首页 > 最新文献

2013 IEEE Nuclear Science Symposium and Medical Imaging Conference (2013 NSS/MIC)最新文献

英文 中文
MPPC based scintillation counters for the internal photon tagger 基于MPPC的内部光子标记闪烁计数器
Pub Date : 2013-10-01 DOI: 10.1109/NSSMIC.2013.6829523
H. Kanda, Y. Akazawa, Y. Fujii, R. Honda, M. Kaneta, Y. Kasai, J. Kusaka, K. Maeda, K. Miwa, S. Nagao, S. Nakamura, T. Nishizawa, K. Tsukada, F. Yamamoto
We developed scintillation counters with Multi-Pixel-Photon-Counters (MPPC's) for an electron detector of a photon tagging system. They were compact, tolerant to a magnetic field, rate tolerant up to 170 kHz and had a good time resolution. These properties were suitable for the electron detector which was placed in a limited space of a bending magnet of an electron synchrotron. The scintillation counters were used for the measurement of the timing of the passage of the post-bremsstrahlung electrons, and the definition of their orbits by the hit positions on the counters to measure their momenta. We prepared two kinds of scintillation counter, one is for finer granularity named as a TagF and the other for the timing measurement named as a TagB. We performed an experiment to measure the properties of the counter unit using an electron beam with the energy of 855 MeV. We obtained the timing resolution of the TagB to be less than 80 ps (σ) almost independent of the hit rate in the range of 25 kHz to 170 kHz. Its gain decrease at the rate of 170 kHz was ~ 5% of the gain at the rate of 25 kHz. These properties satisfied our requirements for the electron detector. The whole electron detector consisting of the counter units are currently being designed.
我们开发了多像素光子计数器(MPPC)的闪烁计数器,用于光子标记系统的电子探测器。它们结构紧凑,能承受磁场,能承受高达170千赫的速率,并且有很好的时间分辨率。这些特性适用于放置在电子同步加速器弯曲磁体有限空间内的电子探测器。闪烁计数器用于测量轫致辐射后电子通过的时间,并通过计数器上的撞击位置来定义它们的轨道,以测量它们的动量。我们制备了两种闪烁计数器,一种是用于更细粒度的闪烁计数器,称为TagF,另一种是用于定时测量的闪烁计数器,称为TagB。我们利用能量为855兆电子伏特的电子束,进行了测量计数器性能的实验。在25 kHz ~ 170 kHz范围内,TagB的时序分辨率小于80 ps (σ),几乎与命中率无关。它在170 kHz速率下的增益衰减是在25 kHz速率下的增益衰减的5%。这些性质满足了我们对电子探测器的要求。由计数器组成的整个电子探测器目前正在设计中。
{"title":"MPPC based scintillation counters for the internal photon tagger","authors":"H. Kanda, Y. Akazawa, Y. Fujii, R. Honda, M. Kaneta, Y. Kasai, J. Kusaka, K. Maeda, K. Miwa, S. Nagao, S. Nakamura, T. Nishizawa, K. Tsukada, F. Yamamoto","doi":"10.1109/NSSMIC.2013.6829523","DOIUrl":"https://doi.org/10.1109/NSSMIC.2013.6829523","url":null,"abstract":"We developed scintillation counters with Multi-Pixel-Photon-Counters (MPPC's) for an electron detector of a photon tagging system. They were compact, tolerant to a magnetic field, rate tolerant up to 170 kHz and had a good time resolution. These properties were suitable for the electron detector which was placed in a limited space of a bending magnet of an electron synchrotron. The scintillation counters were used for the measurement of the timing of the passage of the post-bremsstrahlung electrons, and the definition of their orbits by the hit positions on the counters to measure their momenta. We prepared two kinds of scintillation counter, one is for finer granularity named as a TagF and the other for the timing measurement named as a TagB. We performed an experiment to measure the properties of the counter unit using an electron beam with the energy of 855 MeV. We obtained the timing resolution of the TagB to be less than 80 ps (σ) almost independent of the hit rate in the range of 25 kHz to 170 kHz. Its gain decrease at the rate of 170 kHz was ~ 5% of the gain at the rate of 25 kHz. These properties satisfied our requirements for the electron detector. The whole electron detector consisting of the counter units are currently being designed.","PeriodicalId":246351,"journal":{"name":"2013 IEEE Nuclear Science Symposium and Medical Imaging Conference (2013 NSS/MIC)","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116769109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of GSO:Ce phosphorescence after low-dose-rate gamma-ray irradiation 低剂量率伽马射线辐照后GSO:Ce磷光的表征
Pub Date : 2013-10-01 DOI: 10.1109/NSSMIC.2013.6829626
