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[The effect of gamma-L-glutamyl histamine on the severity of experimental anaphylactic reaction, hormonal status and liver cytochrome p-450]. [γ - l -谷氨酰组胺对实验性过敏反应严重程度、激素状态及肝细胞色素p-450的影响]。
Pub Date : 1999-11-01
V E Nebol'sin, V V Krzhechkovskaia, G A Zheltukhina, R P Evstigneeva, V L Kovaleva

gamma-L-Glutamyl-histamine (gamma-GluHA) was synthesized at Department of the chemistry and technology of fine organic compounds M. V. Lomonosov Moscow state academy of fine chemical technology. It was investigated the influence of gamma-L-glutamyl-histamine on the severity of experimental anaphylactic reaction, hormonal content in blood plasma and liver cytochrome P-450. The induction of liver cytochrome P-450, the elevation of hormonal content (thyroxine and glucocorticoids) in blood plasma and decrease of the severity of experimental anaphylactic reaction are observed.

γ - l-谷氨酰胺组胺(γ - gluha)是在莫斯科国立精细化学技术学院精细有机化合物化学与技术部合成的。探讨γ - l-谷氨酰胺组胺对实验性过敏反应严重程度、血浆激素含量及肝细胞色素P-450的影响。观察到肝细胞色素P-450的诱导,血浆中激素(甲状腺素和糖皮质激素)含量的升高,实验过敏反应的严重程度降低。
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引用次数: 0
[Lipid peroxidation, peroxyl radical-scavenging system of plasma and liver and heart pathology in adolescence heroin users]. [青少年海洛因使用者血浆、肝脏和心脏的脂质过氧化、过氧自由基清除系统病理]。
Pub Date : 1999-11-01
L F Panchenko, S V Pirozhkov, A V Nadezhdin, V Iu Baronets, N N Usmanova

Chronic opiate intoxication has been shown to cause various pathologic changes in the liver almost in 100% of cases. Earlier it has been demonstrated that acute or chronic morphine intoxication evokes activation of lipid peroxidation in the liver, heart, and brain cells. The aim of the present work was to assess parameters reflecting cytolysis in the liver and heart, and the plasma content of factors contributing to the peroxyl radical-scavenging system of the blood of teenagers using heroin. Blood samples were obtained from 20 male patients from 14 to 16 years old, with a mean duration of regular heroin use of 1.7 years. The control group included 13 healthy teenagers which denied the previous drug use. Mean plasma ALT and myocardial isoform of LDH activities were significantly higher (1.7- and 1.4-times respectively) in the heroin users than in the control group. The mean plasma level of lipid peroxides in the heroin users is increased by 20% compared to the control individuals. In teenagers using heroin a high level of correlation was observed between the plasma content of lipid peroxides and myocardial LDH activity (r = 0.76; P < 0.01). The effect of heroin use on the content of the plasma peroxyl radical-scavenging factors--vitamin E, ascorbic acid, and protein SH-groups--was not found. It has been concluded that heart injury during heroin use in teenagers may be associated with activation of lipid peroxidation reactions in the myocardium.

慢性阿片类药物中毒已被证明在几乎100%的病例中引起肝脏的各种病理改变。早些时候已经证明急性或慢性吗啡中毒会引起肝脏、心脏和脑细胞的脂质过氧化活化。本研究的目的是评估反映肝脏和心脏细胞溶解的参数,以及青少年使用海洛因血液中过氧化氢自由基清除系统的血浆含量。采集了20例14 ~ 16岁男性患者的血液样本,这些患者的平均海洛因使用时间为1.7年。对照组包括13名健康青少年,他们否认以前使用过药物。海洛因使用者的平均血浆ALT和心肌LDH活性显著高于对照组(分别为1.7倍和1.4倍)。与对照组相比,海洛因使用者的平均血浆脂质过氧化物水平增加了20%。使用海洛因的青少年血浆脂质过氧化物含量与心肌LDH活性之间存在高度相关(r = 0.76;P < 0.01)。海洛因使用对血浆过氧自由基清除因子(维生素E、抗坏血酸和sh蛋白)含量的影响未被发现。结论:青少年海洛因使用过程中的心脏损伤可能与心肌脂质过氧化反应的激活有关。
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引用次数: 0
[Common properties of pharmacological agonists and antagonists of surface membrane receptors]. [表面膜受体的药物激动剂和拮抗剂的共同特性]。
Pub Date : 1999-11-01
A I Luĭk, V V Prokopenko, V Iu Tanchuk, V V Kholodovich, I V Semeniuta

Using experimental transcription model in vitro, and method of electron-topological calculations the elements of pharmacological and structural community have been found in the groups of physiologically active compounds (PAC), blocking and activating external cellular receptors. This finding confirms the necessity of subdivision special groups of bio-substrates blockators and activators for hierarchical classification, of PAC.

