Neuropeptide and chemokine receptors of the G protein-coupled receptor (GPCR) family belong to different classes and subgroups providing different docking sites and special binding behavior at extracellular and also transmembrane domains for small molecules potentially suitable for positron emission tomography (PET). The contribution gives an overview updating developments of small-molecule, nonpeptide ligands at a selection of peptide and chemokine receptors, expressed in neurons and microglia of the brain, regarding the last five years. Orexin 1 and orexin 2 receptors (OX1R; OX2R) and neuropeptide Y1 and Y2 receptors (NPY1R, NPY2R) were chosen as representatives of Class A neuropeptide receptors, chemokine receptor CX3C (CX3CR1) as Class A, protein-activated receptor, highly expressed in activated microglia, and corticotropin releasing factor receptor 1 (CRFR1) as representative Class B1 receptor. Structural differences between binding domains and their endogenous ligands as well as parallel expression in different types of cells and generally low density of these receptors in brain tissue are factors making the search for selective and sensitive ligands more difficult than for classical GPCR receptors. Main progress in ligand development is observed for NPY receptor antagonists and orexin receptor antagonists. For orexin receptors, search for suitable ligands can be supported with modelling approaches, as recently the complete molecular structure of these receptors is available. Small molecules, binding at CRFR1, as for other Class B1 receptor ligands, in PET and investigations of pharmacodynamics revealed rather allosteric binding modes, although, the complete crystal structure of CRFR1 as prototype of Class B1 provides, hitherto, improved possibilities for understanding binding mechanisms. Highly specific as a marker of microglia among the GPCRs, CX3CR1 is focused as target of PET during inflammation of brain and spinal cord.
{"title":"Small-Molecule Ligands as Challenge for Positron Emission Tomography of Peptide Receptors in Neurons and Microglia of the Brain","authors":"M. Pissarek","doi":"10.4236/wjns.2019.94022","DOIUrl":"https://doi.org/10.4236/wjns.2019.94022","url":null,"abstract":"Neuropeptide and chemokine receptors of the G protein-coupled receptor (GPCR) family belong to different classes and subgroups providing different docking sites and special binding behavior at extracellular and also transmembrane domains for small molecules potentially suitable for positron emission tomography (PET). The contribution gives an overview updating developments of small-molecule, nonpeptide ligands at a selection of peptide and chemokine receptors, expressed in neurons and microglia of the brain, regarding the last five years. Orexin 1 and orexin 2 receptors (OX1R; OX2R) and neuropeptide Y1 and Y2 receptors (NPY1R, NPY2R) were chosen as representatives of Class A neuropeptide receptors, chemokine receptor CX3C (CX3CR1) as Class A, protein-activated receptor, highly expressed in activated microglia, and corticotropin releasing factor receptor 1 (CRFR1) as representative Class B1 receptor. Structural differences between binding domains and their endogenous ligands as well as parallel expression in different types of cells and generally low density of these receptors in brain tissue are factors making the search for selective and sensitive ligands more difficult than for classical GPCR receptors. Main progress in ligand development is observed for NPY receptor antagonists and orexin receptor antagonists. For orexin receptors, search for suitable ligands can be supported with modelling approaches, as recently the complete molecular structure of these receptors is available. Small molecules, binding at CRFR1, as for other Class B1 receptor ligands, in PET and investigations of pharmacodynamics revealed rather allosteric binding modes, although, the complete crystal structure of CRFR1 as prototype of Class B1 provides, hitherto, improved possibilities for understanding binding mechanisms. Highly specific as a marker of microglia among the GPCRs, CX3CR1 is focused as target of PET during inflammation of brain and spinal cord.","PeriodicalId":23878,"journal":{"name":"World Journal of Neuroscience","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88904389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Gnonlonfoun, M. Agbétou, A. Wanvoegbe, C. Adjien, R. Gnimavo, A. Sowanou, R. Domingo, Joseph Adoco, D. Zannou, D. Houinato
