World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering最新文献
Minky Son, Chanin Park, Ayoung Baek, Shalini John, Keun Woo Lee
3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) catalyzes the conversion of HMG-CoA to mevalonate using NADPH and the enzyme is involved in rate-controlling step of mevalonate. Inhibition of HMGR is considered as effective way to lower cholesterol levels so it is drug target to treat hypercholesterolemia, major risk factor of cardiovascular disease. To discover novel HMGR inhibitor, we performed structure-based pharmacophore modeling combined with molecular dynamics (MD) simulation. Four HMGR inhibitors were used for MD simulation and representative structure of each simulation were selected by clustering analysis. Four structure-based pharmacophore models were generated using the representative structure. The generated models were validated used in virtual screening to find novel scaffolds for inhibiting HMGR. The screened compounds were filtered by applying drug-like properties and used in molecular docking. Finally, four hit compounds were obtained and these complexes were refined using energy minimization. These compounds might be potential leads to design novel HMGR inhibitor. Keywords—Anti-hypercholesterolemia drug, HMGR inhibitor, Molecular dynamics simulation, Structure-based pharmacophore modeling.
{"title":"Discovery of Human HMG-Coa Reductase Inhibitors Using Structure-Based Pharmacophore Modeling Combined with Molecular Dynamics Simulation Methodologies","authors":"Minky Son, Chanin Park, Ayoung Baek, Shalini John, Keun Woo Lee","doi":"10.5281/zenodo.1333334","DOIUrl":"https://doi.org/10.5281/zenodo.1333334","url":null,"abstract":"3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) catalyzes the conversion of HMG-CoA to mevalonate using NADPH and the enzyme is involved in rate-controlling step of mevalonate. Inhibition of HMGR is considered as effective way to lower cholesterol levels so it is drug target to treat hypercholesterolemia, major risk factor of cardiovascular disease. To discover novel HMGR inhibitor, we performed structure-based pharmacophore modeling combined with molecular dynamics (MD) simulation. Four HMGR inhibitors were used for MD simulation and representative structure of each simulation were selected by clustering analysis. Four structure-based pharmacophore models were generated using the representative structure. The generated models were validated used in virtual screening to find novel scaffolds for inhibiting HMGR. The screened compounds were filtered by applying drug-like properties and used in molecular docking. Finally, four hit compounds were obtained and these complexes were refined using energy minimization. These compounds might be potential leads to design novel HMGR inhibitor. Keywords—Anti-hypercholesterolemia drug, HMGR inhibitor, Molecular dynamics simulation, Structure-based pharmacophore modeling.","PeriodicalId":23673,"journal":{"name":"World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering","volume":"31 1","pages":"54-59"},"PeriodicalIF":0.0,"publicationDate":"2013-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75657667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hironobu Murayama, Shohei Shimizu, Masakazu Ohnuki, H. Mihara, T. Kanada
Disordered function of maniphalanx and difficulty with ambulation will occur insofar as a human has a failure in the spinal marrow. Cervical spondylotic myelopathy as one of the myelopathy emanates from not only external factors but also increased age. In addition, the diacrisis is difficult since cervical spondylotic myelopathy is evaluated by a doctor’s neurological remark and imaging findings. As a quantitative method for measuring the degree of disability, hand-operated triangle step test (for short, TST) has formulated. In this research, a full automatic triangle step counter apparatus is designed and developed to measure the degree of disability in an accurate fashion according to the principle of TST. The step counter apparatus whose shape is a low triangle pole displays the number of stepping upon each corner. Furthermore, the apparatus has two modes of operation. Namely, one is for measuring the degree of disability and the other for rehabilitation exercise. In terms of usefulness, clinical practice should be executed before too long.
