Sajjad Ahmad Chughtai, Ove Ketil Bergdal, Casper Smedegaard Ottesen, Niels Wolfram, Kåre Fugleholm
Ulnar nerve neuropathy is the second most common neuropathy of the upper extremity. The condition can easily be recognized clinically. The diagnosis can further be supported by either ultrasound or neurophysiological examination. Most cases can be treated conservatively. Surgery is recommended if conservative treatment fails or in severe clinical cases. Decompression is the primary procedure performed with a success rate of up to 87%. In some cases, a transposition of the ulnar nerve is necessary. We recommend early referral and consideration of surgery when conservative treatment fails, as argued in this review.
{"title":"[Ulnar nerve neuropathy].","authors":"Sajjad Ahmad Chughtai, Ove Ketil Bergdal, Casper Smedegaard Ottesen, Niels Wolfram, Kåre Fugleholm","doi":"10.61409/V06250504","DOIUrl":"https://doi.org/10.61409/V06250504","url":null,"abstract":"<p><p>Ulnar nerve neuropathy is the second most common neuropathy of the upper extremity. The condition can easily be recognized clinically. The diagnosis can further be supported by either ultrasound or neurophysiological examination. Most cases can be treated conservatively. Surgery is recommended if conservative treatment fails or in severe clinical cases. Decompression is the primary procedure performed with a success rate of up to 87%. In some cases, a transposition of the ulnar nerve is necessary. We recommend early referral and consideration of surgery when conservative treatment fails, as argued in this review.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"188 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146182665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ankylose af hallux som senfølge til infektion efter negleresektion.","authors":"Tine S Madsen, Daniel Bomark, Yvette A Cramer","doi":"10.61409/V73073","DOIUrl":"https://doi.org/10.61409/V73073","url":null,"abstract":"","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"188 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146182707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Makrofagaktiveringssyndrom.","authors":"Daniel El Fassi","doi":"10.61409/V10250885","DOIUrl":"https://doi.org/10.61409/V10250885","url":null,"abstract":"","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"188 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146182630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gilbert-Meulengracht syndrom hos 17-årig mand med langvarig ikterus.","authors":"Rasmus Würgler Hansen","doi":"10.61409/V73072","DOIUrl":"https://doi.org/10.61409/V73072","url":null,"abstract":"","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"188 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146087302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Niels Bach Sørensen, Kristina Stamenkovic, Ellen Hollands Steffensen, Inge Ring Kofoed
In this case report, we present an 11-year-old girl who developed super-refractory status epilepticus (SRSE) after focal seizures. Initial investigations, including MRI, CSF analysis, and autoimmune panels, were normal. Despite extensive treatment with several anti-seizure medications, immunotherapy, attempt of treatment with ketogenic diet and anesthetic infusions targeting burst-suppression, no improvement occurred. Trio whole genome sequencing revealed compound heterozygous pathogenic variants in POLG, confirming mitochondrial disease. Due to poor prognosis and deterioration, treatment was withdrawn, and she died in ICU.
{"title":"[Super-refractory status epilepticus caused by hereditary mitochondrial disease].","authors":"Niels Bach Sørensen, Kristina Stamenkovic, Ellen Hollands Steffensen, Inge Ring Kofoed","doi":"10.61409/V07250609","DOIUrl":"https://doi.org/10.61409/V07250609","url":null,"abstract":"<p><p>In this case report, we present an 11-year-old girl who developed super-refractory status epilepticus (SRSE) after focal seizures. Initial investigations, including MRI, CSF analysis, and autoimmune panels, were normal. Despite extensive treatment with several anti-seizure medications, immunotherapy, attempt of treatment with ketogenic diet and anesthetic infusions targeting burst-suppression, no improvement occurred. Trio whole genome sequencing revealed compound heterozygous pathogenic variants in POLG, confirming mitochondrial disease. Due to poor prognosis and deterioration, treatment was withdrawn, and she died in ICU.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"188 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146087281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zoha Shezadi Shaukat, Ida Nikoline Mandic, Hilde Hylland Uhlving, Kia Hee Schultz Dungu, Amar Ali Mousa, Marie Hauerslev, Alexandra Kruse, Maren Johanne Heilskov Rytter
Language barriers between healthcare professionals and families are increasingly common in Denmark and pose a serious threat to the quality and safety of healthcare for children. This review examines how these barriers lead to poorer outcomes for children, including diagnostic uncertainty and increased risks of adverse events. Although the use of professional interpreters - an entitlement in Denmark - can mitigate these risks, interpreters remain consistently underused. Furthermore, the absence of certification or educational requirements for medical interpreters in Denmark may further hinder the effectiveness and reliability of interpretation services in paediatric healthcare.
