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MICROBIOLOGICAL ANALYTICAL METHOD FOR DETERMINATION OF SERTACONAZOLE NITRATE IN PHARMACEUTICAL FORMULATIONS 制剂中硝酸舍他康唑含量的微生物分析方法
Pub Date : 2022-07-28 DOI: 10.37896/ymer21.07/91
N. Raghavendra Babu
Sertaconazole nitrate is a third generation synthetic broad-spectrum, benzothiophene imidazole antifungal agent. A new microbiological method was developed for analysis of sertaconazole tablets using candida Albicans as test microorganism. The diffusion assay method was optimized by using different media, organisms and conditions. Prospective validation of the method showed adequate linearity (r = 0.9964), precision (% RSD<2%) and accuracy (mean recovery = 98.26%). Highperformance liquid chromatography was chosen as a comparison method for voriconazole determination. Results of both the microbiological and HPLC methods were compared with student ttest and the contents of voriconazole determined by both methods, showed a strong correlation. Highperformance liquid chromatography was chosen as a comparison method. Results of both the microbiological and HPLC methods were compared with student t-test and the contents of sertaconazole determined by both methods showed a strong correlation. The microbiological analytical method which was developed gives true indication of biological activity and can be used for routine quality control analysis of sertaconazole nitrate in dosage forms. Key words: Sertaconazole nitrate, t-test, Candida albicans, Diffusion method, HPLC, Method validation.
硝酸舍他康唑是合成的第三代广谱、苯并噻吩类咪唑类抗真菌剂。建立了以白色念珠菌为检测微生物分析舍他康唑片的新方法。采用不同的培养基、微生物和条件对扩散法进行了优化。前瞻性验证表明,该方法具有良好的线性(r = 0.9964)、精密度(% RSD<2%)和准确度(平均回收率= 98.26%)。采用高效液相色谱法测定伏立康唑。将微生物法和高效液相色谱法测定的结果与学生测定的结果进行比较,发现伏立康唑的含量与学生测定的结果有较强的相关性。采用高效液相色谱法进行比较。将微生物法和高效液相色谱法测定的结果与学生t检验进行比较,两种方法测定的舍他康唑含量具有较强的相关性。所建立的微生物学分析方法能准确反映制剂的生物活性,可用于制剂中硝酸舍他康唑的常规质量控制分析。关键词:硝酸塞他康唑,t检验,白色念珠菌,扩散法,高效液相色谱法,方法验证
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引用次数: 0
JUXTAPOSITION BETWEEN TWO CONVOLUTIONAL NEURAL NETWORK FOR MUSIC GENRE CLASSIFICATION 两种卷积神经网络并置的音乐体裁分类
Pub Date : 2022-07-28 DOI: 10.37896/ymer21.07/89
J. Shana, N. Priyadharshini Jayadurga, Pratiba K R, P. R
Music genre classification is the fundamental step involved in building a strong recommendation system. If music classification has to be carried out manually, then one has to listen to numerous songs and then select the genre. This process is not only time-consuming, it is quite a tedious task. The music industry has seen an excellent flow of latest channels to browse and distribute music. This doesn't return without drawbacks. With the increase in data, manual curation has become a difficult task. Audio files have a plethora of features that could be used to make parts of this process a lot easier. Advancements in technology have made it possible to extract the features of audio files. However, the most effective way to handle these for various tasks is unknown. This paper compared the two deep learning models of convolutional neural networks namely Alex-net and Res-net for the purpose of music genre classification using mel-spectrogram images for training. These aforementioned models were tested on GTZAN datasets. It was found that the results showed 56.0% accuracy for the res-net model which was outperformed by alex-net with an accuracy of 80.5%. Keywords: GTZAN Dataset, Alex-net, Res-net, Convolutional Neural Network
音乐类型分类是构建强大推荐系统的基本步骤。如果必须手动进行音乐分类,那么就必须听大量的歌曲,然后选择流派。这个过程不仅耗时,而且是一项相当乏味的任务。音乐产业已经看到了浏览和分发音乐的最新渠道的优秀流。这并非没有缺点。随着数据量的增加,人工管理已成为一项艰巨的任务。音频文件有很多功能,可以让这个过程变得更简单。技术的进步使得提取音频文件的特征成为可能。然而,处理各种任务的最有效方法是未知的。本文比较了卷积神经网络的两种深度学习模型,即Alex-net和Res-net,目的是使用mel- spectrum图像进行音乐类型分类训练。上述模型在GTZAN数据集上进行了测试。结果表明,res-net模型的准确率为56.0%,而alexnet模型的准确率为80.5%。关键词:GTZAN数据集,Alex-net, Res-net,卷积神经网络
