Carbapenems are the prime choice of treatment for severe cases of infections caused by Multi-Drug-Resistant Pseudomonas aeruginosa and Proteus mirabilis. Nevertheless, Metallo-Beta-Lactamase (MBL) production by these organisms has led to carbapenem resistance which is a global threat. This study aimed to determine the prevalence and antimicrobial susceptibility profile of MBL in clinical isolates of Pseudomonas aeruginosa and Proteus mirabilis in Benin City, Nigeria. 354 non monotonous clinical isolates of Pseudomonas aeruginosa (282) and Proteus mirabilis (72) used were obtained from various clinical samples from tertiary hospitals in Benin City. Identification of these isolates were done using standard microbiological techniques. Antimicrobial susceptibility test was performed using Kirby-Bauer disk diffusion method. MBL production was detected using Imipenem Ethylene-Diamine-Tetra-Acetic Acid combined disc test method. Of the total 354 clinical isolates tested, 115 (32.48%) were MBL and the prevalence of this resistant isolates was significantly higher in Pseudomonas aeruginosa (46.8%) compared to Proteus mirabilis (P=0.0001). Among the metallo-beta-lactamase producing isolates of Pseudomonas aeruginosa higher prevalence were reported from Pleural fluid and cerebrospinal fluid samples with 6 (100%) and 3 (100%) respectively. This difference was statistically significant (P=0.0001). Susceptibility testing showed that isolates that produced beta-lactamase demonstrated poorly against cephalosporin, amoxicillin-clavulanate, gentamicin and floroquinones than non-beta- lactamase producers. A prevalence of 46.8% was reported for MBL producing Pseudomonas aeruginosa and 12.5% was reported for MBL producing Proteus mirabilis. Isolates that produced the MBL enzyme were more resistant to antibacterial agents. Measures to control and curb the spread of MBL producing clinical isolates are highly advocated
{"title":"Prevalence of metallo-beta-lactamase in clinical isolates of Pseudomonas aeruginosa and Proteus mirabilis in Benin City, Nigeria","authors":"Olabisi Promise Lawal, Ibrahim Ayo Olanipekun, Bukola Ikuejamoye-Omotore, Adedoyin Tinuade Buari, Omowunmi Ramota Gbadamosi, Cynthia Amarachukwu Ibe-Chukwuemeka","doi":"10.30574/wjarr.2024.23.1.2060","DOIUrl":"https://doi.org/10.30574/wjarr.2024.23.1.2060","url":null,"abstract":"Carbapenems are the prime choice of treatment for severe cases of infections caused by Multi-Drug-Resistant Pseudomonas aeruginosa and Proteus mirabilis. Nevertheless, Metallo-Beta-Lactamase (MBL) production by these organisms has led to carbapenem resistance which is a global threat. This study aimed to determine the prevalence and antimicrobial susceptibility profile of MBL in clinical isolates of Pseudomonas aeruginosa and Proteus mirabilis in Benin City, Nigeria. 354 non monotonous clinical isolates of Pseudomonas aeruginosa (282) and Proteus mirabilis (72) used were obtained from various clinical samples from tertiary hospitals in Benin City. Identification of these isolates were done using standard microbiological techniques. Antimicrobial susceptibility test was performed using Kirby-Bauer disk diffusion method. MBL production was detected using Imipenem Ethylene-Diamine-Tetra-Acetic Acid combined disc test method. Of the total 354 clinical isolates tested, 115 (32.48%) were MBL and the prevalence of this resistant isolates was significantly higher in Pseudomonas aeruginosa (46.8%) compared to Proteus mirabilis (P=0.0001). Among the metallo-beta-lactamase producing isolates of Pseudomonas aeruginosa higher prevalence were reported from Pleural fluid and cerebrospinal fluid samples with 6 (100%) and 3 (100%) respectively. This difference was statistically significant (P=0.0001). Susceptibility testing showed that isolates that produced beta-lactamase demonstrated poorly against cephalosporin, amoxicillin-clavulanate, gentamicin and floroquinones than non-beta- lactamase producers. A prevalence of 46.8% was reported for MBL producing Pseudomonas aeruginosa and 12.5% was reported for MBL producing Proteus mirabilis. Isolates that produced the MBL enzyme were more resistant to antibacterial agents. Measures to control and curb the spread of MBL producing clinical isolates are highly advocated","PeriodicalId":23739,"journal":{"name":"World Journal of Advanced Research and Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141795997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-30DOI: 10.30574/wjarr.2024.23.1.2027
Vaibhav D. Misal, Ashok M. Chavan
Stevia rebaudiana Bertoni, an ancient perennial herb produces steviol glycosides including stevioside and rebaudioside-A that are valuable as low calorie sweeteners, about 300-400 times sweeter than saccharose. Conventional propagation methods are not produce adequate planting material. Micro propagation is an imperative technology that could be extensively exploited to meet the growing demands of elite planting material for commercially cultivated. The prime objective of this study was to established standard protocol for in vitro regeneration and mass multiplication in Stevia. In present investigation, different concentrations of Auxin and Cytokinin were tried for optimization of shoot initiation, shoot multiplication, root initiation and callus induction of Stevia from different explant. BAP and IBA (1.0+0.5) mg/l, IBA (2.0) mg/l shows promising results of shoot multiplication and root initiation respectively.
