Pub Date : 2023-06-22DOI: 10.37022/wjcmpr.v5i3.267
Putu Nindya, Ayu Ningrum Subadra, Wayan Sunaka
Chronic kidney disease (CKD), also known as renal failure, primarily affects people with a history of hypertension and diabetes. In this medical condition, the rate of filtration or kidney function can decrease over the course of a month or a year. Several studies have found an increase in pro-inflammatory cytokines in patients with CKD. Platelet dysfunction and hyperreactivity have been linked to chronic inflammation. When the platelet count exceeds 450,000/l, thrombocytosis occurs. It is also referred to as thrombocythemia. Reactive thrombocytosis accounts for 80-90% of all thrombocytosis events, with inflammation being one of the most common causes. We report a 67-year-old man presenting to the hospital with fever and weakness. The patient had a history of CKD stage V and currently was rceiving hemodialysis treatment. Laboratory finding showed patient had thrombocytosis. Further examination is required to determine the cause of thrombocytosis in CKD patient.
{"title":"Evaluation Thrombocytosis in CKD Stage V Patient on Hemodialysis Treatment : Case Report","authors":"Putu Nindya, Ayu Ningrum Subadra, Wayan Sunaka","doi":"10.37022/wjcmpr.v5i3.267","DOIUrl":"https://doi.org/10.37022/wjcmpr.v5i3.267","url":null,"abstract":"Chronic kidney disease (CKD), also known as renal failure, primarily affects people with a history of hypertension and diabetes. In this medical condition, the rate of filtration or kidney function can decrease over the course of a month or a year. Several studies have found an increase in pro-inflammatory cytokines in patients with CKD. Platelet dysfunction and hyperreactivity have been linked to chronic inflammation. When the platelet count exceeds 450,000/l, thrombocytosis occurs. It is also referred to as thrombocythemia. Reactive thrombocytosis accounts for 80-90% of all thrombocytosis events, with inflammation being one of the most common causes. We report a 67-year-old man presenting to the hospital with fever and weakness. The patient had a history of CKD stage V and currently was rceiving hemodialysis treatment. Laboratory finding showed patient had thrombocytosis. Further examination is required to determine the cause of thrombocytosis in CKD patient.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"99 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79294054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-16DOI: 10.37022/wjcmpr.v5i3.269
M. Y, Divyajyothi B, B. P., D. K, Sagarika T
The most prevalent hereditary renal cystic disease, is a set of conditions defined by the formation of renal cysts and a variety of extra renal symptoms, is known as autosomal dominant Poly-cystic kidney disease(ADPKD). ADPKD is sometimes referred to as "adult PKD." It is typically diagnosed between the ages of 30 and 50 when signs and symptoms first arise. Two genes have been found to cause ADPKD, is PKD1 (chromosome 16p13.3) and PKD2 (4q21).Urinary blood in the urine, hypertension, anaemia brought on by CKD, and liver cysts may all be risk factors for ADPKD. Hypertension, impaired renal function, palpable kidneys, microscopic or gross hematuria, recurrent urinary tract infections, lower back pain, and shortness of breath are the most typical clinical manifestations of ADPKD. In our study we are aimed to summarize the case report is to mainly slows the cyst growth and Urine accumulates within cysts and delays ensuing loss of kidney function, which ultimately delays the need for renal replacement therapy and improves patients' quality of life. It has been observed that a variety of treatments can reduce the symptoms and progression of ADPKD.