Introduction: Headache disorders are common in HIV-infected patients. These disorders are either primary or secondary. Objective: Determine prevalence and factors associated with primary headache disorders in HIV+ patients. Method: It was a cross-sectional, descriptive and analytical study conducted from 2nd May 2017 to 2nd August 2017 which included HIV+ patients aged 18 years and above. Diagnosis of primary headache disorders was carried out by a Neurologist on the basis of ICHD-II diagnostic criteria. The dependent variable was primary headache disorders. Epi Info Version 7.2.1.0 and STATA11 were used for data analysis. P Results: Primary headache disorders prevalence was 25.2% (124/493).Tension-type headache represented 77.41%. HIV+ patients were aged 42.63 ± 10.14 years. Sex-ratio was estimated at 0.14. Factors associated with primary headache disorders in HIV+ patients were: male (0.36 [0.17 - 0.77]; P = 0.008), Dendi ethnicity (14.8 [2.08 - 101.99]; P = 0.007), trader (3.09 [01.25 - 7.62]; P = 0.02), WHO clinical stage (3.20 [1.43 - 7.17]; P = 0.005), screening duration (1.01 [1.00 - 1.01]; P = 0.00), hypertension (10.28 [4.44 - 23.83]; P ≤ 0.001). Conclusion: This study helped to determine the standard profile of HIV+ patient with primary headache disorders. It will contribute to save costs associated with paraclinical examinations, while in search of secondary etiologies within an African context with limited financial resources.
{"title":"Primary Headache Disorders in HIV-Infected Patients within a Hospital Setting in Sub-Saharan Africa, Benin Case: Prevalence and Associated Factors","authors":"D. Gnonlonfoun, M. Agbétou, A. Wanvoegbe, C. Adjien, R. Gnimavo, A. Sowanou, R. Domingo, Joseph Adoco, D. Zannou, D. Houinato","doi":"10.4236/wjns.2019.94021","DOIUrl":"https://doi.org/10.4236/wjns.2019.94021","url":null,"abstract":"Introduction: Headache disorders are common in HIV-infected patients. These disorders are either primary or secondary. Objective: Determine prevalence and factors associated with primary headache disorders in HIV+ patients. Method: It was a cross-sectional, descriptive and analytical study conducted from 2nd May 2017 to 2nd August 2017 which included HIV+ patients aged 18 years and above. Diagnosis of primary headache disorders was carried out by a Neurologist on the basis of ICHD-II diagnostic criteria. The dependent variable was primary headache disorders. Epi Info Version 7.2.1.0 and STATA11 were used for data analysis. P Results: Primary headache disorders prevalence was 25.2% (124/493).Tension-type headache represented 77.41%. HIV+ patients were aged 42.63 ± 10.14 years. Sex-ratio was estimated at 0.14. Factors associated with primary headache disorders in HIV+ patients were: male (0.36 [0.17 - 0.77]; P = 0.008), Dendi ethnicity (14.8 [2.08 - 101.99]; P = 0.007), trader (3.09 [01.25 - 7.62]; P = 0.02), WHO clinical stage (3.20 [1.43 - 7.17]; P = 0.005), screening duration (1.01 [1.00 - 1.01]; P = 0.00), hypertension (10.28 [4.44 - 23.83]; P ≤ 0.001). Conclusion: This study helped to determine the standard profile of HIV+ patient with primary headache disorders. It will contribute to save costs associated with paraclinical examinations, while in search of secondary etiologies within an African context with limited financial resources.","PeriodicalId":23878,"journal":{"name":"World Journal of Neuroscience","volume":"8 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79976914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acute cervical radiculoplexus neuropathy contralateral to influenza vaccination preceded proximal and distal leg weakness, sensory loss and corresponding deficits of lumbosacral radiculoplexus neuropathy. Treatment with pulse corticosteroids followed by tapering oral corticosteroids and monthly low dose intravenous immune globulin was associated with eventual improvement.