{"title":"In vitro micropropagation and mass multiplication of Stevia rebaudiana Bertoni","authors":"Vaibhav D. Misal, Ashok M. Chavan","doi":"10.30574/wjarr.2024.23.1.2027","DOIUrl":"https://doi.org/10.30574/wjarr.2024.23.1.2027","url":null,"abstract":"Stevia rebaudiana Bertoni, an ancient perennial herb produces steviol glycosides including stevioside and rebaudioside-A that are valuable as low calorie sweeteners, about 300-400 times sweeter than saccharose. Conventional propagation methods are not produce adequate planting material. Micro propagation is an imperative technology that could be extensively exploited to meet the growing demands of elite planting material for commercially cultivated. The prime objective of this study was to established standard protocol for in vitro regeneration and mass multiplication in Stevia. In present investigation, different concentrations of Auxin and Cytokinin were tried for optimization of shoot initiation, shoot multiplication, root initiation and callus induction of Stevia from different explant. BAP and IBA (1.0+0.5) mg/l, IBA (2.0) mg/l shows promising results of shoot multiplication and root initiation respectively.","PeriodicalId":23739,"journal":{"name":"World Journal of Advanced Research and Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141796014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-30DOI: 10.30574/wjarr.2024.23.1.2013
Sérgio Murta Maciel, Breno Bitencourt Brás, Gabriel Toledo
Introduction: The anatomical study cannot be limited to memorization and identification of structures. It is essential that, in a modern and dynamic approach to this discipline, contextualization is adopted, and above all, the clinical applications of what is studied, in addition to other methods such as 3D images. It is necessary to understand the student's conception of such methods – the didactic and scientific evidence at the moment – so that they can make the connection – in the present and the future – with professional life. Methodology: The research, carried out with 163 medical students from two educational institutions in Juiz de Fora, aimed to find out which methodologies were used in their anatomy course; Which one(s) among them is(are) seen as the most effective, and most facilitator(s) of the learning process and approach to clinical practice. The data obtained were processed using the SPSS program, version 20.0. Results: It was evident that the approach to anatomical content based on clinical direction, contextualization of the subject, and use of radiological images is more widespread in Medicine. The application of seminars and clinical debates was scarcely explored. The use of alternative technologies to slides was notable in the Medicine course. Medical students, markedly, advocate for contextualizations and clinical applications. Conclusions: Students, in general, recognize the effectiveness of contextualization, clinical correlations, and the use of images. Few students support the use of seminars. As much as the interviewees do not prefer more summarized theoretical classes, they would like fewer structures to lean about, with more direct books.