{"title":"Case Report on Autosomal Dominant Polycystic Kidney Disease","authors":"M. Y, Divyajyothi B, B. P., D. K, Sagarika T","doi":"10.37022/wjcmpr.v5i3.269","DOIUrl":"https://doi.org/10.37022/wjcmpr.v5i3.269","url":null,"abstract":"The most prevalent hereditary renal cystic disease, is a set of conditions defined by the formation of renal cysts and a variety of extra renal symptoms, is known as autosomal dominant Poly-cystic kidney disease(ADPKD). ADPKD is sometimes referred to as \"adult PKD.\" It is typically diagnosed between the ages of 30 and 50 when signs and symptoms first arise. Two genes have been found to cause ADPKD, is PKD1 (chromosome 16p13.3) and PKD2 (4q21).Urinary blood in the urine, hypertension, anaemia brought on by CKD, and liver cysts may all be risk factors for ADPKD. Hypertension, impaired renal function, palpable kidneys, microscopic or gross hematuria, recurrent urinary tract infections, lower back pain, and shortness of breath are the most typical clinical manifestations of ADPKD. In our study we are aimed to summarize the case report is to mainly slows the cyst growth and Urine accumulates within cysts and delays ensuing loss of kidney function, which ultimately delays the need for renal replacement therapy and improves patients' quality of life. It has been observed that a variety of treatments can reduce the symptoms and progression of ADPKD.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84389845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-16DOI: 10.37022/wjcmpr.v5i3.268
Sri Tejaswi Suravarapu, Koushik Yetukuri
The opportunity to successfully develop and roll out patient-centric digital health platforms is represented by Software as a medical device (SaMD).Software is now a crucial component of all products and is widely integrated into digital platforms that are used for medical purposes as technology in all areas of health care continues to progress. Artificial intelligence (AI) is a potent and currently evolving technology that has the potential to enhance capabilities in a wide range of sectors. Medical device companies have been fascinated in artificial intelligence. Nowadays Artificial intelligence based medical devices are gaining a lot of attention. Artificial intelligence-enabled medical devices have the potential to completely transform the way that healthcare is provided by enabling physicians to diagnose and treat their patients more precisely and successfully while also enhancing their overall level of care. The three primary objectives of the medical devices that are incorporated with AI are being developed by medical device companies as technology progresses are chronic disease management, medical imaging and Internet of Things (IoT). Quite apart from its advantages, artificial intelligence in medical devices also has drawbacks, such as the necessity for regulation to keep up with the rate of technological innovation. The softwares such as Eye Art and IDxDR for the identification of diabetic retinopathy, Quant X for breast abnormalities, Gleamer BoneView for fractures on X rays and software for the management of type 1 diabetes i.e., Dreamed Advisor Pro and as well as the AI-ECG platform are just a few instances of the artificial intelligence-infused software’s that are discussed in this article.
{"title":"Software programmes employed as medical devices","authors":"Sri Tejaswi Suravarapu, Koushik Yetukuri","doi":"10.37022/wjcmpr.v5i3.268","DOIUrl":"https://doi.org/10.37022/wjcmpr.v5i3.268","url":null,"abstract":"The opportunity to successfully develop and roll out patient-centric digital health platforms is represented by Software as a medical device (SaMD).Software is now a crucial component of all products and is widely integrated into digital platforms that are used for medical purposes as technology in all areas of health care continues to progress. Artificial intelligence (AI) is a potent and currently evolving technology that has the potential to enhance capabilities in a wide range of sectors. Medical device companies have been fascinated in artificial intelligence. Nowadays Artificial intelligence based medical devices are gaining a lot of attention. Artificial intelligence-enabled medical devices have the potential to completely transform the way that healthcare is provided by enabling physicians to diagnose and treat their patients more precisely and successfully while also enhancing their overall level of care. The three primary objectives of the medical devices that are incorporated with AI are being developed by medical device companies as technology progresses are chronic disease management, medical imaging and Internet of Things (IoT). Quite apart from its advantages, artificial intelligence in medical devices also has drawbacks, such as the necessity for regulation to keep up with the rate of technological innovation. The softwares such as Eye Art and IDxDR for the identification of diabetic retinopathy, Quant X for breast abnormalities, Gleamer BoneView for fractures on X rays and software for the management of type 1 diabetes i.e., Dreamed Advisor Pro and as well as the AI-ECG platform are just a few instances of the artificial intelligence-infused software’s that are discussed in this article.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"121 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86165909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-13DOI: 10.37022/wjcmpr.v5i3.266
Frans Lazio, Triharto Banjaran Sakti, Agus Eka Wiradiputra
Unicameral bone cysts (UBCs) are benign bone lesions predominantly affecting children and teenagers. This case report highlights the rare occurrence of a simple bone cyst in the proximal radius in a 29-year-old woman with a pathological fracture. Although the proximal radius is an uncommon site for UBC occurrence, the surgical approach required special care due to the complex anatomical structures near the fracture site. The surgical management of UBCs aims to prevent or manage pathological fractures, facilitate cyst healing, prevent recurrence, and reduce the risk of refracture. Understanding the treatment options and involving patients in the decision-making process are crucial for achieving the best possible results in managing UBCs with pathological fractures. The decision to pursue nonoperative or operative treatment should be made in consultation with healthcare professionals, considering factors such as clinical presentation, radiological features, and symptoms.
