Pub Date : 2023-11-01Epub Date: 2022-12-21DOI: 10.1007/s10354-022-00992-5
Roko Habek, Dubravko Habek
This historical account is a departure from the oblivion of the historical circumstances surrounding the introduction of the open method of wound healing by Vincenz Kern, a Viennese professor of surgery in 1809, and which is still used today in most surgical professions. Thanks are also due to the famous Medical University of Vienna from where Kern ultimately established numerous schools throughout Europe, including Croatia, as a then part of the great Austrian Empire.
{"title":"Wound healing at a Viennese medical school 200 years ago.","authors":"Roko Habek, Dubravko Habek","doi":"10.1007/s10354-022-00992-5","DOIUrl":"10.1007/s10354-022-00992-5","url":null,"abstract":"<p><p>This historical account is a departure from the oblivion of the historical circumstances surrounding the introduction of the open method of wound healing by Vincenz Kern, a Viennese professor of surgery in 1809, and which is still used today in most surgical professions. Thanks are also due to the famous Medical University of Vienna from where Kern ultimately established numerous schools throughout Europe, including Croatia, as a then part of the great Austrian Empire.</p>","PeriodicalId":23882,"journal":{"name":"Wiener medizinische Wochenschrift","volume":" ","pages":"397-400"},"PeriodicalIF":0.9,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10768260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01Epub Date: 2023-01-20DOI: 10.1007/s10354-022-00997-0
František Šimon, Florian Steger
A relationship between literature and medicine has existed since antiquity. A physician often appears in the literary genre of satire as the representative of medicine and is the object of the satire. The barely known humanistic author Johannes Gregor Macer Szepsius (ca. 1530-nach 1579) was a humanist who sharply criticized the work and behavior of physicians. We have read, translated and analyzed the satirical verses from his comprehensive poetical work De vera gloria, On the true glory, with respect to content, structure and sources. According to this, physicians are characterized by conceit, ignorance and laziness and therapeutic ineptitude. The comparison with other satirical works shows that much of that which he accuses physicians of is repeated in the history of medicine. Some places are similar to the proverbs from Walter's collection of proverbs from the Middle Ages and others are similar to the invectives of Petrarch. Macer also levels criticism against physicians in his poem about the family tree of his friend Anton Schneeberger that appears in Schneeberger's work De bona valetudine militum conservanda liber.
文学和医学之间的关系自古就存在。医生经常作为医学的代表出现在讽刺文学流派中,是讽刺的对象。鲜为人知的人文主义作家Johannes Gregor Macer Szepsius(约1530年,1579年)是一位尖锐批评医生工作和行为的人文主义者。我们从内容、结构和来源三个方面阅读、翻译和分析了他的综合性诗歌《论真正的荣耀》中的讽刺诗。据此,医生的特点是自负、无知、懒惰和治疗无能。与其他讽刺作品的比较表明,他指责医生的大部分内容在医学史上都有重复。有些地方与沃尔特的中世纪谚语集中的谚语相似,而另一些地方则与彼特拉克的谩骂相似。Macer在他的诗中也对医生提出了批评,这首诗是关于他的朋友Anton Schneeberger的家谱,出现在Schneebergr的作品《De bona valetudine militum conservanda liber》中。
{"title":"[O vos mendici medici. Criticism of medical doctors by Johannes Gregor Macer Szepsius (ca. 1530-after 1579)].","authors":"František Šimon, Florian Steger","doi":"10.1007/s10354-022-00997-0","DOIUrl":"10.1007/s10354-022-00997-0","url":null,"abstract":"<p><p>A relationship between literature and medicine has existed since antiquity. A physician often appears in the literary genre of satire as the representative of medicine and is the object of the satire. The barely known humanistic author Johannes Gregor Macer Szepsius (ca. 1530-nach 1579) was a humanist who sharply criticized the work and behavior of physicians. We have read, translated and analyzed the satirical verses from his comprehensive poetical work De vera gloria, On the true glory, with respect to content, structure and sources. According to this, physicians are characterized by conceit, ignorance and laziness and therapeutic ineptitude. The comparison with other satirical works shows that much of that which he accuses physicians of is repeated in the history of medicine. Some places are similar to the proverbs from Walter's collection of proverbs from the Middle Ages and others are similar to the invectives of Petrarch. Macer also levels criticism against physicians in his poem about the family tree of his friend Anton Schneeberger that appears in Schneeberger's work De bona valetudine militum conservanda liber.</p>","PeriodicalId":23882,"journal":{"name":"Wiener medizinische Wochenschrift","volume":" ","pages":"393-396"},"PeriodicalIF":0.9,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9101309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01Epub Date: 2021-08-02DOI: 10.1007/s10354-021-00869-z
