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[Christmas article: Christmas article: The professors take up the master's program at Rigshospitalet]. [圣诞文章:圣诞文章:教授们在Rigshospitalet攻读硕士课程]。
Q4 Medicine Pub Date : 2024-12-09 DOI: 10.61409/V20244
Henrik Permin, Niels H Secher

Caricatures highlight personal characteristics. The caricature drawing of the four prominent professors from the transition from the Royal Frederik's Hospital to Rigshospitalet, Copenhagen in 1910, shows the dominant surgeon Niels Thorkild Rovsing (1862-1927), who takes up half of the drawing; the reserved organizationally interested physician Knud Helge Faber (1862-1956) in the middle; the thoughtful surgeon Oscar Thorvald Bloch (1847-1926), and the somewhat isolated physician Hans Christian Joachim Gram (1853-1938), who became known for his staining method to separate Gram-positive from Gram-negative bacteria.

漫画突出个人特征。1910年,四位著名的教授从哥本哈根的皇家弗雷德里克医院(Royal Frederik’s Hospital)过渡到Rigshospitalet,这幅漫画画中,占了一半篇幅的外科医生尼尔斯·托基尔德·罗辛(Niels Thorkild rosing, 1862-1927)占据了主导地位;中间是对组织感兴趣的内科医生Knud Helge Faber (1862-1956);一位是思想缜密的外科医生奥斯卡·托瓦尔德·布洛赫(1847-1926),另一位是有些与世隔绝的内科医生汉斯·克里斯蒂安·约阿希姆·格拉姆(1853-1938),他以用染色法分离革兰氏阳性细菌和革兰氏阴性细菌而闻名。
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引用次数: 0
[Christmas article: collisions between roe deer and ambulances]. [圣诞文章:鹿与救护车的碰撞]。
Q4 Medicine Pub Date : 2024-12-09 DOI: 10.61409/V20247
Marianne Winther, Oliver Beierholm Sørensen, Lars Bak Nielsen, Daniel Wittrock, Søren Mikkelsen

Introduction: Due to the Danish fauna, reindeer are not immediately available should Santa Claus need to replace his reindeer while traveling across Denmark with Christmas gifts. Instead, Santa Claus should rely on roe deer, which are predominant in Denmark. However, the population of roe deer may be threatened by collisions between ambulances and roe deer. We decided to study the extent of the problem.

Methods: We conducted a register-based study of all traffic accidents involving animals in the Region of Southern Denmark from 2017 through 2022. All traffic accidents were investigated and the number of roe deer accidents were registered.

Results: During six years, 317,288 ambulances were dispatched. A total of 334 traffic accidents were reported. Of these, 32 roe deer accidents.

Conclusion: To ensure the children that Santa Claus can replace his reindeer and thus contribute to the children's feelings of safety during Christmas, the emergency medical service in Denmark should consider finding means to reduce the number of collisions between roe deer and ambulances.

Funding: None.

Trial registration: None.

简介:由于丹麦的动物群,驯鹿不能立即可用,如果圣诞老人需要替换他的驯鹿,而在丹麦旅行的圣诞礼物。相反,圣诞老人应该依靠在丹麦占主导地位的狍。然而,救护车和狍之间的碰撞可能会威胁到狍的数量。我们决定研究这个问题的严重程度。方法:我们对2017年至2022年丹麦南部地区所有涉及动物的交通事故进行了一项基于登记册的研究。对所有交通事故进行了调查,并登记了事故数量。结果:6年间共出动救护车317288辆。共报告了334起交通事故。其中32起是鹿事故。结论:为了让孩子们知道圣诞老人可以代替他的驯鹿,从而有助于孩子们在圣诞节期间的安全感,丹麦的急救医疗部门应该考虑寻找减少鹿与救护车碰撞次数的方法。资金:没有。试验注册:无。
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引用次数: 0
[Christmas article: Maximum bladder capacity at an anesthesiology department’s Christmas party]. [圣诞文章:鹿与救护车的碰撞]。
Q4 Medicine Pub Date : 2024-12-09 DOI: 10.61409/V20245
Kasper Gevargez Lyngby, Jakob Mejdahl Bentin

Introduction: Christmas parties, a longstanding Danish tradition, became festive occasions in the 1960s. This study examines if healthcare professionals, especially doctors and nurses, have larger bladder capacities than the general population, as they often delay restroom breaks.