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引用次数: 0
Atomic drift-less electromigration model for submicron copper interconnects 亚微米铜互连的原子无漂移电迁移模型
Pub Date : 2022-07-28 DOI: 10.37896/ymer21.07/94
A. Adhikari, A. Roy, C. Tan
Electromigration in chip level interconnect is commonly described by atomic drift due to electron-wind force that arises from electron-ion momentum transfer. As an alternative to this model, in early 1980’s, Sah proposed a two dimensional analytical ‘void-surface bond-breaking’ model by dropping the atomic drift term that resulted from electron-wind force (in his book ‘Fundamentals of Solid-State Electronics’) and the rate of change of area of void is computed. Due to the continuous down scaling and evolution of interconnect patterning technologies, the void growth process in modern interconnect becomes more complex and electromigration failures are found to be catastrophic in nature instead of gradual type failures observed in early days. In this work, Sah’s model is revisited from the perspective of its applicability to modern submicron copper interconnects. The electromigration-induced resistance change behavior is analytically derived considering a three-dimensional atomic drift-less model. A good correlation between the findings of our model with experimental observations is presented. Keywords: Analytical model, Copper, Drift-less, Electromigration, Resistance change, Time to failure
芯片级互连中的电迁移通常用由电子-离子动量转移引起的电子风力引起的原子漂移来描述。作为该模型的替代方案,在20世纪80年代初,Sah提出了一个二维解析的“空洞表面断键”模型,通过放弃由电子-风力引起的原子漂移项(在他的书《固态电子学基础》中),并计算了空洞面积的变化率。由于互连技术的不断缩小和发展,现代互连中的空洞生长过程变得更加复杂,电迁移失效的性质是灾难性的,而不是早期观察到的渐进式失效。在这项工作中,Sah的模型从其对现代亚微米铜互连的适用性的角度进行了重新审视。考虑三维原子无漂移模型,对电迁移引起的电阻变化行为进行了解析推导。我们的模型的发现与实验观察之间有很好的相关性。关键词:解析模型,铜,无漂移,电迁移,电阻变化,失效时间
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引用次数: 0
Antimicrobial properties of biodegradable polymer based ternary blend for wastewater treatment 废水处理中可生物降解聚合物基三元共混物的抗菌性能
Pub Date : 2022-07-28 DOI: 10.37896/ymer21.07/93
N. Prakash
Biodegradable based ternary blends has good antimicrobial properties and it has been verified against gram / negative E. coli, Pseudomonas sp. aeruoginosa, and gram-positive Staphylococcus sp. S. aureus bacteria. The comparison of binary and ternary blended reveals that more inhibition zone efficiency is found for ternary blended. Chitosan/nylon 6/clay (1:1:2), (2:1:1) and (1:2:1) respectively were reported. The binary blends inhibition zone chitosan/clay (2:1) recorded the maximum zone of inhibition in comparison with the standard chloramphenicol against E. coli (39 mm), Pseudomonas sp. aeuroginosa (36 mm), followed by S.aureus (22 mm). Most of the polymer blends showed higher inhibitory activity against Gram-negative strains than the Gram-positive bacteria. The antifungal activity of the chitosan polymer blends is seen and this activity is more pronounced against fungi. The inhibition was stronger in the order of chitosan/nylon 6/clay (2:1:1) followed by Chitosan/nylon 6/clay (1:1:1) and (1:1:2) against Aspergillus niger, Candida albicans and candida tropicalis. A higher inhibitory zone was recorded against Aspergillus niger (36 mm), Candida albicans (33 mm), and Candida tropicalis (36 mm) by chitosan/clay (2:1:1) when compared with standard amphoterecin B. Meanwhile Chitosan/nylon 6/clay (1:2:1) showed less activity. The present study is aimed to fetch the knowledge about the antimicrobial properties of biodegradable polymer based ternary blends in detail. Keywords: Chitosan; Nylon 6; Clay; Antimicrobial activity; Antifungal activity
