Pub Date : 2024-02-21DOI: 10.37022/wjcmpr.v6i1.311
Ahmed tawfeeq Ahmed, Dr.inas Hazim, Nibras hazim Hameed
Achondroplasia is a genetic condition with an autosomal dominant inheritance pattern. It is caused by detrimental heterozygous FGFR3 gene mutations. Gain-of-function mutations in the FGFR3 gene impair chondrocyte differentiation and proliferation, which has a negative impact on the formation of new bone. Vosoritide, also known as voxzogo, is the first pharmacological intervention to receive approval for the treatment of achondroplasia. This therapeutic agent has been sanctioned for administration via at-home injections, which are to be performed under the supervision of a proficient nurse.
{"title":"Role of vosoritide drug on children's with achondroplasia","authors":"Ahmed tawfeeq Ahmed, Dr.inas Hazim, Nibras hazim Hameed","doi":"10.37022/wjcmpr.v6i1.311","DOIUrl":"https://doi.org/10.37022/wjcmpr.v6i1.311","url":null,"abstract":"Achondroplasia is a genetic condition with an autosomal dominant inheritance pattern. It is caused by detrimental heterozygous FGFR3 gene mutations. Gain-of-function mutations in the FGFR3 gene impair chondrocyte differentiation and proliferation, which has a negative impact on the formation of new bone. Vosoritide, also known as voxzogo, is the first pharmacological intervention to receive approval for the treatment of achondroplasia. This therapeutic agent has been sanctioned for administration via at-home injections, which are to be performed under the supervision of a proficient nurse.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"16 48","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140442436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-12DOI: 10.37022/wjcmpr.v6i1.312
Thakur Tark Aseem, Jangid Vimla Prithvidas, Saurabh Tiwari, Ritesh Singh Harendra, Yadav Pradeep Lalbahadur, R. Chitti, Prakash Tigari, Megha Shri
Hypertension refers to a condition where the systemic artery blood pressure exceeds normal levels, necessitating increased cardiac effort to counteract the elevated pressure and ensure adequate blood flow to tissues. The heightened systemic arterial pressure places stress on the heart and other arteries, contributing to the development of hypertension. In our cross-sectional observational study, we employed questionnaires to gather data from volunteers over a three-month period. The inclusion and exclusion criteria were carefully applied to ensure the relevance of the collected data. Our study included 120 individuals from the selected region, aiming to assess blood pressure monitoring. The study revealed a dominance of males, constituting 51.67% of the total participants, while women accounted for 48.33%. The age distribution showed that 46.67% of the volunteers fell within the 31 to 40 age group. Our findings indicated that age, gender, and occupation significantly influenced blood pressure monitoring. Upon analysis, we observed a statistically significant improvement in volunteers' knowledge, attitudes, and practices regarding hypertension following counseling. This suggests the potential efficacy of intervention strategies in enhancing awareness and management of hypertension among the studied population.
{"title":"Health pulse initiative: tracking blood pressure in akshaya group's teaching and non-teaching staff","authors":"Thakur Tark Aseem, Jangid Vimla Prithvidas, Saurabh Tiwari, Ritesh Singh Harendra, Yadav Pradeep Lalbahadur, R. Chitti, Prakash Tigari, Megha Shri","doi":"10.37022/wjcmpr.v6i1.312","DOIUrl":"https://doi.org/10.37022/wjcmpr.v6i1.312","url":null,"abstract":"Hypertension refers to a condition where the systemic artery blood pressure exceeds normal levels, necessitating increased cardiac effort to counteract the elevated pressure and ensure adequate blood flow to tissues. The heightened systemic arterial pressure places stress on the heart and other arteries, contributing to the development of hypertension. In our cross-sectional observational study, we employed questionnaires to gather data from volunteers over a three-month period. The inclusion and exclusion criteria were carefully applied to ensure the relevance of the collected data. Our study included 120 individuals from the selected region, aiming to assess blood pressure monitoring. The study revealed a dominance of males, constituting 51.67% of the total participants, while women accounted for 48.33%. The age distribution showed that 46.67% of the volunteers fell within the 31 to 40 age group. Our findings indicated that age, gender, and occupation significantly influenced blood pressure monitoring. Upon analysis, we observed a statistically significant improvement in volunteers' knowledge, attitudes, and practices regarding hypertension following counseling. This suggests the potential efficacy of intervention strategies in enhancing awareness and management of hypertension among the studied population.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"5 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139783249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-12DOI: 10.37022/wjcmpr.v6i1.312