利用体外实验转录模型和电子拓扑计算方法,在阻断和激活细胞外受体的生理活性化合物(PAC)基团中发现了药理学和结构群落的元素。这一发现证实了将生物底物阻断剂和活化剂细分为PAC分层分类的必要性。
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引用次数: 0
[Functional role of vitamin K]. [维生素K的功能作用]。
Pub Date : 1999-11-01
A A Sokol'nikov, V M Kodentsova

Three basic functions of vitamin K in organism are considered. Besides (vitamin K-dependent) posttranslational modification of Ca-binding proteins, this vitamin can operate via vitamin D hormonal system, and can directly influence membranes.

论述了维生素K在机体中的三种基本功能。除了(维生素k依赖性)钙结合蛋白的翻译后修饰外,该维生素还可以通过维生素D激素系统起作用,并直接影响膜。
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引用次数: 0
[Protection of mice by carbamates cholinesterase inhibitors against poisoning by armin and its dependence on certain physico-chemical indicators]. 氨基甲酸酯类胆碱酯酶抑制剂对armin中毒小鼠的保护作用及其对某些理化指标的依赖性。
Pub Date : 1999-11-01
V B Prozorovskiĭ, L V Pavlova, I M Suslova, A V Sazonova, A V Kokushkina

A series of aminostigmin derivatives with various substituents at nitrogen in the second position of the pyridine ring, has been tested. The efficacy of preventing the death of mice poisoned by armine in five of the seven substances correlates with the constant of the rate of carbamylation of acetylcholinesterase in the in vitro experiments and with the hydrophobic nature. It is suggested that the phenomenon of protection of animals against the toxic effect of organophosphorous compounds involves the "leaving portion" of the molecule of carbamates.

对一系列在吡啶环第二位置的氮上具有不同取代基的氨基蛋白酶衍生物进行了测试。7种物质中5种物质对氨基中毒小鼠的预防作用与体外实验中乙酰胆碱酯酶氨甲酰化速率恒定以及其疏水性有关。有人认为,保护动物免受有机磷化合物毒性作用的现象涉及氨基甲酸酯分子的“残留部分”。
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引用次数: 0
[Changes in the activity of neutral and acidic isoforms of sphingomyelinase in hepatoma-22, regenerating and ischemic liver]. [肝癌-22、再生肝和缺血肝鞘磷脂酶中性和酸性同工型活性的变化]。
Pub Date : 1999-11-01
A V Alesenko, E S Zubova, L B Dudnik, E I Gal'perin, L V Platonova, N Shono, A Iu Chevokin, E V Diatlovitskaia

Activity of neutral and acidic sphingomyelinases (N- and A-SMases) were studied in regenerating liver after partial hepatectomy (during 48 hrs after operation), in ischemic liver during 15, 30 min and 1 and 2 hrs ischemia and during following reperfusion (from 5 min up to 2 hrs), in hepatoma- 22 after 15 days of transplantation and in liver of tumor bearing animals. It was shown that activity of N-SMase is increased in hepatoma-22 and in regenerating liver and it is decreased in ischemic liver. Following reperfusion of ischemic liver area activity of enzyme was found to have returned to baseline in dependence on time of ischemia and reperfusion. Activity of A-SMase is decreased in tumor, is not changed in regenerating liver and increased after long time of ischemia. It was supposed that N-SMase is involved in cell proliferation, but A-SMase is connected with cell damage.

研究了中性和酸性鞘磷脂酶(N-和A-SMases)在肝部分切除后再生肝脏(术后48小时)、缺血后15、30分钟、1和2小时以及再灌注后(5分钟至2小时)、肝癌移植后15天- 22天以及荷瘤动物肝脏中的活性。结果表明,N-SMase活性在肝癌22和再生肝中升高,在缺血肝中降低。缺血肝区再灌注后,酶活性随缺血再灌注时间的延长而恢复到基线水平。A-SMase活性在肿瘤组织中降低,在再生肝组织中无变化,长时间缺血后升高。N-SMase被认为与细胞增殖有关,而A-SMase则与细胞损伤有关。
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引用次数: 0
[The use of ion-selective field transistors (ISFT) with photopolymerizable polyurethane membranes in nephrology for determination of potassium concentration (activity)]. [离子选择场晶体管(ISFT)和光聚合聚氨酯膜在肾脏病学中用于钾浓度(活性)的测定]。
Pub Date : 1999-11-01
N Iu Abramova, Iu A Borisov, A V Bratov, P V Gavrilenkov, K Dominguez, V N Spiridonov, E D Suglobova

The applicability is examined of ion selective field transistors with photocurable polyurethane membranes to control of the electrolytic composition of dialyzing solutions used in artificial kidney apparatus, and also of plasma in patient treated by chronic hemodialysis. The short- and long-time characteristics of the efficiency of K(+)-selective field transistors in continuous contact with solutions. Comparative testing of such transistors and other sensing systems is made. It is demonstrated that a sufficient reliability of measurements in the range of physiological concentrations in combination with low cost provide the possibility of using K(+)-selective field transistors for monitoring of the potassium concentration both in dialyzing solutions and plasma in patients on chronic hemodialysis treatment.