{"title":"Treatment of Pathological Fracture Following Unicameral Bone Cyst in Unusual Location of Proximal Radius: Rare Case Report","authors":"Frans Lazio, Triharto Banjaran Sakti, Agus Eka Wiradiputra","doi":"10.37022/wjcmpr.v5i3.266","DOIUrl":"https://doi.org/10.37022/wjcmpr.v5i3.266","url":null,"abstract":"Unicameral bone cysts (UBCs) are benign bone lesions predominantly affecting children and teenagers. This case report highlights the rare occurrence of a simple bone cyst in the proximal radius in a 29-year-old woman with a pathological fracture. Although the proximal radius is an uncommon site for UBC occurrence, the surgical approach required special care due to the complex anatomical structures near the fracture site. The surgical management of UBCs aims to prevent or manage pathological fractures, facilitate cyst healing, prevent recurrence, and reduce the risk of refracture. Understanding the treatment options and involving patients in the decision-making process are crucial for achieving the best possible results in managing UBCs with pathological fractures. The decision to pursue nonoperative or operative treatment should be made in consultation with healthcare professionals, considering factors such as clinical presentation, radiological features, and symptoms.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85139618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-09DOI: 10.37022/wjcmpr.v5i3.265
Soni Gaddam, Haritha Pasupulati, S. Padi
Recent pandemic of coronavirus disease 2019 (COVID-19) has made a serious threat to public health and became a global burden with millions of people at risk of death. At that time, there were no approved antiviral drugs and vaccines for COVID-19, but few drugs are repurposed with limited benefit. In less than a year, several COVID-19 vaccines have already been approved and hundreds of vaccines are undergoing clinical evaluation. This review focuses on need for vaccines, benefits of vaccination, the World Health Organization initiated new global strategy ‘the Immunization Agenda 2030’ (IA2030), stages and timeline of development, and clinical evaluation of traditional vaccines. We have summarized comparison of clinical evaluation between traditional vaccines and conventional drugs in the pre-pandemic era. The review briefly discusses the prioritized approaches, accelerated timeline of clinical evaluation, and seamless and immunobridging clinical trial designs of COVID-19 vaccines in the pandemic period. We have thoroughly searched recent literature and data on this topic and made a summary of current advances, regulatory amendments, and future perspectives of development and approval of vaccines.
{"title":"VACCINES VERSUS COVID-19 VACCINES: MANEUVER TIMELINE OF DEVELOPMENT AND TRIAL DESIGNS","authors":"Soni Gaddam, Haritha Pasupulati, S. Padi","doi":"10.37022/wjcmpr.v5i3.265","DOIUrl":"https://doi.org/10.37022/wjcmpr.v5i3.265","url":null,"abstract":"Recent pandemic of coronavirus disease 2019 (COVID-19) has made a serious threat to public health and became a global burden with millions of people at risk of death. At that time, there were no approved antiviral drugs and vaccines for COVID-19, but few drugs are repurposed with limited benefit. In less than a year, several COVID-19 vaccines have already been approved and hundreds of vaccines are undergoing clinical evaluation. This review focuses on need for vaccines, benefits of vaccination, the World Health Organization initiated new global strategy ‘the Immunization Agenda 2030’ (IA2030), stages and timeline of development, and clinical evaluation of traditional vaccines. We have summarized comparison of clinical evaluation between traditional vaccines and conventional drugs in the pre-pandemic era. The review briefly discusses the prioritized approaches, accelerated timeline of clinical evaluation, and seamless and immunobridging clinical trial designs of COVID-19 vaccines in the pandemic period. We have thoroughly searched recent literature and data on this topic and made a summary of current advances, regulatory amendments, and future perspectives of development and approval of vaccines.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80938039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-03DOI: 10.37022/wjcmpr.v5i3.264
F. Mohammad, Doaa Abd Alabas Muhammed Ridh, Osamah Faisal Kokaz
Cryptosporidium parvum is one causes of severe diarrheal disease worldwide and contributed to neonatal and early infect mortality. C. parvum is responsible for most zoonotic infections in human. Cryptosporidium is intra cellular protozoan parasite belong to phylum Apicomplexa. Cryptosporidium can spread to various organs and systems of the body especially pancreatic, hepatobiliary as well as extra- intestinal such as pulmonary system and leading to chronic disease and weakness.The infection can be acute and self-limiting illness in immunocomponent patients, whereas in immunocompromised cryptosporidiosis can become a chronic and life threaten disease.