{"title":"Cervical and Lumbosacral Radiculoplexus Neuropathy Following Influenza Vaccination","authors":"D. Younger","doi":"10.4236/wjns.2019.94019","DOIUrl":"https://doi.org/10.4236/wjns.2019.94019","url":null,"abstract":"Acute cervical radiculoplexus neuropathy contralateral to influenza vaccination preceded proximal and distal leg weakness, sensory loss and corresponding deficits of lumbosacral radiculoplexus neuropathy. Treatment with pulse corticosteroids followed by tapering oral corticosteroids and monthly low dose intravenous immune globulin was associated with eventual improvement.","PeriodicalId":23878,"journal":{"name":"World Journal of Neuroscience","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88996696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Our conscious day-to-day self is often described as the “tip of the iceberg” of a much greater cognitive system. The edge of the water divides the phenomenal self from the sub/unconscious underlying it. Similar to an iceberg, the unconscious activity below the water vastly outweighs the conscious activity above it. What exactly lies beneath the surface of this murky water is a tantalizing topic of research and theory. The current research predominantly focuses on the physiology of the brain and the default mode network has been identified as an intrinsic mode of functioning. It is well known that autonomic nervous system sympathovagal balance orchestrated by the central autonomic network is strongly associated with modulation of cardiac, respiratory rate and other visceral physiological activity. In this article, we use existing research and a novel theory to tie together the default mode network, the autonomic nervous system, and non-neural physiology to describe a hypothesis on a greater biological system from which intrinsic brain activity may be founded. This hypothesis is that intrinsic brain activity and connectivities are significantly founded on activity of the body. We review how cardiorespiratory and other rhythms and electrical activity of the body may modulate and even underlie fundamental activity of the human brain and ultimately the mind. A more holistic biological system that could interface the brain and body via mechanisms such as neurovascular coupling would more accurately describe the nature of neural systems. Greater knowledge on the association and interface of brain and body via isomorphic physiologic counterparts to mind may carry profound implications in understanding intrinsic activity of the brain, consciousness, mind, and mental illness.
{"title":"From Biological Rhythms to the Default Mode Network: What Lies beneath the Tip of the Iceberg of Mind?","authors":"R. Jerath, Connor Beveridge","doi":"10.4236/wjns.2019.94020","DOIUrl":"https://doi.org/10.4236/wjns.2019.94020","url":null,"abstract":"Our conscious day-to-day self is often described as the “tip of the iceberg” of a much greater cognitive system. The edge of the water divides the phenomenal self from the sub/unconscious underlying it. Similar to an iceberg, the unconscious activity below the water vastly outweighs the conscious activity above it. What exactly lies beneath the surface of this murky water is a tantalizing topic of research and theory. The current research predominantly focuses on the physiology of the brain and the default mode network has been identified as an intrinsic mode of functioning. It is well known that autonomic nervous system sympathovagal balance orchestrated by the central autonomic network is strongly associated with modulation of cardiac, respiratory rate and other visceral physiological activity. In this article, we use existing research and a novel theory to tie together the default mode network, the autonomic nervous system, and non-neural physiology to describe a hypothesis on a greater biological system from which intrinsic brain activity may be founded. This hypothesis is that intrinsic brain activity and connectivities are significantly founded on activity of the body. We review how cardiorespiratory and other rhythms and electrical activity of the body may modulate and even underlie fundamental activity of the human brain and ultimately the mind. A more holistic biological system that could interface the brain and body via mechanisms such as neurovascular coupling would more accurately describe the nature of neural systems. Greater knowledge on the association and interface of brain and body via isomorphic physiologic counterparts to mind may carry profound implications in understanding intrinsic activity of the brain, consciousness, mind, and mental illness.","PeriodicalId":23878,"journal":{"name":"World Journal of Neuroscience","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75401513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ning Bei, M. Guo, Ping Huang, Jun-Cheng Guo, Xiang-Ling Jiang, H. Gao, D. Long
Objective: To analyse the correlation of 5-HTTLPR gene polymorphism and PTSD in Li and Han nationalities of Hainan Province. Methods: Essen trauma inventory (ETI), clinician administered post-traumatic stress disorders scale, (CAPS), tower of Hanoi (TOH), wsiconsin card sorting test (WCST), trail making test (TMT) and wechsler adult intelligence scale revised China (WAIS-RC) were used to investigate patients with PTSD and healthy volunteers (control group). PCR and PPGE were used to detect the polymorphism of 5-HTTLPR gene and analyze its correlation with PTSD. Results: The ETI score, total PTSD score and TMT time of Li nationality patients with PTSD were significantly higher than those of Han nationality patients with PTSD, and the IQ of comprehension and operation in WAIS-RC was significantly lower than that of Han nationality patients with PTSD (P HTTLPR genotype in Li nationality and Han nationality patients with PTSD were significantly higher than those of LL genotype, and the perception, calculation and block diagram in WAIS-RC were significantly lower than those of LL genotype patients (P Conclusions: The SS genotype can increase the risk of PTSD in Li nationality and Han nationality people in Hainan. LL genotype is associated with PTSD of Li and Han nationalities in Hainan, and is an important protective factor for PTSD of Li and Han nationalities in Hainan.