Methods: At the North Zealand University Hospital Department of Anesthesiology's 2023 Christmas party, participants delayed urination until a strong urge occurred. Bladder volumes were measured using a Biocon-700 ultrasound bladder scanner. The primary endpoint was maximum bladder capacity, which was analysed as a continuous variable and compared with population data from the literature. Data included gender, profession, and scanning time. Statistical analyses were done using t-tests and multiple linear regression analysis.

Results: Of the 60 bladder scans, the average bladder capacity was 644 ml (SD: ± 248 ml). No significant difference was found between healthcare professionals and the general population (p = 0.55). However, excluding measurements within functional capacity (less-than 400 ml), healthcare professionals showed significantly larger maximal bladder capacities. Men and doctors had larger capacities than women and nurses.

Conclusion: Although the primary analysis showed no significant difference, the secondary analysis suggests that healthcare professionals may have larger bladder capacities. Potential limitations include measurement uncertainties and a lack of data on comorbidities. Further research is needed to confirm these findings.

圣诞派对是丹麦悠久的传统,在20世纪60年代成为节日场合。这项研究调查了医疗保健专业人员,尤其是医生和护士,是否比一般人的膀胱容量更大,因为他们经常推迟上厕所的时间。方法:在新西兰大学医院麻醉科的2023年圣诞派对上,参与者推迟排尿,直到出现强烈的冲动。使用Biocon-700超声膀胱扫描仪测量膀胱体积。主要终点是最大膀胱容量,作为一个连续变量进行分析,并与文献中的人群数据进行比较。数据包括性别、职业和扫描时间。统计学分析采用t检验和多元线性回归分析。结果:60例膀胱扫描中,平均膀胱容量为644 ml (SD:±248 ml)。卫生保健专业人员与一般人群之间无显著差异(p = 0.55)。然而,排除功能容量(小于400毫升)的测量,医疗保健专业人员显示明显更大的最大膀胱容量。男性和医生的能力高于女性和护士。结论:虽然初步分析显示无显著性差异,但二次分析提示医护人员可能有较大的膀胱容量。潜在的限制包括测量的不确定性和缺乏合并症的数据。需要进一步的研究来证实这些发现。
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引用次数: 0
[Christmas article: Can chili improve the performance of Santa Claus and goblins? A randomized study]. 圣诞文章:辣椒能提高圣诞老人和小妖精的表现吗?一项随机研究]。
Q4 Medicine Pub Date : 2024-12-09 DOI: 10.61409/V202410
Sten Rasmussen, Johannes Kristiansen Rasmussen
<p><strong>Introduction: </strong>Many children expect a visit from Santa Claus, preferably on Christmas Eve and the teasing goblins are active teasing throughout the month of December. Therefore, Santa Claus and goblins must be in good shape for the activities of December. Rice pudding, Christmas pancakes, and other goodies are consumed in large quantities to help both the size of Santa Claus as well as the activity level of the Christmas teasing. Chili peppers and spicy foods contain the compound capsaicin, responsible for their heat and spiciness. Some research suggests that capsaicin may have potential benefits for physical function, although the evidence is not conclusive, and more studies are needed to fully understand its effects. Thus, the purpose of this study was to investigate the acute effect of chili supplementation on strength performance.