Sanne Ørnfeldt Larsen, Jacob Bodilsen, Birgitte Mørn
Histoplasmosis capsulatum is a dimorphic fungus, recognised for its endemic presence in multiple global regions. It may cause severe opportunistic disseminated infection in immunocompromised individuals. This is a case report of a 33-year-old man from Thailand who was admitted at a Danish hospital with fever, weight loss, cough, nosebleeds, and newly diagnosed HIV. The clinical condition rapidly deteriorated with lung and kidney failure. The patient was diagnosed with H. capsulatum fungaemia first detected on blood smear. He was treated with intravenous amphotericin B followed by oral itraconazole as well as antiretroviral therapy.
荚膜组织胞浆菌病是一种二形真菌,因其在全球多个地区的流行而被公认。在免疫力低下的人群中,它可能会引起严重的机会性播散感染。本病例报告的是一名来自泰国的 33 岁男子,因发热、体重减轻、咳嗽、流鼻血和新诊断出的艾滋病毒而被丹麦一家医院收治。临床病情迅速恶化,出现肺和肾功能衰竭。患者被诊断为首次在血液涂片中发现的荚膜真菌血症。他接受了静脉注射两性霉素 B 和口服伊曲康唑以及抗逆转录病毒治疗。
{"title":"Disseminated Histoplasma captulatum infection in a patient with HIV.","authors":"Sanne Ørnfeldt Larsen, Jacob Bodilsen, Birgitte Mørn","doi":"10.61409/V03240205","DOIUrl":"https://doi.org/10.61409/V03240205","url":null,"abstract":"<p><p>Histoplasmosis capsulatum is a dimorphic fungus, recognised for its endemic presence in multiple global regions. It may cause severe opportunistic disseminated infection in immunocompromised individuals. This is a case report of a 33-year-old man from Thailand who was admitted at a Danish hospital with fever, weight loss, cough, nosebleeds, and newly diagnosed HIV. The clinical condition rapidly deteriorated with lung and kidney failure. The patient was diagnosed with H. capsulatum fungaemia first detected on blood smear. He was treated with intravenous amphotericin B followed by oral itraconazole as well as antiretroviral therapy.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mondors sygdom på overekstremiteten.","authors":"Harald Welling, Lisa Toft Jensen","doi":"10.61409/V72036","DOIUrl":"https://doi.org/10.61409/V72036","url":null,"abstract":"","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jeanette Kaae, Berit Christina Carlsen, Aska Drljevic-Nielsen, Jesper Palshof, Inge Marie Svane, Christian Vestergaard
Over the past decade, treatment with immune checkpoint inhibitors (ICI) has been implemented in cancer treatment. It has led to a significant improvement in the prognosis for many types of cancer. ICIs work by inducing the body's immune response against cancer cells. Unfortunately, they can also cause immune-related adverse events in most organ systems, with skin-related adverse events being among the most common. This review provides an overview of existing evidence and clinical experience regarding managing dermatological adverse events associated with ICIs.
{"title":"Cutaneous side effects of treatment with immune checkpoint inhibitors.","authors":"Jeanette Kaae, Berit Christina Carlsen, Aska Drljevic-Nielsen, Jesper Palshof, Inge Marie Svane, Christian Vestergaard","doi":"10.61409/V03240216","DOIUrl":"https://doi.org/10.61409/V03240216","url":null,"abstract":"<p><p>Over the past decade, treatment with immune checkpoint inhibitors (ICI) has been implemented in cancer treatment. It has led to a significant improvement in the prognosis for many types of cancer. ICIs work by inducing the body's immune response against cancer cells. Unfortunately, they can also cause immune-related adverse events in most organ systems, with skin-related adverse events being among the most common. This review provides an overview of existing evidence and clinical experience regarding managing dermatological adverse events associated with ICIs.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marie Louise Hounsgaard, Per Karkov Cramon, Anne Jarlðv
Primary hyperparathyroidism (PHPT) is the most prevalent cause of hypercalcaemia, affecting 0.3% of the population. The only curative procedure is parathyroidectomy. Ectopic adenomas are challenging to localize and frequently result in persistent PHPT. This is a case report of a 29-year-old male patient who was diagnosed with PHPT prior to neck surgery and reoperated with bilateral neck exploration. However, the PHPT was not cured, until diagnostic CT with contrast had helped localizing a 1 cm ectopic parathyroid adenoma in the right horn of the thymus gland. The adenoma was then removed successfully.
{"title":"Ectopic parathyroid adenoma proved by diagnostic CT.","authors":"Marie Louise Hounsgaard, Per Karkov Cramon, Anne Jarlðv","doi":"10.61409/V03240169","DOIUrl":"https://doi.org/10.61409/V03240169","url":null,"abstract":"<p><p>Primary hyperparathyroidism (PHPT) is the most prevalent cause of hypercalcaemia, affecting 0.3% of the population. The only curative procedure is parathyroidectomy. Ectopic adenomas are challenging to localize and frequently result in persistent PHPT. This is a case report of a 29-year-old male patient who was diagnosed with PHPT prior to neck surgery and reoperated with bilateral neck exploration. However, the PHPT was not cured, until diagnostic CT with contrast had helped localizing a 1 cm ectopic parathyroid adenoma in the right horn of the thymus gland. The adenoma was then removed successfully.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Person-centered care and user involvement have gained focus in the public welfare agenda, as well as in the health sector. However, it has become clear that there is a bias in favor of resourceful citizens in the organisational user involvement. This bias can enhance disparities in health and social care. In this review, reasons that may underlie the bias in organisational user involvement are elucidated, and examples of ways to create more inclusive user involvement are given.
