Pub Date : 2021-10-08DOI: 10.37022/WJCMPR.V3I5.191
I. Made, Bayu Puradipa, Cyndiana Widia, Dewi Sinardja
Background. Global Pandemic of COVID-19 is a viral infection caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that primary target in respiratory system and spread rapidly around the world through droplets and direct contact. On the other side, COVID-19 affects to damage the myocardial causing acute heart attacks including Unstable Angina (UAP), Non-ST Elevation Myocardial Infraction (NSTEMI) or ST Elevation Myocardial Infarction (STEMI) and still represents a major cause of morbidity and mortality worldwide that affects about 15.5 million in the United States. The common risk factors of ACS are male sex, family history of early myocardial infarction (55 years old), hypertension, diabetes, hyperlipidemia, smoking, sedentary lifestyle, and obesity. However, in this case report the viral infection is the only main cause of ACS Case Description. A male 65 years old came to ER complained shortness of breath with no comobid. The ECG showed sinus rhythm, right bundle branch block, lateral ischemia. The COVID-19 RT-PCR resulted was positive with elevation of cardiac enzymes. Discussion. ACE2 mediated SARS-CoV-2 enters into the lung alveolar epithelial cell and host cell. ACE2 is also spread widely in human heart, and vessels. Infection of endothelial and pericytes could lead to microvascular and microvascular dysfunction. Cytokine storm, increasing interleukin (IL)-6, IL-7, IL-22, and CXCL10 may leading to atherosclerosis plaque instability or rupture and contributing to development of acute coronary events. Conclusion. COVID-19 can lead to NSTEMI. Although cardiac biomarker was high, NSTEMI need further examination including coronary angiography.
{"title":"Coronavirus Disease 19 (COVID-19) Affects the Occurrence of Acute Heart Attacks: Case Report","authors":"I. Made, Bayu Puradipa, Cyndiana Widia, Dewi Sinardja","doi":"10.37022/WJCMPR.V3I5.191","DOIUrl":"https://doi.org/10.37022/WJCMPR.V3I5.191","url":null,"abstract":"Background. Global Pandemic of COVID-19 is a viral infection caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that primary target in respiratory system and spread rapidly around the world through droplets and direct contact. On the other side, COVID-19 affects to damage the myocardial causing acute heart attacks including Unstable Angina (UAP), Non-ST Elevation Myocardial Infraction (NSTEMI) or ST Elevation Myocardial Infarction (STEMI) and still represents a major cause of morbidity and mortality worldwide that affects about 15.5 million in the United States. The common risk factors of ACS are male sex, family history of early myocardial infarction (55 years old), hypertension, diabetes, hyperlipidemia, smoking, sedentary lifestyle, and obesity. However, in this case report the viral infection is the only main cause of ACS \u0000Case Description. A male 65 years old came to ER complained shortness of breath with no comobid. The ECG showed sinus rhythm, right bundle branch block, lateral ischemia. The COVID-19 RT-PCR resulted was positive with elevation of cardiac enzymes. \u0000Discussion. ACE2 mediated SARS-CoV-2 enters into the lung alveolar epithelial cell and host cell. ACE2 is also spread widely in human heart, and vessels. Infection of endothelial and pericytes could lead to microvascular and microvascular dysfunction. Cytokine storm, increasing interleukin (IL)-6, IL-7, IL-22, and CXCL10 may leading to atherosclerosis plaque instability or rupture and contributing to development of acute coronary events. \u0000Conclusion. COVID-19 can lead to NSTEMI. Although cardiac biomarker was high, NSTEMI need further examination including coronary angiography.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73682233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-08DOI: 10.37022/WJCMPR.V3I5.192
Chudamani Sunandini Katikala, Ramaiah Maddi
The United States (US) remains the greatest medical device (MD) market on earth $156 billion (40 percent of the overall MD market in 2017). By 2023, it is depended upon to create to $208 billion. As per USFDA, the MD are orchestrated into three classifications. The U.S. Food and Drug Administration's and Center for Devices and Radiological Health (CDRH) supervises MD advertised in the United States. The United States Federal Food, Drug, and Cosmetic Act (abbreviated as FFDCA, FDCA, or FD&C) is a group of laws passed by Congress in 1938 offering power to the U.S. Food and Drug organization (FDA) to administer the safety of food, drugs, cosmetic products and MD’s. An Emergency Use Authorization (EUA) under Section 564 of the FD&C Act considers the unique utilization of medications and other clinical products during particular kinds of crises. This review articles focused the process of EUA of medical products u/s 564 of the Federal Food Drug and Cosmetic Act, USA.