</p><p><strong>Methods: </strong>The study used a randomized, double-blind design. The subjects completed three plank tests measuring the maximum time before and after having pancakes including capsaicin or placebo. Pancake recipe for four persons was 500 g all-purpose flour, 10 dl milk, six eggs, half a teaspoon salt, 50 g melted butter, one teaspoon vanilla, one teaspoon cinnamon, one teaspoon ginger. For the intervention group one teaspoon chili was added. Vanilla, cinnamon and ginger blinded the taste of chili and the adding red tint blinded the visual of chili. When eating the pancakes, sugar and strawberry or blackcurrant jam were added.</p><p><strong>Results: </strong>In august 2023, four Santa Claus-sized Santas and four smaller teasing goblins met the inclusion criteria. There was an overall effect of chili Christmas pancakes compared to control in improving plank time from 111.7 (± 14.6) sec. to 156.3 (± 26.17) sec. (p = 0.043, paired t-test), compared to the change in the control group from 88.8 (± 14.7) sec. to 97.3 (± 19.7) sec. (p = 0.34, paired t-test). In the pooled sample of all eight participants there was evidence that the Christmas pancake meal by itself influenced a change in plank time from 100.2 (± 10.4) sec. to 126.8 (± 17.2) sec. (p = 0.025, paired t-test). However, all the goblins improved in plank time from 133.6 (± 12.5) sec. to 181.22 (± 22.7) sec. (p = 0.035, paired t-test), the Santas did not.</p><p><strong>Conclusion: </strong>In this study, we found that adding chili to Christmas pancakes can improve plank test performance. However, the effect was not detectable for Santas. It was probably the best outcome of the test, that the goblins had a good impact eating chili Christmas pancakes. We therefore recommend that Santa Clauses and teasing goblins use chili in the Christmas pancakes to have the strength to solve the big Christmas tasks in December. It could also be a recommendation based on the literature to use chili in cooking in December, both to keep warm in the cold month of December and perhaps to avoid unnecessary excess weight.</p><p><strong>Funding: </strong
许多孩子都期待圣诞老人的到来,最好是在平安夜,而顽皮的小妖精在整个12月都在积极地戏弄他们。因此,圣诞老人和小妖精们必须保持良好的状态才能参加12月的活动。米布丁,圣诞煎饼,和其他的好东西被大量消耗,以帮助圣诞老人的大小和圣诞戏弄的活动水平。辣椒和辛辣食物中含有复合辣椒素,这是它们的热和辛辣的原因。一些研究表明,辣椒素可能对身体机能有潜在的好处,尽管证据还不是决定性的,需要更多的研究来充分了解它的作用。因此,本研究的目的是研究补充辣椒对力量性能的急性影响。方法:采用随机、双盲设计。受试者完成了三个平板支撑测试,测量在吃含有辣椒素或安慰剂的煎饼之前和之后的最长时间。四个人的煎饼食谱是500克普通面粉,10分升牛奶,6个鸡蛋,半茶匙盐,50克融化的黄油,一茶匙香草,一茶匙肉桂,一茶匙姜。干预组加了一茶匙辣椒。香草、肉桂和姜掩盖了辣椒的味道,添加的红色掩盖了辣椒的视觉。在吃煎饼的时候,会加入糖和草莓或黑加仑果酱。结果:2023年8月,四个圣诞老人大小的圣诞老人和四个较小的戏弄妖精符合纳入标准。与对照组相比,辣椒圣诞煎饼的整体效果是将平板支撑时间从111.7(±14.6)秒提高到156.3(±26.17)秒(p = 0.043,配对t检验),而对照组从88.8(±14.7)秒提高到97.3(±19.7)秒(p = 0.34,配对t检验)。在所有8名参与者的汇总样本中,有证据表明,圣诞煎饼本身影响了平板支撑时间的变化,从100.2(±10.4)秒到126.8(±17.2)秒(p = 0.025,配对t检验)。然而,所有地精的平板支撑时间从133.6(±12.5)秒提高到181.22(±22.7)秒(p = 0.035,配对t检验),而圣诞老人没有。结论:在本研究中,我们发现在圣诞煎饼中加入辣椒可以提高平板测试的表现。然而,这种影响在圣诞老人身上没有检测到。这可能是测试中最好的结果,妖精吃辣椒圣诞煎饼有很好的影响。因此,我们建议圣诞老人和调皮的小妖精在圣诞煎饼里加点辣椒,这样才有力量解决12月的圣诞大任务。根据文献,在12月烹饪时使用辣椒也可能是一种建议,既可以在寒冷的12月保暖,也可以避免不必要的超重。资金:没有。试验注册:无。
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引用次数: 0
[Christmas article: A quantitative analysis of the correlation between the size of the femoral head and shoe size – a help for the busy orthopedic surgeon]. [圣诞文章:鹿与救护车的碰撞]。
Q4 Medicine Pub Date : 2024-12-09 DOI: 10.61409/V202411
Ahmed Abood, Sarah Stammose Freund, Michael Bendtsen, Bjarne Hauge Hansen, Thomas Baad-Hansen