{"title":"The most effective strategies in teaching theoretical Anatomy in Medical schools, from a student’s view","authors":"Sérgio Murta Maciel, Breno Bitencourt Brás, Gabriel Toledo","doi":"10.30574/wjarr.2024.23.1.2013","DOIUrl":"https://doi.org/10.30574/wjarr.2024.23.1.2013","url":null,"abstract":"Introduction: The anatomical study cannot be limited to memorization and identification of structures. It is essential that, in a modern and dynamic approach to this discipline, contextualization is adopted, and above all, the clinical applications of what is studied, in addition to other methods such as 3D images. It is necessary to understand the student's conception of such methods – the didactic and scientific evidence at the moment – so that they can make the connection – in the present and the future – with professional life. Methodology: The research, carried out with 163 medical students from two educational institutions in Juiz de Fora, aimed to find out which methodologies were used in their anatomy course; Which one(s) among them is(are) seen as the most effective, and most facilitator(s) of the learning process and approach to clinical practice. The data obtained were processed using the SPSS program, version 20.0. Results: It was evident that the approach to anatomical content based on clinical direction, contextualization of the subject, and use of radiological images is more widespread in Medicine. The application of seminars and clinical debates was scarcely explored. The use of alternative technologies to slides was notable in the Medicine course. Medical students, markedly, advocate for contextualizations and clinical applications. Conclusions: Students, in general, recognize the effectiveness of contextualization, clinical correlations, and the use of images. Few students support the use of seminars. As much as the interviewees do not prefer more summarized theoretical classes, they would like fewer structures to lean about, with more direct books.","PeriodicalId":23739,"journal":{"name":"World Journal of Advanced Research and Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141796017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-30DOI: 10.30574/wjarr.2024.23.1.2133
Martha Jepkemboi Tubei, Michael Kimotho, Jennifer Munyua
The study sought find out the effects of reduced personal accomplishment and delivery of professional functions among university lecturers in Uasin Gishu County, Kenya. The study adopted the Multidimensional Theory of burnout by Christina Maslach (1946). The study used embedded research design in the mixed method approach and Ex Post Facto approach. Simple random sampling technique was used to sample 178 lecturers. Three counselors were sampled using purposive sampling from the sampled universities. Qualitative research was analyzed in theme derived from the in-depth interviews while quantitative data was coded and analyzed using the Statistical Package for Social Science Version 26.0. Using descriptive statistics and presented using frequencies, percentages, mean and standard deviation. The study found out that reduced personal accomplishment had a moderate level (66%) of burnout. The hypotheses were tested using linear and multiple regression which showed that reduced personal accomplishment, F (1, 95) = 16.935, p = 0.02 had statistically significant relationship with the delivery of professional functions. The study will be beneficial to the Ministry of Education, university lecturers and the counsellors. The study recommends that university administration regularizes the workload and working schedules to ensure that lecturers are not overwhelmed by workload to reduce work burnout.
该研究试图找出肯尼亚 Uasin Gishu 县大学讲师个人成就感降低和履行专业职能的影响。研究采用了 Christina Maslach（1946 年）提出的职业倦怠多维理论。研究采用了混合方法中的嵌入式研究设计和事后研究方法。采用简单随机抽样技术抽取了 178 名讲师。采用目的性抽样法从被抽样大学中抽取了 3 名辅导员。定性研究以深入访谈得出的主题进行分析，定量数据则使用社会科学统计软件包 26.0 版进行编码和分析。使用描述性统计，并以频率、百分比、平均值和标准偏差的形式呈现。研究发现，个人成就感降低对职业倦怠的影响程度适中（66%）。使用线性回归和多元回归对假设进行了检验，结果表明，个人成就感降低（F (1, 95) = 16.935, p = 0.02）与专业职能的履行有显著的统计学关系。这项研究将有益于教育部、大学讲师和辅导员。研究建议大学管理部门规范工作量和工作时间表，确保讲师不被工作量压垮，以减少工作倦怠。
{"title":"Effects of reduced personal accomplishment on delivery of professional functions among University Lecturer’s in Uasin Gishu County, Kenya","authors":"Martha Jepkemboi Tubei, Michael Kimotho, Jennifer Munyua","doi":"10.30574/wjarr.2024.23.1.2133","DOIUrl":"https://doi.org/10.30574/wjarr.2024.23.1.2133","url":null,"abstract":"The study sought find out the effects of reduced personal accomplishment and delivery of professional functions among university lecturers in Uasin Gishu County, Kenya. The study adopted the Multidimensional Theory of burnout by Christina Maslach (1946). The study used embedded research design in the mixed method approach and Ex Post Facto approach. Simple random sampling technique was used to sample 178 lecturers. Three counselors were sampled using purposive sampling from the sampled universities. Qualitative research was analyzed in theme derived from the in-depth interviews while quantitative data was coded and analyzed using the Statistical Package for Social Science Version 26.0. Using descriptive statistics and presented using frequencies, percentages, mean and standard deviation. The study found out that reduced personal accomplishment had a moderate level (66%) of burnout. The hypotheses were tested using linear and multiple regression which showed that reduced personal accomplishment, F (1, 95) = 16.935, p = 0.02 had statistically significant relationship with the delivery of professional functions. The study will be beneficial to the Ministry of Education, university lecturers and the counsellors. The study recommends that university administration regularizes the workload and working schedules to ensure that lecturers are not overwhelmed by workload to reduce work burnout.","PeriodicalId":23739,"journal":{"name":"World Journal of Advanced Research and Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141796098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-30DOI: 10.30574/wjarr.2024.23.1.2089