{"title":"Development and Assessment of Measuring/Rehabilitation Device for Myelopathy Patients with Lower Extremity Function","authors":"Hironobu Murayama, Shohei Shimizu, Masakazu Ohnuki, H. Mihara, T. Kanada","doi":"10.5281/ZENODO.1333394","DOIUrl":"https://doi.org/10.5281/ZENODO.1333394","url":null,"abstract":"Disordered function of maniphalanx and difficulty with ambulation will occur insofar as a human has a failure in the spinal marrow. Cervical spondylotic myelopathy as one of the myelopathy emanates from not only external factors but also increased age. In addition, the diacrisis is difficult since cervical spondylotic myelopathy is evaluated by a doctor’s neurological remark and imaging findings. As a quantitative method for measuring the degree of disability, hand-operated triangle step test (for short, TST) has formulated. In this research, a full automatic triangle step counter apparatus is designed and developed to measure the degree of disability in an accurate fashion according to the principle of TST. The step counter apparatus whose shape is a low triangle pole displays the number of stepping upon each corner. Furthermore, the apparatus has two modes of operation. Namely, one is for measuring the degree of disability and the other for rehabilitation exercise. In terms of usefulness, clinical practice should be executed before too long.","PeriodicalId":23673,"journal":{"name":"World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering","volume":"17 1","pages":"60-63"},"PeriodicalIF":0.0,"publicationDate":"2013-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85314078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Berkimbayeva, A. Mansharipova, E. Khussainova, L. Djansugurova
It is believed that DNA damaging toxic metabolites contributes to the development of different pathological conditions. To prevent harmful influence of toxic agents, cells developed number of protecting mechanisms, such as enzymatic reaction of detoxification of reactive metabolites and repair of DNA damage. The aim of the study was to examine the association between polymorphism of GSTT1/GSTM1 and XRCC1/3 genes and coronary artery disease (CAD) incidence. To examine a polymorphism of these genes in CAD susceptibility in patients and controls, PCR based genotyping assay was performed. For GST genes, frequency of GSTM1 null genotype among CAD affected group was significantly increased than in control group (P 0.1). We found that neither XRCC1 Arg399Gln nor XRCC3 Thr241Met were associated with CAD risk. Obtained data suggests that GSTM1 null genotype carriers are more susceptible to CAD development.
{"title":"Variant Polymorphisms Of Gst And Xrcc Genes And The Early Risk Of Age Associated Disease In Kazakhstan","authors":"Z. Berkimbayeva, A. Mansharipova, E. Khussainova, L. Djansugurova","doi":"10.5281/ZENODO.1057846","DOIUrl":"https://doi.org/10.5281/ZENODO.1057846","url":null,"abstract":"It is believed that DNA damaging toxic metabolites contributes to the development of different pathological conditions. To prevent harmful influence of toxic agents, cells developed number of protecting mechanisms, such as enzymatic reaction of detoxification of reactive metabolites and repair of DNA damage. The aim of the study was to examine the association between polymorphism of GSTT1/GSTM1 and XRCC1/3 genes and coronary artery disease (CAD) incidence. To examine a polymorphism of these genes in CAD susceptibility in patients and controls, PCR based genotyping assay was performed. For GST genes, frequency of GSTM1 null genotype among CAD affected group was significantly increased than in control group (P 0.1). We found that neither XRCC1 Arg399Gln nor XRCC3 Thr241Met were associated with CAD risk. Obtained data suggests that GSTM1 null genotype carriers are more susceptible to CAD development.","PeriodicalId":23673,"journal":{"name":"World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering","volume":"32 1","pages":"561-566"},"PeriodicalIF":0.0,"publicationDate":"2012-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85129633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
José Esteves da Costa, M. Ortigueira, A. Batista, T. Paiva
Sleep spindles are the most interesting hallmark of stage 2 sleep EEG. Their accurate identification in a polysomnographic signal is essential for sleep professionals to help them mark Stage 2 sleep. Sleep Spindles are also promising objective indicators for neurodegenerative disorders. Visual spindle scoring however is a tedious workload. In this paper three different approaches are used for the automatic detection of sleep spindles: Short Time Fourier Transform, Wavelet Transform and Wave Morphology for Spindle Detection. In order to improve the results, a combination of the three detectors is presented and comparison with human expert scorers is performed. The best performance is obtained with a combination of the three algorithms which resulted in a sensitivity and specificity of 94% when compared to human expert scorers.