{"title":"Regulatory considerations for emergency use authorizations of medical products U/s 564 of the federal food drug and cosmetic act, usa","authors":"Chudamani Sunandini Katikala, Ramaiah Maddi","doi":"10.37022/WJCMPR.V3I5.192","DOIUrl":"https://doi.org/10.37022/WJCMPR.V3I5.192","url":null,"abstract":"The United States (US) remains the greatest medical device (MD) market on earth $156 billion (40 percent of the overall MD market in 2017). By 2023, it is depended upon to create to $208 billion. As per USFDA, the MD are orchestrated into three classifications. The U.S. Food and Drug Administration's and Center for Devices and Radiological Health (CDRH) supervises MD advertised in the United States. The United States Federal Food, Drug, and Cosmetic Act (abbreviated as FFDCA, FDCA, or FD&C) is a group of laws passed by Congress in 1938 offering power to the U.S. Food and Drug organization (FDA) to administer the safety of food, drugs, cosmetic products and MD’s. An Emergency Use Authorization (EUA) under Section 564 of the FD&C Act considers the unique utilization of medications and other clinical products during particular kinds of crises. This review articles focused the process of EUA of medical products u/s 564 of the Federal Food Drug and Cosmetic Act, USA.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88260264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-04DOI: 10.37022/WJCMPR.V3I5.190
Shirisha Jakkula, Pravalika Pasupuleti, Mujeebuddin C.S, Ravi Gaur, Sujay S. Patil
In clinical research, Decentralized clinical trials (DCTs) can provide opportunities to maximize efficiencies. Unlike the traditional clinical trial model, Decentralized Clinical Trials (DCTs) promote telemedicine, mobile/local healthcare providers (HCPs), mobile/web-based technology, and direct distribution of Investigational Medicinal Products (IMP) to patients, among other things. Hence, DCTs are in the spotlight as technology, infrastructure, and knowledge providing a backbone in clinical research. Background: Advances in electronic communication, data storage, emerging technologies, and biosensor development provides new opportunities to exchange information, such as the patient is tested from their home locations and are with locations distant from the investigator. Trials that take place at locations distant from the investigator (i.e., spectrum: CCTs → Hybrid Models → DCTs) in any or all study-related procedures and data is collected electronically fall in the category of the decentralized clinical trial. Trials should be designed to integrate the current healthcare system of the study subject, optimize convenience for study subjects and take advantage of existing programs and data sources including The study subjects themselves through the utilization of telecommunication, videoconferences, mobile or internet-based tools for patient reporting, mobile technology tools and biosensors. Local healthcare providers, home-based healthcare services, pharmacies, clinics, regional hospitals, their perceived obstacles have impeded the widespread use of mobile devices in clinical trials. To encourage solutions to these challenges, The Clinical Trial Transformation Initiative (CTTI) has released best practices and practical methods to advance solutions to these issues that clinical trial sponsors can now use. Conclusion: Decentralized clinical trials are not only operationally feasible and show high recruitment rates, have better compliance, lower dropout rates, and are conducted faster. DCT meets the goal of the industry in being low-risk, high returns trials and can offer a reliable, time-based, and cost-effective approach.