{"title":"Correlation Analysis of 5-HTTLPR Polymorphism and Post-Traumatic Stress Disorder in Li and Han Nationalities of Hainan Province","authors":"Ning Bei, M. Guo, Ping Huang, Jun-Cheng Guo, Xiang-Ling Jiang, H. Gao, D. Long","doi":"10.4236/wjns.2019.94018","DOIUrl":"https://doi.org/10.4236/wjns.2019.94018","url":null,"abstract":"Objective: To analyse the correlation of 5-HTTLPR gene polymorphism and PTSD in Li and Han nationalities of Hainan \u0000Province. Methods: Essen trauma inventory (ETI), clinician \u0000administered post-traumatic stress disorders scale, (CAPS), tower of Hanoi \u0000(TOH), wsiconsin card sorting test (WCST), trail making test (TMT) and wechsler \u0000adult intelligence scale revised China (WAIS-RC) were used to \u0000investigate patients with PTSD and healthy volunteers (control group). PCR and \u0000PPGE were used to detect the polymorphism of 5-HTTLPR gene and analyze its correlation with PTSD. Results: The ETI score, total PTSD score and TMT time of Li \u0000nationality patients with PTSD were significantly higher than those of Han \u0000nationality patients with PTSD, and the IQ of comprehension and operation in \u0000WAIS-RC was significantly lower than that of Han nationality patients with PTSD \u0000(P HTTLPR genotype in Li nationality and Han nationality patients with PTSD were \u0000significantly higher than those of LL genotype, and the perception, calculation \u0000and block diagram in WAIS-RC were significantly lower than those of LL genotype \u0000patients (P Conclusions: The SS genotype can increase the risk of PTSD in Li \u0000nationality and Han nationality people in Hainan. LL genotype is associated \u0000with PTSD of Li and Han nationalities in Hainan, and is an important protective \u0000factor for PTSD of Li and Han nationalities in Hainan.","PeriodicalId":23878,"journal":{"name":"World Journal of Neuroscience","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81724170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. C. Valente, Matheus Simões Oliveira, Karlos Eduardo Alves Silva, Berkmis Viana Santos, J. D. Pai, Reginaldo Melo Filho, Fany Pereira de Araújo Soares, Júlia Maria Pacheco Lins, K. C. Mousinho, M. V. Costa, E. M. Trindade-Filho
Listening to music, or part of it, may stir the memory of a past moment, along with its associated emotions, such occurrences are known as autobiographical memories. Electroencephalographic (EEG) studies have shown alterations in memory recall and musical processing. However, no research was found showing a relation among music, autobiographical memories and associated emotions. The purpose of this study was to identify cortical areas involved in the evocation of autobiographical memory (associated with positive and negative events) mediated by musical stimuli. For that, gamma rhythm was analyzed through EEG recordings performed by 45 male volunteers while they were submitted to two stimuli: 1) the music capable of recalling memories associated to a positive event; 2) the music capable of evoking memories associated to a negative event. Gamma band analysis was used in search of greater brain electrical activity. As results, researchers observed increased activity in right brain hemisphere during the musical processing, besides its hypoactivation when volunteers were submitted to musical stimuli related to memories of negative events.