{"title":"An Automatic Sleep Spindle Detector based on WT, STFT and WMSD","authors":"José Esteves da Costa, M. Ortigueira, A. Batista, T. Paiva","doi":"10.5281/ZENODO.1056589","DOIUrl":"https://doi.org/10.5281/ZENODO.1056589","url":null,"abstract":"Sleep spindles are the most interesting hallmark of stage 2 sleep EEG. Their accurate identification in a polysomnographic signal is essential for sleep professionals to help them mark Stage 2 sleep. Sleep Spindles are also promising objective indicators for neurodegenerative disorders. Visual spindle scoring however is a tedious workload. In this paper three different approaches are used for the automatic detection of sleep spindles: Short Time Fourier Transform, Wavelet Transform and Wave Morphology for Spindle Detection. In order to improve the results, a combination of the three detectors is presented and comparison with human expert scorers is performed. The best performance is obtained with a combination of the three algorithms which resulted in a sensitivity and specificity of 94% when compared to human expert scorers.","PeriodicalId":23673,"journal":{"name":"World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering","volume":"389 1","pages":"397-400"},"PeriodicalIF":0.0,"publicationDate":"2012-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75149389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-01-21DOI: 10.3923/AJDD.2011.200.208
F. Khorshid
Breast cancer is the most common malignancy in the world among women. Many therapies have been designed to treat this disease. Mamectomy, chemotherapy and radiotherapy are still the main therapies of breast cancer. However, the results were unsatisfactory and still far from the ideal treatment. PM 701is a natural product, has anticancer activity. The bioactive fraction PMF and subfraction PMFK had been isolated from PM701. PM 701 and its fractions were proved to have a cytotoxic properties against different cancer cell lines. This article is directed for the further examination of lyophilized PM701 and its active fractions on the growth of breast cancer cells (MCF-7). PM 701, PMF or PMFK were adding to the cultural medium, where MCF-7 is incubated. PM 701, PMF or PMFK were able to inhibit significantly the proliferation of MCF-7 cells, Moreover these new agents were proved to induce apoptosis of the breast cancer cells; through its direct effect on the nuclei. Keywords—Anticancer agent, breast carcinoma, MCF-7 cell line, PM 701
{"title":"The Cytotoxic Effect of PM 701 and its Fractions on Cell Proliferation of Breast Cancer Cells, McF7","authors":"F. Khorshid","doi":"10.3923/AJDD.2011.200.208","DOIUrl":"https://doi.org/10.3923/AJDD.2011.200.208","url":null,"abstract":"Breast cancer is the most common malignancy in the world among women. Many therapies have been designed to treat this disease. Mamectomy, chemotherapy and radiotherapy are still the main therapies of breast cancer. However, the results were unsatisfactory and still far from the ideal treatment. PM 701is a natural product, has anticancer activity. The bioactive fraction PMF and subfraction PMFK had been isolated from PM701. PM 701 and its fractions were proved to have a cytotoxic properties against different cancer cell lines. This article is directed for the further examination of lyophilized PM701 and its active fractions on the growth of breast cancer cells (MCF-7). PM 701, PMF or PMFK were adding to the cultural medium, where MCF-7 is incubated. PM 701, PMF or PMFK were able to inhibit significantly the proliferation of MCF-7 cells, Moreover these new agents were proved to induce apoptosis of the breast cancer cells; through its direct effect on the nuclei. Keywords—Anticancer agent, breast carcinoma, MCF-7 cell line, PM 701","PeriodicalId":23673,"journal":{"name":"World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering","volume":"1 1","pages":"15-19"},"PeriodicalIF":0.0,"publicationDate":"2011-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86800773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-10-21DOI: 10.1108/03321641211227320
C. Antunes, T. Almeida, N. Raposeiro, B. Gonçalves, Paulo Almeida, A. Antunes
In the last two decades radiofrequency ablation (RFA) has been considered a promising medical procedure for the treatment of primary and secondary malignancies. However, the needle-based electrodes so far developed for this kind of treatment are not suitable for the thermal ablation of tumors located in hollow organs like esophagus, colon or bile duct. In this work a tubular electrode solution is presented. Numerical and experimental analyses were performed to characterize the volume of the lesion induced. Results show that this kind of electrode is a feasible solution and numerical simulation might provide a tool for planning RFA procedure with some accuracy.