可生物降解的三元共混物具有良好的抗菌性能,并已对革兰氏阴性大肠杆菌、铜绿假单胞菌和革兰氏阳性金黄色葡萄球菌进行了抑菌试验。二元共混与三元共混的对比表明,三元共混的缓蚀带效率更高。壳聚糖/尼龙6/粘土分别为(1:1:2)、(2:1:1)和(1:2:1)。壳聚糖/粘土(2:1)二元混合抑制带对大肠杆菌(39 mm)、铜绿假单胞菌(36 mm)、金黄色葡萄球菌(22 mm)的抑制带最大。大多数聚合物共混物对革兰氏阴性菌的抑制活性高于革兰氏阳性菌。壳聚糖聚合物共混物的抗真菌活性是可见的,这种活性对真菌更明显。壳聚糖/尼龙6/粘土(2:1:1)对黑曲霉、白色念珠菌和热带念珠菌的抑制作用最强,其次为壳聚糖/尼龙6/粘土(1:1:1)和(1:1:2)。壳聚糖/粘土(2:1:1)对黑曲霉(36 mm)、白色念珠菌(33 mm)和热带念珠菌(36 mm)的抑制范围较标准两性霉素b高,而壳聚糖/尼龙6/粘土(1:2:1)的抑制范围较低。本研究旨在详细了解可生物降解聚合物基三元共混物的抗菌性能。关键词:壳聚糖;尼龙6;粘土;抗菌活性;抗真菌活性
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引用次数: 0
Free fatty acids in some tissue of parasitized bug, Leptocoris augur Fabr., a pest of Kusum tree, Schleichera oleosa Lour. 被寄生的纤毛虫部分组织的游离脂肪酸。,是一种库苏姆树的害虫。
Pub Date : 2022-07-28 DOI: 10.37896/ymer21.07/95
Dr Kumkum
Leptocoris augur is a pest of kusum plant (Schleichera oleosa), which in turn is a host of lac insect. The bug is parasitized by a mermithid nematode, Hexamermis vishwakarma, which naturally checks rapid built-up of bug population. In the present studies free fatty acids content in different tissue such as gonads (i.e., testes and ovaries), muscles and haemolymph of parasitized bugs, L. augur have been studied. H. vishwakarma not only utilize fat body proteins but also the lipid content of the fat as a result of which fat bodies disappears from the haemolymph of L. augur. The fatty acid composition of the host haemolymph is not significantly changed by H. vishwakarma parasitism in L. augur of both the sexes. H. vishwakarma Dhiman takes nutrition from the haemolymph and muscles of insect body cavity Dhiman and Singh [3]. Availability of free fatty acids in the haemolymph of host bug help the parasitoid to establish in the haemocoel. After establishment, the parasitoid induces changes in the availability of biochemicals and composition of haemolymph, by the secretion of enzymes. The parasitoid’s enzymes cause degeneration or dissolution of muscles, adipose tissues, testes as well as ovaries and the material of these organs is made available to the parasitoid. Hence, parasitoid grows at the expense of host tissues. Keywords: Leptocoris augur, Hexamermis vishwakarma, Haemolymph, Free fatty acids, Parasitoid
augur Leptocoris是一种有害植物,它是紫虱的宿主。这种臭虫寄生在一种叫做Hexamermis vishwakarma的带刺线虫上,这种带刺线虫可以自然地抑制臭虫数量的快速增长。目前研究了被寄生臭虫生殖腺(即睾丸和卵巢)、肌肉和血淋巴等不同组织中游离脂肪酸的含量。H. vishwakarma不仅利用脂肪体蛋白质,而且利用脂肪的脂质含量,因此脂肪体从L. augur的血淋巴中消失。寄主血淋巴的脂肪酸组成不因寄主寄生而发生显著变化。H. vishwakarma Dhiman从昆虫体腔Dhiman和Singh b[3]的血淋巴和肌肉中获取营养。宿主虫血淋巴中游离脂肪酸的可用性有助于拟寄生物在血腔中建立。建立后,寄生蜂通过酶的分泌诱导生化物质的有效性和血淋巴成分的变化。类寄生虫的酶导致肌肉、脂肪组织、睾丸和卵巢的退化或溶解,这些器官的物质为类寄生虫所利用。因此,寄生物的生长是以牺牲寄主组织为代价的。关键词:吉兆细钩绦虫,维氏六鳃蝇,血淋巴,游离脂肪酸,拟寄生物
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引用次数: 0
Impact of Artificial Intelligence, Robotics, and Automation on Employment 人工智能、机器人技术和自动化对就业的影响
Pub Date : 2022-07-28 DOI: 10.37896/ymer21.07/92
Ravi Kumar, Vikky Kumar, C. Kumar
Machine learning is the ability of machines to learn from past experiences using historical data (supervised and semisupervised cases) to solve a given problem. Machines make decisions using Artificial Intelligence (past experiences). Companies adequately understand that increasing business efficiency and employee productivity are of supreme importance to thriving in a highly competitive digital environment. Any process can be automated as long as there is a clear operating procedure available. In today’s time, almost every sector is automating things to minimise cost and improve reliability. So, we need something that will resolve this. In this paper, we will study the many good and bad impacts of artificial intelligence, robotics, and automation on employment. We will also discuss some ideas to minimise the bad impact and maximise the good impact in the related fields