{"title":"Electroencephalographic Study of Gamma Rhythm in the Autobiographical Memory Evocation Mediated by Musical Stimuli","authors":"M. C. Valente, Matheus Simões Oliveira, Karlos Eduardo Alves Silva, Berkmis Viana Santos, J. D. Pai, Reginaldo Melo Filho, Fany Pereira de Araújo Soares, Júlia Maria Pacheco Lins, K. C. Mousinho, M. V. Costa, E. M. Trindade-Filho","doi":"10.4236/WJNS.2019.93013","DOIUrl":"https://doi.org/10.4236/WJNS.2019.93013","url":null,"abstract":"Listening to music, or part of it, may stir the memory of a past moment, along \u0000with its associated emotions, such occurrences are known as autobiographical \u0000memories. Electroencephalographic (EEG) studies have shown alterations in \u0000memory recall and musical processing. However, no research was found showing a \u0000relation among music, autobiographical memories and \u0000associated emotions. The purpose of this study was to identify cortical areas \u0000involved in the evocation of autobiographical memory (associated with positive and negative events) mediated by musical \u0000stimuli. For that, gamma rhythm was analyzed through EEG recordings \u0000performed by 45 male volunteers while they were submitted to two stimuli: 1) the music capable of recalling memories associated to a positive event; 2) the music capable of evoking \u0000memories associated to a negative event. Gamma band analysis was used in search \u0000of greater brain electrical activity. As results, researchers observed \u0000increased activity in right brain hemisphere during the musical processing, \u0000besides its hypoactivation when volunteers were submitted to musical stimuli \u0000related to memories of negative events.","PeriodicalId":23878,"journal":{"name":"World Journal of Neuroscience","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89454761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Coulibaly, M. Dama, O. Diallo, D. Sissoko, B. Sogoba, S. Alpha, Y. Sogoba, D. Kanikomo
Introduction: Gold panning is the research and artisanal exploitation of gold in the auriferous areas (rivers or others). Traumatisms arising from these activities are due to severe spinal cord injury and generally affect young people in full activity. They constitute a real social handicap in Mali and even in Africa. The aim of our study is to share our expertise in the management of these vertebro-medullary traumasin these miners who currently escape to all controls in Mali. Material and Methods: From 2013 to 2016, 76 Traumatic Spine Cord Injuries (TSCI) were treated in the department of Neurosurgery of “Hopital du Mali”. There were 73 males (96.05%) versus 03 Females (3.95%), aged between 21 - 43 years old. Results: All of our patients were admitted with deficit differing from paraparesis to tetraplegia. According to Frankel scale, we found 59 patients with complete deficits (A grade, 77.63%), and incomplete deficits in 17 cases (12 grade B, 04 grade C, 01 grade D). The X-ray standard radiographies were done in 24 cases (31.58%) from which 02 patients had been operated with these data. CT scan centered on the injured spinal segment was performed in 74 cases (97.37%). The lumbar spine was affected in 39 cases, followed by thoracolumbar junction in 19 cases and thoracic spine in 16 cases. The cervical spine was only interested in two cases. Fractures dislocations are the most frequently lesions encountered in our series. The surgical approach was performed in 74 patients and 02 patients received conservative treatment. Conclusion: Traumatic Spinal Cord Injuries (TSCI) among miners are a real disaster in Mali and continue to plague thousands of families or increase the number of disabled people in our society. It is the only work, where the person concerned is making of his own grave. And according to witnesses, several miners remained at the bottom of the wells. Their prevention must first involve users by raising the awareness of local residents and traditional therapists, but also the country that must participate in regional development and ensure strict enforcement of regulatory measures. Our structure must have enough resources to acquire and treat these patients at any time.