Thakur Tark Aseem, Jangid Vimla Prithvidas, Saurabh Tiwari, Ritesh Singh Harendra, Yadav Pradeep Lalbahadur, R. Chitti, Prakash Tigari, Megha Shri
Hypertension refers to a condition where the systemic artery blood pressure exceeds normal levels, necessitating increased cardiac effort to counteract the elevated pressure and ensure adequate blood flow to tissues. The heightened systemic arterial pressure places stress on the heart and other arteries, contributing to the development of hypertension. In our cross-sectional observational study, we employed questionnaires to gather data from volunteers over a three-month period. The inclusion and exclusion criteria were carefully applied to ensure the relevance of the collected data. Our study included 120 individuals from the selected region, aiming to assess blood pressure monitoring. The study revealed a dominance of males, constituting 51.67% of the total participants, while women accounted for 48.33%. The age distribution showed that 46.67% of the volunteers fell within the 31 to 40 age group. Our findings indicated that age, gender, and occupation significantly influenced blood pressure monitoring. Upon analysis, we observed a statistically significant improvement in volunteers' knowledge, attitudes, and practices regarding hypertension following counseling. This suggests the potential efficacy of intervention strategies in enhancing awareness and management of hypertension among the studied population.
{"title":"Health pulse initiative: tracking blood pressure in akshaya group's teaching and non-teaching staff","authors":"Thakur Tark Aseem, Jangid Vimla Prithvidas, Saurabh Tiwari, Ritesh Singh Harendra, Yadav Pradeep Lalbahadur, R. Chitti, Prakash Tigari, Megha Shri","doi":"10.37022/wjcmpr.v6i1.312","DOIUrl":"https://doi.org/10.37022/wjcmpr.v6i1.312","url":null,"abstract":"Hypertension refers to a condition where the systemic artery blood pressure exceeds normal levels, necessitating increased cardiac effort to counteract the elevated pressure and ensure adequate blood flow to tissues. The heightened systemic arterial pressure places stress on the heart and other arteries, contributing to the development of hypertension. In our cross-sectional observational study, we employed questionnaires to gather data from volunteers over a three-month period. The inclusion and exclusion criteria were carefully applied to ensure the relevance of the collected data. Our study included 120 individuals from the selected region, aiming to assess blood pressure monitoring. The study revealed a dominance of males, constituting 51.67% of the total participants, while women accounted for 48.33%. The age distribution showed that 46.67% of the volunteers fell within the 31 to 40 age group. Our findings indicated that age, gender, and occupation significantly influenced blood pressure monitoring. Upon analysis, we observed a statistically significant improvement in volunteers' knowledge, attitudes, and practices regarding hypertension following counseling. This suggests the potential efficacy of intervention strategies in enhancing awareness and management of hypertension among the studied population.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"311 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139843026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-23DOI: 10.37022/wjcmpr.v5i6.310
G. M, Jahnavi S, Reena Priyadarshini G, Swathi Priya K, Niveditha D
Diabetes is due to either the pancreas not producing enough insulin, or the cells of the body not responding properly to the insulin produced. This study was carried out with an objective to determine the efficacy of Metformin with other oral hypoglycemic agents, to educate the patients about the disease and use of drugs in diabetes mellitus and to evaluate which class of drugs in oral hypoglycemic agents with Metformin shows more effectiveness. The patients in each group received the medication for 8 weeks duration. A study was carried out about the comparative, efficacy of glimepiride and metformin in type-2 DM which was a meta-analysis of randomized controlled trials. The results of the study were that metformin alone does not show the efficacy than with Metformin+ Teneligliptin and Metformin + Glimepiride in overall efficacy of controlling FBS and PPBS. Combination of Metformin+ Glimepiride is more effective than Metformin+ Teneligliptin and Metformin alone. The findings from the study observed the combination of metformin efficacy to some extent.