{"title":"Clinical trials tranformation intiative-decentralized clinical trials: a review article","authors":"Shirisha Jakkula, Pravalika Pasupuleti, Mujeebuddin C.S, Ravi Gaur, Sujay S. Patil","doi":"10.37022/WJCMPR.V3I5.190","DOIUrl":"https://doi.org/10.37022/WJCMPR.V3I5.190","url":null,"abstract":"In clinical research, Decentralized clinical trials (DCTs) can provide opportunities to maximize efficiencies. Unlike the traditional clinical trial model, Decentralized Clinical Trials (DCTs) promote telemedicine, mobile/local healthcare providers (HCPs), mobile/web-based technology, and direct distribution of Investigational Medicinal Products (IMP) to patients, among other things. Hence, DCTs are in the spotlight as technology, infrastructure, and knowledge providing a backbone in clinical research. \u0000Background: Advances in electronic communication, data storage, emerging technologies, and biosensor development provides new opportunities to exchange information, such as the patient is tested from their home locations and are with locations distant from the investigator. Trials that take place at locations distant from the investigator (i.e., spectrum: CCTs → Hybrid Models → DCTs) in any or all study-related procedures and data is collected electronically fall in the category of the decentralized clinical trial. Trials should be designed to integrate the current healthcare system of the study subject, optimize convenience for study subjects and take advantage of existing programs and data sources including The study subjects themselves through the utilization of telecommunication, videoconferences, mobile or internet-based tools for patient reporting, mobile technology tools and biosensors. Local healthcare providers, home-based healthcare services, pharmacies, clinics, regional hospitals, their perceived obstacles have impeded the widespread use of mobile devices in clinical trials. To encourage solutions to these challenges, The Clinical Trial Transformation Initiative (CTTI) has released best practices and practical methods to advance solutions to these issues that clinical trial sponsors can now use. \u0000Conclusion: Decentralized clinical trials are not only operationally feasible and show high recruitment rates, have better compliance, lower dropout rates, and are conducted faster. DCT meets the goal of the industry in being low-risk, high returns trials and can offer a reliable, time-based, and cost-effective approach.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87575528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-31DOI: 10.37022/wjcmpr.v3i4.188
A. Bala, A. Singh, A. Singh
Ficus thonningii is a plant that is widely utilised in African ethnomedicine to cure a variety of ailments. a rational examination of F. thonningii's nutritional, phytochemical, and pharmacological characteristics in connection to its medicinal uses.Alkaloids, terpenoids, flavonoids, tannins, and active proteins are among the bioactive components found in Ficus thonningii, all of which contribute to its therapeutic qualities.Continue to discover, isolate, and quantify the active components, as well as establish the processes behind its curative powers.
{"title":"Phytopharmaceutical profile of Ficus thonningii : An updated Review","authors":"A. Bala, A. Singh, A. Singh","doi":"10.37022/wjcmpr.v3i4.188","DOIUrl":"https://doi.org/10.37022/wjcmpr.v3i4.188","url":null,"abstract":"Ficus thonningii is a plant that is widely utilised in African ethnomedicine to cure a variety of ailments. a rational examination of F. thonningii's nutritional, phytochemical, and pharmacological characteristics in connection to its medicinal uses.Alkaloids, terpenoids, flavonoids, tannins, and active proteins are among the bioactive components found in Ficus thonningii, all of which contribute to its therapeutic qualities.Continue to discover, isolate, and quantify the active components, as well as establish the processes behind its curative powers.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75059442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-24DOI: 10.37022/wjcmpr.v3i4.184
L S Afinisha Deepam, M. Krishnan, S AswathySudhakar, S PaulrajL
Cellulose is a prominent scaffolding polysaccharide found in plants as micro fibrils which form the structurally strong framework in the cell walls. It has wide variety of uses such as attacking agent, emulsifier, stabilizer etc. Its use can be further enhanced by converting cellulose into cellulose derivatives. One of the most important cellulose derivatives is carboxy methyl cellulose (CMC). In the present study, cellulose is converted to CMC thereby preparing CMC – curcumin nanofiber by using electro spinning method. The functional groups identification was done by using UV Visible spectroscopy and FT-IR. Surface structure was analyzed by using Scanning Electron Microscopy. The antifungal activity was studied against Aspergillus niger and Candida albicans. . The antibacterial activities also studied for the samples against E.coli, Klebsiella pneumonia, Streptococcus mutans and Staphylococcus aureus.