{"title":"A General Review on Cryptosporidium Parvum: Pathogenesis, Diagnosis and Treatment","authors":"F. Mohammad, Doaa Abd Alabas Muhammed Ridh, Osamah Faisal Kokaz","doi":"10.37022/wjcmpr.v5i3.264","DOIUrl":"https://doi.org/10.37022/wjcmpr.v5i3.264","url":null,"abstract":"Cryptosporidium parvum is one causes of severe diarrheal disease worldwide and contributed to neonatal and early infect mortality. C. parvum is responsible for most zoonotic infections in human. Cryptosporidium is intra cellular protozoan parasite belong to phylum Apicomplexa. Cryptosporidium can spread to various organs and systems of the body especially pancreatic, hepatobiliary as well as extra- intestinal such as pulmonary system and leading to chronic disease and weakness.The infection can be acute and self-limiting illness in immunocomponent patients, whereas in immunocompromised cryptosporidiosis can become a chronic and life threaten disease.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84220052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-25DOI: 10.37022/wjcmpr.v5i3.263
Viren Ranpariya, Neha Tarpara
Antibiotics are chemicals that prevent or eliminate bacterial growth and are widely used in various applications. They were first discovered by Alexander Fleming in 1928 when he noticed that a mold called Penicillium notatum inhibited the growth of Staphylococcus aureus bacteria. Since then, antibiotics have been extensively studied and utilized to combat bacterial infections.There are several potential sources of antibiotic-producing microorganisms, including soil, water, plants, animals, and even fermented foods. Actinomycetes, a type of bacteria commonly found in soil, are known for their ability to produce a wide range of antibiotics. Marine environments are also considered a rich source of antibiotic-producing microorganisms.The production of antibiotics by bacteria is of great interest, as it offers the potential for the development of new natural product-based drugs. Actinomycetes, particularly Streptomyces species, have been a major focus of antibiotic research and have yielded thousands of distinct secondary metabolites, many of which are antibiotics.Antibiotics play various natural functions in microbial interactions in different environments. They can act as weapons or shields, protecting bacteria from predators or competing microbes. Antibiotics can also have concentration-dependent effects, acting as inhibitors at high concentrations and mediators of intracellular signaling at low concentrations.The production of antibiotics by bacteria in soil and plant-associated environments has been extensively studied. Bacterial genera such as Bacillus, Pseudomonas, and Streptomyces have been found to produce bioactive peptides with antimicrobial properties. These antibiotics can help bacteria survive in harsh environments by inhibiting the growth of predators or competitors.
