Pub Date : 2026-01-08DOI: 10.1016/j.toxicon.2025.108698
Vadym Biloshytsky , Maryna Biloshytska
{"title":"Ukrainian National Consensus Statement on Botulinum Toxin Therapy for Neuropathic Pain: A Multidisciplinary Initiative in Times of War","authors":"Vadym Biloshytsky , Maryna Biloshytska","doi":"10.1016/j.toxicon.2025.108698","DOIUrl":"10.1016/j.toxicon.2025.108698","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108698"},"PeriodicalIF":2.4,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-08DOI: 10.1016/j.toxicon.2025.108764
Christian Hartmann, Kay Marquardt, Christina Wollenburg, Thomas Hengl
{"title":"Cellular Responses to Botulinum Neurotoxin A Formulations: Implications With HSA and Polysorbates on Skin-Derived Cell Types","authors":"Christian Hartmann, Kay Marquardt, Christina Wollenburg, Thomas Hengl","doi":"10.1016/j.toxicon.2025.108764","DOIUrl":"10.1016/j.toxicon.2025.108764","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108764"},"PeriodicalIF":2.4,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-08DOI: 10.1016/j.toxicon.2025.108704
Soumaya Boudokhane, Houda Migaou, Amr Chaabeni, Amine Kalai, Zohra Ben Salah Frih
{"title":"Influence of Low-Dose Botulinum Neurotoxin Therapy on Balance and Gait Control in Children With Cerebral Palsy","authors":"Soumaya Boudokhane, Houda Migaou, Amr Chaabeni, Amine Kalai, Zohra Ben Salah Frih","doi":"10.1016/j.toxicon.2025.108704","DOIUrl":"10.1016/j.toxicon.2025.108704","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108704"},"PeriodicalIF":2.4,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-08DOI: 10.1016/j.toxicon.2026.108992
Patryck Érmerson Monteiro dos Santos , Matheus Cavalcanti de Barros , Thaís Paes de Freitas , Amanda Vieira de Barros , Juliane Nancy de Oliveira Silva , Simone da Paz Leôncio Alves , Juliano Matheus de Lima Maux , Maria Betânia Melo de Oliveira , Thâmarah de Albuquerque Lima , Renata Mendonça Araújo , Jacinto da Costa Silva Neto , Thiago Henrique Napoleão , Ana Patrícia Silva de Oliveira Santos , Patrícia Maria Guedes Paiva
Croton pulegiodorus Baill. leaf essential oil (CPLEO) has demonstrated insecticidal activity and is a promising candidate for the development of formulations aimed at controlling insect pests, as well as for use as a repellent. This study investigated the phytochemical composition and dermal toxicity of CPLEO following single-dose topical application in Swiss mice. The major components of CPLEO were ascaridole (27.57 %), camphor (15.39 %), and 1,8-cineole (14.16 %). No mortality, behavioral changes, or signs of skin irritation were observed. Hematological parameters remained unchanged at doses of 200 and 2000 mg/kg; however, significant reductions in erythrocyte count, hematocrit, hemoglobin, leukocytes, and platelet counts were observed in animals treated with 1000 mg/kg. All treated groups showed a significant decrease in serum AST levels, although no associated histopathological changes were detected. The primary irritation index classified CPLEO as non-irritating at all tested doses. Overall, the results indicate that CPLEO does not exhibit acute dermal toxicity, suggesting it is safe for topical exposure. Given its strong insecticidal potential, this essential oil may be a promising candidate for inclusion in insecticidal formulations that come into contact with the skin.
{"title":"Assessment of acute dermal toxicity of Croton pulegiodorus Baill. leaf essential oil in mice","authors":"Patryck Érmerson Monteiro dos Santos , Matheus Cavalcanti de Barros , Thaís Paes de Freitas , Amanda Vieira de Barros , Juliane Nancy de Oliveira Silva , Simone da Paz Leôncio Alves , Juliano Matheus de Lima Maux , Maria Betânia Melo de Oliveira , Thâmarah de Albuquerque Lima , Renata Mendonça Araújo , Jacinto da Costa Silva Neto , Thiago Henrique Napoleão , Ana Patrícia Silva de Oliveira Santos , Patrícia Maria Guedes Paiva","doi":"10.1016/j.toxicon.2026.108992","DOIUrl":"10.1016/j.toxicon.2026.108992","url":null,"abstract":"<div><div><em>Croton pulegiodorus</em> Baill. leaf essential oil (CPLEO) has demonstrated insecticidal activity and is a promising candidate for the development of formulations aimed at controlling insect pests, as well as for use as a repellent. This study investigated the phytochemical composition and dermal toxicity of CPLEO following single-dose topical application in Swiss mice. The major components of CPLEO were ascaridole (27.57 %), camphor (15.39 %), and 1,8-cineole (14.16 %). No mortality, behavioral changes, or signs of skin irritation were observed. Hematological parameters remained unchanged at doses of 200 and 2000 mg/kg; however, significant reductions in erythrocyte count, hematocrit, hemoglobin, leukocytes, and platelet counts were observed in animals treated with 1000 mg/kg. All treated groups showed a significant decrease in serum AST levels, although no associated histopathological changes were detected. The primary irritation index classified CPLEO as non-irritating at all tested doses. Overall, the results indicate that CPLEO does not exhibit acute dermal toxicity, suggesting it is safe for topical exposure. Given its strong insecticidal potential, this essential oil may be a promising candidate for inclusion in insecticidal formulations that come into contact with the skin.</div></div>","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"272 ","pages":"Article 108992"},"PeriodicalIF":2.4,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145948883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Botulinum Toxin Type A in the Treatment of Synkinesis: Clinical Case Study","authors":"M.A. Akulov , V.N. Shimansky , V.K. Poshataev , O.R. Orlova , V.O. Zakharov","doi":"10.1016/j.toxicon.2025.108676","DOIUrl":"10.1016/j.toxicon.2025.108676","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108676"},"PeriodicalIF":2.4,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-08DOI: 10.1016/j.toxicon.2025.108756
Ana Lucia Gonzaga da Cunha , Rossana Vasconcelos , David Di Sessa , Gabriel Sampaio , Pitila Ramalhoto , Bruno F. Zampieri , Bárbara S. Deus , Suyan Vasconcelos , Talitha Bellote , Juliano Carvalho , Giseli Petrone , Vinicius Figueredo , Gustavo Limongi Moreira
{"title":"IncobotulinumtoxinA for the Treatment of Glabellar and Forehead Dynamic Lines: A Brazilian Multicenter Real-Life Study","authors":"Ana Lucia Gonzaga da Cunha , Rossana Vasconcelos , David Di Sessa , Gabriel Sampaio , Pitila Ramalhoto , Bruno F. Zampieri , Bárbara S. Deus , Suyan Vasconcelos , Talitha Bellote , Juliano Carvalho , Giseli Petrone , Vinicius Figueredo , Gustavo Limongi Moreira","doi":"10.1016/j.toxicon.2025.108756","DOIUrl":"10.1016/j.toxicon.2025.108756","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108756"},"PeriodicalIF":2.4,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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