Agus Dahlan, Putri Melinda Iradani
Factors that affect a person's quality of life can be influenced by aesthetics. In the case of involving orbits, it is a big problem in aesthetic factors and must be done immediately so as not to affect the quality of life of a person. A 76-year-old male patient came to the prosthodontic dental and oral hospital on a referral from an ophthalmologist to have an eye prosthesis because he wanted to improve his appearance. The patient wants to have an eye prosthesis immediately because of embarrassment. The creation of an eye prosthesis by printing with extraoral scans and orbital contour design is the treatment plan given to the patient. After that, the first visit to the orbital socket is scanned, the color of the eye is selected and the patient can go home. The contour of the orbit of the eye can be designed with 3D software and 3D printed for the working model, as well as the search for a suitable stock eye for the patient. The next visit can be done by selecting colors and trying them out. This speeds up visits, prosthetic comfort and aesthetics.
{"title":"Custom made orbital prosthesis using digital approach: A case report","authors":"Agus Dahlan, Putri Melinda Iradani","doi":"10.30574/wjarr.2024.23.1.2089","DOIUrl":"https://doi.org/10.30574/wjarr.2024.23.1.2089","url":null,"abstract":"Factors that affect a person's quality of life can be influenced by aesthetics. In the case of involving orbits, it is a big problem in aesthetic factors and must be done immediately so as not to affect the quality of life of a person. A 76-year-old male patient came to the prosthodontic dental and oral hospital on a referral from an ophthalmologist to have an eye prosthesis because he wanted to improve his appearance. The patient wants to have an eye prosthesis immediately because of embarrassment. The creation of an eye prosthesis by printing with extraoral scans and orbital contour design is the treatment plan given to the patient. After that, the first visit to the orbital socket is scanned, the color of the eye is selected and the patient can go home. The contour of the orbit of the eye can be designed with 3D software and 3D printed for the working model, as well as the search for a suitable stock eye for the patient. The next visit can be done by selecting colors and trying them out. This speeds up visits, prosthetic comfort and aesthetics.","PeriodicalId":23739,"journal":{"name":"World Journal of Advanced Research and Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141796103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-30DOI: 10.30574/wjarr.2024.23.1.1983
Girish Chandrappa, Sowmya Anand
The amount of waste has been increasing due to the increase in human population and urbanization. In cities, the overflowed bin creates an unhygienic environment. Thus degrades the environment, to overcome this situation, “Solar Powered Solid Waste Management System Using IoT” is developed. The system is powered by solar energy and separates the waste into three categories namely wet, dry and metallic. Each of the wastes are detected by the respective sensors and gets segregated to respective bins. IoT is used to continuous monitor the dustbin in order to check whether the dustbin is full or not. The present work updates the real time data using IoT and the same can be conveyed to concerned administrators and can fetch the information using Android Application.
{"title":"Solar powered solid waste management system using IoT","authors":"Girish Chandrappa, Sowmya Anand","doi":"10.30574/wjarr.2024.23.1.1983","DOIUrl":"https://doi.org/10.30574/wjarr.2024.23.1.1983","url":null,"abstract":"The amount of waste has been increasing due to the increase in human population and urbanization. In cities, the overflowed bin creates an unhygienic environment. Thus degrades the environment, to overcome this situation, “Solar Powered Solid Waste Management System Using IoT” is developed. The system is powered by solar energy and separates the waste into three categories namely wet, dry and metallic. Each of the wastes are detected by the respective sensors and gets segregated to respective bins. IoT is used to continuous monitor the dustbin in order to check whether the dustbin is full or not. The present work updates the real time data using IoT and the same can be conveyed to concerned administrators and can fetch the information using Android Application.","PeriodicalId":23739,"journal":{"name":"World Journal of Advanced Research and Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141796143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-30DOI: 10.30574/wjarr.2024.23.1.1987
Meryem Sassi, Alexandre Lecis
We report a case involving a patient who developed a polymorphic rash and prurigo lesions on the limbs and anterior thorax, accompanied by an urticarial reaction on the back, following the endovascular placement of a femoral and iliac nitinol stent for critical limb ischemia. Patch testing identified a nickel allergy. The patient responded well to corticosteroid therapy, showing significant clinical improvement. This report discusses the epidemiology, pathophysiology, and clinical implications of nickel allergy, particularly in the context of using nickel-alloy stents.
