Wiadomosci lekarskie最新文献

Objective: Aim: To analyze the results of treatment of patients with oropharyngeal carcinoma.

Patients and methods: Materials and Methods: 276 patients with oropharyngeal carcinoma were treated in 2008-2021. Neoadjuvant chemotherapy consisted of three to six cycles: paclitaxel 175 mg/m2 and carboplatin 350 mg/m2 (or cisplatin 100 mg/m2) on the first day. The interval between cycles was 21 days. After the cycles, all patients were prescribed a course of radiation therapy in a total focal dose (TFD) of 65 Gy. The outcome of treatment was assessed by the degree of tumor regression according to RECIST criteria one month after the end of combination treatment. Statistical processing was performed using STATISTICA 6.1 software (StatSoftInc).

Results: Results: The three- and five-year survival rates of the examined patients with oropharyngeal carcinoma after treatment were 40.8% respectively (95% CI 33.7 - 47.9) and 27.0%, (95% CI 20.6 - 33, 4) with a median survival of 36 months with 95% CI (35.5 - 40.2). Processing was performed using STATISTICA 6.1 software (StatSoftInc).

Conclusion: Сonclusions: Analysis of treatment of patients with oropharyngeal carcinoma with predominance of squamous cell carcinoma (90.6%), localized primarily in the palatine tonsil (73.2%), with the most common stages T3N1M0 (30.1%) and T3N1M0 %), with regional metastases to the lymph nodes of the neck (89.9%), showed that the effectiveness of treatment of patients is quite high, because in most of the examined in the short term after combined treatment there was complete or partial regression of the tumor (91.7%), no progression of the oncological process was detected in any of them.

Objective: Aim: Phenylketonuria is the most prevalent inherited metabolic disorder. Early detection and prompt treatment can prevent serious neurological consequences. This has become possible thanks to the implementation of newborn screening programmes. The objective of this review is to provide readers with a comprehensive understanding of the phenylketonuria and the role that neonatal screening plays in the protection of public health.

Patients and methods: Materials and Methods: A review of the literature was conducted using the PubMed database, with the search period encompassing the most recently published scientific sources. Analysis of the literature. This article presents phenylketonuria as an example of an inherited metabolic disorder, outlines the treatment options, and discusses the potential implications of hyperphenylalaninemia. Furthermore, it also delineates the various aspects of health that are influenced by newborn screening.

Conclusion: Conclusions: Phenylketonuria represents a significant health problem in the population. The development of screening tests has transformed healthcare, including improvements in quality of life, prognosis, and reductions in the number of comorbidities in patients. It is essential to disseminate knowledge among the society about the importance of newborn screening tests in order to enhance awareness and prevent refusal to participate.

Objective: Aim: To study the spectrum, frequency of isolation and level of colonization of dental biofilm with microorganisms in generalized periodontitis against the background of different body reactivity.

Patients and methods: Materials and Methods: 216 people with the diagnosis of generalized periodontitis. Depending on the state of reactivity of the organism, the patients were divided into 3 groups: with normo-, hyper- and with hyporeaction. The patients underwent patch surgery. After the surgery, dental biofilm was taken. Microbiological studies included the isolation and species identification of dental biofilm microorganisms, the results of quantitative studies of microflora: the level of colonization was expressed in colony-forming units per 1 ml (CFU/ml); the frequency of microorganisms isolation was expressed in absolute numbers. Statistical processing of the obtained digital data was performed using the computer program Statistica 8.0.

Results: Results: The studies have shown that in different states of the body's reactivityi n patients with generalized periodontitis after flap surgery, different quantitative and qualitative composition of the microflora of the dental biofilm is determined. In case of normal body reactivity, there are predominantly aerobic-anaerobic associations with a wide range and quantitative predominance of aerobic microflora; in case of impaired (hyper- and hypo-) reactivity, there are predominantly aerobic-anaerobic associations with an expansion of the spectrum, frequency of isolation and level of colonization of facultative and obligate anaerobes.

Conclusion: Conclusions: The identified differences in the quantitative and qualitative composition of the microflora of the dental biofilm indicate the key role of the body's reactivity in the studied processes.

Objective: Aim: To study the anatomy of the posterior inferior tibiof i bular ligament (PITFL) and specify the features of its morphology and linear parameters.