{"title":"The Ability of Microorganisms to Produce Antibiotics- A Review","authors":"Viren Ranpariya, Neha Tarpara","doi":"10.37022/wjcmpr.v5i3.263","DOIUrl":"https://doi.org/10.37022/wjcmpr.v5i3.263","url":null,"abstract":"Antibiotics are chemicals that prevent or eliminate bacterial growth and are widely used in various applications. They were first discovered by Alexander Fleming in 1928 when he noticed that a mold called Penicillium notatum inhibited the growth of Staphylococcus aureus bacteria. Since then, antibiotics have been extensively studied and utilized to combat bacterial infections.There are several potential sources of antibiotic-producing microorganisms, including soil, water, plants, animals, and even fermented foods. Actinomycetes, a type of bacteria commonly found in soil, are known for their ability to produce a wide range of antibiotics. Marine environments are also considered a rich source of antibiotic-producing microorganisms.The production of antibiotics by bacteria is of great interest, as it offers the potential for the development of new natural product-based drugs. Actinomycetes, particularly Streptomyces species, have been a major focus of antibiotic research and have yielded thousands of distinct secondary metabolites, many of which are antibiotics.Antibiotics play various natural functions in microbial interactions in different environments. They can act as weapons or shields, protecting bacteria from predators or competing microbes. Antibiotics can also have concentration-dependent effects, acting as inhibitors at high concentrations and mediators of intracellular signaling at low concentrations.The production of antibiotics by bacteria in soil and plant-associated environments has been extensively studied. Bacterial genera such as Bacillus, Pseudomonas, and Streptomyces have been found to produce bioactive peptides with antimicrobial properties. These antibiotics can help bacteria survive in harsh environments by inhibiting the growth of predators or competitors.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74205859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.37022/wjcmpr.v5i2.261
Kadhim H. A Al-Ameri, S. Ali
Citric acid is one of the important organic acids in the fields of industry, agriculture, medicine, etc., and it can be obtained in many ways, the best of which is biological methods using microorganisms. The current study aimed to prepare two cheap and environmentally friendly culture media for the purpose of producing citric acid from Aspergillus niger. The two media, one from rice husks and the other from Wheat bran, where a comparison was made between them regarding which is more efficient in supporting the fungus A. niger compared to the standard medium, the best temperature and pH for production were also assessed. Eight isolates were obtained, all of which produced acid to varying degrees. No.1 was the highest and best in terms of production 3.1 gm/l, followed by isolate No. 2 with an amount of 2.5 g/l. It was observed that the amount of acid produced increased with the increase of the biomass of the fungus. The study showed variable results regarding the production of citric acid from isolates of A. niger, where the wheat bran medium was the best result, where the resulting concentration of acid was 5.1 gm/l, compared to 4.4 g/l for the medium of rice husks. The results showed that the best temperature was 25°C, as it gave a concentration of citric acid of 3.4 g/l, while the best pH was 6 where the concentration of citric acid produced It was 3 grams per liter.the study showed that there were no significant differences with regard to the sugars adopted in this experiment, as it gave significant similar results in terms of the amount of acid produced as well as the biomass of the fungus Aspergillus niger, while ammonium nitrate was the best among the nitrate sources used, with a production quantity of 4 gm/l .
{"title":"A comparative study of the ability of the fungus Aspergillus niger on two alternative media, wheat bran and rice husk.","authors":"Kadhim H. A Al-Ameri, S. Ali","doi":"10.37022/wjcmpr.v5i2.261","DOIUrl":"https://doi.org/10.37022/wjcmpr.v5i2.261","url":null,"abstract":"Citric acid is one of the important organic acids in the fields of industry, agriculture, medicine, etc., and it can be obtained in many ways, the best of which is biological methods using microorganisms. The current study aimed to prepare two cheap and environmentally friendly culture media for the purpose of producing citric acid from Aspergillus niger. The two media, one from rice husks and the other from Wheat bran, where a comparison was made between them regarding which is more efficient in supporting the fungus A. niger compared to the standard medium, the best temperature and pH for production were also assessed. \u0000Eight isolates were obtained, all of which produced acid to varying degrees. No.1 was the highest and best in terms of production 3.1 gm/l, followed by isolate No. 2 with an amount of 2.5 g/l. It was observed that the amount of acid produced increased with the increase of the biomass of the fungus. \u0000The