Introduction: Preoperative templating in hip arthroplasty surgery is crucial for accurate implant selection and reducing postoperative complications. This study examines whether there is a correlation between femoral head size and shoe size, with the aim of simplifying the preoperative planning process.

Methods: A total of 14 patients had their shoe size and femoral head size measured. Data were analyzed using linear regression and Pearson's correlation analysis to quantify the relationship between the two variables.

Results: The Pearson correlation coefficient revealed a value of 0.80 (p = 0.0007), and the linear regression model showed that 63% of the variation in shoe size was based on femoral head size.

Conclusion: The study demonstrates a strong and significant correlation between shoe size and femoral head size. This correlation could potentially be used to develop a simple calculation method, where femoral head size = (shoe size - 23.9) / 0.36, which may streamline preoperative planning in orthopedic surgery and reduce workload.

Funding: None.

Trial registration: None.

前言:在髋关节置换术中,术前模板对于准确选择植入物和减少术后并发症至关重要。本研究旨在探讨股骨头尺寸与鞋码之间是否存在相关性,以简化术前计划流程。方法:测定14例患者的鞋号和股骨头大小。数据分析采用线性回归和Pearson相关分析来量化两个变量之间的关系。结果:Pearson相关系数为0.80 (p = 0.0007),线性回归模型显示63%的鞋码变化与股骨头大小有关。结论:本研究显示鞋码与股骨头大小之间有很强且显著的相关性。这种相关性可能用于开发一种简单的计算方法,股骨头尺寸=(鞋码- 23.9)/ 0.36,这可能简化骨科手术的术前计划并减少工作量。资金:没有。试验注册:无。
{"title":"[Christmas article: A quantitative analysis of the correlation between the size of the femoral head and shoe size – a help for the busy orthopedic surgeon].","authors":"Ahmed Abood, Sarah Stammose Freund, Michael Bendtsen, Bjarne Hauge Hansen, Thomas Baad-Hansen","doi":"10.61409/V202411","DOIUrl":"10.61409/V202411","url":null,"abstract":"<p><strong>Introduction: </strong>Preoperative templating in hip arthroplasty surgery is crucial for accurate implant selection and reducing postoperative complications. This study examines whether there is a correlation between femoral head size and shoe size, with the aim of simplifying the preoperative planning process.</p><p><strong>Methods: </strong>A total of 14 patients had their shoe size and femoral head size measured. Data were analyzed using linear regression and Pearson's correlation analysis to quantify the relationship between the two variables.</p><p><strong>Results: </strong>The Pearson correlation coefficient revealed a value of 0.80 (p = 0.0007), and the linear regression model showed that 63% of the variation in shoe size was based on femoral head size.</p><p><strong>Conclusion: </strong>The study demonstrates a strong and significant correlation between shoe size and femoral head size. This correlation could potentially be used to develop a simple calculation method, where femoral head size = (shoe size - 23.9) / 0.36, which may streamline preoperative planning in orthopedic surgery and reduce workload.</p><p><strong>Funding: </strong>None.</p><p><strong>Trial registration: </strong>None.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"186 50","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Christmas article: Point-of-care test of optimal meat structure in Danish Pork Roasts - a prospective observational study]. [圣诞文章:丹麦烤猪肉中最佳肉类结构的即时测试-一项前瞻性观察研究]。
Q4 Medicine Pub Date : 2024-12-09 DOI: 10.61409/V20241
Gustav Normann, Phillip Kaasgaard Sperling

Introduction: Pork Roast is an important part of the Danish holidays. The precise cooking of the pork roast is a controversial debate, which has been going on for decades. Newer techniques such as sous vide have been gaining popularity, but the optimal pork roast is yet to be determined. This study sought to evaluate the optimal meat structure for Christmas pork roast.