{"title":"Electro-spun nano fiber of carboxymethyl cellulose – curcumin and its applications","authors":"L S Afinisha Deepam, M. Krishnan, S AswathySudhakar, S PaulrajL","doi":"10.37022/wjcmpr.v3i4.184","DOIUrl":"https://doi.org/10.37022/wjcmpr.v3i4.184","url":null,"abstract":"Cellulose is a prominent scaffolding polysaccharide found in plants as micro fibrils which form the structurally strong framework in the cell walls. It has wide variety of uses such as attacking agent, emulsifier, stabilizer etc. Its use can be further enhanced by converting cellulose into cellulose derivatives. One of the most important cellulose derivatives is carboxy methyl cellulose (CMC). In the present study, cellulose is converted to CMC thereby preparing CMC – curcumin nanofiber by using electro spinning method. The functional groups identification was done by using UV Visible spectroscopy and FT-IR. Surface structure was analyzed by using Scanning Electron Microscopy. The antifungal activity was studied against Aspergillus niger and Candida albicans. . The antibacterial activities also studied for the samples against E.coli, Klebsiella pneumonia, Streptococcus mutans and Staphylococcus aureus.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"127 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75681315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A 3-year-old boy presented to our atoll hospital in H.A Alif Dhidhoo, with severe pallor, jaundice, easy fatigability and recurrent episodes of passage of dark-colored urine for past 3 days. He was born mature at 39 weeks of gestation with no past significant medical history. Recent history revealed the consumption of 2 cans of fava beans and application of some medicinal herbs. On admission, physical examination revealed fever of 101 degree Fahrenheit, severe pallor, jaundice, cervical lymphadenopathy and mild hepatomegaly. Laboratory investigation results showed a hemoglobin level of 5.4 g/dl with a hemolytic blood picture and serum Bilirubin of 6mg/dl. The patient's G6PD level was measured which showed marked deficiency. Other causes of hemolytic anemia were excluded. Patient required urgent packed RBC transfusion and antibiotics for infection. He responded well to the treatment and was discharged in a stable condition. Parents were appropriately advised on the condition and the importance of avoiding certain foods and medication. Folic acid was prescribed for maintaining normal hemoglobin concentration. This is a first case report in North Maldives of G6PD presenting with severe hemolytic anemia requiring blood transfusion.
{"title":"G6Pd deficiency with severe hemolytic anemia: a case report","authors":"Zahoor Hussain Daraz, Berkheez Shabir, Rehana Afshan, Pamelle Yadav, Mohamed Rashwan Meselhy shady","doi":"10.37022/wjcmpr.v3i4.179","DOIUrl":"https://doi.org/10.37022/wjcmpr.v3i4.179","url":null,"abstract":"A 3-year-old boy presented to our atoll hospital in H.A Alif Dhidhoo, with severe pallor, jaundice, easy fatigability and recurrent episodes of passage of dark-colored urine for past 3 days. He was born mature at 39 weeks of gestation with no past significant medical history. Recent history revealed the consumption of 2 cans of fava beans and application of some medicinal herbs. On admission, physical examination revealed fever of 101 degree Fahrenheit, severe pallor, jaundice, cervical lymphadenopathy and mild hepatomegaly. Laboratory investigation results showed a hemoglobin level of 5.4 g/dl with a hemolytic blood picture and serum Bilirubin of 6mg/dl. The patient's G6PD level was measured which showed marked deficiency. Other causes of hemolytic anemia were excluded. Patient required urgent packed RBC transfusion and antibiotics for infection. He responded well to the treatment and was discharged in a stable condition. Parents were appropriately advised on the condition and the importance of avoiding certain foods and medication. Folic acid was prescribed for maintaining normal hemoglobin concentration. This is a first case report in North Maldives of G6PD presenting with severe hemolytic anemia requiring blood transfusion.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90482578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37022/wjcmpr.v3i4.186
D. Paramita, Putu Indri Widiani, Wayan Sunaka
Liver cirrhosis is caused by necrosis of liver cells leading to fibrosis and nodule formation. Structural abnormalities of the liver causing impaired hepatocyte function and portal hypertension. Hepatic hydrothorax is a less common pulmonary complication of portal hypertension. We present a 47 years old man with liver cirrhosis and recurrent massive pleural effusion. Diagnosis can be challenging because it can be associated with pulmonary or systemic disorders. Pleural fluid analysis is necessary to differentiate transudate or exudate as the cause of pleural effusion. Thoracentesis is done to reduce the complaints experienced by the patient.