{"title":"[Clinical consequences and the handling of language barriers in paediatric healthcare].","authors":"Zoha Shezadi Shaukat, Ida Nikoline Mandic, Hilde Hylland Uhlving, Kia Hee Schultz Dungu, Amar Ali Mousa, Marie Hauerslev, Alexandra Kruse, Maren Johanne Heilskov Rytter","doi":"10.61409/V07250558","DOIUrl":"https://doi.org/10.61409/V07250558","url":null,"abstract":"<p><p>Language barriers between healthcare professionals and families are increasingly common in Denmark and pose a serious threat to the quality and safety of healthcare for children. This review examines how these barriers lead to poorer outcomes for children, including diagnostic uncertainty and increased risks of adverse events. Although the use of professional interpreters - an entitlement in Denmark - can mitigate these risks, interpreters remain consistently underused. Furthermore, the absence of certification or educational requirements for medical interpreters in Denmark may further hinder the effectiveness and reliability of interpretation services in paediatric healthcare.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"188 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146087222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Helene Benedikte Hansen, Julia Almer Bromann, Dan Høgdall, Jakob Hagen Vasehus Schou, Rikke Eefsen
Encorafenib, cetuximab, and binimetinib are targeted therapies developed for metastatic colorectal cancer with a BRAF V600E mutation. This case report describes a patient with metastatic duodenal cancer with a BRAF V600E mutation who achieved durable complete remission following this treatment. The case highlights the potential use of BRAF V600E targeted therapy in BRAF V600E-mutated duodenal cancer and the importance of molecular profiling in rare cancers. Further research is needed on the effect and safety of targeted therapy for small bowel adenocarcinoma.
{"title":"[Remission of metastatic duodenal cancer after treatment with BRAF inhibitor].","authors":"Helene Benedikte Hansen, Julia Almer Bromann, Dan Høgdall, Jakob Hagen Vasehus Schou, Rikke Eefsen","doi":"10.61409/V08250650","DOIUrl":"https://doi.org/10.61409/V08250650","url":null,"abstract":"<p><p>Encorafenib, cetuximab, and binimetinib are targeted therapies developed for metastatic colorectal cancer with a BRAF V600E mutation. This case report describes a patient with metastatic duodenal cancer with a BRAF V600E mutation who achieved durable complete remission following this treatment. The case highlights the potential use of BRAF V600E targeted therapy in BRAF V600E-mutated duodenal cancer and the importance of molecular profiling in rare cancers. Further research is needed on the effect and safety of targeted therapy for small bowel adenocarcinoma.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"188 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146087250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmed A Abood, Christian Lind Nielsen, Christina Enciso Holm, Michael Mørk Petersen, Thomas Baad-Hansen
The diagnostic evaluation of sarcomas is carried out in one of the two sarcoma centres in Denmark - Aarhus University Hospital and Copenhagen University Hospital. Sarcomas are classified into soft tissue sarcomas and bone sarcomas. Furthermore, they are divided into low-grade and high-grade sarcomas according to the histopathology. This review confirms that the primary treatment for all sarcomas is surgical excision; however, chemotherapy and radiation therapy may be applied depending on the type of sarcoma. All sarcoma patients receive a minimum of five years of follow-up after treatment.
