯的上调。总之,我们的研究结果表明,全氟辛烷磺酸可诱导性别特异性效应,并在幼虫发育和变态过程中发生变化。我们的研究表明,在环境相关浓度下,PFAS会通过不同的机制改变脂质代谢,这些机制可能与PPARs无关,但对身体状况没有影响,这表明需要进行更多的分子研究,以阐明PFAS诱导两栖动物和其他类群脂质失调的机制。
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引用次数: 0
Biodegradation of the Antiretroviral Tenofovir Disoproxil by a Cyanobacteria/Bacterial Culture. 蓝藻/细菌培养对抗逆转录病毒药物替诺福韦酯的生物降解。
IF 3.9 3区 环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2024-10-10 DOI: 10.3390/toxics12100729
Sandra Regina Silva, Gabriel Souza-Silva, Carolina Paula de Souza Moreira, Olívia Maria de Sousa Ribeiro Vasconcelos, Micheline Rosa Silveira, Francisco Antonio Rodrigues Barbosa, Sergia Maria Starling Magalhães, Marcos Paulo Gomes Mol

Tenofovir disoproxil fumarate (TDF) is an antiretroviral drug extensively used by people living with HIV. The TDF molecule is hydrolysed in vivo and liberates tenofovir, the active part of the molecule. Tenofovir is a very stable drug and the discharge of its residues into the environment can potentially lead to risk for aquatic species. This study evaluated the TDF biodegradation and removal by cultures of Microcystis novacekii with the bacteria Pseudomonas pseudoalcaligenes. Concentrations of TDF of 12.5, 25.0, and 50.0 mg/L were used in this study. The process occurred in two stages. In the first 72 h, TDF was de-esterified, forming the tenofovir monoester intermediate by abiotic and enzymatic processes associated in an extracellular medium. In a second step, the monoester was removed from the culture medium by intracellular processes. The tenofovir or other by-products of TDF were not observed in the test conditions. At the end of the experiment, 88.7 to 94.1% of TDF and its monoester derivative were removed from the culture medium over 16 days. This process showed higher efficiency of TDF removal at the concentration of 25 mg/L. Tenofovir isoproxil monoester has partial antiviral activity and has shown to be persistent, maintaining a residual concentration after 16 days in the culture medium, therefore indicating the need to continue research on methods for total removal of this product from the aquatic environment.

富马酸替诺福韦二吡呋酯(TDF)是一种抗逆转录病毒药物,被艾滋病毒感染者广泛使用。TDF 分子在体内水解,释放出替诺福韦,即分子中的活性部分。替诺福韦是一种非常稳定的药物,其残留物排放到环境中可能会对水生生物造成危害。本研究评估了新微囊藻与假单胞菌(Pseudoalcaligenes)培养物对替诺福韦的生物降解和去除作用。本研究使用的 TDF 浓度分别为 12.5、25.0 和 50.0 mg/L。整个过程分为两个阶段。在最初的 72 小时内,TDF 被去酯化,在细胞外培养基中通过非生物和酶的作用形成替诺福韦单酯中间体。第二步,单酯通过细胞内过程从培养基中去除。在试验条件下没有观察到替诺福韦或 TDF 的其他副产品。实验结束时,经过 16 天,88.7%-94.1% 的 TDF 及其单酯衍生物从培养液中清除。在浓度为 25 毫克/升时,该过程显示出较高的 TDF 去除效率。替诺福韦酯单酯具有部分抗病毒活性,并显示出持久性,在培养基中 16 天后仍能保持残留浓度,因此表明有必要继续研究从水生环境中完全去除该产品的方法。
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引用次数: 0
Health Implications of Widespread Micro- and Nanoplastic Exposure: Environmental Prevalence, Mechanisms, and Biological Impact on Humans. 广泛接触微塑料和纳米塑料对健康的影响:环境普遍性、机制和对人类的生物影响。
IF 3.9 3区 环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2024-10-10 DOI: 10.3390/toxics12100730
Olivia-Teodora Preda, Ana-Maria Vlasceanu, Cristina Veronica Andreescu, Aristidis Tsatsakis, Yaroslav Mezhuev, Carolina Negrei, Daniela Luiza Baconi

