Veterinary journal最新文献_第5页

Comprehensive surveillance of fowl adenovirus in the Americas reveals the circulation of multiple serotypes and evidence of recombination 对美洲家禽腺病毒的全面监测揭示了多种血清型的流行和重组的证据

IF 3.1 2区农林科学 Q1 VETERINARY SCIENCES

Veterinary journal

Pub Date : 2026-02-01 Epub Date: 2026-01-14 DOI: 10.1016/j.tvjl.2026.106563

Ruy D. Chacón , Claudete S. Astolfi-Ferreira , Henrique Lage Hagemann , Dilan Suárez-Agüero , Alex Laurindo da Silva , Priscilla Cavalcante Rocha , Claudia Carranza , Mario S. Assayag Jr , Jorge L. Chacón , Antonio J. Piantino Ferreira

Fowl adenoviruses (FAdVs) comprise five species and twelve serotypes that infect chickens, several of which are associated with disease and significant economic losses in poultry farming. Although they are globally distributed, molecular characterization studies remain limited in many regions. This study aimed to elucidate the frequency and circulation of FAdV serotypes in South America, Central America, and the Caribbean. FAdV detection was conducted using qPCR and hexon gene sequencing on samples from chicken farms in Brazil, Peru, Guyana, Colombia, and El Salvador. In Brazil, FAdV was detected in 21.26 % of broiler flocks, 14.75 % of layer flocks, and 7.71 % of breeder flocks. A weekly increase in the positivity rate was observed in broilers (R² = 0.9356). FAdV was detected from the first day of life and persisted in long-lived layer and breeder flocks, up to 94 and 70 weeks of age, respectively. Phylogenetic analyses revealed serotypes FAdV-1, FAdV-2, FAdV-4, FAdV-6, FAdV-8a, FAdV-8b, and FAdV-11 in Brazil; FAdV-8b and FAdV-11 in Peru; FAdV-6 in Colombia; FAdV-4 and FAdV-11 in Guyana; and FAdV-11 in El Salvador. Overall, FAdV-11, FAdV-8a, and FAdV-8b were the most prevalent serotypes in the region. Notably, recombination signals involving sequences related to FAdV-6, FAdV-7, and FAdV-8b were detected in a Brazilian strain (USP-2858–3). These findings update the epidemiological landscape of FAdVs in the Americas, highlight the need for continued molecular surveillance and serotype monitoring to strengthen regional immunisation strategies, and contribute to a better understanding of the evolution and emergence of potential new FAdV genotypes.

禽腺病毒（FAdVs）包括感染鸡的5种和12种血清型，其中一些与家禽养殖中的疾病和重大经济损失有关。虽然它们在全球分布，但在许多地区的分子表征研究仍然有限。本研究旨在阐明南美、中美洲和加勒比地区FAdV血清型的频率和传播。对巴西、秘鲁、圭亚那、哥伦比亚和萨尔瓦多的养鸡场样本采用qPCR和六邻体基因测序进行FAdV检测。在巴西，肉鸡、蛋鸡和种鸡的FAdV检出率分别为21.26% %、14.75% %和7.71% %。肉鸡阳性率呈周递增趋势（R²= 0.9356）。FAdV从出生第一天就被检测到，并在长寿命的蛋鸡和种鸡群中持续存在，分别持续到94周龄和70周龄。系统发育分析在巴西发现FAdV-1、FAdV-2、FAdV-4、FAdV-6、fadva、FAdV-8b和FAdV-11血清型；秘鲁的FAdV-8b和FAdV-11；哥伦比亚的FAdV-6；FAdV-4和FAdV-11在圭亚那；以及萨尔瓦多的FAdV-11。总体而言，FAdV-11、FAdV-8a和FAdV-8b是该地区最常见的血清型。值得注意的是，在巴西菌株（USP-2858-3）中检测到涉及fadv6、fadv7和fadv8b相关序列的重组信号。这些发现更新了美洲FAdV的流行病学格局，强调需要继续进行分子监测和血清型监测，以加强区域免疫战略，并有助于更好地了解潜在的新FAdV基因型的演变和出现。