František Šimon, Florian Steger
In 1573, Georg Henisch published a short pharmaceutical handbook, Enchiridion medicinae, which contains remedies for individual health problems, without making any further comments on the effects and method of use. However, this manual had a predecessor which was published in Paris in 1571 without mentioning the author. The text of both editions is practically identical, there are only minimal differences, but the second edition has been expanded to a foreword and final sections with some recipes. A comparison of the work with contemporary medical literature revealed that Enchiridion medicinae is a compilation of three works by other authors, De materia medicinali et compositione medicamentorum by G. Rondelet from 1556, a commentary by the French author Sebastien Coquillat Scipio on Galen's work Quos, quibus, quando purgare oporteat from 1553 and the book Lilium medicinae by Bernard de Gordon from 1550. Henisch probably acquired this compilation from 1571 as a young student in France, added some passages by Rendelet and passages from two others books, wrote a foreword which he signed with his name and published in Basel in 1573.
1573年,Georg Henisch出版了一本简短的药物手册《Enchiridion medicinae》,其中包含了治疗个人健康问题的药物,但没有对使用效果和方法发表任何进一步的评论。然而,这本手册的前身是1571年在巴黎出版的,没有提及作者。两个版本的文本实际上是相同的,只有最小的差异,但第二个版本已经扩展到前言和最后部分,其中包含一些食谱。将这部作品与当代医学文献进行比较后发现,《Enchiridion medicinae》是其他作者的三部作品的汇编,G.Rondelet于1556年的《De material medicinali et compositone medicalmentorum》,法国作家Sebastien Coquillat Scipio对Galen的作品《Quos,quibus,1553年出版的《炼狱论》和1550年伯纳德·德·戈登的《百合花》一书。Henisch可能是从1571年在法国的一个年轻学生那里获得这本汇编的,他添加了Rendelet的一些段落和另外两本书的段落,写了一篇前言,并以自己的名字签名,于1573年在巴塞尔出版。
{"title":"[Enchiridion medicinae (1573)-a short pharmaceutical manual compiled by Georg Henisch].","authors":"František Šimon, Florian Steger","doi":"10.1007/s10354-021-00869-z","DOIUrl":"10.1007/s10354-021-00869-z","url":null,"abstract":"<p><p>In 1573, Georg Henisch published a short pharmaceutical handbook, Enchiridion medicinae, which contains remedies for individual health problems, without making any further comments on the effects and method of use. However, this manual had a predecessor which was published in Paris in 1571 without mentioning the author. The text of both editions is practically identical, there are only minimal differences, but the second edition has been expanded to a foreword and final sections with some recipes. A comparison of the work with contemporary medical literature revealed that Enchiridion medicinae is a compilation of three works by other authors, De materia medicinali et compositione medicamentorum by G. Rondelet from 1556, a commentary by the French author Sebastien Coquillat Scipio on Galen's work Quos, quibus, quando purgare oporteat from 1553 and the book Lilium medicinae by Bernard de Gordon from 1550. Henisch probably acquired this compilation from 1571 as a young student in France, added some passages by Rendelet and passages from two others books, wrote a foreword which he signed with his name and published in Basel in 1573.</p>","PeriodicalId":23882,"journal":{"name":"Wiener medizinische Wochenschrift","volume":" ","pages":"352-357"},"PeriodicalIF":0.9,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10354-021-00869-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39267953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.1007/s10354-021-00852-8
Andreas Hummel
{"title":"Briefsammlung Wittelshöfer : Brief von Alois Czedik an Leopold Wittelshöfer vom 28.03.1871.","authors":"Andreas Hummel","doi":"10.1007/s10354-021-00852-8","DOIUrl":"10.1007/s10354-021-00852-8","url":null,"abstract":"","PeriodicalId":23882,"journal":{"name":"Wiener medizinische Wochenschrift","volume":" ","pages":"347-351"},"PeriodicalIF":0.9,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39672438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01Epub Date: 2021-09-28DOI: 10.1007/s10354-021-00882-2