{"title":"Nickel allergy in a patient after nitinol stent placement","authors":"Meryem Sassi, Alexandre Lecis","doi":"10.30574/wjarr.2024.23.1.1987","DOIUrl":"https://doi.org/10.30574/wjarr.2024.23.1.1987","url":null,"abstract":"We report a case involving a patient who developed a polymorphic rash and prurigo lesions on the limbs and anterior thorax, accompanied by an urticarial reaction on the back, following the endovascular placement of a femoral and iliac nitinol stent for critical limb ischemia. Patch testing identified a nickel allergy. The patient responded well to corticosteroid therapy, showing significant clinical improvement. This report discusses the epidemiology, pathophysiology, and clinical implications of nickel allergy, particularly in the context of using nickel-alloy stents.","PeriodicalId":23739,"journal":{"name":"World Journal of Advanced Research and Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141796179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-30DOI: 10.30574/wjarr.2024.23.1.1880
Denan Kong, Yuzhong Sun
Starting from a systematic perspective, this study divides the rural revitalization system into five subsystems: Prosperous industries, Ecological livability, Rural cultural civilization, Effective governance, and Prosperous life , as well as 14 secondary indicators based on the rural revitalization strategy. It uses the coefficient of variation method and relative weighting method to determine the weight of each indicator. Based on this, the fuzzy comprehensive evaluation method is used to calculate the level of rural revitalization in Daqing City. The research shows that due to the continuous development of the prosperous industries subsystem and the prosperous life subsystem in Daqing, the level of rural revitalization in Daqing City has continued to rise. However, the fluctuation of the ecological livability subsystem caused by the increase in clean fuel use and the decrease in rural greening in Daqing City requires continuous improvement in rural greening. Further increasing the consumption expenditure of rural residents in education, culture, and entertainment can promote the continuous rise of the rural cultural civilization subsystem.
{"title":"Research on the evaluation of rural revitalization level in Daqing City","authors":"Denan Kong, Yuzhong Sun","doi":"10.30574/wjarr.2024.23.1.1880","DOIUrl":"https://doi.org/10.30574/wjarr.2024.23.1.1880","url":null,"abstract":"Starting from a systematic perspective, this study divides the rural revitalization system into five subsystems: Prosperous industries, Ecological livability, Rural cultural civilization, Effective governance, and Prosperous life , as well as 14 secondary indicators based on the rural revitalization strategy. It uses the coefficient of variation method and relative weighting method to determine the weight of each indicator. Based on this, the fuzzy comprehensive evaluation method is used to calculate the level of rural revitalization in Daqing City. The research shows that due to the continuous development of the prosperous industries subsystem and the prosperous life subsystem in Daqing, the level of rural revitalization in Daqing City has continued to rise. However, the fluctuation of the ecological livability subsystem caused by the increase in clean fuel use and the decrease in rural greening in Daqing City requires continuous improvement in rural greening. Further increasing the consumption expenditure of rural residents in education, culture, and entertainment can promote the continuous rise of the rural cultural civilization subsystem.","PeriodicalId":23739,"journal":{"name":"World Journal of Advanced Research and Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141796207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-30DOI: 10.30574/wjarr.2024.23.1.2067
Meryem Sassi, Alexandre Lecis
Superior vena cava syndrome is secondary to obstruction of the superior vena cava and/or brachiocephalic venous trunk, which are currently common during venous catheterization (implantable chamber, dialysis catheter or during placement of an endocavitary stimulation lead). We report the case of a 50-year-old patient with beta thalassemia who had been wearing a chemotherapy box for 2 years, and presented with clinically symptomatic superior vena cava syndrome. A phleboscanner was ordered, showing a tight stenosis of the superior vena cava. A double-approach angioplasty was performed with good postoperative results.