Patients and methods: Materials and Methods: The peculiarities of morphology and linear parameters of PITFL on 10 fresh amputated lower limbs were studied. The average age of the patients was 64.7 ± 9.3 (7 males, 3 females). Macroscopic characteristics, insertion, orientation in relation to the corresponding bony and ligamentous anatomical structures were studied, and linear parameters of PITFL were measured using a caliper. Average values were calculated.

Results: Results: PITFL was detected in all the studied samples. It represented a strong, compact anatomical structure of a trapezoidal or triangular shape. The proximal width of the PITFL averaged 20 ± 3.65 mm, while the distal width was 36.6 ± 4.62 mm. The attachment length of PITFL to the posterior part of the tibia was 28.6 ± 5.13 mm and to the fi bula was 17.4 ± 3.2 mm. The ligament is closely connected to the posterior intermalleolar ligament, the inferior transverse ligament, and the tendinous sheaths of the posterior tibial and fi bular muscles.

Conclusion: Conclusions: The obtained results of the study of linear and morphological parameters of PITFL should contribute to a better understanding of the anatomy of the posterior part of the ankle joint and improve surgical approaches to the treatment of posterior malleolus fractures and related PITFL injuries.

Objective: Aim: To determine the level structure of the graph model of the system of clinical and instrumental indicators of athletes with herniated intervertebral discs complicated by spinal stenosis, and to determine the regression model for these indicators.

Patients and methods: Materials and Methods: This observational study involved 64 athletes (14 - rugby players, 16 - handball players, 15 - basketball players, 19 - football players) with intervertebral disc herniation, complicated by stenosis of spinal canal. Research methods: visual method to evaluate the likelihood of a data set's normal distribution; correlation and regression analysis; method for determining the ordinal function of a graph through the application of an adjacency matrix, specif i cally utilizing Demucron's algorithm. This process is accompanied using a topological sorting of the graph.

Results: Results: The results showed the lack of correlation between age and VAS, muscle strength and VAS, as well as VAS and the channel space; little feedback between age and the channel space; weak positive relationship between size of herniated intervertebral disc had a with the length of the illness. The data showed, strong feedback was observed for hernia size and the channel space, hernia size and muscle strength, the channel space, and length of the illness.

Conclusion: Conclusions: The evaluation on the complexity and depth of the interconnections between clinical and instrumental metrics in athletes was conducted. The hierarchical organization within the graphical representation was ascertained. A predictive regression model delineating the correlations between clinical and instrumental variables in patients suf f ering from herniated intervertebral discs, with the complication of spinal canal stenosis was established.

Objective: Aim is to analyze the possibilities of using the electronic system Moodle for the formation of professional and terminological competence of medical students during the study of terminological competence for improving the quality of medical education.

Patients and methods: Materials and Methods: The research used a number of scientific methods: general scientific (analysis, synthesis, generalization), specific research and others which ensured the selection and analysis of the source base, made it possible to determine the general trends in the study of the problem of using the electronic system Moodle for the formation of professional and terminological competence of medical students during the study of terminological competence for improving the quality of medical education.

Conclusion: Conclusions: At I. Horbachevsky Ternopil National Medical University we actively use the e-learning system Moodle (Modular Object Oriented Distance Learning Environment), to which there is free and unrestricted access. Using this program, the student takes on the role of an active subject who independently acquires knowledge, forms his/her own system of skills, of course with the help of certain sources, and the role of the teacher in this scheme is to motivate and suport learners, prepare information sources used in self-study, etc. This is due to a significant increase in the requirements for quality training of future specialists n the medical field and market conditions in Ukraine, which set before the higher school the task of training specialists of the new generation who would be highly qualified, competitive, literate, and have perfect command of their professional terminology. The Moodle system is able to optimize the learning process, promote the formation of terminological competence and master professional vocabulary. When creating educational and methodological complexes for the formation of terminological competence, the means of teaching, as well as the ways of presenting educational material and the principles of organizing the educational activities of students become important. The electronic platform Moodle, which has a wide range of resources for teaching and testing, is able to expand the communicative competencies and skills of students needed to effectively master professional Latin terminology. The Moodle system has the optimal set of resource opportunities for the implementation of blended learning - classroom and extracurricular, which is its main advantage.

Objective: Aim: To improve the results of treatment of patients with pseudomembranous colitis against the background of coronavirus infection.

Patients and methods: Materials and Methods: The study presents the results of a retrospective analysis of 96 patients with pseudomembranous colitis, who were treated in the infectious Covid department at the base of the Uzhhorod City Clinical Hospital since 2020 to 2022. The average age of patients was 55.2 years, there were 38 (39.5%) men and 58 (60.5%) women. Diagnosis of complications - pseudomembranous colitis (PMC) - was based on clinical data, ultrasound and CT of the abdominal organs, fibrocolonoscopy, laparoscopy.