{"title":"Traumatic Spinal Cord Injuries in Gold Miners in Mali: Preliminary Study on 76 Cases","authors":"O. Coulibaly, M. Dama, O. Diallo, D. Sissoko, B. Sogoba, S. Alpha, Y. Sogoba, D. Kanikomo","doi":"10.4236/WJNS.2019.93014","DOIUrl":"https://doi.org/10.4236/WJNS.2019.93014","url":null,"abstract":"Introduction: Gold panning is the research and artisanal exploitation of gold in the auriferous areas (rivers or others). Traumatisms arising from these activities are due to severe spinal cord injury and generally affect young people in full activity. They constitute a real social handicap in Mali and even in Africa. The aim of our study is to share our expertise in the management of these vertebro-medullary traumasin these miners who currently escape to all controls in Mali. Material and Methods: From 2013 to 2016, 76 Traumatic Spine Cord Injuries (TSCI) were treated in the department of Neurosurgery of “Hopital du Mali”. There were 73 males (96.05%) versus 03 Females (3.95%), aged between 21 - 43 years old. Results: All of our patients were admitted with deficit differing from paraparesis to tetraplegia. According to Frankel scale, we found 59 patients with complete deficits (A grade, 77.63%), and incomplete deficits in 17 cases (12 grade B, 04 grade C, 01 grade D). The X-ray standard radiographies were done in 24 cases (31.58%) from which 02 patients had been operated with these data. CT scan centered on the injured spinal segment was performed in 74 cases (97.37%). The lumbar spine was affected in 39 cases, followed by thoracolumbar junction in 19 cases and thoracic spine in 16 cases. The cervical spine was only interested in two cases. Fractures dislocations are the most frequently lesions encountered in our series. The surgical approach was performed in 74 patients and 02 patients received conservative treatment. Conclusion: Traumatic Spinal Cord Injuries (TSCI) among miners are a real disaster in Mali and continue to plague thousands of families or increase the number of disabled people in our society. It is the only work, where the person concerned is making of his own grave. And according to witnesses, several miners remained at the bottom of the wells. Their prevention must first involve users by raising the awareness of local residents and traditional therapists, but also the country that must participate in regional development and ensure strict enforcement of regulatory measures. Our structure must have enough resources to acquire and treat these patients at any time.","PeriodicalId":23878,"journal":{"name":"World Journal of Neuroscience","volume":"135 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86828059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Small fiber polyneuropathy is a well-recognized syndrome mitigated by somatic sensory afferent and autonomic efferent nerve fibers that respectively mediate pain, heat and cold temperature afferent and autonomic efferent function in the skin. A patient with low serum titers of neuronal acetylcholine receptor ganglionic antibodies and autonomic failure had symptomatic small fiber polyneuropathy late in life in the setting of autoimmune dementia and encephalopathy and prostate cancer. Large and small fiber polyneuropathy and dysautonomia were detected in routine electrodiagnostic and autonomic laboratory studies, and epidermal nerve fiber analysis of the calf and thigh. Clinical improvement for one year concomitant with intravenous immune globulin therapy preceded a clinical decline in neurocognitive function and death. Postmortem examination showed typical features of Alzheimer disease with neuropathic neuropathological changes in the peripheral nervous system, and viable autonomic ganglia consistent with a channelopathy mechanism involving postsynaptic neuronal nAChRs.
{"title":"A Postmortem Study of a Patient with Low Titer Nicotinic Acetylcholine Receptor Ganglionic Antibody: Implications for Clinical Neurologic Disease","authors":"D. Younger","doi":"10.4236/WJNS.2019.93005","DOIUrl":"https://doi.org/10.4236/WJNS.2019.93005","url":null,"abstract":"Small fiber polyneuropathy is a well-recognized syndrome mitigated by somatic sensory afferent and autonomic efferent nerve fibers that respectively mediate pain, heat and cold temperature afferent and autonomic efferent function in the skin. A patient with low serum titers of neuronal acetylcholine receptor ganglionic antibodies and autonomic failure had symptomatic small fiber polyneuropathy late in life in the setting of autoimmune dementia and encephalopathy and prostate cancer. Large and small fiber polyneuropathy and dysautonomia were detected in routine electrodiagnostic and autonomic laboratory studies, and epidermal nerve fiber analysis of the calf and thigh. Clinical improvement for one year concomitant with intravenous immune globulin therapy preceded a clinical decline in neurocognitive function and death. Postmortem examination showed typical features of Alzheimer disease with neuropathic neuropathological changes in the peripheral nervous system, and viable autonomic ganglia consistent with a channelopathy mechanism involving postsynaptic neuronal nAChRs.","PeriodicalId":23878,"journal":{"name":"World Journal of Neuroscience","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91094098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We are all aware that our experience is structured into left and right, up and down, and we can understand from our own experience that consciousness is unified into a singular whole. Although we can understand such basic phenomenological axioms of experience, there are many more principles that we cannot elucidate from our natural perspective alone. In this article, we review potential principles of consciousness revealed by prominent consciousness models, theories, and experimental observations such as the Default Space Theory, Operational Architectonics Theory, and Integrated Information Theory, which reveal biological and phenomenological foundations upon which consciousness is formed and maintained. The fundamental concepts we explore and consider worthy have largely emerged from commonalties shared by the various models which have gained attention. The concepts we review include the unity of consciousness, bioelectric operations as the substrate of consciousness, the emergence of a virtual 3D matrix, and the top-down dominance of perception.