{"title":"Superior vena cava thrombosis induced by chemotherapy port: About a case","authors":"Meryem Sassi, Alexandre Lecis","doi":"10.30574/wjarr.2024.23.1.2067","DOIUrl":"https://doi.org/10.30574/wjarr.2024.23.1.2067","url":null,"abstract":"Superior vena cava syndrome is secondary to obstruction of the superior vena cava and/or brachiocephalic venous trunk, which are currently common during venous catheterization (implantable chamber, dialysis catheter or during placement of an endocavitary stimulation lead). We report the case of a 50-year-old patient with beta thalassemia who had been wearing a chemotherapy box for 2 years, and presented with clinically symptomatic superior vena cava syndrome. A phleboscanner was ordered, showing a tight stenosis of the superior vena cava. A double-approach angioplasty was performed with good postoperative results.","PeriodicalId":23739,"journal":{"name":"World Journal of Advanced Research and Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141796237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Several of the bacteria responsible for pneumonia had become resistant to available antibiotics. According to the WHO, the resistance of Klebsiella pneumonia to Ciprofloxacin is 79.4%, making infections such as pneumonia and several diseases more difficult, if not impossible to treat. The prevalence of antimicrobial resistance is a global problem and among the 10 top global health threats facing humanity. With the projection of 10 million deaths per year by 2050 due to bacterial infections associated with antibiotic resistance according to WHO, there is an urgent need to identify an alternative approach to curb the incessant antimicrobial resistance and a complementary approach is to employ the use of naturally occurring compounds with potent antibacterial activities. We employed structural bioinformatics and theoretical chemistry techniques via molecular docking, and pharmacokinetic study, to identify novel S. pneumoniae topoisomerase IV inhibitors. The stringent molecular docking identified Arg140, Arg81, Glu55, Pro84, Met83, and Asn51, as principal amino acid residues for topoisomerase IV ligand interactions. Ten of the bioactive compounds found in Vernonia amygdalina showed a higher binding energy when compared to the reference compound (Ciprofloxacin). The overall analysis of MD results and binding free energy calculations reveal that Luteolin and 7-O-methylwogonin displayed stable trajectories with acceptable RMSD values and sufficient high negative energies throughout the MD simulation run of 100ns. These identified bioactive compounds in this study can be taken further for in vitro and In vivo studies to examine their efficacy against Pneumonia.
{"title":"Computational study of phytochemical derived bioactive compounds of Vernonia amygdalina as a potential inhibitor of Topoisomerase IV in pneumonia","authors":"Ayobami Fidelix, Tomilola Akingbade, Jatin Jangra, Olutola Adeyemo, Damilola Adeniji","doi":"10.30574/wjarr.2024.23.1.2130","DOIUrl":"https://doi.org/10.30574/wjarr.2024.23.1.2130","url":null,"abstract":"Several of the bacteria responsible for pneumonia had become resistant to available antibiotics. According to the WHO, the resistance of Klebsiella pneumonia to Ciprofloxacin is 79.4%, making infections such as pneumonia and several diseases more difficult, if not impossible to treat. The prevalence of antimicrobial resistance is a global problem and among the 10 top global health threats facing humanity. With the projection of 10 million deaths per year by 2050 due to bacterial infections associated with antibiotic resistance according to WHO, there is an urgent need to identify an alternative approach to curb the incessant antimicrobial resistance and a complementary approach is to employ the use of naturally occurring compounds with potent antibacterial activities. We employed structural bioinformatics and theoretical chemistry techniques via molecular docking, and pharmacokinetic study, to identify novel S. pneumoniae topoisomerase IV inhibitors. The stringent molecular docking identified Arg140, Arg81, Glu55, Pro84, Met83, and Asn51, as principal amino acid residues for topoisomerase IV ligand interactions. Ten of the bioactive compounds found in Vernonia amygdalina showed a higher binding energy when compared to the reference compound (Ciprofloxacin). The overall analysis of MD results and binding free energy calculations reveal that Luteolin and 7-O-methylwogonin displayed stable trajectories with acceptable RMSD values and sufficient high negative energies throughout the MD simulation run of 100ns. These identified bioactive compounds in this study can be taken further for in vitro and In vivo studies to examine their efficacy against Pneumonia.","PeriodicalId":23739,"journal":{"name":"World Journal of Advanced Research and Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141796244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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