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High-Dose Botulinum Neurotoxin Type A as a Predictive Tool for Selective Dorsal Rhizotomy Outcomes in Pediatric Spastic Diplegia 高剂量A型肉毒杆菌神经毒素作为儿童痉挛性双瘫选择性背根切断术结果的预测工具
IF 2.4 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Toxicon
Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.toxicon.2025.108746
Flaminia Frascarelli , Giacomo Esposito , Alessandro De Benedictis , Riccardo Carbonetti , Donatella Lettori
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引用次数: 0
Gelsemium elegans poisoning-induced acute respiratory failure treated with respiratory support and hemoperfusion: A case report 呼吸支持加血液灌流治疗秀丽隐杆线虫中毒致急性呼吸衰竭1例。
IF 2.4 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Toxicon
Pub Date : 2026-03-01 Epub Date: 2025-12-08 DOI: 10.1016/j.toxicon.2025.108932
Zhichu Dai , Jiankun Liao , Liwei He
We report a case of severe Gelsemium elegans poisoning in a 64-year-old male following ingestion of approximately 40 mL of a Gelsemium decoction. Shortly after presentation with blurred vision, the patient developed sudden respiratory arrest during gastric lavage. Immediate endotracheal intubation and mechanical ventilation were performed, followed by hemoperfusion and supportive care in the intensive care unit. The patient regained spontaneous respiration, was weaned off ventilation, and achieved full recovery without residual complications. This case highlights the critical role of prompt respiratory support and hemoperfusion in successful management of Gelsemium elegans poisoning.
我们报告了一例严重的秀丽隐杆线虫中毒在一个64岁的男性摄入约40毫升的凝胶汤。在出现视力模糊后不久，患者在洗胃时出现呼吸骤停。立即气管插管和机械通气，随后在重症监护室进行血液灌流和支持治疗。患者恢复了自主呼吸，停止了通气，完全康复，无遗留并发症。本病例强调了及时的呼吸支持和血液灌流在成功治疗秀丽隐杆线虫中毒中的关键作用。
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引用次数: 0
Clinical Effects of Botulinum Toxin Type A Combined With Extracorporeal Shockwave Therapy on Plantar Flexor Spasticity in Cerebral Palsy: A Pilot Study A型肉毒毒素联合体外冲击波治疗脑瘫足底屈肌痉挛的临床效果：一项初步研究
IF 2.4 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Toxicon
Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.toxicon.2025.108674
Ismail Hakan Akbulut , Belgin Erhan
{"title":"Clinical Effects of Botulinum Toxin Type A Combined With Extracorporeal Shockwave Therapy on Plantar Flexor Spasticity in Cerebral Palsy: A Pilot Study","authors":"Ismail Hakan Akbulut ,&nbsp;Belgin Erhan","doi":"10.1016/j.toxicon.2025.108674","DOIUrl":"10.1016/j.toxicon.2025.108674","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108674"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Restoring Affection: Botulinum Neurotoxin for Facial Allodynia in a Severely Disabled Person 恢复情感：肉毒杆菌神经毒素治疗严重残疾人面部异常痛
IF 2.4 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Toxicon
Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.toxicon.2025.108686
Cristina Baptista, Mónica Jorge, Ana Vieira, Inês Cabral, Tiago Cunha, Diogo Portugal
{"title":"Restoring Affection: Botulinum Neurotoxin for Facial Allodynia in a Severely Disabled Person","authors":"Cristina Baptista,&nbsp;Mónica Jorge,&nbsp;Ana Vieira,&nbsp;Inês Cabral,&nbsp;Tiago Cunha,&nbsp;Diogo Portugal","doi":"10.1016/j.toxicon.2025.108686","DOIUrl":"10.1016/j.toxicon.2025.108686","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108686"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studying Botulinum Toxin Diffusion in Spastic Patients Using High-Density Surface EMG: A Clinical and Electrophysiological Perspective 应用高密度表面肌电图研究痉挛患者肉毒毒素扩散：临床和电生理的观点
IF 2.4 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Toxicon
Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.toxicon.2025.108751
Marco Gagliardi , Leonardo Malimpensa , Matias Fröhlich , Chiara Esposito , Giorgio Leodori , Daniele Belvisi , Alberto Botter , Giacinto Luigi Cerone , Giovanni Fabbrini , Antonella Conte , Gina Ferrazzano , Taian Martins Vieira
{"title":"Studying Botulinum Toxin Diffusion in Spastic Patients Using High-Density Surface EMG: A Clinical and Electrophysiological Perspective","authors":"Marco Gagliardi ,&nbsp;Leonardo Malimpensa ,&nbsp;Matias Fröhlich ,&nbsp;Chiara Esposito ,&nbsp;Giorgio Leodori ,&nbsp;Daniele Belvisi ,&nbsp;Alberto Botter ,&nbsp;Giacinto Luigi Cerone ,&nbsp;Giovanni Fabbrini ,&nbsp;Antonella Conte ,&nbsp;Gina Ferrazzano ,&nbsp;Taian Martins Vieira","doi":"10.1016/j.toxicon.2025.108751","DOIUrl":"10.1016/j.toxicon.2025.108751","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108751"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reduction of Masseter Muscle Prominence After Treatment With OnabotulinumtoxinA: Results From a Phase 3 Double-Blind, Randomized, Placebo-Controlled Study Period in Europe 肉毒杆菌毒素治疗后咬肌隆起的减少：来自欧洲的一项3期双盲、随机、安慰剂对照研究的结果