{"title":"A prospective observational study on safety and efficacy of metformin and its combination used in type-ii diabetes mellitus patients","authors":"G. M, Jahnavi S, Reena Priyadarshini G, Swathi Priya K, Niveditha D","doi":"10.37022/wjcmpr.v5i6.310","DOIUrl":"https://doi.org/10.37022/wjcmpr.v5i6.310","url":null,"abstract":"Diabetes is due to either the pancreas not producing enough insulin, or the cells of the body not responding properly to the insulin produced. This study was carried out with an objective to determine the efficacy of Metformin with other oral hypoglycemic agents, to educate the patients about the disease and use of drugs in diabetes mellitus and to evaluate which class of drugs in oral hypoglycemic agents with Metformin shows more effectiveness. The patients in each group received the medication for 8 weeks duration. A study was carried out about the comparative, efficacy of glimepiride and metformin in type-2 DM which was a meta-analysis of randomized controlled trials. The results of the study were that metformin alone does not show the efficacy than with Metformin+ Teneligliptin and Metformin + Glimepiride in overall efficacy of controlling FBS and PPBS. Combination of Metformin+ Glimepiride is more effective than Metformin+ Teneligliptin and Metformin alone. The findings from the study observed the combination of metformin efficacy to some extent.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"161 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139161202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-17DOI: 10.37022/wjcmpr.v5i6.308
Sameera Begum, Rajasekhar S
Non-communicable diseases like diabetes mellitus are becoming major health problem these days. There is an increasing demand by patients to use the natural products (plants) with anti-diabetic activity due to the severe side effects associated with the use of insulin and oral anti-diabetic drugs. One such plant is Justicia tranquebareinsis which has been traditionally used for the treatment of diabetes mellitus. The aim of this study was, therefore, to evaluate hypoglycemic activity of ethanol extract of Justicia tranquebareinsis in streptozotocin-induced diabetic rats, respectively and to carry out acute toxicity test. Two doses (200 mg/kg and 400 mg/kg) of the ethanol extract of Justicia tranquebareinsis were administered to normal glucose loaded and diabetic rat to study blood glucose lowering effect. Ethanol extract of Justicia tranquebareinsis (200mg/kg and 400mg/kg, p.o.) showed significant tolerance (P < 0.05) to oral glucose load at 1 and 2 hrs after glucose load. The extract also produced significant (P < 0.05) blood glucose reduction at 4 hours after its administration in normoglycemic mice. The extract at 400mg/kg dose level produced significant (P < 0.05) reduction in blood glucose level at 2, 3 and 4 hours of treatment in streptozotocin (45 mg/kg) induced diabetic mice. Acute oral toxicity studies of ethanol extract of Justicia tranquebareinsis in rats showed no death or signs of toxicity at the dose of 2000 mg/kg indicating the safety nature of the extract. The results of the experiments showed that ethanol extract of Justicia tranquebareinsis has significant antihyperglycemic activity in streptozotocin induced diabetic rat and improvement in glucose tolerance and slight hypoglycemic activity in normal rat justifying the traditional claim for its use in diabetes.
{"title":"Pharmacological screening of antidiabetic activity of ethanolic extracts of justicia tranquebarensis on streptozocin induced rats.","authors":"Sameera Begum, Rajasekhar S","doi":"10.37022/wjcmpr.v5i6.308","DOIUrl":"https://doi.org/10.37022/wjcmpr.v5i6.308","url":null,"abstract":"Non-communicable diseases like diabetes mellitus are becoming major health problem these days. There is an increasing demand by patients to use the natural products (plants) with anti-diabetic activity due to the severe side effects associated with the use of insulin and oral anti-diabetic drugs. One such plant is Justicia tranquebareinsis which has been traditionally used for the treatment of diabetes mellitus. The aim of this study was, therefore, to evaluate hypoglycemic activity of ethanol extract of Justicia tranquebareinsis in streptozotocin-induced diabetic rats, respectively and to carry out acute toxicity test. Two doses (200 mg/kg and 400 mg/kg) of the ethanol extract of Justicia tranquebareinsis were administered to normal glucose loaded and diabetic rat to study blood glucose lowering effect. Ethanol extract of Justicia tranquebareinsis (200mg/kg and 400mg/kg, p.o.) showed significant tolerance (P < 0.05) to oral glucose load at 1 and 2 hrs after glucose load. The extract also produced significant (P < 0.05) blood glucose reduction at 4 hours after its administration in normoglycemic mice. The extract at 400mg/kg dose level produced significant (P < 0.05) reduction in blood glucose level at 2, 3 and 4 hours of treatment in streptozotocin (45 mg/kg) induced diabetic mice. Acute oral toxicity studies of ethanol extract of Justicia tranquebareinsis in rats showed no death or signs of toxicity at the dose of 2000 mg/kg indicating the safety nature of the extract. The results of the experiments showed that ethanol extract of Justicia tranquebareinsis has significant antihyperglycemic activity in streptozotocin induced diabetic rat and improvement in glucose tolerance and slight hypoglycemic activity in normal rat justifying the traditional claim for its use in diabetes.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"15 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138966280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-05DOI: 10.37022/wjcmpr.v5i6.301