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引用次数: 0

Grayanotoxin poisoning in animals following the ingestion of Ericaceae plants 动物在摄入Ericaceae植物后的灰灰毒素中毒

IF 3.1 2区农林科学 Q1 VETERINARY SCIENCES

Veterinary journal

Pub Date : 2026-02-01 Epub Date: 2026-01-15 DOI: 10.1016/j.tvjl.2026.106564

Íris J. Fidalgo , Joana C. Prata

Plant poisoning in animals, often associated with wild and ornamental species, is a significant concern in veterinary medicine. Due to clinical signs observed in humans after consuming “mad honey”, interest in grayanotoxins, produced by Ericaceae plants, has increased. However, effects on animal health have been scarcely addressed despite their interest for veterinary toxicology. This systematic review, following PRISMA guidelines, identified 31 records of grayanotoxin poisoning in animals following the ingestion of plants, affecting a total of 111 livestock and 11 companion animals. Cases were predominantly reported in livestock, namely sheep and goats, and less frequently in companion animals, including dogs, cats, rabbits, tortoises, and pigs. Studies report an estimated toxic dose of 0.1 % of body weight in fresh foliage for ruminants. Rhododendron spp. and Pieris japonica were the most frequently reported plants. Common clinical signs and treatment were summarized. Retching, regurgitation, and vomiting were common and might be suggestive of plant poisoning in ruminants. Reports on grayanotoxin poisoning in animals must be improved to address existing knowledge gaps.

动物植物中毒，通常与野生和观赏物种有关，是兽医学的一个重要问题。由于在人类食用“疯狂蜂蜜”后观察到的临床症状，对由Ericaceae植物产生的灰色毒素的兴趣增加了。然而，尽管他们对兽医毒理学感兴趣，但对动物健康的影响几乎没有得到解决。根据PRISMA指南进行的系统审查确定了31例动物在摄入植物后出现灰灰色毒素中毒的记录，共影响111头牲畜和11只伴侣动物。报告的病例主要发生在牲畜中，即绵羊和山羊，较少发生在伴侣动物中，包括狗、猫、兔子、乌龟和猪。研究报告估计反刍动物在新鲜树叶中的毒性剂量为体重的0.1% %。杜鹃花（Rhododendron spp.）和Pieris japonica是报告最多的植物。总结常见临床症状及治疗方法。反刍动物常见干呕、反刍和呕吐，可能提示植物中毒。必须改进关于动物灰色毒素中毒的报告，以弥补现有的知识空白。

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引用次数: 0

I feel your pain: Individual differences in welfare indicators after castration in horses 我能感受到你的痛苦：马阉割后福利指标的个体差异。

IF 3.1 2区农林科学 Q1 VETERINARY SCIENCES

Veterinary journal

Pub Date : 2026-02-01 Epub Date: 2025-12-16 DOI: 10.1016/j.tvjl.2025.106538

Sabrina Briefer-Freymond , Emanuela Dalla Costa , Aurelie Jolivald , Rupert M. Bruckmaier , Elie Atallah , Maria Giorgia Riva , Carrie Ijichi

Personality affects both experience and expression of pain and the welfare impact of castration on horses is poorly understood. Therefore, the current study observed 19 horses to determine: the welfare impact of standard castration on horses; whether individuals consistently vary in their behavioural and emotional responses to pain; the influence of personality on behavioural and physiological responses to pain; whether Horse Grimace Scale (HGS) indicates how individuals feel about painful experiences. Eye temperature (IRT), salivary cortisol, HGS and a pain ethogram were measured at intervals before, throughout and during recovery from castration. IRT (p < 0.005), Cortisol (p < 0.024), HGS (p < 0.03) and Maintenance behaviour (p < 0.004) significant changed from baseline. Physiological and behavioural responses to castration were varied but not consistent within individuals. Veterinarian influenced responses, presumably reflecting the importance of clinician’s skill. Personality explained differences in cortisol responses with Neuroticism negatively (estimate=-0.275; p = 0.035), and Extroversion positively (estimate=0.406; p = 0.001) associated with the magnitude of response to castration. HGS was not confounded by personality suggesting that this pain indicator may be resilient to individual differences in pain expression and appears to reflect underlying affective pain states as it was associated with cortisol (r = 0.568, p = 0.027). Therefore, it is potentially an important tool in recognition of pain at an individual level. Further research should be done utilising a larger sample with greater standardisation of castration method to determine both the effect of baseline welfare on pain resilience and the sensitivity of Grimace Scales as an indicator of suffering during painful experiences.