Results: Results: The frequency of PMC from the total number of patients who were in hospital treatment (8205 patients) due to COVID-19 was 1.17%, and this indicator was 0.62% in 2020, and 2.28% in 2021. Indications for operative treatment were: colon perforation - 9.4% of patients; peritonitis (diffuse, widespread) without obvious perforation of the colon wall - 85.5% of patients; mesenteric thrombosis - 4.1% of patients. In the case of perforation of the colon, resection of the colon was performed with the formation of a proximal colostomy and ileostomy. In case of mesenteric thrombosis, resection of the affected part of the small intestine was performed. In case of peritonitis without clear intraoperative detection of perforation of the colon wall, intraoperative lavage was performed.

Conclusion: Conclusions: 1) The frequency of detection of PMC in patients with COVID-19 in 2020 was 0.62%, and in 2021 - 2.28%. 2) The sensitivity of CT in the diagnosis of surgical complications of PMC was 72%, and the specificity was 58%. 3) Conservative treatment was effective in patients with PMC in 88.8% of cases, 21.2% had complications that required emergency surgical interventions. 4) The total mortality in patients with PMC was 11.36%, although this indicator was significantly higher in the event of surgical complications and operative treatment (22.4%).

Objective: Aim: To investigate the effect of high-intensity interval training (HIIT) based on the CrossFit system on the level of students' functional state and physical development.

Patients and methods: Materials and Methods: The research involved 36 male students who were engaged in HIIT during their studies. Indicators of students' functional state and physical development after 1 and 3 years of HIIT were studied. The functional state was assessed by indicators of the cardiovascular and respiratory systems, and physical development - by physical education tests.

Results: Results: It has been found that HIIT has a positive effect on the indicators of the functional state of the cardiovascular and respiratory systems of the body and the physical development of students. After three years of HIIT sessions, students significantly improved their heart rate, vital capacity of the lungs, Stange test, Genchi test, duration of recovery heart rate, as well as the level of development of speed qualities, strength qualities, endurance and flexibility.

Conclusion: Conclusions: It has been established that the sports-oriented form of organization of physical education training sessions with the use of HIIT based on the CrossFit system is quite effective in improving the indicators of the functional state and physical development of students. A high level of these indicators will help to improve students' health, improve their well-being, and increase the effectiveness of their educational and, in the future, professional activities.

Objective: Aim: data study on the results of treatment of acute non-specific purulent-destructive pleura diseases with the purpose of further improvement of its results on the basis of improvement of diagnostics, identification of factors of disease prognosis and by implementing differential tactics of surgical treatment with the use of minimally invasive interventions.

Patients and methods: Materials and Methods: We have studied modern literary sources on the topic of current trends in the treatment of acute pleural empyema and its complications. The studied material is summarized and presented in the form of a literature review in this article.

Conclusion: Conclusions: These issues cannot be considered to be completely solved and require further study. Everything mentioned above dictates the search of new effective methods of the treatment of the mentioned pathology and proves the relevance of the theme. The outlined information highlights the necessity of improvement of surgical tactics in patients with pleural empyema.

Objective: Aim: To study the study the impact of negative factors of professional activities on the health of law enforcement officers.

Patients and methods: Materials and Methods: The research involved 89 law enforcement officers (58 men, and 31 women) who served for a year in practical police units after graduating from a higher educational institution. Methods: analysis and generalization of scientific and methodological literature, anthropometry, physiometry, testing, and statistical methods. The health status was assessed by body mass index, Robinson index, and vital index.

Results: Results: It was found that the body mass index of law enforcement officers for one year of service in practical units deteriorated in both men and women by 1.3 kg/m2 and 0.9 kg/m2, respectively. More negative changes were observed in men. At the same time, after one year of service, the number of men with overweight (27.5 %) and even obesity of the first (13.9 %) and second (5.2 %) degrees increased significantly. In women, the changes were less pronounced. The dynamics of Robinson and vital indices, as well as the level of physical fitness, were also negative.

Conclusion: Conclusions: The results of the research indicate a negative impact of professional factors in terms of professional activities on the health of law enforcement officers. It has been found that adherence to the principles of a healthy lifestyle, in particular, a regimen of rationally organized motor activity, is an important area in combating the impact of negative factors of professional activities on the health of law enforcement officers.