H. Simões, S. Ghithan, M. Loureiro, P. Crespo
Measurements of the phosphorescence of cerium-doped gadolinium oxyorthosilicate (GSO:Ce) crystals in a high-radiation environment with dose rates higher than 5 Gy/h have revealed the presence of a strong component of phosphorescent light. Such component, at times reaching values as high as the irradiation itself, could disturb planned orthogonal ray imaging systems, where megavoltage linacs deliver target doses of the order of 2 Gy/min. In two previous studies of orthogonal ray imaging a crystal of cerium-doped lutetium yttrium oxyorthosilicate (LYSO:Ce) was utilized for obtaining first orthogonal ray images with a single-pixel collimated detector. Because an orthogonal ray imaging device must comprise a multi-pixel system, the possibility of utilizing GSO as a scintillator suiting that purpose is currently under investigation. In order to rule out the possibility that the aforementioned phosphorescence of GSO disturbs future orthogonal ray imaging systems, we have performed spectroscopic measurements of a finger-like GSO crystals before, during, and after irradiation with both a 22Na and 60Co radioactive source with activities of 1.6 and 7.0MBq, respectively. A dosimetric Geiger detector positioned adjacent to the 60Co source revealed a dose rate of 1 mGy/h, i.e. more than 3 orders of magnitude lower than the aforementioned study. This value, nevertheless, is still above the expected dose rate value to be experienced by an orthogonal ray imaging detector since such detector is to be positioned behind a multi-hole or a multi-slit collimator. Cunha et al. calculated that the radiation dispersed onto such detectors is diminished by a factor of at least 105, which renders the dose-rate values measured in this work pertinent. We found no evidence of GSO phosphorescence at these very-low dose rates. Pulse shape analysis revealed nevertheless the existence of a very small amount of intrinsic radioactivity due to the alpha decay of 152Gd. GSO is therefore a suitable scintillator for planned orthogonal ray imaging systems.
在剂量率高于5 Gy/h的高辐射环境下,对掺铈氧化硅酸钆(GSO:Ce)晶体的磷光进行了测量,发现存在强磷光成分。这种成分有时会达到与辐照本身一样高的值,可能会干扰计划中的正交射线成像系统,在正交射线成像系统中,兆压直线加速器提供的目标剂量为2 Gy/min。在之前的两项正交射线成像研究中,利用掺杂铈的氧化硅酸镥钇(LYSO:Ce)晶体获得了单像素准直探测器的第一次正交射线图像。由于正交射线成像装置必须包含一个多像素系统,因此目前正在研究利用GSO作为适合该目的的闪烁体的可能性。为了排除上述GSO的磷光干扰未来正交射线成像系统的可能性,我们在22Na和60Co放射源(活度分别为1.6和7.0MBq)照射之前、期间和之后对手指状GSO晶体进行了光谱测量。放置在60Co源附近的剂量学盖革探测器显示,剂量率为1 mGy/h,即比上述研究低3个数量级以上。然而,这个值仍然高于正交射线成像探测器的预期剂量率值,因为这种探测器被放置在多孔或多缝准直器的后面。Cunha等人计算出,分散到这种探测器上的辐射至少减少了105倍,这使得本工作中测量的剂量率值具有相关性。在如此低的剂量率下,我们没有发现GSO磷光的证据。然而,脉冲形状分析表明,由于152Gd的α衰变,存在非常少量的本征放射性。因此,GSO是一种适合于正交射线成像系统的闪烁体。
{"title":"Characterization of GSO:Ce phosphorescence after low-dose-rate gamma-ray irradiation","authors":"H. Simões, S. Ghithan, M. Loureiro, P. Crespo","doi":"10.1109/NSSMIC.2013.6829626","DOIUrl":"https://doi.org/10.1109/NSSMIC.2013.6829626","url":null,"abstract":"Measurements of the phosphorescence of cerium-doped gadolinium oxyorthosilicate (GSO:Ce) crystals in a high-radiation environment with dose rates higher than 5 Gy/h have revealed the presence of a strong component of phosphorescent light. Such component, at times reaching values as high as the irradiation itself, could disturb planned orthogonal ray imaging systems, where megavoltage linacs deliver target doses of the order of 2 Gy/min. In two previous studies of orthogonal ray imaging a crystal of cerium-doped lutetium yttrium oxyorthosilicate (LYSO:Ce) was utilized for obtaining first orthogonal ray images with a single-pixel collimated detector. Because an orthogonal ray imaging device must comprise a multi-pixel system, the possibility of utilizing GSO as a scintillator suiting that purpose is currently under investigation. In order to rule out the possibility that the aforementioned phosphorescence of GSO disturbs future orthogonal ray imaging systems, we have performed spectroscopic measurements of a finger-like GSO crystals before, during, and after irradiation with both a 22Na and 60Co radioactive source with activities of 1.6 and 