个性影响痛苦的体验和表达，阉割对马的福利影响尚不清楚。因此，本研究通过对19匹马的观察来确定：标准阉割对马的福利影响；个体对疼痛的行为和情绪反应是否始终不同；人格对疼痛行为和生理反应的影响马鬼脸量表（HGS）是否表明了个人对痛苦经历的感受。眼温（IRT）、唾液皮质醇、HGS和疼痛心电图分别在去势前、去势中和去势恢复期间进行测量。红外热成像(p

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引用次数: 0

Iron deficiency anemia in suckling piglets: When physiology cannot keep up with breeding goals 哺乳仔猪缺铁性贫血：当生理不能满足饲养目标时

IF 3.1 2区农林科学 Q1 VETERINARY SCIENCES

Veterinary journal

Pub Date : 2026-02-01 Epub Date: 2025-12-09 DOI: 10.1016/j.tvjl.2025.106530

Paweł Lipiński , Rafał R. Starzyński , Małgorzata Lenartowicz , Xiuying Wang , Magdalena Ogłuszka , Martyna Batorska

Suckling piglets are the only neonates among mammals to show a disruption in the balance between iron supply and demand that results in spontaneous and progressive iron deficiency anemia (IDA). IDA in piglets exhibits a biphasic pathology with a mild manifestation just after birth due to critically low hepatic iron stores, which subsequently develops into severe anemia as a result of the extremely high growth rate in the early postnatal period produced by intensive selective breeding. Intriguingly, no cases of IDA have been reported in the offspring of wild boar, the major ancestor of contemporary pigs, still living in the wild in many regions of the world. Comparison of iron metabolism in the domestic pig and wild boar shows that the physiological mechanisms delivering iron for domestic piglets are similar to those established in wild boar offspring and thus are largely insufficient for their needs. Therefore, IDA in domestic pig neonates may be considered a man-made disorder whose symptoms manifest themselves in a particularly acute form in the offspring of modern breeds of domestic pig. Decades of breeding for economically important traits such as large litter size, high birthweight and rapid growth, has excessively increased iron demand. Effective prevention and treatment of IDA was introduced in the 1950s when iron-polysaccharide compounds suitable for parenteral administration were first employed extensively. However, anemic piglets remain an appropriate animal model of neonatal IDA for testing the effectiveness of new iron supplements and formulas, and for exploring and deciphering mechanisms of neonatal iron metabolism.

哺乳仔猪是哺乳动物中唯一表现出铁供需平衡被破坏，从而导致自发性和进行性缺铁性贫血（IDA）的新生动物。仔猪的IDA表现为两期病理，刚出生时由于肝铁储量极低而表现为轻度，随后由于集约选择性育种在产后早期产生的极高生长速率而发展为严重贫血。有趣的是，在世界许多地区仍然生活在野外的野猪（现代猪的主要祖先）的后代中，没有报道过IDA病例。家猪和野猪铁代谢的比较表明，家仔猪的铁代谢生理机制与野猪后代相似，因此在很大程度上不足以满足它们的需要。因此，家猪新生儿的IDA可能被认为是一种人为疾病，其症状在现代家猪品种的后代中以特别急性的形式表现出来。几十年来对经济上重要性状（如产仔量大、出生重高和生长迅速）的培育，过度增加了对铁的需求。20世纪50年代，适合肠外给药的铁多糖化合物首次被广泛应用，有效预防和治疗IDA。然而，贫血仔猪仍然是测试新铁补充剂和配方的有效性以及探索和解读新生儿铁代谢机制的合适动物模型。