{"title":"Recurrent pleural effusion in patient with liver cirrhosis – a case report","authors":"D. Paramita, Putu Indri Widiani, Wayan Sunaka","doi":"10.37022/wjcmpr.v3i4.186","DOIUrl":"https://doi.org/10.37022/wjcmpr.v3i4.186","url":null,"abstract":"Liver cirrhosis is caused by necrosis of liver cells leading to fibrosis and nodule formation. Structural abnormalities of the liver causing impaired hepatocyte function and portal hypertension. Hepatic hydrothorax is a less common pulmonary complication of portal hypertension. We present a 47 years old man with liver cirrhosis and recurrent massive pleural effusion. Diagnosis can be challenging because it can be associated with pulmonary or systemic disorders. Pleural fluid analysis is necessary to differentiate transudate or exudate as the cause of pleural effusion. Thoracentesis is done to reduce the complaints experienced by the patient.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89847884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37022/wjcmpr.v3i4.182
S. Wiranata, I. W. Eka Sutyawan, I. P. Budhiastra
Purpose: The purpose of the study was to perceive epidemiology, predisposing and varied risk factors, age, gender, profession, ulcus location, lateralization, visus category, medication. It also determines the relationship between each factor with infection and non-infection in Sanglah General Hospital, Bali. Methods: This is a cross-sectional study with method was used with 44 patients conferred in the Ophthalmology Department. The purposive sampling technique was also used in this study by considering exclusion and inclusion criteria. Then, the data were analyzed and assessed for medication and surgery for treatment between January 2017 and October 2018 using SPSS 25 version. Results: The mean age at diagnosis was 49.16±2.58 years, where samples of corneal ulcer infection made up 56.8%, and most of the cases occurred within the age group 30 - 60 years. Meanwhile, the infection mostly occurred in males, at a proportion of 77.3%, and based on the profession, 43.2% of the corneal ulcer were farmers. The most predisposing factor for infectious corneal ulcers was trauma, at 36.4%, as 39 patients had a central ulcus, where 47.7% were infectious, and 36.4% were non-infectious. However, not all the study variables were statistically significant (p > 0.05) with the patient's corneal. Conclusion: The findings of this study showed that corneal ulcer is common and mostly affects male. Furthermore, the epidemiological trends from developing countries with a predominance of infectious corneal ulcers were additional or less common. Therefore, more analysis with larger and specific sample sizes is required to be developed for resultant analytical research
{"title":"The prevalence of characteristic corneal ulcer patients in sanglah general hospital, in indonesia","authors":"S. Wiranata, I. W. Eka Sutyawan, I. P. Budhiastra","doi":"10.37022/wjcmpr.v3i4.182","DOIUrl":"https://doi.org/10.37022/wjcmpr.v3i4.182","url":null,"abstract":"Purpose: The purpose of the study was to perceive epidemiology, predisposing and varied risk factors, age, gender, profession, ulcus location, lateralization, visus category, medication. It also determines the relationship between each factor with infection and non-infection in Sanglah General Hospital, Bali. Methods: This is a cross-sectional study with method was used with 44 patients conferred in the Ophthalmology Department. The purposive sampling technique was also used in this study by considering exclusion and inclusion criteria. Then, the data were analyzed and assessed for medication and surgery for treatment between January 2017 and October 2018 using SPSS 25 version. Results: The mean age at diagnosis was 49.16±2.58 years, where samples of corneal ulcer infection made up 56.8%, and most of the cases occurred within the age group 30 - 60 years. Meanwhile, the infection mostly occurred in males, at a proportion of 77.3%, and based on the profession, 43.2% of the corneal ulcer were farmers. The most predisposing factor for infectious corneal ulcers was trauma, at 36.4%, as 39 patients had a central ulcus, where 47.7% were infectious, and 36.4% were non-infectious. However, not all the study variables were statistically significant (p > 0.05) with the patient's corneal. Conclusion: The findings of this study showed that corneal ulcer is common and mostly affects male. Furthermore, the epidemiological trends from developing countries with a predominance of infectious corneal ulcers were additional or less common. Therefore, more analysis with larger and specific sample sizes is required to be developed for resultant analytical research","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83264725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37022/wjcmpr.v3i4.185