{"title":"Emerging Phenomenological and Biological Principles of Consciousness: Top Insights of Prevailing Models, Concepts, and Observations","authors":"R. Jerath, Connor Beveridge","doi":"10.4236/WJNS.2019.93011","DOIUrl":"https://doi.org/10.4236/WJNS.2019.93011","url":null,"abstract":"We are all aware that our experience is structured into left and right, up and down, and we can understand from our own experience that consciousness is unified into a singular whole. Although we can understand such basic phenomenological axioms of experience, there are many more principles that we cannot elucidate from our natural perspective alone. In this article, we review potential principles of consciousness revealed by prominent consciousness models, theories, and experimental observations such as the Default Space Theory, Operational Architectonics Theory, and Integrated Information Theory, which reveal biological and phenomenological foundations upon which consciousness is formed and maintained. The fundamental concepts we explore and consider worthy have largely emerged from commonalties shared by the various models which have gained attention. The concepts we review include the unity of consciousness, bioelectric operations as the substrate of consciousness, the emergence of a virtual 3D matrix, and the top-down dominance of perception.","PeriodicalId":23878,"journal":{"name":"World Journal of Neuroscience","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78119445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neurexan is a multicomponent natural medicinal product used for stress-related symptoms such as nervous restlessness and insomnia. The present study investigated the efficacy of Neurexan on stress-induced changes of brainwave frequencies using quantitative analysis of spectral EEG power. Thirty healthy male and female volunteers were tested in a randomized, placebo controlled cross-over trial under conditions of relaxation and experimental stress-in- duction. Recording of the EEG was performed over four hours after drug administration. Data was analyzed using the proprietary fast dynamic EEG technology Neurocode-Tracking. Quantitative EEG revealed a task dependent increase of beta2 power as a surrogate parameter of stress induced anxiety. The elevated frontotemporal beta2 power was ameliorated by intake of Neurexan during the second and third hour after administration. This indicates that Neurexan is effectively helping subjects to better cope with task-related stress situations.
{"title":"Effects of Neurexan on Stress-Induced Changes of Spectral EEG Power: A Double-Blind, Randomized, Placebo-Controlled, Crossover Exploratory Trial in Human Volunteers","authors":"W. Dimpfel","doi":"10.4236/WJNS.2019.93007","DOIUrl":"https://doi.org/10.4236/WJNS.2019.93007","url":null,"abstract":"Neurexan is a multicomponent natural medicinal product used for stress-related symptoms such as nervous restlessness and insomnia. The present study investigated the efficacy of Neurexan on stress-induced changes of brainwave frequencies using quantitative analysis of spectral EEG power. Thirty healthy male and female volunteers were tested in a randomized, placebo controlled cross-over trial under conditions of relaxation and experimental stress-in- duction. Recording of the EEG was performed over four hours after drug administration. Data was analyzed using the proprietary fast dynamic EEG technology Neurocode-Tracking. Quantitative EEG revealed a task dependent increase of beta2 power as a surrogate parameter of stress induced anxiety. The elevated frontotemporal beta2 power was ameliorated by intake of Neurexan during the second and third hour after administration. This indicates that Neurexan is effectively helping subjects to better cope with task-related stress situations.","PeriodicalId":23878,"journal":{"name":"World Journal of Neuroscience","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87201026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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