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引用次数: 0

Postmortem findings in lame cattle which underwent on farm emergency slaughter in Norway 挪威农场紧急屠宰的瘸腿牛的尸检结果。

IF 3.1 2区农林科学 Q1 VETERINARY SCIENCES

Veterinary journal

Pub Date : 2026-02-01 Epub Date: 2026-01-17 DOI: 10.1016/j.tvjl.2026.106568

Ingeborg Evensen , Cecilie Ersdal , Åse Margrethe Sogstad , Adam Dunstan Martin

According to on-farm emergency slaughter (OFES) veterinary certificates almost half of OFES cases in Norway are the result of locomotory disorders. However, beyond certification the diagnosis of these cases is unconfirmed. The aim of this study was to describe the gross lesions found at PME of cattle that underwent OFES for disorders of locomotion. During 2023, OFES cases entering two slaughterhouses underwent a regular PME and the pathological findings recorded. Complementary data were obtained from the veterinary certificate and Norwegian Food Safety Authority’s record system. In total, 492 cases met the study’s inclusion criteria. Descriptive statistics were generated, and logistic regression analyses were performed to examine relationship of sex, breed, production form and age with the post-mortem diagnosis. Gross lesions found at PME were categorized. The most common categories were soft tissue trauma (24 %), fracture (23 %), joint pathology (23 %), and joint dislocation (18 %). Most joint pathology cases involved the hock joint with males having a higher risk than females. Multivariable analysis found that joint dislocations (93 % hip dislocations) were associated with older, female Holstein cows. The high number of trauma cases was to be expected as suffering an accident is a prerequisite for the animal being eligible for OFES. However, the high number of spinal fractures, hip dislocations in female cattle, as well as hock lesions in bulls should be investigated further to find ways to prevent these painful lesions.

根据农场紧急屠宰（OFES）兽医证书，挪威几乎一半的OFES病例是运动障碍的结果。然而，除了证明之外，这些病例的诊断尚未得到证实。本研究的目的是描述在因运动障碍而接受OFES治疗的牛的PME中发现的大体病变。在2023年期间，进入两个屠宰场的OFES病例进行了定期PME检查并记录了病理结果。补充数据来自兽医证书和挪威食品安全局的记录系统。总共有492例病例符合研究的纳入标准。进行描述性统计，并进行逻辑回归分析，以检验性别、品种、生产形式和年龄与死后诊断的关系。在PME发现的肉眼病变被分类。最常见的类别是软组织创伤（24%）、骨折（23%）、关节病理（23%）和关节脱位（18%）。大多数关节病理病例涉及飞节，男性比女性有更高的风险。多变量分析发现，关节脱位（93%髋脱位）与年龄较大的雌性荷斯坦奶牛有关。高数量的创伤病例是意料之中的，因为遭受事故是动物有资格获得OFES的先决条件。然而，应该进一步研究大量的牛脊柱骨折、髋关节脱位以及公牛的飞节损伤，以找到预防这些痛苦损伤的方法。

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引用次数: 0

Perception and use of cannabidiol (CBD) by French pet owners 法国宠物主人对大麻二酚（CBD）的认知和使用

IF 3.1 2区农林科学 Q1 VETERINARY SCIENCES

Veterinary journal

Pub Date : 2026-02-01 Epub Date: 2025-12-12 DOI: 10.1016/j.tvjl.2025.106536

Audrey Besegher , Sarah Jeannin , Narcisse Niamba , Thierry Bedossa , Dalila Bovet , Sara Hoummady