机器学习是机器使用历史数据(监督和半监督案例)从过去的经验中学习以解决给定问题的能力。机器利用人工智能(过去的经验)做出决策。公司充分理解提高业务效率和员工生产力对于在竞争激烈的数字环境中蓬勃发展至关重要。只要有明确的操作程序,任何过程都可以自动化。如今,几乎每个行业都在实现自动化,以最大限度地降低成本,提高可靠性。所以,我们需要解决这个问题。在本文中,我们将研究人工智能、机器人和自动化对就业的许多好的和坏的影响。我们还将讨论一些在相关领域最小化坏影响和最大化好影响的想法
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引用次数: 2
A brief study on standardization and evaluation of ayurvedic preparations of Ushirasava 阿育吠陀乌苏沙制剂的标准化及评价研究
Pub Date : 2022-07-28 DOI: 10.37896/ymer21.07/90
Sukriti Upadhyay, B. Kumar
Ushirasava is the polyherbal hydroalcoholic product prepared from about 27 ingredients. It is a liquid preparation popularly used for bleeding disorders, skin diseases, diabetes and many more. Due to the cooling properties of Ushirasava, it is widely used in the diseases where excessive heat occurs in the body. This study aimed to standardize and evaluate some marketed formulations of Ushirasava with special reference to its physicochemical properties. The organoleptic and physicochemical properties of Ushirasava were standardized with reference to the protocol of testing Ayurvedic, Siddha and Unani medicines. The results were further compared with specifications given in Ayurvedic Pharmacopoeia of India. The results of this study serve a reference tool for standardizing and evaluating formulations of Ushirasava. Keywords: Standardization, Physicochemical, Organoleptic, Fermentation, Bioefficacy
Ushirasava是由大约27种成分制成的多草药水酒精产品。它是一种液体制剂,广泛用于出血性疾病、皮肤病、糖尿病等。由于Ushirasava的冷却特性,它被广泛用于体内过热的疾病。本研究旨在规范和评价一些已上市的乌苏菌制剂,特别是乌苏菌的理化性质。参照阿育吠陀、悉达陀和乌纳尼药物的测试方案,对乌苏拉萨瓦的感官和物理化学特性进行了标准化。结果进一步与印度阿育吠陀药典给出的规范进行了比较。本研究结果可为乌苏泻配方的标准化和评价提供参考。关键词:标准化,理化,感官,发酵,生物功效
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引用次数: 0
Challenges and Support during Project Stage: A Case Study of Women Entrepreneurs of Udupi District 项目阶段的挑战与支持:以乌都皮地区女企业家为例
Pub Date : 2022-07-28 DOI: 10.37896/ymer21.07/a0
A. S. Shiralashetti, Lata Poojari
Women entrepreneurs are the women who initiate a business, gather all resources, take risks, face challenges, provide employment to others, and manage the business independently. "Women Entrepreneurship” means an act of business ownership and business creation that empowers women economically in a position in society. Women entrepreneurship provides effective framework for sustainable development of the country. It helps in sustainable revitalization of GDP of a country by generating the employment. Women Entrepreneurship needs to be encouraged, prompted and supplemented by the benefit of the aggregate economy of the country. In this study, the researcher attempted to examine challenges faced and support received by the women entrepreneur during project stage in the district of Udupi. The research paper is based on the primary data. The collected data is analysed using Simple Percentage Method, Ranking Method. The study found that very few women entrepreneurs have professional qualification and have received formal training. Furthermore, most women were housewives prior to entering the business and lacked practical experience. The majority of women entrepreneurs have experienced difficulties with finance, meeting regulatory standards, and technical difficulties, including project reports, and have benefited from support from family members, particularly spouses. Keywords: Women Entrepreneurs, Challenges, Support, Start-up Problems, Project Planning
女企业家是指那些创办企业、聚集所有资源、承担风险、面对挑战、为他人提供就业机会并独立管理企业的女性。“妇女创业”是指企业所有权和企业创造行为,赋予妇女在经济上的社会地位。妇女创业为国家的可持续发展提供了有效的框架。它通过创造就业机会,有助于一个国家GDP的可持续振兴。妇女的企业家精神需要得到鼓励、推动和国家总体经济利益的补充。在本研究中,研究者试图考察乌杜皮地区女企业家在项目阶段面临的挑战和获得的支持。这篇研究论文是以原始数据为基础的。收集的数据采用简单百分比法、排名法进行分析。研究发现,很少有女企业家具有专业资格并接受过正式培训。此外,大多数妇女在进入这一行业之前是家庭主妇,缺乏实际经验。大多数女企业家在资金、符合管理标准和技术困难(包括项目报告)方面遇到困难,并受益于家庭成员,特别是配偶的支持。关键词:女性创业者,挑战,支持,创业问题,项目规划