The increasing awareness of the potential health risks associated with microplastics' (MPs) and nanoplastics' (NPs) presence in the environment has led to a significant rise in research focused on these particles over the past few years. This review focuses on the research on MPs'/NPs' presence and spread, pathways of exposure, toxicological effects on human health and legal framework related to MP/NP challenges. Several research projects have aimed to assess their potential harm to human health, focusing on different systems and organs. After exposure (independent of the pathway), these hazards reach the blood stream and concentrate in different organs. Further, they are responsible for harmful changes, having an immediate effect (pain, inflammation, or hormone imbalance) or lead to a long-term disease (e.g., infertility, chronic obstructive pulmonary disease, or cancer). Toxicological effects have been noticed at high concentrations of MPs, specifically polystyrene, the most widespread typical MP, but only short-term effects have been mostly studied. Significant quantities of consumed MPs have been discovered to have diverse detrimental effects, posing a threat to human welfare. The exact concentrations of microplastics that are inhaled and swallowed and then build up in the human body are still not known. Further investigation is necessary to evaluate the impact of MP/NP contamination at minimal concentrations and for prolonged durations.

随着人们对环境中存在的微塑料(MPs)和纳米塑料(NPs)所带来的潜在健康风险的认识不断提高,过去几年中有关这些微粒的研究显著增加。本综述重点关注有关微塑料/纳米塑料的存在和传播、接触途径、对人类健康的毒理学影响以及与微塑料/纳米塑料挑战相关的法律框架的研究。一些研究项目旨在评估它们对人体健康的潜在危害,重点关注不同的系统和器官。在接触后(与接触途径无关),这些危害物质会进入血流并集中在不同的器官中。此外,它们还会造成有害变化,产生直接影响(疼痛、炎症或荷尔蒙失调)或导致长期疾病(如不孕症、慢性阻塞性肺病或癌症)。人们已经注意到高浓度 MPs(特别是聚苯乙烯,最常见的典型 MPs)的毒理效应,但大部分研究只涉及短期效应。大量消耗的 MPs 已被发现具有多种有害影响,对人类福祉构成威胁。吸入和吞咽的微塑料在人体内积聚的确切浓度尚不清楚。有必要开展进一步调查,以评估MP/NP污染在最低浓度和较长时间内的影响。
{"title":"Health Implications of Widespread Micro- and Nanoplastic Exposure: Environmental Prevalence, Mechanisms, and Biological Impact on Humans.","authors":"Olivia-Teodora Preda, Ana-Maria Vlasceanu, Cristina Veronica Andreescu, Aristidis Tsatsakis, Yaroslav Mezhuev, Carolina Negrei, Daniela Luiza Baconi","doi":"10.3390/toxics12100730","DOIUrl":"https://doi.org/10.3390/toxics12100730","url":null,"abstract":"<p><p>The increasing awareness of the potential health risks associated with microplastics' (MPs) and nanoplastics' (NPs) presence in the environment has led to a significant rise in research focused on these particles over the past few years. This review focuses on the research on MPs'/NPs' presence and spread, pathways of exposure, toxicological effects on human health and legal framework related to MP/NP challenges. Several research projects have aimed to assess their potential harm to human health, focusing on different systems and organs. After exposure (independent of the pathway), these hazards reach the blood stream and concentrate in different organs. Further, they are responsible for harmful changes, having an immediate effect (pain, inflammation, or hormone imbalance) or lead to a long-term disease (e.g., infertility, chronic obstructive pulmonary disease, or cancer). Toxicological effects have been noticed at high concentrations of MPs, specifically polystyrene, the most widespread typical MP, but only short-term effects have been mostly studied. Significant quantities of consumed MPs have been discovered to have diverse detrimental effects, posing a threat to human welfare. The exact concentrations of microplastics that are inhaled and swallowed and then build up in the human body are still not known. Further investigation is necessary to evaluate the impact of MP/NP contamination at minimal concentrations and for prolonged durations.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11511527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficient Degradation of Ofloxacin by Magnetic CuFe2O4 Coupled PMS System: Optimization, Degradation Pathways and Toxicity Evaluation. 磁性 CuFe2O4 耦合 PMS 系统对氧氟沙星的高效降解:优化、降解途径和毒性评估。
IF 3.9 3区 环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2024-10-10 DOI: 10.3390/toxics12100731
Chuanhong Xing, Kang Chen, Limin Hu, Lanhua Liu