Ramos Silalahi, Frans Lazio, Silvia Witarsih
Osteoarthritis (OA) is the most prevalent type of joint disorder. Symptomatic hip OA was observed in 9.2% of adults aged 45 and above, with 27% displaying radiographic evidence of the condition. While there is no definitive cure for OA, numerous research studies have explored the application of PRP (Platelet-Rich Plasma) for addressing knee OA, there is a relatively limited number of investigations dedicated to hip OA. It is important to note that the hip joint possesses distinct characteristics compared to the other three joints. Therefore, in this systematic review, we wanted to focus on hip osteoarthritis and gave a brief update from the previous studies. This systematic review was conducted in accordance with the Preferred Reporting Items of Systematic Reviews (PRISMA) guidelines. All randomized control trials that compared injection of Platelet-Rich Plasma and Hyaluronic Acid in hip osteoarthritis patients using English language from 2018 until 2023 will be included. Six studies involved in this study with total samples of 237 in PRP group and 220 in HA group. The injection site, injection volume, number of injections, interval, and follow up were varied between these studies. All of the patients are undergoing treatment with ultrasound-guided intraarticular injections of PRP. The outcomes tabulated were Visual Analog Scale (VAS), Harris Hip Score (HHS), and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score which showed improvements from the baseline. All of the studies showed improvement of the score from the baseline. Although, there were improvements, it can be concluded that there was not enough evidence to promote the utilization of intra-articular PRP injections as a treatment for hip osteoarthritis. Since international guidelines only recommend intra-articular steroid injections for managing hip OA, it would be advantageous to conduct additional studies comparing PRP to steroids to assess the effectiveness of PRP injections in treating hip OA.
骨关节炎（OA）是最常见的关节疾病。在 45 岁及以上的成年人中，有 9.2% 的人出现有症状的髋关节 OA，27% 的人有影像学证据。虽然目前还没有彻底治愈 OA 的方法，但已有许多研究探索了应用血小板丰富血浆（PRP）治疗膝关节 OA 的方法，但专门针对髋关节 OA 的研究却相对有限。值得注意的是，与其他三个关节相比，髋关节具有独特的特点。因此，在本系统综述中，我们希望重点关注髋关节骨性关节炎，并简要介绍了以往研究的最新进展。本系统综述是根据系统综述首选报告项目（PRISMA）指南进行的。将纳入2018年至2023年期间使用英语对髋关节骨关节炎患者注射富血小板血浆和透明质酸进行比较的所有随机对照试验。本研究共涉及六项研究，PRP 组样本总数为 237 个，HA 组样本总数为 220 个。 这些研究的注射部位、注射量、注射次数、间隔时间和随访情况各不相同。所有患者都接受了超声引导下的 PRP 关节内注射治疗。研究结果表明，视觉模拟量表（VAS）、哈里斯髋关节评分（HHS）和西安大略和麦克马斯特大学骨关节炎指数（WOMAC）评分均比基线有所改善。所有的研究都显示，与基线相比，评分有所提高。虽然有所改善，但可以得出结论，没有足够的证据表明关节内注射 PRP 可作为髋关节骨关节炎的治疗方法。由于国际指南只推荐关节内注射类固醇来治疗髋关节OA，因此最好进行更多的研究，比较PRP和类固醇，以评估PRP注射治疗髋关节OA的效果。
{"title":"Platelet-rich plasma injections for hip osteoarthritis : a systematic review","authors":"Ramos Silalahi, Frans Lazio, Silvia Witarsih","doi":"10.37022/wjcmpr.v5i6.301","DOIUrl":"https://doi.org/10.37022/wjcmpr.v5i6.301","url":null,"abstract":"Osteoarthritis (OA) is the most prevalent type of joint disorder. Symptomatic hip OA was observed in 9.2% of adults aged 45 and above, with 27% displaying radiographic evidence of the condition. While there is no definitive cure for OA, numerous research studies have explored the application of PRP (Platelet-Rich Plasma) for addressing knee OA, there is a relatively limited number of investigations dedicated to hip OA. It is important to note that the hip joint possesses distinct characteristics compared to the other three joints. Therefore, in this systematic review, we wanted to focus on hip osteoarthritis and gave a brief update from the previous studies. This systematic review was conducted in accordance with the Preferred Reporting Items of Systematic Reviews (PRISMA) guidelines. All randomized control trials that compared injection of Platelet-Rich Plasma and Hyaluronic Acid in hip osteoarthritis patients using English language from 2018 until 2023 will be included. Six studies involved in this study with total samples of 237 in PRP group and 220 in HA group. The injection site, injection volume, number of injections, interval, and follow up were varied between these studies. All of the patients are undergoing treatment with ultrasound-guided intraarticular injections of PRP. The outcomes tabulated were Visual Analog Scale (VAS), Harris Hip Score (HHS), and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score which showed improvements from the baseline. All of the studies showed improvement of the score from the baseline. Although, there were improvements, it can be concluded that there was not enough evidence to promote the utilization of intra-articular PRP injections as a treatment for hip osteoarthritis. Since international guidelines only recommend intra-articular steroid injections for managing hip OA, it would be advantageous to conduct additional studies comparing PRP to steroids to assess the effectiveness of PRP injections in treating hip OA.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"244 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138985124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-26DOI: 10.37022/wjcmpr.v5i6.302