Martin Kuhar, Stella Fatović-Ferenčić
Croatia is a Central European and Mediterranean country with a long maritime border with Italy. Throughout history, it was not only goods but also knowledge and medical practices that were exchanged over its borders. Following archival sources, individual informal networks, professional publications, daily newspapers, and public lectures, we aimed to present main channels by which Croatian intellectuals embraced Lombroso's criminal anthropology at the end of the 19th and the beginning of the 20th centuries. We illuminated the fact that the adoption of Cesare Lombroso's concepts stimulated the joint engagement and communication of medical and legal realms in Croatia. Our analysis exposed the traces of Lombroso's ideas within the reform of the penal code, thus influencing forensic psychiatric practice. We showed how those ideas were translated into policy, politically exploited, and pitched into discussions employing rhetorical techniques, which led to the stigmatization of certain groups of people, particularly patients suffering from epilepsy. Our results also showed that, contrary to other countries that formed Austria-Hungary, the discussions about Lombroso's criminology waned in Croatia after the First World War. We believe that our results can close the gap on this topic, adding the evidence about the spread and influence of Lombroso's concepts within Austria-Hungary in the analyzed period.
{"title":"\"I would not wait for them to commit crime\": Cesare Lombroso's criminal anthropology in Croatia.","authors":"Martin Kuhar, Stella Fatović-Ferenčić","doi":"10.1007/s10354-021-00882-2","DOIUrl":"10.1007/s10354-021-00882-2","url":null,"abstract":"<p><p>Croatia is a Central European and Mediterranean country with a long maritime border with Italy. Throughout history, it was not only goods but also knowledge and medical practices that were exchanged over its borders. Following archival sources, individual informal networks, professional publications, daily newspapers, and public lectures, we aimed to present main channels by which Croatian intellectuals embraced Lombroso's criminal anthropology at the end of the 19th and the beginning of the 20th centuries. We illuminated the fact that the adoption of Cesare Lombroso's concepts stimulated the joint engagement and communication of medical and legal realms in Croatia. Our analysis exposed the traces of Lombroso's ideas within the reform of the penal code, thus influencing forensic psychiatric practice. We showed how those ideas were translated into policy, politically exploited, and pitched into discussions employing rhetorical techniques, which led to the stigmatization of certain groups of people, particularly patients suffering from epilepsy. Our results also showed that, contrary to other countries that formed Austria-Hungary, the discussions about Lombroso's criminology waned in Croatia after the First World War. We believe that our results can close the gap on this topic, adding the evidence about the spread and influence of Lombroso's concepts within Austria-Hungary in the analyzed period.</p>","PeriodicalId":23882,"journal":{"name":"Wiener medizinische Wochenschrift","volume":" ","pages":"358-367"},"PeriodicalIF":0.9,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39467546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01Epub Date: 2023-02-02DOI: 10.1007/s10354-022-01002-4
Mariam ElSaban, Gaurang Bhatt, Joanna Lee, Hiren Koshiya, Taha Mansoor, Tanya Amal, Rahul Kashyap
Neurocritical care is a multidisciplinary field managing patients with a wide range of aliments. Specifically, neurotrauma is a rapidly growing field with increasing demands. The history of how neurotrauma management came to its current form has not been extensively explored before. Our review delves into the history, timeline, and noteworthy pioneers of neurotrauma-focused neurocritical care. We explore the historical development during early times, the 18th-20th centuries, and modern times, as well as warfare- and sports-related concussions. Research is ever growing in this budding field, with several promising innovations on the horizon.