study showed variable results regarding the production of citric acid from isolates of A. niger, where the wheat bran medium was the best result, where the resulting concentration of acid was 5.1 gm/l, compared to 4.4 g/l for the medium of rice husks. \u0000The results showed that the best temperature was 25°C, as it gave a concentration of citric acid of 3.4 g/l, while the best pH was 6 where the concentration of citric acid produced It was 3 grams per liter.the study showed that there were no significant differences with regard to the sugars adopted in this experiment, as it gave significant similar results in terms of the amount of acid produced as well as the biomass of the fungus Aspergillus niger, while ammonium nitrate was the best among the nitrate sources used, with a production quantity of 4 gm/l .","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78189074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-14DOI: 10.37022/wjcmpr.v5i2.258
N. N, P. S, V. S, V. M, P. R., A. A
The use of herbal gum paint in the treatment of dental problems is not very common. Most of the drugs used are synthetic and are in used over the years mainly for antibacterial activity in the oral cavity. It includes various side effects that are always a limit for their use. Natural remedies are always more desirable and acceptable and are more effective with fewer side effects. ThemicroorganismincludesEscherichiacoli, Klebsiella pneumonia, Staphylococcusepidermidis, and staphylococcus aureus which causegingivitisanddent cavities. The current study objective is to formulate and evaluate an herbal gum paint that is useful in the long term and has rheological characteristics and stability too. The local anesthetic activity is studied and the antimicrobial activity of gum paint is examined by disc diffusion method and compared activity between F1-betel leaf oil, F2- clove oil, and an F3 (F1+F2) – both betel leaf and clove oil. F3 shows a synergistic effect on microbes than the other two and has the maximum zone of inhibition.
{"title":"A herbo health care for gums and throat","authors":"N. N, P. S, V. S, V. M, P. R., A. A","doi":"10.37022/wjcmpr.v5i2.258","DOIUrl":"https://doi.org/10.37022/wjcmpr.v5i2.258","url":null,"abstract":"The use of herbal gum paint in the treatment of dental problems is not very common. Most of the drugs used are synthetic and are in used over the years mainly for antibacterial activity in the oral cavity. It includes various side effects that are always a limit for their use. Natural remedies are always more desirable and acceptable and are more effective with fewer side effects. ThemicroorganismincludesEscherichiacoli, Klebsiella pneumonia, Staphylococcusepidermidis, and staphylococcus aureus which causegingivitisanddent cavities. The current study objective is to formulate and evaluate an herbal gum paint that is useful in the long term and has rheological characteristics and stability too. The local anesthetic activity is studied and the antimicrobial activity of gum paint is examined by disc diffusion method and compared activity between F1-betel leaf oil, F2- clove oil, and an F3 (F1+F2) – both betel leaf and clove oil. F3 shows a synergistic effect on microbes than the other two and has the maximum zone of inhibition.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90400202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-12DOI: 10.37022/wjcmpr.v5i2.257
S. A, Umarani G, Tamilarasi G, Senthilkumar R, M. K
A new drug takes a long time and is expensive to introduce.By using insilico drug design, you can save time and money. Utilizing computational software, a novel Schiff's base Dibenzosuberenone derivative was designed and molecular docking studies were performed using autodock software. To predict Absorption, Distribution, Metabolism, Excretion, and Molecular Properties of Dibenzosuberenone derivatives, insilico screening was performed. It should be examined how its Dibenzosuberenone derivatives interact with specific targets. The Dibenzosuberenone derivatives were successfully identified as targets in this study.
{"title":"Insilico pharmacological evaluation of dibenzosuberenone derivatives as antidepressant","authors":"S. A, Umarani G, Tamilarasi G, Senthilkumar R, M. K","doi":"10.37022/wjcmpr.v5i2.257","DOIUrl":"https://doi.org/10.37022/wjcmpr.v5i2.257","url":null,"abstract":"A new drug takes a long time and is expensive to introduce.By using insilico drug design, you can save time and money. Utilizing computational software, a novel Schiff's base Dibenzosuberenone derivative was designed and molecular docking studies were performed using autodock software. To predict Absorption, Distribution, Metabolism, Excretion, and Molecular Properties of Dibenzosuberenone derivatives, insilico screening was performed. It should be examined how its Dibenzosuberenone derivatives interact with specific targets. The Dibenzosuberenone derivatives were successfully identified as targets in this study.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79946098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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