研究了光固化聚氨酯膜离子选择场晶体管在控制人工肾脏透析液电解组成和慢性血液透析患者血浆电解组成中的适用性。溶液连续接触下K(+)选择性场晶体管效率的短期和长期特性。对这种晶体管和其他传感系统进行了比较测试。研究表明,在生理浓度范围内的测量具有足够的可靠性,再加上低成本,使得使用K(+)选择性场晶体管监测慢性血液透析患者透析溶液和血浆中的钾浓度成为可能。
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引用次数: 0
[The dynamic of biochemical stress reaction inductors in various tactics for surgical treatment of patients with a combined trauma of cranium and lower limbs ]. [生化应激反应诱导因子在颅下肢联合创伤手术治疗中的动态变化]。
Pub Date : 1999-11-01
V V Lebedev, P P Golikov, B V Davydov, K I Rakhimi, A G Suvalian, N Iu Nikolaeva, N V Fedorova, V V Marchenko

In 31 patients after a craniocerebral trauma combined with a trauma of locomotor system (CCCT), and in 28 patients with only a limb fractures a time course (1, 3, 7, and 14 days) of biochemical stress reaction inductors (cortisol, serotonin, histamine, lipid peroxidation products) in various tactics of surgical treatment was studied. It was established that CCCT in a significantly stronger degree increases cortisol and lipid peroxidation products' levels than an isolated locomotor system trauma. An early postponed surgical intervention in lower extremities in CCCT results in the same increase in the biochemical stress reaction inductors as a late postpone surgical intervention in the lower extremities. In an early postponed osteosynthesis in CCCT patients, a mean term of hospital stay was 67 days, and in a late postponed one 117 days. The disability period was correspondingly 200 vs 315 days.

在31例颅脑损伤合并运动系统损伤(CCCT)患者和28例仅肢体骨折患者中,研究了不同手术治疗策略下生化应激反应诱导因子(皮质醇、血清素、组胺、脂质过氧化产物)的时间过程(1、3、7和14天)。研究证实,与孤立的运动系统损伤相比,CCCT在更大程度上增加了皮质醇和脂质过氧化产物的水平。在CCCT患者中,早期延迟下肢手术干预与晚期延迟下肢手术干预导致生化应激反应诱导因子的增加相同。在早期延迟的CCCT患者中,平均住院时间为67天,而在晚期延迟患者中,平均住院时间为117天。伤残期分别为200天和315天。
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引用次数: 0
[Intensity of free radical process and antioxidant enzymes activity in human saliva and plasma under emotional stress]. [情绪应激下唾液和血浆中自由基过程强度及抗氧化酶活性]。
Pub Date : 1999-11-01
A I Lukash, V G Zaika, N P Miliutina, A O Kucherenko

The intensity of free radical processes (FRP) and the activity of antioxidant (AO) systems in human blood plasma and saliva were studied under physiological emotional strain and depressive pathologies (before and after treatment). The significant alterations in the dynamics of investigative indexes under different emotional strain were revealed. These alterations in saliva were more intensive than in blood plasma. The treatment led to the stabilization of FRP intensity and the activity of AO protection. The correlation between saliva and blood plasma parametres allows to use saliva for the estimation of emotional strain and of the efficiency of therapeutics under depressive pathologies.

在生理情绪紧张和抑郁病理(治疗前后)下,研究了人血浆和唾液中自由基过程(FRP)强度和抗氧化系统(AO)活性。不同情绪压力下调查指标动态变化显著。唾液中的这些变化比血浆中的更强烈。处理后玻璃钢强度稳定,AO保护活性增强。唾液和血浆参数之间的相关性允许使用唾液来估计抑郁病理下的情绪紧张和治疗效率。
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引用次数: 0
[Ethanol inhibits platelet monoamine oxidase type B activity in patients with alcoholism]. [乙醇抑制酗酒患者血小板单胺氧化酶 B 型活性]。
Pub Date : 1999-11-01
E M Krupitskiĭ, G F Karandashova, V V Vostrikov, N M Lavrova, N I Grinenko, T Iu Slavina, A Ia Grinenko

The influence of 400 mM ethanol on the activity of monoamine oxidase type B (MAO-B) of blood platelets has been studied in vitro in 30 alcoholic patients and 30 healthy volunteers. Benzylamine was used as a substrate for MAO-B. MAO-B inhibition by ethanol was higher in alcoholics compared to healthy volunteers. The higher vulnerability of MAO-B of alcoholics inhibiting action to of ethanol may be one of the mechanisms underlying some symptoms of alcoholism.

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引用次数: 0
期刊
Voprosy meditsinskoi khimii
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