{"title":"A historical delve into neurotrauma-focused critical care.","authors":"Mariam ElSaban, Gaurang Bhatt, Joanna Lee, Hiren Koshiya, Taha Mansoor, Tanya Amal, Rahul Kashyap","doi":"10.1007/s10354-022-01002-4","DOIUrl":"10.1007/s10354-022-01002-4","url":null,"abstract":"<p><p>Neurocritical care is a multidisciplinary field managing patients with a wide range of aliments. Specifically, neurotrauma is a rapidly growing field with increasing demands. The history of how neurotrauma management came to its current form has not been extensively explored before. Our review delves into the history, timeline, and noteworthy pioneers of neurotrauma-focused neurocritical care. We explore the historical development during early times, the 18th-20th centuries, and modern times, as well as warfare- and sports-related concussions. Research is ever growing in this budding field, with several promising innovations on the horizon.</p>","PeriodicalId":23882,"journal":{"name":"Wiener medizinische Wochenschrift","volume":" ","pages":"368-373"},"PeriodicalIF":0.9,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10646513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01Epub Date: 2022-12-21DOI: 10.1007/s10354-022-00989-0
Daniel Cejka, Robert Wakolbinger-Habel, Emanuel Zitt, Astrid Fahrleitner-Pammer, Karin Amrein, Hans Peter Dimai, Christian Muschitz
<p><strong>Definition and epidemiology: </strong>Chronic kidney disease (CKD): abnormalities of kidney structure or function, present for over 3 months. Staging of CKD is based on GFR and albuminuria (not graded). Osteoporosis: compromised bone strength (low bone mass, disturbance of microarchitecture) predisposing to fracture. By definition, osteoporosis is diagnosed if the bone mineral density T‑score is ≤ -2.5. Furthermore, osteoporosis is diagnosed if a low-trauma (inadequate trauma) fracture occurs, irrespective of the measured T‑score (not graded). The prevalence of osteoporosis, osteoporotic fractures and CKD is increasing worldwide (not graded). PATHOPHYSIOLOGY, DIAGNOSIS AND TREATMENT OF CHRONIC KIDNEY DISEASE-MINERAL AND BONE DISORDER (CKD-MBD): Definition of CKD-MBD: a systemic disorder of mineral and bone metabolism due to CKD manifested by either one or a combination of the following: abnormalities of calcium, phosphorus, PTH, or vitamin D metabolism; renal osteodystrophy; vascular calcification (not graded). Increased, normal or decreased bone turnover can be found in renal osteodystrophy (not graded). Depending on CKD stage, routine monitoring of calcium, phosphorus, alkaline phosphatase, PTH and 25-OH-vitamin D is recommended (2C). Recommendations for treatment of CKD-MBD: Avoid hypercalcemia (1C). In cases of hyperphosphatemia, lower phosphorus towards normal range (2C). Keep PTH within or slightly above normal range (2D). Vitamin D deficiency should be avoided and treated when diagnosed (1C).</p><p><strong>Diagnosis and risk stratification of osteoporosis in ckd: </strong>Densitometry (using dual X‑ray absorptiometry, DXA): low T‑score correlates with increased fracture risk across all stages of CKD (not graded). A decrease of the T‑score by 1 unit approximately doubles the risk for osteoporotic fracture (not graded). A T-score ≥ -2.5 does not exclude osteoporosis (not graded). Bone mineral density of the lumbar spine measured by DXA can be increased and therefore should not be used for the diagnosis or monitoring of osteoporosis in the presence of aortic calcification, osteophytes or vertebral fracture (not graded). FRAX can be used to aid fracture risk estimation in all stages of CKD (1C). Bone turnover markers can be measured in individual cases to monitor treatment (2D). Bone biopsy may be considered in individual cases, especially in patients with CKD G5 (eGFR < 15 ml/min/1.73 m<sup>2</sup>) or CKD 5D (dialysis).</p><p><strong>Specific treatment of osteoporosis in patients with ckd: </strong>Hypocalcemia should be treated and serum calcium normalized before initiating osteoporosis therapy (1C). CKD G1-G2 (eGFR ≥ 60 ml/min/1.73 m<sup>2</sup>): treat osteoporosis as recommended for the general population (1A). CKD G3-G5D (eGFR < 60 ml/min/1.73 m<sup>2</sup> to dialysis): treat CKD-MBD first before initiating osteoporosis treatment (2C). CKD G3 (eGFR 30-59 ml/min/1.73 m<sup>2</sup>) with PTH within normal limits and osteoporot