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引用次数: 0
DWT based Image Super Resolution using Segmentation and Edge Detection 基于小波变换的图像超分辨率分割和边缘检测
Pub Date : 2022-07-28 DOI: 10.37896/ymer21.07/98
P. Kiran, Fathima Jabeen
An image super-resolution is the development of creating a high-resolution image from low-resolution images for better image visualization for several recent applications. In this research paper, we propose DWT-based Image Super Resolution using Segmentation and Edge Detection for better picturing of images. The different kinds of colore images are considered and converted into greyscale images and resized to a uniform size of 166x304. The Discrete Wavelet Transform (DWT) is used to get one low-frequency and three high-frequency bands with a size of 83x152. The four bands are fused and dividing each coefficient by two to get Low Resolution (LR) images. Each coefficient of the LR image is inflated into 2x2 coefficients to get High Resolution (HR) image. The HR matrix is segmented into a 3x3 overlapped matrix and an average value is calculated and assigned to the whole HR matrix. The Canny edge detection is used on the original image to get the edge detected image. The pixel values of HR and canny edge detected images are compared and high-value coefficients are considered. The guided filter is applied to the highvalue coefficients matrix to improve the quality of the image by refining the image. The LL band of the DWT matrix is padded with zeros to convert matrix size to 166x304 and Inverse Discrete Wavelet Transform (IDWT) is used on it. The refined and IDWT images are merged by computing the average values to acquire Super Resolution (SR) image. It is noted that the anticipated system results are enhanced compared to current methods. Keywords: DWT, Fusion, Image Processing, Segmentation, Super Resolution
图像超分辨率是一种从低分辨率图像创建高分辨率图像的发展,以便在最近的几个应用程序中实现更好的图像可视化。在这篇研究论文中,我们提出了基于dwt的图像超分辨率,使用分割和边缘检测来更好地描绘图像。考虑不同种类的彩色图像并将其转换为灰度图像,并将大小调整为166x304的统一大小。采用离散小波变换(DWT)得到大小为83x152的1个低频带和3个高频带。将四个波段进行融合,每个系数除以2,得到低分辨率图像。将LR图像的每个系数膨胀为2x2个系数,得到高分辨率(HR)图像。HR矩阵被分割成一个3x3的重叠矩阵,计算一个平均值并分配给整个HR矩阵。对原始图像进行Canny边缘检测,得到边缘检测图像。比较了HR和canny边缘检测图像的像素值,并考虑了高值系数。将引导滤波器应用于高值系数矩阵,通过对图像进行细化来提高图像质量。DWT矩阵的LL波段用零填充以将矩阵大小转换为166x304,并对其使用逆离散小波变换(IDWT)。通过计算均值将精化图像与IDWT图像合并,得到超分辨率图像。值得注意的是,与目前的方法相比,预期的系统结果得到了提高。关键词:DWT,融合,图像处理,分割,超分辨率
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引用次数: 0
Seismic Vulnerability Assessment of Buildings: A Review and Comparative Study 建筑地震易损性评价综述与比较研究
Pub Date : 2022-07-28 DOI: 10.37896/ymer21.07/96
Prabhu Agrawal, S. Jaiswal
India is one of the fastest developing countries in the world, where its economic stability is hugely reliant on its infrastructure and people. In India, 85% of existing buildings are unreinforced masonry (URM) and 5-7% are reinforced concrete and 5-7% are traditional buildings. And most buildings do not qualify to resist earthquakes, technically we can say they would not be able to resist earthquake loads. In the past, we have seen at the time of several earthquakes, we lost millions of lives and the economy of that region. In the Study, we have reviewed various research papers on Seismic Vulnerability and conclude its findings. Keywords: Seismic vulnerability, Existing Building, Vulnerability Assessment
印度是世界上发展最快的国家之一,其经济稳定在很大程度上依赖于基础设施和人民。在印度,85%的现有建筑是无加固砌体(URM), 5-7%是钢筋混凝土,5-7%是传统建筑。大多数建筑都不具备抗震能力,从技术上讲,我们可以说它们无法抵抗地震荷载。在过去的几次地震中,我们看到,我们失去了数百万人的生命和该地区的经济。在本研究中,我们回顾了各种关于地震易损性的研究论文,并总结了研究结果。关键词:地震易损性,既有建筑,易损性评估
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引用次数: 0
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