This study explored pet owners’ perceptions and use of cannabidiol (CBD) for dogs and cats in France, examining factors associated with CBD use and attitudes toward the product. A total of 2050 pet owners completed an online survey including demographic characteristics, pet health, knowledge, and attitudes toward CBD. Findings revealed that CBD use was not widespread but remained notable, with 29 % of dog owners and 13 % of cat owners reporting administration, rates lower than those reported in countries such as the United States, Canada, or Slovenia. Use was more prevalent among younger owners and those with prior personal experience of CBD or other alternative treatments. No significant difference was observed between urban and rural residents, likely due to widespread internet access facilitating information and online purchases. A higher proportion of dogs than cats received CBD, possibly due to the greater difficulty of administering oral substances to cats. Despite its relatively limited use, owners generally held positive views of CBD’s safety and benefits. Longer durations of CBD administration were linked to higher satisfaction levels. Importantly, discussions with veterinarians were significantly associated with CBD use, and veterinary recommendation was reported as a strong motivator for purchase decisions. Behavioral issues and pain were the main reasons for CBD use across species. Limitations include potential selection bias, a strong sex imbalance that limits representativeness for male owners, and reliance on self-reported data without clinical confirmation. These findings underline the need for clearer regulations, enhanced veterinary education, and clinical trials to provide evidence-based guidance on CBD use in veterinary medicine.

这项研究探讨了法国宠物主人对狗和猫使用大麻二酚（CBD）的看法和使用情况，研究了与CBD使用相关的因素以及对该产品的态度。共有2050名宠物主人完成了一项在线调查，包括人口特征、宠物健康、对CBD的认识和态度。调查结果显示，CBD的使用并不普遍，但仍然值得注意，29% %的狗主人和13% %的猫主人报告使用大麻，这一比例低于美国、加拿大或斯洛文尼亚等国家的报告。在年轻的业主和那些之前有过CBD或其他替代治疗经验的人中，大麻的使用更为普遍。城乡居民之间没有观察到显著差异，可能是由于广泛的互联网接入促进了信息和网上购物。接受CBD的狗比猫的比例更高，可能是因为给猫口服这种物质更困难。尽管CBD的使用相对有限，但业主普遍对CBD的安全性和效益持积极态度。服用CBD的时间越长，满意度越高。重要的是，与兽医的讨论与CBD的使用显著相关，兽医的建议被报道为购买决定的强烈动机。行为问题和疼痛是跨物种使用CBD的主要原因。局限性包括潜在的选择偏差，严重的性别不平衡限制了男性所有者的代表性，以及依赖没有临床证实的自我报告数据。这些发现强调需要更明确的法规，加强兽医教育和临床试验，为CBD在兽药中的使用提供循证指导。

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引用次数: 0

The gut microbiome of Australian cats and dogs: Dietary influences, health impacts, and emerging research 澳大利亚猫和狗的肠道微生物组：饮食影响，健康影响和新兴研究。

IF 3.1 2区农林科学 Q1 VETERINARY SCIENCES

Veterinary journal

Pub Date : 2026-02-01 Epub Date: 2026-01-15 DOI: 10.1016/j.tvjl.2026.106566

Mithila Banik , Saroj Bashyal , Khandaker Asif Ahmed PhD , Kakon Banik , Kamal Dua PhD , Jaesung P. Choi PhD , Keshav Raj Paudel PhD , Rajib Majumder PhD