{"title":"A Tubular Electrode for Radiofrequency Ablation Therapy","authors":"C. Antunes, T. Almeida, N. Raposeiro, B. Gonçalves, Paulo Almeida, A. Antunes","doi":"10.1108/03321641211227320","DOIUrl":"https://doi.org/10.1108/03321641211227320","url":null,"abstract":"In the last two decades radiofrequency ablation (RFA) \u0000has been considered a promising medical procedure for the treatment \u0000of primary and secondary malignancies. However, the needle-based \u0000electrodes so far developed for this kind of treatment are not suitable \u0000for the thermal ablation of tumors located in hollow organs like \u0000esophagus, colon or bile duct. In this work a tubular electrode \u0000solution is presented. Numerical and experimental analyses were \u0000performed to characterize the volume of the lesion induced. Results \u0000show that this kind of electrode is a feasible solution and numerical \u0000simulation might provide a tool for planning RFA procedure with \u0000some accuracy.","PeriodicalId":23673,"journal":{"name":"World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering","volume":"39 1","pages":"514-520"},"PeriodicalIF":0.0,"publicationDate":"2010-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78688046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose of this work is measurement of the system presampling MTF of a variable resolution x-ray (VRX) CT scanner. In this paper, we used the parameters of an actual VRX CT scanner for simulation and study of effect of different focal spot sizes on system presampling MTF by Monte Carlo method (GATE simulation software). Focal spot size of 0.6 mm limited the spatial resolution of the system to 5.5 cy/mm at incident angles of below 17o for cell#1. By focal spot size of 0.3 mm the spatial resolution increased up to 11 cy/mm and the limiting effect of focal spot size appeared at incident angles of below 9o. The focal spot size of 0.3 mm could improve the spatial resolution to some extent but because of magnification non-uniformity, there is a 10 cy/mm difference between spatial resolution of cell#1 and cell#256. The focal spot size of 0.1 mm acted as an ideal point source for this system. The spatial resolution increased to more than 35 cy/mm and at all incident angles the spatial resolution was a function of incident angle. By the way focal spot size of 0.1 mm minimized the effect of magnification nonuniformity.
{"title":"A Novel Method Based on Monte Carlo for Simulation of Variable Resolution X-ray CT Scanner: Measurement of System Presampling MTF","authors":"Hossein ARABI, A. K. Asl","doi":"10.5281/ZENODO.1070916","DOIUrl":"https://doi.org/10.5281/ZENODO.1070916","url":null,"abstract":"The purpose of this work is measurement of the\u0000system presampling MTF of a variable resolution x-ray (VRX) CT\u0000scanner. In this paper, we used the parameters of an actual VRX CT\u0000scanner for simulation and study of effect of different focal spot sizes\u0000on system presampling MTF by Monte Carlo method (GATE\u0000simulation software). Focal spot size of 0.6 mm limited the spatial\u0000resolution of the system to 5.5 cy/mm at incident angles of below 17o\u0000for cell#1. By focal spot size of 0.3 mm the spatial resolution\u0000increased up to 11 cy/mm and the limiting effect of focal spot size\u0000appeared at incident angles of below 9o. The focal spot size of 0.3\u0000mm could improve the spatial resolution to some extent but because\u0000of magnification non-uniformity, there is a 10 cy/mm difference\u0000between spatial resolution of cell#1 and cell#256. The focal spot size\u0000of 0.1 mm acted as an ideal point source for this system. The spatial\u0000resolution increased to more than 35 cy/mm and at all incident angles\u0000the spatial resolution was a function of incident angle. By the way\u0000focal spot size of 0.1 mm minimized the effect of magnification nonuniformity.","PeriodicalId":23673,"journal":{"name":"World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering","volume":"64 1","pages":"355-359"},"PeriodicalIF":0.0,"publicationDate":"2010-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80334228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Gooroochurn, M. Ovinis, D. Kerr, K. Bouazza-Marouf, M. Vloeberghs
