Ugeskrift for laeger最新文献

Synkinesis is a sequela of moderate to severe facial palsy, caused by aberrant nerve regeneration. It leads to involuntary co-movements, impaired facial expression, and thus reduced quality of life. Treatment includes facial therapy, EMG biofeedback, botulinum toxin (BTX-A), and, in selected cases, surgery. This case report presents a case from Rigshospitalet demonstrating symptom relief and improved facial symmetry after treatment with BTX-A injections and facial therapy. Synkinesis is a complex condition that requires a multidisciplinary approach. Early detection, prevention and appropriate referral are crucial.

This is an editorial erratum to the article DOI: 10.61409/V01250023.

This case report presents a woman with post-partum depression treated with cabergoline for lactation inhibition who developed psychotic symptoms. She was admitted with moderate depression following a suicide attempt, and started on cabergoline and sertraline, with initial improvement of the depressive symptoms. Six days after starting cabergoline, she developed severe psychotic symptoms. Symptoms rapidly improved with antipsychotics and ECT. Due to the long half-life of cabergoline, this case potentially highlights a rare but serious adverse effect of cabergoline.

The antidepressant effect of high-frequency left prefrontal (HLPF) repetitive transcranial magnetic stimulation (rTMS) is well-documented, while scientific interest in the more patient-friendly alternative, low-frequency right prefrontal (LRPF), has been limited. This review finds the antidepressant efficacy of LRPF rTMS equivalent to that of HLPF rTMS. Considering the more advantageous side-effect profile, LRPF is found to have the potential to take a more prominent place in the treatment of depression. In consequence, there is a need to strengthen research on the issue.

Multidisciplinary team conferences (MDTs) enhance quality and care coordination in contemporary cancer treatment. This review provides an overview of the history and current role of MDTs in cancer care and highlights their potential to strengthen individualized treatment, promote interdisciplinary learning, and create more consistent patient pathways. To fully realize this potential, more systematic development, and greater involvement of patients and healthcare professionals across specialities and sectors may be beneficial.

Therapeutic drug monitoring (TDM) is useful for planning and individualizing drug therapy. Proper interpretation of plasma levels requires both certain prerequisites and physician knowledge. This review outlines the rational use of TDM, key indications, timing of blood samples, and the evidence for therapeutic ranges. It also highlights common pitfalls and provides guidance to support clinicians in the effective use of TDM when prescribing medications to patients.

Tobacco exposure is a known but underrecognized cause and risk factor of interstitial lung diseases (ILD). This review covers the clinical, radiological and histopathological features of key smoking-related ILDs, including those caused directly by smoking and with smoking as a risk factor. These conditions often share overlapping features, making diagnosis challenging. The widespread use of high-resolution computed tomography allows earlier detection, even in asymptomatic smokers. A systematic multidisciplinary approach is crucial for optimal and accurate diagnosis and appropriate management.

Clozapine is a potent antipsychotic mainly used in treatment-resistant schizophrenia. Its clinical efficacy in elderly patients is sparsely documented. Elderly patients achieve higher plasma levels of clozapine, requiring careful dose adjustments to minimize side effects such as sedation, hypotension, metabolic disorders, and notably pneumonia and ileus - both associated with significant mortality. Individualized dosing and regular monitoring are essential to ensure optimal safety and tolerability in elderly patients receiving clozapine, as argued in this review.