The gut microbiome plays a pivotal role in the health, metabolism, and behaviour of companion animals, yet comprehensive syntheses of its composition and functional relevance in cats and dogs in Australia are overlooked and remain limited globally. This review synthesises current knowledge on the gut microbial communities inhabiting the gastrointestinal tracts of dog and cats, with a particular focus on taxonomic diversity, dietary modulation, and associations with disease states within Australian context. Core phyla including Firmicutes, Bacteroidetes, Proteobacteria, and Actinobacteria dominate the canine and feline gut, but marked interspecies and individual variability is shaped by factors such as feeding practices, living environment, obesity, and chronic disease. Recent studies have elucidated functional signatures linked to conditions ranging from the influence of microplastics to pet gut health, as well as gut-microbiome transmission between pets and their owners, highlighting this area as a promising field of investigation. In parallel, this review contextualizes the broader landscape of pet ownership in Australia, where nearly 70 % of households own pets, and significant resources are devoted to nutrition, veterinary care, and preventive health. Emerging evidence also suggests bidirectional influences between pets and their human companions’ microbiota, highlighting opportunities for integrated approaches. We identify critical knowledge gaps, including the need for region-specific microbial baselines, standardized methodologies, and controlled intervention trials targeting microbiome modulation and transmission. By consolidating advances across microbial ecology, veterinary medicine, and translational research, this review provides a foundation for future studies that aim to harness the diagnostic and therapeutic potential of the pet microbiome, thereby improving health outcomes for animals and humans alike.

肠道微生物组在伴侣动物的健康、代谢和行为中起着关键作用，但对澳大利亚猫和狗的组成和功能相关性的全面综合却被忽视，在全球范围内仍然有限。这篇综述综合了目前关于居住在狗和猫胃肠道的肠道微生物群落的知识，特别关注澳大利亚背景下的分类多样性、饮食调节以及与疾病状态的关联。包括厚壁菌门、拟杆菌门、变形菌门和放线菌门在内的核心门在犬和猫的肠道中占主导地位，但明显的种间和个体差异是由喂养方式、生活环境、肥胖和慢性疾病等因素决定的。最近的研究已经阐明了与微塑料对宠物肠道健康的影响以及宠物与其主人之间肠道微生物群传播有关的功能特征，强调了这一领域是一个有前途的研究领域。与此同时，本综述将澳大利亚更广泛的宠物饲养情况置于背景下，在澳大利亚，近70%的家庭拥有宠物，大量资源用于营养、兽医护理和预防健康。新出现的证据还表明，宠物及其人类伴侣的微生物群之间存在双向影响，这凸显了采用综合方法的机会。我们确定了关键的知识空白，包括对特定区域微生物基线、标准化方法和针对微生物组调节和传播的对照干预试验的需求。通过整合微生物生态学、兽医学和转化研究的进展，本综述为未来的研究提供了基础，旨在利用宠物微生物组的诊断和治疗潜力，从而改善动物和人类的健康结果。

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引用次数: 0

Development and evaluation of a nanozyme-based lateral flow assay strip for avian leukosis virus detection 基于纳米酶的禽白血病病毒横向流动检测试纸条的研制与评价

IF 3.1 2区农林科学 Q1 VETERINARY SCIENCES

Veterinary journal

Pub Date : 2026-02-01 Epub Date: 2025-11-24 DOI: 10.1016/j.tvjl.2025.106508

Liyan Cao , Kexiong Wang , Jie Wang , Xiaoying Jin , Bin Li , Xiaomei Wang , Ying Shen , Rui Zeng , Kai Li

Avian leukosis (AL) is a common neoplastic disease in poultry caused by the Avian leukosis virus (ALV). As there are no specific drugs or vaccines for preventing and treating this disease, population purification is currently primarily achieved by culling affected individuals and selecting and breeding leukemia-free chicken flocks. To address the lack of a rapid and accurate ALV detection method, this study developed a lateral flow strip detection system based on Fe-Co nanozyme-antibody probes. Owing to the efficient signal amplification property of nanozymes, the system significantly improved detection sensitivity, with a minimum detection limit of 12.5 TCID₅₀/mL for ALV and 0.20 ng/mL for its related proteins. Furthermore, this test strip was eight times more sensitive than the commercial enzyme-linked immunosorbent assay (ELISA) group-specific antigen detection kit. Specificity verification results showed that the detection test strip only produced a positive reaction to ALV and no cross-reactions with six common avian viruses, namely Newcastle disease virus (NDV), Marek's disease virus (MDV), infectious bursal disease virus (IBDV), fowlpox virus (FPV), infectious laryngotracheitis virus (ILTV), and avian influenza virus (AIV). Additionally, the strip exhibited excellent intra- and inter-batch repeatability, with the corresponding coefficient of variation (CV) being less than 10 %. Clinical sample detection data indicated that the results of the nanozyme-based test strip were consistent with those of the commercial double-antibody sandwich ELISA detection kit, achieving a coincidence rate of up to 100 %. Collectively, the results of this study provide a novel technical method characterized by high sensitivity, high specificity, and simple operation for the on-site rapid screening of ALV.