{"title":"[Diagnosis and treatment of osteoporosis in patients with chronic kidney disease : Joint guidelines of the Austrian Society for Bone and Mineral Research (ÖGKM), the Austrian Society of Physical and Rehabilitation Medicine (ÖGPMR) and the Austrian Society of Nephrology (ÖGN)].","authors":"Daniel Cejka, Robert Wakolbinger-Habel, Emanuel Zitt, Astrid Fahrleitner-Pammer, Karin Amrein, Hans Peter Dimai, Christian Muschitz","doi":"10.1007/s10354-022-00989-0","DOIUrl":"10.1007/s10354-022-00989-0","url":null,"abstract":"<p><strong>Definition and epidemiology: </strong>Chronic kidney disease (CKD): abnormalities of kidney structure or function, present for over 3 months. Staging of CKD is based on GFR and albuminuria (not graded). Osteoporosis: compromised bone strength (low bone mass, disturbance of microarchitecture) predisposing to fracture. By definition, osteoporosis is diagnosed if the bone mineral density T‑score is ≤ -2.5. Furthermore, osteoporosis is diagnosed if a low-trauma (inadequate trauma) fracture occurs, irrespective of the measured T‑score (not graded). The prevalence of osteoporosis, osteoporotic fractures and CKD is increasing worldwide (not graded). PATHOPHYSIOLOGY, DIAGNOSIS AND TREATMENT OF CHRONIC KIDNEY DISEASE-MINERAL AND BONE DISORDER (CKD-MBD): Definition of CKD-MBD: a systemic disorder of mineral and bone metabolism due to CKD manifested by either one or a combination of the following: abnormalities of calcium, phosphorus, PTH, or vitamin D metabolism; renal osteodystrophy; vascular calcification (not graded). Increased, normal or decreased bone turnover can be found in renal osteodystrophy (not graded). Depending on CKD stage, routine monitoring of calcium, phosphorus, alkaline phosphatase, PTH and 25-OH-vitamin D is recommended (2C). Recommendations for treatment of CKD-MBD: Avoid hypercalcemia (1C). In cases of hyperphosphatemia, lower phosphorus towards normal range (2C). Keep PTH within or slightly above normal range (2D). Vitamin D deficiency should be avoided and treated when diagnosed (1C).</p><p><strong>Diagnosis and risk stratification of osteoporosis in ckd: </strong>Densitometry (using dual X‑ray absorptiometry, DXA): low T‑score correlates with increased fracture risk across all stages of CKD (not graded). A decrease of the T‑score by 1 unit approximately doubles the risk for osteoporotic fracture (not graded). A T-score ≥ -2.5 does not exclude osteoporosis (not graded). Bone mineral density of the lumbar spine measured by DXA can be increased and therefore should not be used for the diagnosis or monitoring of osteoporosis in the presence of aortic calcification, osteophytes or vertebral fracture (not graded). FRAX can be used to aid fracture risk estimation in all stages of CKD (1C). Bone turnover markers can be measured in individual cases to monitor treatment (2D). Bone biopsy may be considered in individual cases, especially in patients with CKD G5 (eGFR < 15 ml/min/1.73 m<sup>2</sup>) or CKD 5D (dialysis).</p><p><strong>Specific treatment of osteoporosis in patients with ckd: </strong>Hypocalcemia should be treated and serum calcium normalized before initiating osteoporosis therapy (1C). CKD G1-G2 (eGFR ≥ 60 ml/min/1.73 m<sup>2</sup>): treat osteoporosis as recommended for the general population (1A). CKD G3-G5D (eGFR < 60 ml/min/1.73 m<sup>2</sup> to dialysis): treat CKD-MBD first before initiating osteoporosis treatment (2C). CKD G3 (eGFR 30-59 ml/min/1.73 m<sup>2</sup>) with PTH within normal limits and osteoporot","PeriodicalId":23882,"journal":{"name":"Wiener medizinische Wochenschrift","volume":" ","pages":"299-318"},"PeriodicalIF":0.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9087232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01Epub Date: 2023-01-25DOI: 10.1007/s10354-022-01000-6