IF 2.4 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Toxicon
Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.toxicon.2025.108752
Juan García-Gavín , Rodrigo Da Mota , Dario Bertossi , Martina Kerscher , Radina Denkova , René Hopfinger , Reva McCaskill , Grace Pan , Catherine Foley , Helena Pavicic
{"title":"Reduction of Masseter Muscle Prominence After Treatment With OnabotulinumtoxinA: Results From a Phase 3 Double-Blind, Randomized, Placebo-Controlled Study Period in Europe","authors":"Juan García-Gavín ,&nbsp;Rodrigo Da Mota ,&nbsp;Dario Bertossi ,&nbsp;Martina Kerscher ,&nbsp;Radina Denkova ,&nbsp;René Hopfinger ,&nbsp;Reva McCaskill ,&nbsp;Grace Pan ,&nbsp;Catherine Foley ,&nbsp;Helena Pavicic","doi":"10.1016/j.toxicon.2025.108752","DOIUrl":"10.1016/j.toxicon.2025.108752","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108752"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics of IncobotulinumtoxinA Treatment for Cervical Dystonia in a Real-World Setting: Dosing and Muscles Injected 在现实世界中，肉毒杆菌毒素治疗颈肌张力障碍的特点：剂量和肌肉注射
IF 2.4 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Toxicon
Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.toxicon.2025.108765
J. Holmes , A. Kong , G. Askin , D. Nomah , D. Joseph , K. Binney , M.A. Hast
{"title":"Characteristics of IncobotulinumtoxinA Treatment for Cervical Dystonia in a Real-World Setting: Dosing and Muscles Injected","authors":"J. Holmes ,&nbsp;A. Kong ,&nbsp;G. Askin ,&nbsp;D. Nomah ,&nbsp;D. Joseph ,&nbsp;K. Binney ,&nbsp;M.A. Hast","doi":"10.1016/j.toxicon.2025.108765","DOIUrl":"10.1016/j.toxicon.2025.108765","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108765"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Dysport® in the Treatment of Tremulous Cervical Dystonia due to Vitamin E Deficiency: About 2 Families Dysport®治疗维生素E缺乏所致震颤性颈肌张力障碍的疗效：约2个家庭
IF 2.4 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Toxicon
Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.toxicon.2025.108705
Chahrazad Boukadir , Wahiba Amer El Khedoud
{"title":"Efficacy of Dysport® in the Treatment of Tremulous Cervical Dystonia due to Vitamin E Deficiency: About 2 Families","authors":"Chahrazad Boukadir ,&nbsp;Wahiba Amer El Khedoud","doi":"10.1016/j.toxicon.2025.108705","DOIUrl":"10.1016/j.toxicon.2025.108705","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108705"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RelabotulinumtoxinA Treatment Improved Moderate to Severe Glabellar Lines and Lateral Canthal Lines Regardless of Baseline Toxin Naivety: Subgroup Analyses of Pooled Phase 3 Study Data relabotulintoxina治疗改善了中度至重度的glabella线和侧眦线，无论基线毒素是否存在：合并的3期研究数据的亚组分析
IF 2.4 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Toxicon
Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.toxicon.2025.108718
Sue Ellen Cox , Michael Gold , Sachin Shridharani , Melanie Palm , Lisa Grunebaum , Mark S. Nestor , Inna Prygova
{"title":"RelabotulinumtoxinA Treatment Improved Moderate to Severe Glabellar Lines and Lateral Canthal Lines Regardless of Baseline Toxin Naivety: Subgroup Analyses of Pooled Phase 3 Study Data","authors":"Sue Ellen Cox ,&nbsp;Michael Gold ,&nbsp;Sachin Shridharani ,&nbsp;Melanie Palm ,&nbsp;Lisa Grunebaum ,&nbsp;Mark S. Nestor ,&nbsp;Inna Prygova","doi":"10.1016/j.toxicon.2025.108718","DOIUrl":"10.1016/j.toxicon.2025.108718","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108718"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe Case of Distant Spread of Botulinum Neurotoxin Type A (BoNT-A) After Cosmetic Treatment, Leading to Jaw Displacement A型肉毒杆菌神经毒素（BoNT-A）在美容治疗后远处扩散，导致下颌移位的严重病例
IF 2.4 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Toxicon
Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.toxicon.2025.108689
Sara Bech , Heidi Biernat , Annemette Lokkegaard , Anette Kirstine Stark
{"title":"Severe Case of Distant Spread of Botulinum Neurotoxin Type A (BoNT-A) After Cosmetic Treatment, Leading to Jaw Displacement","authors":"Sara Bech ,&nbsp;Heidi Biernat ,&nbsp;Annemette Lokkegaard ,&nbsp;Anette Kirstine Stark","doi":"10.1016/j.toxicon.2025.108689","DOIUrl":"10.1016/j.toxicon.2025.108689","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108689"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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