禽白血病（AL）是由禽白血病病毒（ALV）引起的一种常见的家禽肿瘤疾病。由于没有预防和治疗这种疾病的特异性药物或疫苗，种群净化目前主要是通过扑杀受影响的个体和选择和繁殖无白血病的鸡群来实现的。为解决目前缺乏快速准确的ALV检测方法的问题，本研究开发了一种基于Fe-Co纳米酶抗体探针的侧流条带检测系统。由于纳米酶的高效信号扩增特性，该系统显著提高了检测灵敏度，对ALV的最低检测限为12.5 TCID50/mL，对其相关蛋白的最低检测限为0.20 ng/mL。此外，该试纸条的灵敏度是市售酶联免疫吸附试验（ELISA）群体特异性抗原检测试剂盒的8倍。特异性验证结果表明，该检测试纸条仅对ALV产生阳性反应，与新城疫病毒（NDV）、马立克病病毒（MDV）、传染性法氏囊病病毒（IBDV）、禽痘病毒（FPV）、传染性喉气管炎病毒（ILTV）、禽流感病毒（AIV） 6种常见禽病毒无交叉反应。此外，该条带具有良好的批内和批间重复性，变异系数（CV）小于10 %。临床样品检测数据表明，纳米酶试纸与市售双抗体夹心ELISA检测试剂盒结果一致，符合率高达100% %。本研究结果为ALV的现场快速筛选提供了一种高灵敏度、高特异性、操作简便的新技术方法。

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引用次数: 0

Immunomodulatory and anti-proliferative effects of canine adipose-derived stromal vascular fraction on peripheral blood mononuclear cells: An in vitro model for therapeutic applications 犬脂肪源性基质血管组分对外周血单核细胞的免疫调节和抗增殖作用：用于治疗应用的体外模型

IF 3.1 2区农林科学 Q1 VETERINARY SCIENCES

Veterinary journal

Pub Date : 2026-02-01 Epub Date: 2025-11-28 DOI: 10.1016/j.tvjl.2025.106520

Hitesh Rana, Ratan Kumar Choudhary

This study investigated the immunomodulatory and anti-proliferative effects of canine adipose-derived stromal vascular fraction (SVF) on peripheral blood mononuclear cells (PBMCs) from healthy and lymphoma-affected dogs. SVF, a rich source of mesenchymal stem cells (MSCs), was isolated from canine periovarian adipose tissue and characterized by flow cytometry (CD45, CD44, and CD90), immunocytochemistry, and gene expression analyses (CD44, CD90, and CD105). Coculturing SVF with PBMCs showed that SVF significantly increased the population doubling time and decreased Ki-67 expression in PBMCs (3.5-fold) in a dose-dependent manner. Furthermore, SVF exhibited immunomodulatory properties by remarkably down-regulating the pro-inflammatory cytokine TNF-α (44-fold; p = 0.0003) and up-regulating the anti-inflammatory cytokine PTGS1 (88-fold; p = 0.008). These findings confirm that canine SVF contains functional MSCs and possesses significant immunomodulatory and anti-proliferative capabilities against PBMCs, suggesting its therapeutic potential. This study also demonstrates coculture of SVF and PBMC as an in vitro model for studying therapeutic applications of stem cells in canine inflammatory and proliferative conditions.