7.0MBq, respectively. A dosimetric Geiger detector positioned adjacent to the 60Co source revealed a dose rate of 1 mGy/h, i.e. more than 3 orders of magnitude lower than the aforementioned study. This value, nevertheless, is still above the expected dose rate value to be experienced by an orthogonal ray imaging detector since such detector is to be positioned behind a multi-hole or a multi-slit collimator. Cunha et al. calculated that the radiation dispersed onto such detectors is diminished by a factor of at least 105, which renders the dose-rate values measured in this work pertinent. We found no evidence of GSO phosphorescence at these very-low dose rates. Pulse shape analysis revealed nevertheless the existence of a very small amount of intrinsic radioactivity due to the alpha decay of 152Gd. GSO is therefore a suitable scintillator for planned orthogonal ray imaging systems.","PeriodicalId":246351,"journal":{"name":"2013 IEEE Nuclear Science Symposium and Medical Imaging Conference (2013 NSS/MIC)","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116808033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polygonal pixel grid based PET image reconstruction algorithm: Development, application and performance comparison 基于多边形像素网格的PET图像重建算法:开发、应用及性能比较
Pub Date : 2013-10-01 DOI: 10.1109/NSSMIC.2013.6829237
Yu Yunhan, Yan Xia, Wei Wang, Yaqiang Liu, K. Ying, Shi Wang, Tianyu Ma
System matrix works as an association between image and detected data. Accurate expression of the system matrix is a key component during PET image reconstruction. However, with numerous Line-of-Responses (LORs) detected in modern 3D PET scanner, the huge storage size of a full system matrix increases computational burden. To solve this essential issue, we designed a rotationally symmetric polygonal pixel grid with fan-shaped segments in the image domain to efficiently compress the matrix with geometrical symmetries. This idea mainly came from the polygonal geometry of detector rings in most PET system.
系统矩阵作为图像和检测数据之间的关联。系统矩阵的准确表达是PET图像重建的关键环节。然而,由于在现代3D PET扫描仪中检测到大量的响应线(LORs),整个系统矩阵的巨大存储尺寸增加了计算负担。为了解决这一关键问题,我们设计了一个旋转对称的多边形像素网格,在图像域中具有扇形的部分,以有效地压缩矩阵的几何对称性。这种想法主要来自于大多数PET系统中探测环的多边形几何结构。
{"title":"Polygonal pixel grid based PET image reconstruction algorithm: Development, application and performance comparison","authors":"Yu Yunhan, Yan Xia, Wei Wang, Yaqiang Liu, K. Ying, Shi Wang, Tianyu Ma","doi":"10.1109/NSSMIC.2013.6829237","DOIUrl":"https://doi.org/10.1109/NSSMIC.2013.6829237","url":null,"abstract":"System matrix works as an association between image and detected data. Accurate expression of the system matrix is a key component during PET image reconstruction. However, with numerous Line-of-Responses (LORs) detected in modern 3D PET scanner, the huge storage size of a full system matrix increases computational burden. To solve this essential issue, we designed a rotationally symmetric polygonal pixel grid with fan-shaped segments in the image domain to efficiently compress the matrix with geometrical symmetries. This idea mainly came from the polygonal geometry of detector rings in most PET system.","PeriodicalId":246351,"journal":{"name":"2013 IEEE Nuclear Science Symposium and Medical Imaging Conference (2013 NSS/MIC)","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123279609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Simulation study of the DOI-PEM scanner DOI-PEM扫描器的仿真研究
Pub Date : 2013-10-01 DOI: 10.1109/nssmic.2013.6829169
Shigeharu Kobayashi, Tokonatsu Yamamoto, F. Kajino
A simple MC simulation using the Mathematica app. is presented for a square-shaped PEM device consisted of the notched scintillating crystal chips. For a previously studied material of a 30 mm length Pr:LuAG with the cross sectional area of either 2×2 mm2 or 4×4 mm2, the imaging spread and the detection efficiency of a point source are examined. Chosen the number of DOI notches as a parameter, an optimum solution to give the sub-millimeter space resolution is obtained. Some more results for the PEM construction also are presented.
