Pub Date : 2010-04-06DOI: 10.4314/WAJPDR.V6I1.53370
P. Okonkwo
{"title":"Adenosine triphosphatase and phosphatase in some African viperine venoms","authors":"P. Okonkwo","doi":"10.4314/WAJPDR.V6I1.53370","DOIUrl":"https://doi.org/10.4314/WAJPDR.V6I1.53370","url":null,"abstract":"","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"213 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76581182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-04-06DOI: 10.4314/WAJPDR.V6I1.53367
A. Coker, Tolu Odugbemi, A. Onitiri
{"title":"In vitro activity of amikacin compared with other amtimicrobials against clinically important bacteria in the Lagos Universety Teaching Hospital","authors":"A. Coker, Tolu Odugbemi, A. Onitiri","doi":"10.4314/WAJPDR.V6I1.53367","DOIUrl":"https://doi.org/10.4314/WAJPDR.V6I1.53367","url":null,"abstract":"","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"265 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77691182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-04-06DOI: 10.4314/WAJPDR.V11I1.53385
P. Akah, K. Gamaniel, C. Wambebe
{"title":"Analysis of the responsed of guinea pig ileum to the root extract of Calliandra protoricensis","authors":"P. Akah, K. Gamaniel, C. Wambebe","doi":"10.4314/WAJPDR.V11I1.53385","DOIUrl":"https://doi.org/10.4314/WAJPDR.V11I1.53385","url":null,"abstract":"","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85609371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-04-06DOI: 10.4314/WAJPDR.V13I1.53395
E. Okoro, J. Marwood
{"title":"Antagonist ligands are not always reliable in the functional identification of 5-HT 2 receptor in rat aorta","authors":"E. Okoro, J. Marwood","doi":"10.4314/WAJPDR.V13I1.53395","DOIUrl":"https://doi.org/10.4314/WAJPDR.V13I1.53395","url":null,"abstract":"","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"127 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79538258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-04-06DOI: 10.4314/WAJPDR.V11I1.53394
S. Oladele, J. Ayo, A. O. Adaudi
{"title":"Medicinal and physiological properties of flavonoids, coumarin derivatives and anthraqoinones of plant origin","authors":"S. Oladele, J. Ayo, A. O. Adaudi","doi":"10.4314/WAJPDR.V11I1.53394","DOIUrl":"https://doi.org/10.4314/WAJPDR.V11I1.53394","url":null,"abstract":"","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"82 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89409078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-04-06DOI: 10.4314/WAJPDR.V11I1.53393
M. Azuine, S. Bhide
{"title":"Antinutagenic and anticarcinogeic acticity of phenolic compounds: possible involvement of the structural activity","authors":"M. Azuine, S. Bhide","doi":"10.4314/WAJPDR.V11I1.53393","DOIUrl":"https://doi.org/10.4314/WAJPDR.V11I1.53393","url":null,"abstract":"","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81475994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2008-10-22DOI: 10.4314/WAJPDR.V22I1.14764
O. Ajayi, O. George
Caffeine is widely consumed in kola nuts and in other products in Sub-Saharan Africa. We examined the acute effect of caffeine on the amplitude of accommodation and near point of convergence of healthy Nigerians. Forty volunteers between ages of 20 and 27 years with refractive power± 0.50 DS were employed. Amplitude of accommodation (AMP) and Near point of convergence (NPC) were measured at 0, 30, 60 and 90 minutes after the ingestion of coffee by two groups of participants, namely the experimental (caffeinated coffee) and control (decaffeinated coffee) groups. The result showed that ingested caffeine increases mean AMP by almost 2.00D within 30 minutes, and the elevation, though variable across patients is sustained for several minutes. The NPC and AMP in the decaffeinated coffee was statically insignificant (P>0.05) within the 0-90minutes of ingestion. However, there was a significant increase in the AMP of the experimental group (P< 0.05). The result suggests that further studies would be most desirable with the older and larger population. Keywords: Caffeine, amplitude of accommodation, near point of convergenceWest African Journal of Pharmacology and Drug Research Vol. 22/23 2007: pp. 27-30