本研究探讨了犬脂肪源性基质血管组分（SVF）对健康犬和淋巴瘤犬外周血单个核细胞（PBMCs）的免疫调节和抗增殖作用。SVF是一种丰富的间充质干细胞（MSCs）来源，从犬骨膜脂肪组织中分离出来，并通过流式细胞术（CD45、CD44和CD90）、免疫细胞化学和基因表达分析（CD44、CD90和CD105）对其进行了表征。SVF与PBMCs共培养表明，SVF显著增加了PBMCs的群体倍增时间，降低了Ki-67的表达（3.5倍），并呈剂量依赖性。此外，SVF通过显著下调促炎细胞因子TNF-α（44倍，p = 0.0003）和上调抗炎细胞因子PTGS1（88倍，p = 0.008）表现出免疫调节特性。这些研究结果证实，犬SVF含有功能性MSCs，对PBMCs具有显著的免疫调节和抗增殖能力，提示其治疗潜力。本研究还证明了SVF和PBMC的共培养作为研究干细胞在犬炎症和增殖条件下的治疗应用的体外模型。

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引用次数: 0

Hypoalbuminemia and altered thyroid parameters in dogs with chronic diarrhoea: Is protein loss driving TSH elevation? 慢性腹泻犬的低白蛋白血症和甲状腺参数改变：蛋白质损失是否驱动TSH升高？

IF 3.1 2区农林科学 Q1 VETERINARY SCIENCES

Veterinary journal

Pub Date : 2026-02-01 Epub Date: 2025-11-25 DOI: 10.1016/j.tvjl.2025.106507

Antoine Lecomte, Manon Baudry, Delphine Boucher, Nicolas Soetart , Laetitia Jaillardon

Systemic effects of chronic gastrointestinal disease can complicate the interpretation of endocrine tests in dogs. In this study, thyroid function was evaluated in 70 dogs with chronic diarrhoea to investigate its association with serum albumin and digestive biomarkers. Dogs were classified according to albumin concentration: ≥ 28 g/L (Group A, normal albuminaemia, N = 24), 20–27 g/L (Group B, moderate hypoalbuminaemia, N = 25), and < 20 g/L (Group C, severe hypoalbuminaemia, N = 21). Total thyroxine (TT4), free thyroxine (FT4), canine thyroid-stimulating hormone (cTSH), TT4/FT4 ratio, albumin, total proteins, cobalamin, folate, and canine trypsin-like immunoreactivity (cTLI) were measured. Thyroid hormones, cobalamin, cTLI, and total protein were significantly lower in hypoalbuminaemic dogs (Groups B and C), while cTSH was higher in Group C. Albumin correlated positively with TT4 and FT4, and negatively with cTSH. Nine dogs (12.9 %) had elevated cTSH (≥0.5 µg/L), including six in Group C (28.5 %), and showed significantly lower albumin, globulin, cobalamin, TT4, FT4, and TT4/FT4 ratio compared to dogs with cTSH< 0.5 µg/L). On multivariate analysis, a decreased TT4/FT4 ratio and lower globulin concentration were independently associated with elevated cTSH. These findings suggest that alterations in thyroid parameters are common in dogs with chronic diarrhoea and hypoalbuminaemia, particularly in severe cases. Low TT4, FT4, and TT4/FT4 ratios, together with elevated cTSH, may reflect thyroid hormone binding protein loss and altered binding dynamics rather than primary hypothyroidism; however, complementary tests, such as antithyroglobulin antibody assessment and/or TSH stimulation tests, were not performed, so subclinical primary hypothyroidism cannot be definitively ruled out. Such results highlight the risk of misdiagnosing hypothyroidism and underscore the need for cautious interpretation of thyroid tests in dogs with gastrointestinal disease.

慢性胃肠疾病的全身性影响会使狗的内分泌测试结果复杂化。在这项研究中，对70只患有慢性腹泻的狗进行了甲状腺功能评估，以探讨其与血清白蛋白和消化生物标志物的关系。按白蛋白浓度分为：≥28g/L (A组，正常白蛋白血症，N = 24), 20-27g/L (B组，中度低白蛋白血症，N = 25)，和

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