利用Mathematica软件对一个由缺口闪烁晶片组成的方形PEM器件进行了简单的MC模拟。对于先前研究的30 mm长Pr:LuAG材料,其横截面积为2×2 mm2或4×4 mm2,研究了点源的成像扩展和检测效率。以DOI缺口数为参数,得到了给出亚毫米空间分辨率的最优解。本文还介绍了PEM结构的一些结果。
{"title":"Simulation study of the DOI-PEM scanner","authors":"Shigeharu Kobayashi, Tokonatsu Yamamoto, F. Kajino","doi":"10.1109/nssmic.2013.6829169","DOIUrl":"https://doi.org/10.1109/nssmic.2013.6829169","url":null,"abstract":"A simple MC simulation using the Mathematica app. is presented for a square-shaped PEM device consisted of the notched scintillating crystal chips. For a previously studied material of a 30 mm length Pr:LuAG with the cross sectional area of either 2×2 mm2 or 4×4 mm2, the imaging spread and the detection efficiency of a point source are examined. Chosen the number of DOI notches as a parameter, an optimum solution to give the sub-millimeter space resolution is obtained. Some more results for the PEM construction also are presented.","PeriodicalId":246351,"journal":{"name":"2013 IEEE Nuclear Science Symposium and Medical Imaging Conference (2013 NSS/MIC)","volume":"136 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123594456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A realistic digital phantom for perfusion C-arm CT based on MRI data 基于MRI数据的灌注c臂CT逼真数字幻象
Pub Date : 2013-10-01 DOI: 10.1109/NSSMIC.2013.6829168
A. Aichert, M. Manhart, Bharath K. Navalpakkam, R. Grimm, J. Hutter, A. Maier, J. Hornegger, A. Doerfler
CTP is an important imaging modality for diagnosis of ischemic stroke, which is computed from of a series of consecutive CT-scans during the injection of contrast agent. Contrast flow at any point in space can be tracked as minor changes in intensity over a period of about 40 seconds to one minute, represented as a time-attenuation curve (TAC) for every voxel. This work presents an isotropic, dense, physiologically realistic and dynamic brain phantom for CT perfusion. The phantom is based on MRI scans of a volunteer and is freely available for download.
CTP是一种诊断缺血性脑卒中的重要成像方式,它是在注射造影剂期间通过一系列连续的ct扫描计算得出的。空间中任何一点的对比流都可以在大约40秒到1分钟的时间内作为强度的微小变化进行跟踪,以每个体素的时间衰减曲线(TAC)表示。本研究为CT灌注提供了一个各向同性、致密、生理逼真和动态的脑幻影。这个幻影是基于志愿者的核磁共振成像扫描,可以免费下载。
{"title":"A realistic digital phantom for perfusion C-arm CT based on MRI data","authors":"A. Aichert, M. Manhart, Bharath K. Navalpakkam, R. Grimm, J. Hutter, A. Maier, J. Hornegger, A. Doerfler","doi":"10.1109/NSSMIC.2013.6829168","DOIUrl":"https://doi.org/10.1109/NSSMIC.2013.6829168","url":null,"abstract":"CTP is an important imaging modality for diagnosis of ischemic stroke, which is computed from of a series of consecutive CT-scans during the injection of contrast agent. Contrast flow at any point in space can be tracked as minor changes in intensity over a period of about 40 seconds to one minute, represented as a time-attenuation curve (TAC) for every voxel. This work presents an isotropic, dense, physiologically realistic and dynamic brain phantom for CT perfusion. The phantom is based on MRI scans of a volunteer and is freely available for download.","PeriodicalId":246351,"journal":{"name":"2013 IEEE Nuclear Science Symposium and Medical Imaging Conference (2013 NSS/MIC)","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123773427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 32
A 20-ps temperature compensated Time-to-Digital Converter (TDC) implemented in FPGA 在FPGA中实现的20ps温度补偿时间-数字转换器(TDC)
Pub Date : 2013-10-01 DOI: 10.1109/NSSMIC.2013.6829535
Weibin Pan, G. Gong, Hongming Li, Jianmin Li
This paper presents a temperature compensation design for carry chain based Time-to-Digital Converter (TDC) in FPGA. The bin-by-bin calibrations under different temperatures are performed for both plain TDC and Wave Union TDC to characterize the influence of temperature variation on the delay time of carry chain which shows all TDC channels have the similar temperature-LUT coefficient. Accordingly, a simplified temperature compensation scheme by using a dedicated correction channel to measure the coefficient and correct fine time result for all TDC channels is implemented and tested. This method shows only few picosecond errors for both simulation and measurement. With this compensation approach, a 21ps RMS TDC resolution has been achieved in Cyclone II FPGA under a wide temperature range from 10°C to 75°C. Several design key points are also described in this paper.