Methods: Three pork roasts were analyzed using an ultrasound scanner regarding fluid content. Then the pork roasts were suis vided for 6 hours at 60 degrees Celsius and oven-roasted for 34 minutes. An unbiased tasting panel tested the pork roasts and rated their juiciness.

Results: The study was able to measure fluid content in the pork roasts. The two pork roasts (2 and 3) with the lowest fluid content were preferred by a panel of 40 taste testers. The pork roast with the highest fluid content also had the highest drop in weight during cooking.

Discussion: Lower fluid content correlated with higher preference. Ultrasound was effective in estimating fluid content, impacting perceived juiciness and quality. The pork roast with more fluid was less juicy and preferred, aligning with studies linking higher fat to juiciness. The study suggests selecting pork roasts with less fluid using ultrasound is viable for finding the best quality roast.

Conclusion: Ultrasound testing is a viable point-of-care modality in selecting the most sensory-pleasing pork roast. Future studies should identify either a cut-off value or investigate if the fluid content to juiciness correlation is linear.

Funding: none.

Trial registration: none.

介绍:烤猪肉是丹麦节日的重要组成部分。烤猪肉的精确烹饪是一个有争议的争论,已经持续了几十年。像真空烹调这样的新技术越来越受欢迎,但最佳的烤猪肉方式还没有确定。本研究旨在评估圣诞烤猪肉的最佳肉结构。方法:用超声扫描仪对三种烤猪肉的液体含量进行分析。然后将猪肉在60摄氏度的温度下烤6小时,然后在烤箱里烤34分钟。一个公正的品尝小组对烤猪肉进行了测试,并对它们的多汁性进行了评级。结果:本研究能够测量出烤猪肉中的液体含量。一个由40名味觉测试者组成的小组更喜欢两种液体含量最低的烤猪肉(2号和3号)。液体含量最高的烤猪肉在烹饪过程中重量下降幅度也最大。讨论:较低的流体含量与较高的偏好相关。超声可以有效地估计液体含量,影响感知的多汁性和质量。多汁的烤猪肉汁少,更受欢迎,这与高脂肪与多汁的研究相一致。该研究表明,使用超声波选择液体较少的猪肉烤肉可以找到质量最好的烤肉。结论:超声检测是一种可行的选择感官最满意的烤猪肉的方法。未来的研究应该确定一个临界值,或者调查液体含量与多汁性的相关性是否为线性。资金:没有。试验注册:无。
{"title":"[Christmas article: Point-of-care test of optimal meat structure in Danish Pork Roasts - a prospective observational study].","authors":"Gustav Normann, Phillip Kaasgaard Sperling","doi":"10.61409/V20241","DOIUrl":"10.61409/V20241","url":null,"abstract":"<p><strong>Introduction: </strong>Pork Roast is an important part of the Danish holidays. The precise cooking of the pork roast is a controversial debate, which has been going on for decades. Newer techniques such as sous vide have been gaining popularity, but the optimal pork roast is yet to be determined. This study sought to evaluate the optimal meat structure for Christmas pork roast.</p><p><strong>Methods: </strong>Three pork roasts were analyzed using an ultrasound scanner regarding fluid content. Then the pork roasts were suis vided for 6 hours at 60 degrees Celsius and oven-roasted for 34 minutes. An unbiased tasting panel tested the pork roasts and rated their juiciness.</p><p><strong>Results: </strong>The study was able to measure fluid content in the pork roasts. The two pork roasts (2 and 3) with the lowest fluid content were preferred by a panel of 40 taste testers. The pork roast with the highest fluid content also had the highest drop in weight during cooking.</p><p><strong>Discussion: </strong>Lower fluid content correlated with higher preference. Ultrasound was effective in estimating fluid content, impacting perceived juiciness and quality. The pork roast with more fluid was less juicy and preferred, aligning with studies linking higher fat to juiciness. The study suggests selecting pork roasts with less fluid using ultrasound is viable for finding the best quality roast.</p><p><strong>Conclusion: </strong>Ultrasound testing is a viable point-of-care modality in selecting the most sensory-pleasing pork roast. Future studies should identify either a cut-off value or investigate if the fluid content to juiciness correlation is linear.</p><p><strong>Funding: </strong>none.</p><p><strong>Trial registration: </strong>none.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"186 50","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Christmas article: A little booze to warm you up - true or false? A thermographic Christmas study]. 圣诞文章:小酒暖身——对还是错?一项圣诞热成像研究]。
Q4 Medicine Pub Date : 2024-12-09 DOI: 10.61409/V20249
Mikkel Thor Boberg, Carina Kirstine Klarskov, Else la Cour Sibbesen, Yasmeen Khudhair Abbas Al-Salih, Louise Schouborg-Brinth