Suresh Balaji N, Kathirvel S, A. N
Aim The aim of the study was to assess the Heavy metal analysis, pesticide residue and aflatoxin assay of Siddha herbal formulation “Madhumega Nivarani Chooranam”, used for the management of Madhumegam (Type-II Diabetes mellitus) Materials and Method According to the procedure that is stated in the Siddha text "The Pharmacopoeia of Siddha Research Medicines," the siddha poly herbal formulation was formulated in accordance with good manufacturing practises (GMP) regulations. Aflatoxin assay, pesticide residue analysis, and heavy metal analysis these studies were all carried out at Nobel Research Solutions in Chennai. Results The above assay, which used AAS to identify Heavy metals in the siddha medicine Madhumega Nivaran iChooranam revealed BDL (below detective level), presence of lead and arsenic at 1.14 PPM and 0.34 PPM level as listed in the table. The study revealed absence of Aflatoxin and pesticide residues in the given sample. It is indicating that this drug is safe to use. Conclusion According to the results, the sample Madhumega Nivarani Chooranam (MNC) has been determined to be safe throughout the present screening process, with the presence of heavy metals below the detection limit, Devoid of aflatoxins, as well as Residues of Pesticides. Hence, the current study reveals the drug was safe for therapeutic use
{"title":"Heavy metal analysis, pesticide residue analysis and aflatoxin assay of siddha herbal formulationmadhumega nivarani chooranam","authors":"Suresh Balaji N, Kathirvel S, A. N","doi":"10.37022/wjcmpr.v5i6.302","DOIUrl":"https://doi.org/10.37022/wjcmpr.v5i6.302","url":null,"abstract":"Aim The aim of the study was to assess the Heavy metal analysis, pesticide residue and aflatoxin assay of Siddha herbal formulation “Madhumega Nivarani Chooranam”, used for the management of Madhumegam (Type-II Diabetes mellitus) Materials and Method According to the procedure that is stated in the Siddha text \"The Pharmacopoeia of Siddha Research Medicines,\" the siddha poly herbal formulation was formulated in accordance with good manufacturing practises (GMP) regulations. Aflatoxin assay, pesticide residue analysis, and heavy metal analysis these studies were all carried out at Nobel Research Solutions in Chennai. Results The above assay, which used AAS to identify Heavy metals in the siddha medicine Madhumega Nivaran iChooranam revealed BDL (below detective level), presence of lead and arsenic at 1.14 PPM and 0.34 PPM level as listed in the table. The study revealed absence of Aflatoxin and pesticide residues in the given sample. It is indicating that this drug is safe to use. Conclusion According to the results, the sample Madhumega Nivarani Chooranam (MNC) has been determined to be safe throughout the present screening process, with the presence of heavy metals below the detection limit, Devoid of aflatoxins, as well as Residues of Pesticides. Hence, the current study reveals the drug was safe for therapeutic use","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"21 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139235525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ivermectin, a broad-spectrum antiparasitic agent, has demonstrated significant therapeutic efficacy against various skin conditions. However, it's poor skin permeability and limited stability often hinder its clinical application. Emulgel, a hybrid dosage form combining the advantages of both emulsions and gels, has emerged as a promising topical delivery system to enhance the skin permeation and stability of poorly permeable drugs. In this study, we aimed to formulate and characterize an Ivermectin emulgel to address the challenges associated with its topical delivery. The emulgel was prepared using a two-step method, involving the preparation of an oil-in-water (o/w) emulsion, which was then gelled with suitable gelling agents. Different concentrations of Ivermectin, oil phase, surfactants, and gelling agents were screened to optimize the formulation for maximum drug loading and stability. The optimized Ivermectin emulgel was characterized for its physicochemical properties, including pH, viscosity, spreadability, drug content, and rheological behavior. The study's findings support the potential application of the emulgel in treating various skin conditions caused by parasites and infectious agents. Further, in vivo studies and clinical trials are required to validate its safety and effectiveness in a clinical setting.