Roland Kocijan, Gabriel Tilmann Mindler, Markus Alexander Hartmann, Danial Arian Kraus, Adalbert Raimann, Jochen Zwerina
X‑linked hypophosphatemia (XLH) is a phosphate wasting disorder. Typical serum constellations include low serum phosphate as well as high alkaline phosphatase (ALP) and fibroblast growth factor 23 (FGF-23 ) levels. Adult XLH patients usually suffer from (pseudo)fractures, enthesopathies, impaired mobility, and osteoarthritis. We report the case of a middle-aged woman with clinically mild disease, relatively balanced laboratory values, but bone non-healing of the femur post-surgery. Transiliac bone biopsy revealed pronounced osteomalacia and severe deterioration of bone microstructure. Due to the lack of XLH-typical symptoms, the patient was not substituted with calcitriol and phosphate in adulthood. Thus, laboratory findings and radiological examinations do not necessarily reflect bone metabolism in XLH. Bone biopsies should be considered in unclear cases or prior to surgery in adults with XLH.
{"title":"Dissociation of clinical, laboratory, and bone biopsy findings in adult X-linked hypophosphatemia: a case report.","authors":"Roland Kocijan, Gabriel Tilmann Mindler, Markus Alexander Hartmann, Danial Arian Kraus, Adalbert Raimann, Jochen Zwerina","doi":"10.1007/s10354-022-01000-6","DOIUrl":"10.1007/s10354-022-01000-6","url":null,"abstract":"<p><p>X‑linked hypophosphatemia (XLH) is a phosphate wasting disorder. Typical serum constellations include low serum phosphate as well as high alkaline phosphatase (ALP) and fibroblast growth factor 23 (FGF-23 ) levels. Adult XLH patients usually suffer from (pseudo)fractures, enthesopathies, impaired mobility, and osteoarthritis. We report the case of a middle-aged woman with clinically mild disease, relatively balanced laboratory values, but bone non-healing of the femur post-surgery. Transiliac bone biopsy revealed pronounced osteomalacia and severe deterioration of bone microstructure. Due to the lack of XLH-typical symptoms, the patient was not substituted with calcitriol and phosphate in adulthood. Thus, laboratory findings and radiological examinations do not necessarily reflect bone metabolism in XLH. Bone biopsies should be considered in unclear cases or prior to surgery in adults with XLH.</p>","PeriodicalId":23882,"journal":{"name":"Wiener medizinische Wochenschrift","volume":" ","pages":"339-345"},"PeriodicalIF":0.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10613850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.1007/s10354-021-00894-y
Georgi Tchernev, Lorraine Joseph Kandathil, Nikhil Oliveira
Giant cell epulis (peripheral giant cell granuloma) typically appears as a reactive benign lesion in the oral cavity in areas following local irritation or chronic trauma. Here we describe the case of a 45-year-old male patient who presented with the chief complaint of a large gingival mass in the anterolateral maxilla. There had been progressive growth within the past few months, with increased painless discomfort during mastication. The patient also reported bleeding during interdental cleaning. A full physical work-up led to the suspicion of giant cell epulis alongside other differentials including mucosal hemangioma and squamous cell carcinoma, with unremarkable laboratory values. Imaging including computed tomography showed signs of previous insertion of metal implants on either side of the lesion alongside mucosal hyperplasia. A confirmatory biopsy was taken and showed multiple giant cells on a reactive bed of stroma, in line with the diagnosis of giant cell epulis. Oral inflammatory conditions such as giant cell epulis have greater chances of local recurrence and, therefore, careful investigation with timely and accurate diagnosis is imperative for appropriate early treatment. Complete surgical excision should then be employed to prevent relapses, as incomplete removal can lead to further recurrence. Identification and eradication of potential sources of irritation should also be considered when treating the patient, to avoid further recurrence.