N. K. Das, S. Samanta
Melatonin is a pineal hormone, secreted at the subjective night. It is involved in the regulation of many physiological functions, including the sleep-wake cycle, gonadal activity, free radical scavenging, immunomodulation, neuro-protection, and cancer progression. Melatonin acts through cell surface receptors (MT1 and MT2) as well as nuclear receptors. Circadian dysfunction can alter the secretion of melatonin. Inappropriate melatonin level promotes the initiation of many pathologies including cancer. Ovarian cancer is a common form of gynecological disease. Several studies indicate the profound link between impaired melatonin secretion and the progression of ovarian cancer. Melatonin exerts oncostatic effects in multiple ways; it acts as a potent antioxidant, induces apoptosis, and regulates metabolism, and chronic inflammatory response in ovarian cancer cells. Moreover, melatonin improves the efficacy of the current treatment regimen of ovarian cancer and can be used as an adjuvant.
{"title":"The promising oncostatic effects of melatonin against ovarian cancer","authors":"N. K. Das, S. Samanta","doi":"10.37022/wjcmpr.v3i4.185","DOIUrl":"https://doi.org/10.37022/wjcmpr.v3i4.185","url":null,"abstract":"Melatonin is a pineal hormone, secreted at the subjective night. It is involved in the regulation of many physiological functions, including the sleep-wake cycle, gonadal activity, free radical scavenging, immunomodulation, neuro-protection, and cancer progression. Melatonin acts through cell surface receptors (MT1 and MT2) as well as nuclear receptors. Circadian dysfunction can alter the secretion of melatonin. Inappropriate melatonin level promotes the initiation of many pathologies including cancer. Ovarian cancer is a common form of gynecological disease. Several studies indicate the profound link between impaired melatonin secretion and the progression of ovarian cancer. Melatonin exerts oncostatic effects in multiple ways; it acts as a potent antioxidant, induces apoptosis, and regulates metabolism, and chronic inflammatory response in ovarian cancer cells. Moreover, melatonin improves the efficacy of the current treatment regimen of ovarian cancer and can be used as an adjuvant.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"84 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86839587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37022/wjcmpr.v3i4.180
Chandrika Sharma, A. Singh, A. Singh
Memory is an important aspect of cognition. For its health-promoting qualities, Ayurveda is gaining popularity and attention in many areas of the globe. Dementia is a condition in which a person's mental and cognitive abilities gradually deteriorate. Dementia has been related to a number of risk factors and circumstances, including inadequate cerebral blood flow, toxin exposure, mitochondrial malfunction, and oxidative damage, and it often coexists with other neurodegenerative diseases, such as Dementia and memory loss. As a consequence, the present research focuses on the many herbal ayurvedic medicinal plants and their connection to memory functions.
{"title":"Memory Potential Herb: A Review","authors":"Chandrika Sharma, A. Singh, A. Singh","doi":"10.37022/wjcmpr.v3i4.180","DOIUrl":"https://doi.org/10.37022/wjcmpr.v3i4.180","url":null,"abstract":"Memory is an important aspect of cognition. For its health-promoting qualities, Ayurveda is gaining popularity and attention in many areas of the globe. Dementia is a condition in which a person's mental and cognitive abilities gradually deteriorate. Dementia has been related to a number of risk factors and circumstances, including inadequate cerebral blood flow, toxin exposure, mitochondrial malfunction, and oxidative damage, and it often coexists with other neurodegenerative diseases, such as Dementia and memory loss. As a consequence, the present research focuses on the many herbal ayurvedic medicinal plants and their connection to memory functions.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79889919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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