{"title":"Formulation and evaluation of ivermectin emulgel formulations","authors":"Vaibhav Joshi, Kapil Kumar, Anjali Negi, Aparna Joshi, Vaishali Rajput","doi":"10.37022/wjcmpr.v5i5.295","DOIUrl":"https://doi.org/10.37022/wjcmpr.v5i5.295","url":null,"abstract":"Ivermectin, a broad-spectrum antiparasitic agent, has demonstrated significant therapeutic efficacy against various skin conditions. However, it's poor skin permeability and limited stability often hinder its clinical application. Emulgel, a hybrid dosage form combining the advantages of both emulsions and gels, has emerged as a promising topical delivery system to enhance the skin permeation and stability of poorly permeable drugs. In this study, we aimed to formulate and characterize an Ivermectin emulgel to address the challenges associated with its topical delivery. The emulgel was prepared using a two-step method, involving the preparation of an oil-in-water (o/w) emulsion, which was then gelled with suitable gelling agents. Different concentrations of Ivermectin, oil phase, surfactants, and gelling agents were screened to optimize the formulation for maximum drug loading and stability. The optimized Ivermectin emulgel was characterized for its physicochemical properties, including pH, viscosity, spreadability, drug content, and rheological behavior. The study's findings support the potential application of the emulgel in treating various skin conditions caused by parasites and infectious agents. Further, in vivo studies and clinical trials are required to validate its safety and effectiveness in a clinical setting.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"27 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135979523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aquaculture sector continues to be an essential source of food, revenue, nutrition, and a means of subsistence for numerous people globally. Intensive aquaculture in a confined region induces environmental stress in farmed fish, which indirectly increases their vulnerability to many diseases. Aeromonas hydrophila, Pseudomonas aeruginosa, and Vibrio harveyi are the causative bacterial pathogens for septicemia, the most prevalent and commonly seen illness. Disease outbreaks result in a rise in mortality or a decrease in the quality of the meat, consequently inflicting substantial economic losses to carp production. In contrast, the continual use of antibiotics for infection management has contributed to the proliferation of drug-resistant bacteria in aquatic environments. In this context, marine actinobacteria are emerging as possible sources of new secondary metabolites to combat the problem. Actinobacteria are undoubtedly the most prolific producers of secondary metabolites, and they comprise several commercially and biotechnologically significant species. In this investigation, marine actinobacteria were isolated and evaluated for their antibacterial effectiveness against septicemia pathogens. Effective strains were identified as Nocardiopsis sp., Streptomyces sp., and Pseudonocardia sp. Candidate strains culture filtrates were treated with acetone to precipitate complete proteins. The antibacterial and anti-quorum sensing properties of the crude protein against A. hydrophila MTCC 1739 and P. aeruginosa MTCC 9425 were also examined using the agar well diffusion method. In addition, in vivo investigations of the low molecular weight fraction on Labeorohita demonstrated the fraction's efficacy in reducing septicemia infection. After the 8th day of bathing, fish were found to have recovered.