{"title":"[Treatment of musculoskeletal sarcomas in adults].","authors":"Ahmed A Abood, Christian Lind Nielsen, Christina Enciso Holm, Michael Mørk Petersen, Thomas Baad-Hansen","doi":"10.61409/V05250391","DOIUrl":"https://doi.org/10.61409/V05250391","url":null,"abstract":"<p><p>The diagnostic evaluation of sarcomas is carried out in one of the two sarcoma centres in Denmark - Aarhus University Hospital and Copenhagen University Hospital. Sarcomas are classified into soft tissue sarcomas and bone sarcomas. Furthermore, they are divided into low-grade and high-grade sarcomas according to the histopathology. This review confirms that the primary treatment for all sarcomas is surgical excision; however, chemotherapy and radiation therapy may be applied depending on the type of sarcoma. All sarcoma patients receive a minimum of five years of follow-up after treatment.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"188 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146087195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Casper Grønlund Larsen, Pia Heckermann Sibbern, Jyoti Shailesh Kolekar, Anders Ravnholt, Schüsler Damlund, Bjarki Ditlev Djurhuus
Dizziness is a common condition that can significantly reduce quality of life and increase the risk of falls. This review examines frequent vestibular causes, including benign paroxysmal positional vertigo, vestibular migraine, Ménière's disease, and vestibular neuritis. Vestibular rehabilitation is evidence-based and enhances compensation, balance, gaze, and functional mobility in daily life through tailored exercises, that include adaptation, substitution, and habituation. Given the significant variation in implementation across Denmark, it is essential to prioritise efforts for improved quality, standardisation, and comprehensive training nationwide.
{"title":"[Vestibular rehabilitation].","authors":"Casper Grønlund Larsen, Pia Heckermann Sibbern, Jyoti Shailesh Kolekar, Anders Ravnholt, Schüsler Damlund, Bjarki Ditlev Djurhuus","doi":"10.61409/V06250492","DOIUrl":"https://doi.org/10.61409/V06250492","url":null,"abstract":"<p><p>Dizziness is a common condition that can significantly reduce quality of life and increase the risk of falls. This review examines frequent vestibular causes, including benign paroxysmal positional vertigo, vestibular migraine, Ménière's disease, and vestibular neuritis. Vestibular rehabilitation is evidence-based and enhances compensation, balance, gaze, and functional mobility in daily life through tailored exercises, that include adaptation, substitution, and habituation. Given the significant variation in implementation across Denmark, it is essential to prioritise efforts for improved quality, standardisation, and comprehensive training nationwide.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"188 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146087230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We present a case of sporadic Creutzfeldt-Jakob disease (sCJD) in a 73-year-old patient, in which initial suspicion arose from unusual magnetic resonance imaging (MRI) findings and was later confirmed by cerebrospinal fluid analysis. This case report highlights the role of MRI in the early diagnosis of sCJD, facilitating timely palliative care, and highlights the key clinical and imaging characteristics of this rare and fatal prion disease.
{"title":"[MRI as a key for early diagnosis of Creutzfeldt-Jakob disease].","authors":"Fabiana Andrade Melchiori, Olha Zhygynas, Harro Bitterling","doi":"10.61409/V08250698","DOIUrl":"https://doi.org/10.61409/V08250698","url":null,"abstract":"<p><p>We present a case of sporadic Creutzfeldt-Jakob disease (sCJD) in a 73-year-old patient, in which initial suspicion arose from unusual magnetic resonance imaging (MRI) findings and was later confirmed by cerebrospinal fluid analysis. This case report highlights the role of MRI in the early diagnosis of sCJD, facilitating timely palliative care, and highlights the key clinical and imaging characteristics of this rare and fatal prion disease.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"188 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146087170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}