{"title":"Acute Effect of Caffeine on Amplitude of Accommodation and Near Point of Convergence","authors":"O. Ajayi, O. George","doi":"10.4314/WAJPDR.V22I1.14764","DOIUrl":"https://doi.org/10.4314/WAJPDR.V22I1.14764","url":null,"abstract":"Caffeine is widely consumed in kola nuts and in other products in Sub-Saharan Africa. We examined the acute effect of caffeine on the amplitude of accommodation and near point of convergence of healthy Nigerians. Forty volunteers between ages of 20 and 27 years with refractive power± 0.50 DS were employed. Amplitude of accommodation (AMP) and Near point of convergence (NPC) were measured at 0, 30, 60 and 90 minutes after the ingestion of coffee by two groups of participants, namely the experimental (caffeinated coffee) and control (decaffeinated coffee) groups. The result showed that ingested caffeine increases mean AMP by almost 2.00D within 30 minutes, and the elevation, though variable across patients is sustained for several minutes. The NPC and AMP in the decaffeinated coffee was statically insignificant (P>0.05) within the 0-90minutes of ingestion. However, there was a significant increase in the AMP of the experimental group (P< 0.05). The result suggests that further studies would be most desirable with the older and larger population. Keywords: Caffeine, amplitude of accommodation, near point of convergenceWest African Journal of Pharmacology and Drug Research Vol. 22/23 2007: pp. 27-30","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"24 1","pages":"27-30"},"PeriodicalIF":0.0,"publicationDate":"2008-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83142170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2008-10-22DOI: 10.4314/WAJPDR.V22I1.14763
K. Wided, Rouibah Hassiba, B. Nadia, B. Lamia, A. Mohamed, L. Mesbah
Our study carried out in vivo, using liver mitochondria isolated from albinos rats, treats the effect of a long term treatment by Algerian propolis ethanolic extract and their flavonic aglycones and glycosides to the amount of 100 mg/kg on mitochondrial antioxidant-prooxidant balance. Our results showed that all extracts produced an antioxidant effect which is better than that of quercetin. They decreased superoxide anion production (O2-°) by mitochondrial respiratory chain complex III, cytosolic and mitochondrial MDA content, increased (Mn-SOD), (Cu-Zn SOD) and (CAT) enzymatic activities as well as the rate of cytosolic glutathione (GSH). Propolis flavonoids reduced free radical DPPH° in a concentration-dependent manner, inhibited PTP opening and calcium-induced mitochondrial swelling. After long term treatment, propolis flavonoids protected liver tissues from oxidative stress by protecting mitochondria and reinforcement of enzymatic and non enzymatic antioxidants. Propolis flavonoids are well tolerated and are free of any prooxidant effect. Keywords : Algerian propolis flavonoids, antioxidant-prooxidant balance, liver mitochondrion, long term effect. West African Journal of Pharmacology and Drug Research Vol. 22/23 2007: pp. 16-26
本研究以白化病大鼠肝脏线粒体为实验对象，观察阿尔及利亚蜂胶乙醇提取物及其黄酮苷元和糖苷长期给予100 mg/kg对线粒体抗氧化-促氧化平衡的影响。结果表明，各提取物的抗氧化作用均优于槲皮素。降低了线粒体呼吸链复合体III产生的超氧阴离子(O2-°)、胞浆和线粒体MDA含量，提高了(Mn-SOD)、(Cu-Zn SOD)和(CAT)酶活性以及胞浆谷胱甘肽(GSH)的含量。蜂胶黄酮类化合物以浓度依赖的方式降低自由基DPPH°，抑制PTP开放和钙诱导的线粒体肿胀。经过长期处理，蜂胶类黄酮通过保护线粒体和增强酶和非酶抗氧化剂来保护肝组织免受氧化应激。蜂胶类黄酮耐受性良好，不含任何促氧化作用。关键词:阿尔及利亚蜂胶类黄酮;抗氧化-促氧化平衡;肝脏线粒体;西非药理学和药物研究杂志Vol 22/23 2007: pp. 16-26
{"title":"Effect of a Long Term Treatment by Algerian Propolis Flavonoids on Mitochondrial Antioxidant-Prooxidant Balance","authors":"K. Wided, Rouibah Hassiba, B. Nadia, B. Lamia, A. Mohamed, L. Mesbah","doi":"10.4314/WAJPDR.V22I1.14763","DOIUrl":"https://doi.org/10.4314/WAJPDR.V22I1.14763","url":null,"abstract":"Our study carried out in vivo, using liver mitochondria isolated from albinos rats, treats the effect of a long term treatment by Algerian propolis ethanolic extract and their flavonic aglycones and glycosides to the amount of 100 mg/kg on mitochondrial antioxidant-prooxidant balance. Our results showed that all extracts produced an antioxidant effect which is better than that of quercetin. They decreased superoxide anion production (O2-°) by mitochondrial respiratory chain complex III, cytosolic and mitochondrial MDA content, increased (Mn-SOD), (Cu-Zn SOD) and (CAT) enzymatic activities as well as the rate of cytosolic glutathione (GSH). Propolis flavonoids reduced free radical DPPH° in a concentration-dependent manner, inhibited PTP opening and calcium-induced mitochondrial swelling. After long term treatment, propolis flavonoids protected liver tissues from oxidative stress by protecting mitochondria and reinforcement of enzymatic and non enzymatic antioxidants. Propolis flavonoids are well tolerated and are free of any prooxidant effect. Keywords : Algerian propolis flavonoids, antioxidant-prooxidant balance, liver mitochondrion, long term effect. West African Journal of Pharmacology and Drug Research Vol. 22/23 2007: pp. 16-26","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"65 1","pages":"16-26"},"PeriodicalIF":0.0,"publicationDate":"2008-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79875222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2008-10-22DOI: 10.4314/WAJPDR.V22I1.14765