Magnetic CuFe2O4 was prepared with the modified sol-gel method and used for enhanced peroxymonosulfate (PMS) activation and ofloxacin (OFL) degradation. The OFL could almost degrade within 30 min at a catalyst dosage of 0.66 g/L, PMS concentration of 0.38 mM, and initial pH of 6.53 without adjustment, using response surface methodology (RSM) with Box-Behnken design (BBD). In the CuFe2O4/PMS system, the coexisting substances, including CO32-, NO3-, SO42-, Cl- and humic acid, have little effect on the OFL degradation. The system also performs well in actual water, such as tap water and surface water (Mei Lake), indicating the excellent anti-interference ability of the system. The cyclic transformation between Cu(II)/Cu(I) and Fe(III)/Fe(II) triggers the generation of active radicals including SO4•-, •OH, •O2- and 1O2. The OFL degradation pathway, mainly involving the dehydrogenation, deamination, hydroxylation, decarboxylation and carboxylation processes, was proposed using mass spectroscopy. Moreover, the toxicity assessment indicated that the end intermediates are environmentally friendly. This study is about how the CuFe2O4/PMS system performs well in PMS activation for refractory organic matter removal in wastewater.

采用改良溶胶-凝胶法制备了磁性 CuFe2O4,并将其用于增强过硫酸盐(PMS)活化和氧氟沙星(OFL)降解。在催化剂用量为 0.66 g/L、PMS 浓度为 0.38 mM、初始 pH 值为 6.53 且无需调节的条件下,采用方框-贝肯设计(BBD)响应面方法(RSM),OFL 在 30 分钟内几乎可以降解。在 CuFe2O4/PMS 系统中,共存物质(包括 CO32-、NO3-、SO42-、Cl- 和腐殖酸)对 OFL 降解的影响很小。该体系在自来水和地表水(梅湖)等实际水中也表现良好,表明该体系具有出色的抗干扰能力。Cu(II)/Cu(I)和Fe(III)/Fe(II)之间的循环转化引发了包括SO4--、-OH、-O2-和1O2在内的活性自由基的生成。利用质谱分析提出了 OFL 的降解途径,主要包括脱氢、脱氨基、羟基化、脱羧和羧基化过程。此外,毒性评估表明,最终中间产物对环境无害。本研究探讨了 CuFe2O4/PMS 系统如何在 PMS 活化去除废水中难熔有机物的过程中发挥良好作用。
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引用次数: 0
High Prevalence of Tobacco Consumption among Pregnant Women in a Southern European City (Seville): A Challenge for the Health System. 南欧城市(塞维利亚)孕妇吸烟率高:卫生系统面临的挑战。
IF 3.9 3区 环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2024-10-09 DOI: 10.3390/toxics12100728
Ramón Mendoza-Berjano, Fatima Leon-Larios, Isabel Corrales-Gutierrez, Diego Gomez-Baya, Rocío Medero-Canela, Francisca Baena-Antequera

The prevalence of prenatal tobacco exposure remains high in many countries, particularly in southern Europe. The aims of this study were to estimate the prevalence of smoking among pregnant women in a southern Spanish city (Seville) and to identify the associated sociodemographic and obstetric characteristics. In a descriptive, cross-sectional study, a random sample of pregnant women who were scheduled to undergo a morphology scan at their public referral hospital in their 20th week of gestation were interviewed in person. At the start of pregnancy, 38.2% of the pregnant women were smokers. In the twentieth week, 19.1% continued to smoke, and the same percentage had quit. The prevalence of smoking in pregnant women was higher among those with a low level of education (60% among pregnant women with no studies and 30.4% in those with primary education) and among those who had had abortions (38.5%). Pregnant smokers with obesity were the least likely to have given up smoking during pregnancy. Women with a lower educational level should be a prime target for cross-sectoral interventions aimed at preventing prenatal tobacco exposure. Implementation of support measures for providing effective clinical advice in preconception and prenatal care regarding healthy lifestyles is particularly needed.