提出了一种基于进位链的FPGA时间-数字转换器(TDC)的温度补偿设计。在不同温度条件下,对普通TDC和Wave Union TDC进行了逐箱校准,表征了温度变化对携带链延迟时间的影响,结果表明所有TDC通道具有相似的温度- lut系数。在此基础上,实现了一种简化的温度补偿方案,即利用专用的校正通道测量系数并对所有TDC通道的精细时间结果进行校正。该方法的仿真和测量误差均小于皮秒。通过这种补偿方法,Cyclone II FPGA在10°C至75°C的宽温度范围内实现了21ps RMS TDC分辨率。本文还介绍了几个设计要点。
{"title":"A 20-ps temperature compensated Time-to-Digital Converter (TDC) implemented in FPGA","authors":"Weibin Pan, G. Gong, Hongming Li, Jianmin Li","doi":"10.1109/NSSMIC.2013.6829535","DOIUrl":"https://doi.org/10.1109/NSSMIC.2013.6829535","url":null,"abstract":"This paper presents a temperature compensation design for carry chain based Time-to-Digital Converter (TDC) in FPGA. The bin-by-bin calibrations under different temperatures are performed for both plain TDC and Wave Union TDC to characterize the influence of temperature variation on the delay time of carry chain which shows all TDC channels have the similar temperature-LUT coefficient. Accordingly, a simplified temperature compensation scheme by using a dedicated correction channel to measure the coefficient and correct fine time result for all TDC channels is implemented and tested. This method shows only few picosecond errors for both simulation and measurement. With this compensation approach, a 21ps RMS TDC resolution has been achieved in Cyclone II FPGA under a wide temperature range from 10°C to 75°C. Several design key points are also described in this paper.","PeriodicalId":246351,"journal":{"name":"2013 IEEE Nuclear Science Symposium and Medical Imaging Conference (2013 NSS/MIC)","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123799968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Evaluation of sympathetic nervous system function in normal and spontaneously hypertensive rat hearts with dynamic SPECT imaging 动态SPECT评价正常和自发性高血压大鼠心脏交感神经系统功能
Pub Date : 2013-10-01 DOI: 10.1109/NSSMIC.2013.6829043
Yunlong Zan, R. Boutchko, Qiu Huang, G. Gullberg
123I-MIBG is an analogue of the norepinephrine uptake in the presynaptic portion of the sympathetic neurons that innervate the heart. The abnormal metabolism of 123I-MIBG is used to diagnose potential heart failure. This paper quantitatively compares the metabolism of 123I-MIBG in SHRs and Wistar-Kyoto normal rats. Dynamic projection data were acquired for 100 min in 1-sec time frames with an angular step of 2 degrees per frame on a dual-head GE Millennium VG Hawkeye SPECT/CT scanner equipped with custom pinhole collimators. The time activity curves of radiotracer in blood pool and myocardium were extracted from the projections through the spatiotemporal dimension reduction method developed previously for dynamic cardiac SPECT reconstruction. The kinetic parameters were estimated by fitting the estimate time activity curves to a compartmental model. The distribution volumes (DVs) of the radiotracer in the myocardium were calculated. The DV of SHRs was greater (p=2.4E-4) than that of WKY normal rats, indicating the development of cardiac hypertrophy in the SHRs.