{"title":"Antibacterial protein fraction derived from Streptomyces fradiae against septicemia infection in Labeorohita: Breakthrough in marine drug discovery","authors":"Petchiyammal S, Ramasubramanian Vekatachalam, Brindha Priyadarisini Venkatesan","doi":"10.37022/wjcmpr.v5i5.299","DOIUrl":"https://doi.org/10.37022/wjcmpr.v5i5.299","url":null,"abstract":"The aquaculture sector continues to be an essential source of food, revenue, nutrition, and a means of subsistence for numerous people globally. Intensive aquaculture in a confined region induces environmental stress in farmed fish, which indirectly increases their vulnerability to many diseases. Aeromonas hydrophila, Pseudomonas aeruginosa, and Vibrio harveyi are the causative bacterial pathogens for septicemia, the most prevalent and commonly seen illness. Disease outbreaks result in a rise in mortality or a decrease in the quality of the meat, consequently inflicting substantial economic losses to carp production. In contrast, the continual use of antibiotics for infection management has contributed to the proliferation of drug-resistant bacteria in aquatic environments. In this context, marine actinobacteria are emerging as possible sources of new secondary metabolites to combat the problem. Actinobacteria are undoubtedly the most prolific producers of secondary metabolites, and they comprise several commercially and biotechnologically significant species. In this investigation, marine actinobacteria were isolated and evaluated for their antibacterial effectiveness against septicemia pathogens. Effective strains were identified as Nocardiopsis sp., Streptomyces sp., and Pseudonocardia sp. Candidate strains culture filtrates were treated with acetone to precipitate complete proteins. The antibacterial and anti-quorum sensing properties of the crude protein against A. hydrophila MTCC 1739 and P. aeruginosa MTCC 9425 were also examined using the agar well diffusion method. In addition, in vivo investigations of the low molecular weight fraction on Labeorohita demonstrated the fraction's efficacy in reducing septicemia infection. After the 8th day of bathing, fish were found to have recovered.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-16DOI: 10.37022/wjcmpr.v5i5.297
Putu Teguh Aryanugraha, I Gusti Ngurah Wien Aryana, Andrew Sutheno, Dominicus Dimitri, Frans Lazio
Introduction: Heterotropic Ossification (HO) is a devastating condition felt by patients and surgeons. It was caused by inflammatory response triggered by injury through various processes. NSAID is thought to have a capability to limit the process, hence preventing the condition.
Materials and Methods: Various database has been used to search for literatures included in this review. Screening and evaluation were conducted for researches.
Results: Seven studies are included in this review and a table has been formed to show the comparison of HO and Control.
Discussion : This study aimed to assess the occurrence of heterotopic ossification (HO) after hip arthroscopy and compare outcomes between those who received prophylactic nonsteroidal anti-inflammatory drugs (NSAIDs) and those who did not. The hypothesis was that NSAIDs could reduce postoperative HO. The significance of this trend varied in retrospective research due to differences in NSAID regimens. The usefulness of NSAID prophylaxis should be carefully weighed against potential side effects, and patient compliance should be assessed in future research, as it was inconsistently reported in the existing literature.
Conclusion: NSAID lower the rate of postoperative HO, however, more studies need to be conducted to analyze certain efficacy of certain type of HO
{"title":"Outcomes comparison between nsaid and placebo in the occurrence of heterotopic ossification after hip surgery: a systematic review","authors":"Putu Teguh Aryanugraha, I Gusti Ngurah Wien Aryana, Andrew Sutheno, Dominicus Dimitri, Frans Lazio","doi":"10.37022/wjcmpr.v5i5.297","DOIUrl":"https://doi.org/10.37022/wjcmpr.v5i5.297","url":null,"abstract":"Introduction: Heterotropic Ossification (HO) is a devastating condition felt by patients and surgeons. It was caused by inflammatory response triggered by injury through various processes. NSAID is thought to have a capability to limit the process, hence preventing the condition.
 Materials and Methods: Various database has been used to search for literatures included in this review. Screening and evaluation were conducted for researches.
 Results: Seven studies are included in this review and a table has been formed to show the comparison of HO and Control.
 Discussion : This study aimed to assess the occurrence of heterotopic ossification (HO) after hip arthroscopy and compare outcomes between those who received prophylactic nonsteroidal anti-inflammatory drugs (NSAIDs) and those who did not. The hypothesis was that NSAIDs could reduce postoperative HO. The significance of this trend varied in retrospective research due to differences in NSAID regimens. The usefulness of NSAID prophylaxis should be carefully weighed against potential side effects, and patient compliance should be assessed in future research, as it was inconsistently reported in the existing literature.
 Conclusion: NSAID lower the rate of postoperative HO, however, more studies need to be conducted to analyze certain efficacy of certain type of HO","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136182884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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