A registration framework for image-guided robotic surgery is proposed for three emergency neurosurgical procedures, namely Intracranial Pressure (ICP) Monitoring, External Ventricular Drainage (EVD) and evacuation of a Chronic Subdural Haematoma (CSDH). The registration paradigm uses CT and white light as modalities. This paper presents two simulation studies for a preliminary evaluation of the registration protocol: (1) The loci of the Target Registration Error (TRE) in the patient's axial, coronal and sagittal views were simulated based on a Fiducial Localisation Error (FLE) of 5 mm and (2) Simulation of the actual framework using projected views from a surface rendered CT model to represent white light images of the patient. Craniofacial features were employed as the registration basis to map the CT space onto the simulated intraoperative space. Photogrammetry experiments on an artificial skull were also performed to benchmark the results obtained from the second simulation. The results of both simulations show that the proposed protocol can provide a 5mm accuracy for these neurosurgical procedures. Keywords—Image-guided Surgery, Multimodality Registration, Photogrammetry, Preoperative to Intraoperative Registration. I. INTRODUCTION HIS paper presents a registration framework designed to support image-guided solutions for three neurosurgical procedures that are routinely employed in the management of head injuries. Registration is a general term used to describe the alignment of two datasets, with respect to a reference coordinate system, with the aim of reducing the disparity between them; alternatively recovering that disparity may be the goal. A registration basis consists of features chosen that relate both datasets in terms of the disparity involved. The
{"title":"Preoperative to Intraoperative Space Registration for Management of Head Injuries","authors":"M. Gooroochurn, M. Ovinis, D. Kerr, K. Bouazza-Marouf, M. Vloeberghs","doi":"10.5281/ZENODO.1082948","DOIUrl":"https://doi.org/10.5281/ZENODO.1082948","url":null,"abstract":"A registration framework for image-guided robotic surgery is proposed for three emergency neurosurgical procedures, namely Intracranial Pressure (ICP) Monitoring, External Ventricular Drainage (EVD) and evacuation of a Chronic Subdural Haematoma (CSDH). The registration paradigm uses CT and white light as modalities. This paper presents two simulation studies for a preliminary evaluation of the registration protocol: (1) The loci of the Target Registration Error (TRE) in the patient's axial, coronal and sagittal views were simulated based on a Fiducial Localisation Error (FLE) of 5 mm and (2) Simulation of the actual framework using projected views from a surface rendered CT model to represent white light images of the patient. Craniofacial features were employed as the registration basis to map the CT space onto the simulated intraoperative space. Photogrammetry experiments on an artificial skull were also performed to benchmark the results obtained from the second simulation. The results of both simulations show that the proposed protocol can provide a 5mm accuracy for these neurosurgical procedures. Keywords—Image-guided Surgery, Multimodality Registration, Photogrammetry, Preoperative to Intraoperative Registration. I. INTRODUCTION HIS paper presents a registration framework designed to support image-guided solutions for three neurosurgical procedures that are routinely employed in the management of head injuries. Registration is a general term used to describe the alignment of two datasets, with respect to a reference coordinate system, with the aim of reducing the disparity between them; alternatively recovering that disparity may be the goal. A registration basis consists of features chosen that relate both datasets in terms of the disparity involved. The","PeriodicalId":23673,"journal":{"name":"World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering","volume":"22 1","pages":"230-237"},"PeriodicalIF":0.0,"publicationDate":"2009-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77685998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Sinescu, M. Negruțiu, M. Rominu, C. Haiduc, E. Petrescu, Marius Leretter, A. Podoleanu
Optical Coherence Tomography (OCT) combined with the Confocal Microscopy, as a noninvasive method, permits the determinations of materials defects in the ceramic layers depth. For this study 256 anterior and posterior metal and integral ceramic fixed partial dentures were used, made with Empress (Ivoclar), Wollceram and CAD/CAM (Wieland) technology. For each investigate area 350 slices were obtain and a 3D reconstruction was perform from each stuck. The Optical Coherent Tomography, as a noninvasive method, can be used as a control technique in integral ceramic technology, before placing those fixed partial dentures in the oral cavity. The purpose of this study is to evaluate the capability of En face Optical Coherence Tomography (OCT) combined with a fluorescent method in detection and analysis of possible material defects in metalceramic and integral ceramic fixed partial dentures. As a conclusion, it is important to have a non invasive method to investigate fixed partial prostheses before their insertion in the oral cavity in order to satisfy the high stress requirements and the esthetic function.