Introduction: In December, it is common to enjoy mulled wine, often believed to warm the body. While alcohol can cause peripheral vasodilation, it remains unclear whether it truly increases body warmth or is merely a subjective sensation. This study aimed to evaluate the warming effect of mulled wine using thermography.

Methods: This randomised, crossover study enrolled 15 participants. Participants consumed mulled wine with 12g alcohol or without alcohol on separate days. Facial temperatures were measured using thermography at baseline and every 10 minutes for 60 minutes after consumption. Participants wore Santa hats to standardise heat loss and maintained room temperature at 22°C. A questionnaire assessed subjective warmth and festive spirit. Blood alcohol concentration was evaluated throughout the study.

Results: Facial thermography showed a significant temperature increase in participants who consumed mulled wine with alcohol of mean (± SD) 33.6°C (± 1.3) vs 32.9 (± 1.0) °C on days with no alcohol, p = 0.039. Subjective warmth ratings were also higher on alcohol days, p = 0.002. However, participants reported an equally increased festive mood, regardless of alcohol content.

Conclusion: Mulled wine with alcohol increases facial temperature and subjective feelings of warmth. However, non-alcoholic versions also elevate the festive spirit, suggesting they offer a seasonal atmosphere without the effects of alcohol.

Funding: None.

Trial registration: Not relevant.

十二月,人们通常会享用热葡萄酒,人们通常认为热葡萄酒可以温暖身体。虽然酒精可以引起外周血管舒张,但尚不清楚它是否真的增加了体温,还是仅仅是一种主观感觉。本研究旨在利用热像仪评价热葡萄酒的增温效果。方法:这项随机交叉研究纳入了15名参与者。参与者在不同的日子里分别饮用含12克酒精或不含酒精的热葡萄酒。使用热像仪在基线时测量面部温度,并在进食后60分钟内每10分钟测量一次面部温度。参与者戴着圣诞老人的帽子,以使热量损失标准化,并将室温保持在22°C。一份调查问卷评估了主观温暖度和节日精神。在整个研究过程中评估血液酒精浓度。结果:面部热成像显示,饮用含酒精热葡萄酒的参与者体温显著升高,平均(±SD)为33.6°C(±1.3),而不饮酒的参与者平均(±SD)为32.9°C(±1.0),p = 0.039。在饮酒的日子里,主观体温评分也更高,p = 0.002。然而,无论酒精含量如何,参与者都报告了同样增加的节日情绪。结论:加酒精的热葡萄酒可提高面部温度和主观温暖感。然而,不含酒精的版本也提升了节日气氛,这表明它们提供了一种没有酒精影响的季节气氛。资金:没有。试验注册:不相关。
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引用次数: 0
Mod større gennemsigtighed: Ugeskrift for Læger styrker fokus på interessekonflikter.
Q4 Medicine Pub Date : 2024-12-09 DOI: 10.61409/V205201
Markus Fally, Bo Hasseriis Hansen, Thomas Benfield
{"title":"Mod større gennemsigtighed: Ugeskrift for Læger styrker fokus på interessekonflikter.","authors":"Markus Fally, Bo Hasseriis Hansen, Thomas Benfield","doi":"10.61409/V205201","DOIUrl":"https://doi.org/10.61409/V205201","url":null,"abstract":"","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"186 50","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Diphtheria-tetanus-pertussis vaccine mortality]. [白喉-破伤风-百日咳疫苗死亡率]。
Q4 Medicine Pub Date : 2024-12-02 DOI: 10.61409/V07240483
Charlotte Strøm