在许多国家,尤其是南欧国家,产前接触烟草的比例仍然很高。本研究旨在估算西班牙南部城市(塞维利亚)孕妇的吸烟率,并确定相关的社会人口学和产科特征。在一项描述性横断面研究中,研究人员随机抽取了妊娠 20 周时计划在公立转诊医院接受形态学扫描的孕妇,并对她们进行了访谈。在怀孕初期,38.2% 的孕妇是吸烟者。在怀孕第 20 周时,19.1% 的孕妇继续吸烟,而戒烟的孕妇比例相同。受教育程度低的孕妇吸烟率较高(未受过教育的孕妇吸烟率为 60%,受过初等教育的孕妇吸烟率为 30.4%),曾经流产的孕妇吸烟率也较高(38.5%)。肥胖孕妇在怀孕期间戒烟的可能性最小。教育程度较低的妇女应成为旨在预防产前烟草暴露的跨部门干预措施的主要目标。尤其需要采取支持措施,在孕前和产前保健中提供有关健康生活方式的有效临床建议。
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引用次数: 0
A Long-Term Assessment of Nitrogen Removal Performance and Microecosystem Evolution in Bioretention Columns Modified with Sponge Iron. 对使用海绵铁改良的生物滞留柱的脱氮性能和微生态系统演变的长期评估
IF 3.9 3区 环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2024-10-09 DOI: 10.3390/toxics12100727
Zizeng Lin, Qinghuan Shi, Qiumei He

The nitrogen removal performance of bioretention urgently needs to be improved, and sponge iron has great potential to address this challenge. This study reported the results of a long-term investigation on bioretention columns improved by sponge iron, examining the durability of sponge iron from nitrogen removal performance, sponge iron properties, and the evolution of biological elements. The results showed that after 9 months of continuous operation, the removal rates of ammonia nitrogen (NH4+-N), nitrate nitrogen (NO3--N), and total nitrogen (TN) in the bioretention columns with an appropriate proportion of sponge iron could reach 80% (some even over 90%). However, the long-term stress of sponge iron exposure, combined with the cumulative effect of pollutants, might lead to the excessive accumulation of reactive oxygen species (ROS) in plants, thereby posing risks of diminished chlorophyll content and enzyme activity. Simultaneously, the extended exposure could also have detrimental effects on microbial diversity and the abundance of dominant bacteria such as Proteobacteria and Sphingorhabdus. Therefore, it is necessary to select plant species and functional genes that demonstrate high adaptability to iron-induced stress.

生物滞留的脱氮性能亟待提高,而海绵铁在应对这一挑战方面具有巨大潜力。本研究报告了对使用海绵铁改进的生物滞留柱进行长期调查的结果,从脱氮性能、海绵铁特性和生物元素演变等方面考察了海绵铁的耐久性。结果表明,经过 9 个月的连续运行,适当比例海绵铁的生物滞留柱对氨氮(NH4+-N)、硝态氮(NO3--N)和总氮(TN)的去除率可达 80%(有些甚至超过 90%)。然而,海绵铁的长期暴露压力加上污染物的累积效应,可能会导致植物体内活性氧(ROS)的过度积累,从而带来叶绿素含量和酶活性降低的风险。同时,长时间接触污染物也会对微生物多样性和优势菌(如变形菌和鞘氨醇杆菌)的数量产生不利影响。因此,有必要选择对铁诱导胁迫具有高度适应性的植物物种和功能基因。
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引用次数: 0
The Metallothionein System in Tetrahymena thermophila Is Iron-Inducible. 嗜热四膜虫的金属硫蛋白系统是铁诱导型的
IF 3.9 3区 环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2024-10-08 DOI: 10.3390/toxics12100725
Davide Gualandris, Davide Rotondo, Candida Lorusso, Antonietta La Terza, Antonio Calisi, Francesco Dondero

Metallothioneins are multifunctional proteins implicated in various cellular processes. They have been used as biomarkers of heavy metal exposure and contamination due to their intrinsic ability to bind heavy metals and their transcriptional response to both physiological and noxious metal ions such as cadmium (Cd) and mercury (Hg). In this study, we aimed to clarify the role of iron and reactive oxygen species (ROSs) in the induction of the metallothionein system (Mtt) in the ciliate protozoan Tetrahymena thermophila. We investigated the relative mRNA abundances of the metallothionein genes Mtt1, Mtt2/4, and Mtt5, revealing for the first time their responsiveness to iron exposure. Furthermore, by using inhibitors of superoxide dismutase (SOD) and catalase (CAT), alone or in combination with iron, we highlighted the roles of superoxide ion and endogenous hydrogen peroxide, as well as the complex interplay between the metal and ROSs. These results enhance our understanding of the metallothionein system in ciliates and suggest that ROSs may be a primary evolutionary driver for the selection of these proteins in nature.