光学相干层析成像(OCT)与共聚焦显微镜相结合，作为一种非侵入性的方法，可以确定陶瓷层深度中的材料缺陷。本研究采用皇后(Ivoclar)、Wollceram和CAD/CAM (Wieland)技术制作的256个前后侧金属和整体陶瓷固定义齿。对于每个研究区域，获得350片切片，并对每个卡进行三维重建。光学相干断层扫描作为一种非侵入性的方法，可以作为整体陶瓷技术的控制技术，在口腔内放置固定局部义齿之前。本研究的目的是评估En face Optical Coherence Tomography (OCT)结合荧光方法检测和分析金属陶瓷和整体陶瓷固定局部义齿可能存在的材料缺陷的能力。因此，为了满足高应力要求和美观功能，在固定部分假体置入口腔前采用无创方法对其进行检查是非常重要的。
{"title":"En-Face Optical Coherence Tomography Combined With Fluorescence In Material Defects Investigations For Ceramic Fixed Partial Dentures","authors":"C. Sinescu, M. Negruțiu, M. Rominu, C. Haiduc, E. Petrescu, Marius Leretter, A. Podoleanu","doi":"10.5281/ZENODO.1082301","DOIUrl":"https://doi.org/10.5281/ZENODO.1082301","url":null,"abstract":"Optical Coherence Tomography (OCT) combined with the Confocal Microscopy, as a noninvasive method, permits the determinations of materials defects in the ceramic layers depth. For this study 256 anterior and posterior metal and integral ceramic fixed partial dentures were used, made with Empress (Ivoclar), Wollceram and CAD/CAM (Wieland) technology. For each investigate area 350 slices were obtain and a 3D reconstruction was perform from each stuck. The Optical Coherent Tomography, as a noninvasive method, can be used as a control technique in integral ceramic technology, before placing those fixed partial dentures in the oral cavity. The purpose of this study is to evaluate the capability of En face Optical Coherence Tomography (OCT) combined with a fluorescent method in detection and analysis of possible material defects in metalceramic and integral ceramic fixed partial dentures. As a conclusion, it is important to have a non invasive method to investigate fixed partial prostheses before their insertion in the oral cavity in order to satisfy the high stress requirements and the esthetic function.","PeriodicalId":23673,"journal":{"name":"World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering","volume":"11 1","pages":"199-203"},"PeriodicalIF":0.0,"publicationDate":"2009-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77876545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
One of the best ways for achievement of conventional vehicle changing to hybrid case is trustworthy simulation result and using of driving realities. For this object, in this paper, at first sevendegree-of-freedom dynamical model of vehicle will be shown. Then by using of statically model of engine, gear box, clutch, differential, electrical machine and battery, the hybrid automobile modeling will be down and forward simulation of vehicle for pedals to wheels power transformation will be obtained. Then by design of a fuzzy controller and using the proper rule base, fuel economy and regenerative braking will be marked. Finally a series of MATLAB/SIMULINK simulation results will be proved the effectiveness of proposed structure. Keywords—Hybrid, Driving, Fuzzy, Regeneration.
{"title":"Forward Simulation of a Parallel Hybrid Vehicle and Fuzzy Controller Design for Driving/Regenerative Propose","authors":"P. Naderi, A. Farhadi, S. Bathaee","doi":"10.7726/jgei.2013.1003","DOIUrl":"https://doi.org/10.7726/jgei.2013.1003","url":null,"abstract":"One of the best ways for achievement of conventional vehicle changing to hybrid case is trustworthy simulation result and using of driving realities. For this object, in this paper, at first sevendegree-of-freedom dynamical model of vehicle will be shown. Then by using of statically model of engine, gear box, clutch, differential, electrical machine and battery, the hybrid automobile modeling will be down and forward simulation of vehicle for pedals to wheels power transformation will be obtained. Then by design of a fuzzy controller and using the proper rule base, fuel economy and regenerative braking will be marked. Finally a series of MATLAB/SIMULINK simulation results will be proved the effectiveness of proposed structure. Keywords—Hybrid, Driving, Fuzzy, Regeneration.","PeriodicalId":23673,"journal":{"name":"World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering","volume":"1 1","pages":"307-314"},"PeriodicalIF":0.0,"publicationDate":"2008-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85522800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering
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