{"title":"Inclusive organisational user involvement can reduce disparities in health and social care.","authors":"Liv Stubbe Østergaard, Signe Groth Andersson","doi":"10.61409/V01240070","DOIUrl":"https://doi.org/10.61409/V01240070","url":null,"abstract":"<p><p>Person-centered care and user involvement have gained focus in the public welfare agenda, as well as in the health sector. However, it has become clear that there is a bias in favor of resourceful citizens in the organisational user involvement. This bias can enhance disparities in health and social care. In this review, reasons that may underlie the bias in organisational user involvement are elucidated, and examples of ways to create more inclusive user involvement are given.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stine Rasch, Charlotte Toftmann Hansen, Niels Abilgaard
Current guidelines recommend screening with serum M-protein and serum-free light chain analysis (S-FLC) when an M-protein-related disorder is suspected. Many patients with multiple myeloma will be overlooked if only serum M-protein is measured. Despite this, the general practitioners in some areas of Denmark cannot order S-FLC. This review aims to disseminate knowledge of the S-FLC analysis, its applicability, and limitations in the diagnostic workup for suspected monoclonal gammopathies.
现行指南建议,当怀疑有 M 蛋白相关疾病时,应进行血清 M 蛋白和无血清轻链分析(S-FLC)筛查。如果只检测血清 M 蛋白,许多多发性骨髓瘤患者会被忽视。尽管如此,丹麦某些地区的全科医生仍无法进行 S-FLC 检测。本综述旨在传播有关 S-FLC 分析的知识、其适用性以及在诊断疑似单克隆丙种球蛋白病时的局限性。
{"title":"Serum-free light chains in the evaluation of M-component disease.","authors":"Stine Rasch, Charlotte Toftmann Hansen, Niels Abilgaard","doi":"10.61409/V12230766","DOIUrl":"https://doi.org/10.61409/V12230766","url":null,"abstract":"<p><p>Current guidelines recommend screening with serum M-protein and serum-free light chain analysis (S-FLC) when an M-protein-related disorder is suspected. Many patients with multiple myeloma will be overlooked if only serum M-protein is measured. Despite this, the general practitioners in some areas of Denmark cannot order S-FLC. This review aims to disseminate knowledge of the S-FLC analysis, its applicability, and limitations in the diagnostic workup for suspected monoclonal gammopathies.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura Vang Sparsø, Christina Laamanen Sommer, Arne Hørlyck, Sverre Barfod
This case report details a rare case of contraceptive implant migration in a young woman. The migration was discovered three years post-insertion during a routine replacement visit. Despite the absence of pulmonary symptoms, a CT scan revealed the implant in the inferior lobe of the right lung. The patient was referred for further evaluation, but immediate surgical removal was deferred. This case report highlights the importance of healthcare providers recognising migration as a rare complication during implantation and suggests self-examination as a potential preventive strategy.
{"title":"Migration of a contraceptive implant to the lung.","authors":"Laura Vang Sparsø, Christina Laamanen Sommer, Arne Hørlyck, Sverre Barfod","doi":"10.61409/V03240203","DOIUrl":"https://doi.org/10.61409/V03240203","url":null,"abstract":"<p><p>This case report details a rare case of contraceptive implant migration in a young woman. The migration was discovered three years post-insertion during a routine replacement visit. Despite the absence of pulmonary symptoms, a CT scan revealed the implant in the inferior lobe of the right lung. The patient was referred for further evaluation, but immediate surgical removal was deferred. This case report highlights the importance of healthcare providers recognising migration as a rare complication during implantation and suggests self-examination as a potential preventive strategy.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Communicating with scientific journals is a central part of the publication process, yet sparsely covered in the medical literature. A cover letter to the editor(s) should always accompany new submissions, whereas response (or rebuttal) letters relate to revisions and replying to referees' comments following peer review. This review describes the two types of letters, focusing on content, style, and structure, and provides helpful tips for handling challenging reviewer scenarios.
{"title":"Practical guide to writing cover letters and response letters for scientific journals.","authors":"Mette Gyldenløve, Jacob Rosenberg","doi":"10.61409/V01240073","DOIUrl":"https://doi.org/10.61409/V01240073","url":null,"abstract":"<p><p>Communicating with scientific journals is a central part of the publication process, yet sparsely covered in the medical literature. A cover letter to the editor(s) should always accompany new submissions, whereas response (or rebuttal) letters relate to revisions and replying to referees' comments following peer review. This review describes the two types of letters, focusing on content, style, and structure, and provides helpful tips for handling challenging reviewer scenarios.</p>","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Vejledning eller vildledning af kunstig intelligens i medicinsk forskning?","authors":"Andreas Pihl","doi":"10.61409/V205183","DOIUrl":"https://doi.org/10.61409/V205183","url":null,"abstract":"","PeriodicalId":23428,"journal":{"name":"Ugeskrift for laeger","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}