O. Adeyemi, E. Iwalewa, M. Akanmu, O. Ukponmwan
Pruritus or itch is associated with malaria infection and/or chloroquine chemotherapy. This study examined the relationship between parasitaemia and chloroquine (CQ) on body scratching (BS) in healthy (un-infected) and malaria-infected rats. The malaria parasite induced a significant (p Keywords : Rats, parasitaemia, chloroquine, opioids, antihistamine, naltrexone West African Journal of Pharmacology and Drug Research Vol. 22/23 2007: pp. 31-38
瘙痒或发痒与疟疾感染和/或氯喹化疗有关。本研究探讨了寄生虫血症与氯喹(CQ)对健康(未感染)和疟疾感染大鼠身体抓伤(BS)的影响。关键词:大鼠，寄生虫血症，氯喹，阿片类药物，抗组胺药，纳曲酮。西非药理学与药物研究Vol 22/23 2007: pp. 31-38
{"title":"Malaria Parasite Infection and Chloroquine-Induced Pruritus: The Role of Opioid-Peptides","authors":"O. Adeyemi, E. Iwalewa, M. Akanmu, O. Ukponmwan","doi":"10.4314/WAJPDR.V22I1.14765","DOIUrl":"https://doi.org/10.4314/WAJPDR.V22I1.14765","url":null,"abstract":"Pruritus or itch is associated with malaria infection and/or chloroquine chemotherapy. This study examined the relationship between parasitaemia and chloroquine (CQ) on body scratching (BS) in healthy (un-infected) and malaria-infected rats. The malaria parasite induced a significant (p Keywords : Rats, parasitaemia, chloroquine, opioids, antihistamine, naltrexone West African Journal of Pharmacology and Drug Research Vol. 22/23 2007: pp. 31-38","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"32 1","pages":"31-38"},"PeriodicalIF":0.0,"publicationDate":"2008-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77839209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2008-10-22DOI: 10.4314/WAJPDR.V22I1.14761
C. Obua, M. Ntale, J. Ogwal-Okeng, L. Hellgren, M. Petzold
The importance of drug concentrations, nutritional status and other host factors were explored in uncomplicated falciparum malaria therapy with fixed-dose chloroquine+sulfadoxine/pyrimethamine (CQ+SP). A total of 83 children were treated. Younger children (6-24months) were given half-strength (HS) and older children (2-5years) full-strength (FS) CQ+SP as recommended. The concentrations of CQ and sulfadoxine (S) were determined by HPLC in 100μl of capillary blood on filter paper. Multiple logistic regressions were used to determine associations with outcomes. Stunting (height-for-age Keywords : Malaria, treatment, nutritional status, chloroquine, sulfadoxine, fixed-dose combination West African Journal of Pharmacology and Drug Research Vol. 22/23 2007: pp. 1-9
探讨药物浓度、营养状况等宿主因素在固定剂量氯喹+磺胺多辛/乙胺嘧啶(CQ+SP)治疗无并发症恶性疟疾中的重要性。共有83名儿童接受了治疗。年龄较小的儿童(6-24个月)推荐给予半强度(HS)，年龄较大的儿童(2-5岁)给予全强度(FS) CQ+SP。采用高效液相色谱法测定100μl滤纸毛细管血中CQ和磺胺多辛的浓度。使用多重逻辑回归来确定与结果的关联。关键词:疟疾，治疗，营养状况，氯喹，磺胺多辛，固定剂量组合西非药理学和药物研究Vol 22/23 2007: pp. 1-9
{"title":"Importance of Drug Concentrations and Nutritional Status During Fixed-Dose Chloroquine and Sulfadoxine/Pyrimethamine Combination Treatment of Malaria","authors":"C. Obua, M. Ntale, J. Ogwal-Okeng, L. Hellgren, M. Petzold","doi":"10.4314/WAJPDR.V22I1.14761","DOIUrl":"https://doi.org/10.4314/WAJPDR.V22I1.14761","url":null,"abstract":"The importance of drug concentrations, nutritional status and other host factors were explored in uncomplicated falciparum malaria therapy with fixed-dose chloroquine+sulfadoxine/pyrimethamine (CQ+SP). A total of 83 children were treated. Younger children (6-24months) were given half-strength (HS) and older children (2-5years) full-strength (FS) CQ+SP as recommended. The concentrations of CQ and sulfadoxine (S) were determined by HPLC in 100μl of capillary blood on filter paper. Multiple logistic regressions were used to determine associations with outcomes. Stunting (height-for-age Keywords : Malaria, treatment, nutritional status, chloroquine, sulfadoxine, fixed-dose combination West African Journal of Pharmacology and Drug Research Vol. 22/23 2007: pp. 1-9","PeriodicalId":23624,"journal":{"name":"West African journal of pharmacology and drug research","volume":"32 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2008-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91061341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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