Although the diphtheria-tetanus-pertussis (DTP) vaccine is lifesaving through decades, it has been voiced that the vaccine is associated with 50% increase in mortality, an alleged negative non-specific vaccine effect prone to girls. Post hoc analyses of historical observational data supporting the hypothesis of the DTP vaccine having detrimental effects have never been replicated in low- or high-income countries. An RCT in Guinea-Bissau found fewer deaths with DTP vaccine than without. The hypothesis seems further rejected by the overall decline over time in child mortality in both girls and boys.

尽管白喉-破伤风-百日咳(DTP)疫苗几十年来一直在挽救生命,但有人说该疫苗与死亡率增加50%有关,据称这种非特异性疫苗的负面效应容易对女孩产生。对支持百白破疫苗具有有害影响的假设的历史观测数据的事后分析从未在低收入或高收入国家得到重复。几内亚比绍的一项随机对照试验发现,接种百白破疫苗的死亡率低于未接种百白破疫苗的死亡率。随着时间的推移,女孩和男孩儿童死亡率的总体下降似乎进一步否定了这一假设。
{"title":"[Diphtheria-tetanus-pertussis vaccine mortality].","authors":"Charlotte Strøm","doi":"10.61409/V07240483","DOIUrl":"10.61409/V07240483","url":null,"abstract":"<p><p>Although the diphtheria-tetanus-pertussis (DTP) vaccine is lifesaving through decades, it has been voiced that the vaccine is associated with 50% increase in mortality, an alleged negative non-specific vaccine effect prone to girls. Post hoc analyses of historical observational data supporting the hypothesis of the DTP vaccine having detrimental effects have never been replicated in low- or high-income countries. An RCT in Guinea-Bissau found fewer deaths with DTP vaccine than without. The hypothesis seems further rejected by the overall decline over time in child mortality in both girls and boys.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"186 49","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Prognosis of unipolar depression]. [单极抑郁症的预后]。
Q4 Medicine Pub Date : 2024-12-02 DOI: 10.61409/V02240120
Mateo Boberg, Poul Videbech

Depression, a severe illness with variable outcomes, requires prompt intervention to mitigate the risk of exacerbation and suicide. This review finds that psychopharmacological treatment is critical in severe cases. In mild cases, medication's side effects frequently outweigh the benefits. Prioritising non-pharmacological strategies, especially psychotherapy, is essential for mild to moderate depression. Given its recurrent nature and the risk of lasting cognitive decline, maintenance treatment is vital to avert relapse, particularly for those with a history of multiple episodes.

抑郁症是一种结局多变的严重疾病,需要及时干预,以减轻病情恶化和自杀的风险。本综述发现,精神药物治疗在重症病例中至关重要。在轻微的情况下,药物的副作用往往大于好处。优先考虑非药物策略,特别是心理治疗,对轻度至中度抑郁症至关重要。鉴于其复发性和持续认知能力下降的风险,维持治疗对于避免复发至关重要,特别是对于那些有多次发作史的患者。
{"title":"[Prognosis of unipolar depression].","authors":"Mateo Boberg, Poul Videbech","doi":"10.61409/V02240120","DOIUrl":"https://doi.org/10.61409/V02240120","url":null,"abstract":"<p><p>Depression, a severe illness with variable outcomes, requires prompt intervention to mitigate the risk of exacerbation and suicide. This review finds that psychopharmacological treatment is critical in severe cases. In mild cases, medication's side effects frequently outweigh the benefits. Prioritising non-pharmacological strategies, especially psychotherapy, is essential for mild to moderate depression. Given its recurrent nature and the risk of lasting cognitive decline, maintenance treatment is vital to avert relapse, particularly for those with a history of multiple episodes.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":"186 49","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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