{"title":"Giant cell epulis.","authors":"Georgi Tchernev, Lorraine Joseph Kandathil, Nikhil Oliveira","doi":"10.1007/s10354-021-00894-y","DOIUrl":"https://doi.org/10.1007/s10354-021-00894-y","url":null,"abstract":"<p><p>Giant cell epulis (peripheral giant cell granuloma) typically appears as a reactive benign lesion in the oral cavity in areas following local irritation or chronic trauma. Here we describe the case of a 45-year-old male patient who presented with the chief complaint of a large gingival mass in the anterolateral maxilla. There had been progressive growth within the past few months, with increased painless discomfort during mastication. The patient also reported bleeding during interdental cleaning. A full physical work-up led to the suspicion of giant cell epulis alongside other differentials including mucosal hemangioma and squamous cell carcinoma, with unremarkable laboratory values. Imaging including computed tomography showed signs of previous insertion of metal implants on either side of the lesion alongside mucosal hyperplasia. A confirmatory biopsy was taken and showed multiple giant cells on a reactive bed of stroma, in line with the diagnosis of giant cell epulis. Oral inflammatory conditions such as giant cell epulis have greater chances of local recurrence and, therefore, careful investigation with timely and accurate diagnosis is imperative for appropriate early treatment. Complete surgical excision should then be employed to prevent relapses, as incomplete removal can lead to further recurrence. Identification and eradication of potential sources of irritation should also be considered when treating the patient, to avoid further recurrence.</p>","PeriodicalId":23882,"journal":{"name":"Wiener medizinische Wochenschrift","volume":"173 11-12","pages":"249-250"},"PeriodicalIF":0.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10501348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Central nervous system (CNS) involvement in dermatomyositis (DM) is seldom observed. However, there are very rare case reports of CNS involvement with juvenile dermatomyositis. Encephalopathy in DM may occur for a number of reasons, such as cerebral vasculitis and hypoperfusion/hypertensive encephalopathy, but mostly as a consequence of immunosuppressant treatment. We report here for the first time the case of a patient with two rare diseases, namely anti-MDA5 antibody-positive dermatomyositis and mild encephalopathy with reversible splenial lesion (MERS).
{"title":"Anti-MDA5 antibody-positive dermatomyositis with mild encephalopathy with reversible splenial lesion: a possible rare association?","authors":"Khadija Saghir, Mohammed Chraa, Najib Kissani, Hajar Joulal, Lamiaa Essaadouni, Nissrine Louhab","doi":"10.1007/s10354-022-00943-0","DOIUrl":"https://doi.org/10.1007/s10354-022-00943-0","url":null,"abstract":"<p><p>Central nervous system (CNS) involvement in dermatomyositis (DM) is seldom observed. However, there are very rare case reports of CNS involvement with juvenile dermatomyositis. Encephalopathy in DM may occur for a number of reasons, such as cerebral vasculitis and hypoperfusion/hypertensive encephalopathy, but mostly as a consequence of immunosuppressant treatment. We report here for the first time the case of a patient with two rare diseases, namely anti-MDA5 antibody-positive dermatomyositis and mild encephalopathy with reversible splenial lesion (MERS).</p>","PeriodicalId":23882,"journal":{"name":"Wiener medizinische Wochenschrift","volume":"173 11-12","pages":"263-266"},"PeriodicalIF":0.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9211780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10501359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}