金属硫蛋白是一种参与多种细胞过程的多功能蛋白质。由于金属硫蛋白具有与重金属结合的内在能力以及对生理和有害金属离子(如镉(Cd)和汞(Hg))的转录反应,它们已被用作重金属暴露和污染的生物标志物。本研究旨在阐明铁和活性氧(ROS)在纤毛虫原生动物嗜热四膜虫金属硫蛋白系统(Mtt)诱导过程中的作用。我们研究了金属硫蛋白基因 Mtt1、Mtt2/4 和 Mtt5 的相对 mRNA 丰度,首次揭示了它们对铁暴露的反应性。此外,通过使用超氧化物歧化酶(SOD)和过氧化氢酶(CAT)抑制剂(单独或与铁结合使用),我们强调了超氧离子和内源性过氧化氢的作用,以及金属和 ROS 之间复杂的相互作用。这些结果加深了我们对纤毛虫金属硫蛋白系统的了解,并表明 ROS 可能是自然界选择这些蛋白质的主要进化驱动力。
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引用次数: 0
New Insights into the Mechanisms of Toxicity of Aging Microplastics. 老化微塑料毒性机理的新见解。
IF 3.9 3区 环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2024-10-08 DOI: 10.3390/toxics12100726
Victor Pavlovich Chelomin, Aleksandra Anatolyevna Istomina, Andrey Alexandrovich Mazur, Valentina Vladimirovna Slobodskova, Avianna Fayazovna Zhukovskaya, Nadezhda Vladimirovna Dovzhenko

Nowadays, synthetic polymer (plastic) particles are ubiquitous in the environment. It is known that for several decades microplastics (MPs) have been accumulating in the World Ocean, becoming available to a large variety of marine organisms. Particularly alarming is the accumulation of aging plastic particles, as the degradation processes of such particles increase their toxicity. The diverse display of negative properties of aging MPs and its effect on biota are still poorly understood. In this study, in vitro experiments modeling the interaction of pristine and UV-irradiated aging polypropylene (PP) fragments with hemocytes and mitochondria of bivalve mollusks Mytilus sp. were performed. The appearance of free radicals in the environment was recorded by spectral characteristics of indicator dyes-methylene blue (MB) and nitroblue tetrazolium (NBT). It was found that due to photooxidation, aging PP fragments sorbed more than threefold MB on their modified surface compared to pristine samples of this polymer. Using NBT, the formation of reactive oxygen species in seawater in the presence of pristine and photoactivated PP was recorded. It was also found that photodegraded PP fragments largely stimulated the development of lipid peroxidation processes in mitochondrial membranes and reduced the stability of hemocyte lysosome membranes compared to pristine PP fragments. In general, the results obtained concretize and supplement with experimental data the previously stated hypothesis of toxicity of aging MPs.

如今,合成聚合物(塑料)颗粒在环境中无处不在。众所周知,几十年来,微塑料(MPs)在世界海洋中不断积累,成为各种海洋生物的食物。尤其令人担忧的是老化塑料颗粒的积累,因为这些颗粒的降解过程会增加其毒性。人们对老化塑料微粒的各种负面特性及其对生物群的影响还知之甚少。本研究进行了体外实验,模拟原始聚丙烯(PP)碎片和经紫外线照射的老化聚丙烯(PP)碎片与双壳类软体动物贻贝(Mytilus sp.)的血细胞和线粒体之间的相互作用。通过指示染料--亚甲基蓝(MB)和硝基蓝四氮唑(NBT)的光谱特征记录了环境中自由基的出现。研究发现,由于光氧化作用,老化的聚丙烯碎片在其改性表面吸附的甲基溴是这种聚合物原始样品的三倍以上。使用 NBT 记录了原始 PP 和光活化 PP 在海水中形成的活性氧。研究还发现,与原始 PP 碎片相比,光降解 PP 碎片在很大程度上刺激了线粒体膜脂质过氧化过程的发展,并降低了血细胞溶酶体膜的稳定性。总之,所获得的结果用实验数据具体说明并补充了之前提出的老化多孔质谱毒性假设。
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