123I-MIBG是支配心脏的交感神经元突触前部分去甲肾上腺素摄取的类似物。123I-MIBG代谢异常可用于诊断潜在心力衰竭。本文定量比较了SHRs和Wistar-Kyoto正常大鼠123I-MIBG的代谢。在配备定制针孔准直器的GE Millennium VG Hawkeye双头SPECT/CT扫描仪上,以每帧2度的角度步长,以1秒的时间帧获取100分钟的动态投影数据。利用动态心肌SPECT重建的时空降维方法,从投影中提取血池和心肌中放射性示踪剂的时间活度曲线。通过将估计时间活度曲线拟合到室室模型中来估计动力学参数。计算示踪剂在心肌中的分布体积(DVs)。与WKY正常大鼠相比,SHRs的DV显著增加(p=2.4E-4),提示SHRs发生心肌肥厚。
{"title":"Evaluation of sympathetic nervous system function in normal and spontaneously hypertensive rat hearts with dynamic SPECT imaging","authors":"Yunlong Zan, R. Boutchko, Qiu Huang, G. Gullberg","doi":"10.1109/NSSMIC.2013.6829043","DOIUrl":"https://doi.org/10.1109/NSSMIC.2013.6829043","url":null,"abstract":"123I-MIBG is an analogue of the norepinephrine uptake in the presynaptic portion of the sympathetic neurons that innervate the heart. The abnormal metabolism of 123I-MIBG is used to diagnose potential heart failure. This paper quantitatively compares the metabolism of 123I-MIBG in SHRs and Wistar-Kyoto normal rats. Dynamic projection data were acquired for 100 min in 1-sec time frames with an angular step of 2 degrees per frame on a dual-head GE Millennium VG Hawkeye SPECT/CT scanner equipped with custom pinhole collimators. The time activity curves of radiotracer in blood pool and myocardium were extracted from the projections through the spatiotemporal dimension reduction method developed previously for dynamic cardiac SPECT reconstruction. The kinetic parameters were estimated by fitting the estimate time activity curves to a compartmental model. The distribution volumes (DVs) of the radiotracer in the myocardium were calculated. The DV of SHRs was greater (p=2.4E-4) than that of WKY normal rats, indicating the development of cardiac hypertrophy in the SHRs.","PeriodicalId":246351,"journal":{"name":"2013 IEEE Nuclear Science Symposium and Medical Imaging Conference (2013 NSS/MIC)","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125437125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A TOF PET detector development using waveform sampling and strip-line based data acquisition 一种基于波形采样和条带线数据采集的TOF PET探测器的研制
Pub Date : 2013-10-01 DOI: 10.1109/NSSMIC.2013.6829212
Heejong Kim, Chin-Tu Chen, H.-T. Chen, A. Ronzhin, E. Ramberg, S. Los, P. Murat, S. Majewski, C. Kao
We are developing a human-brain imaging TOF PET detector with high sensitivity and lower radioactive dose to patients. The proposed detector design consists of 36 detector modules, and each module has 4×8 LYSO scintillators coupled to SiPMs individually. For signal readout for detector modules, the transmission-line readout with high speed waveform sampling is adopted to fully exploit the fast time response of SiPM with reduced electronics channels. A detector simulation has been developed using Geant4 package to check the performances of the proposed detector. Previously we demonstrated that our signal readout approach is feasible with SiPM. Based on the experience with the proto-type readout board, second generation readout board has been developed to implement the transmission-line signal readout for the proposed detector. In the paper, we present the initial results obtained from the simulation studies and experimental tests using the newly developed strip-line board.
我们正在开发一种灵敏度高、对患者放射性剂量低的TOF PET人脑成像探测器。提出的探测器设计由36个探测器模块组成,每个模块都有4×8 LYSO闪烁体单独耦合到sipm。检测器模块的信号读出采用高速波形采样的传输在线读出,充分利用SiPM在减少电子通道的情况下的快速时间响应。利用Geant4软件包进行了探测器仿真,验证了该探测器的性能。之前我们证明了我们的信号读出方法在SiPM中是可行的。根据原型读出板的经验,研制了第二代读出板,实现了探测器的传输在线信号读出。在本文中,我们介绍了利用新开发的带状线板进行模拟研究和实验测试的初步结果。
{"title":"A TOF PET detector development using waveform sampling and strip-line based data acquisition","authors":"Heejong Kim, Chin-Tu Chen, H.-T. Chen, A. Ronzhin, E. Ramberg, S. Los, P. Murat, S. Majewski, C. Kao","doi":"10.1109/NSSMIC.2013.6829212","DOIUrl":"https://doi.org/10.1109/NSSMIC.2013.6829212","url":null,"abstract":"We are developing a human-brain imaging TOF PET detector with high sensitivity and lower radioactive dose to patients. The proposed detector design consists of 36 detector modules, and each module has 4×8 LYSO scintillators coupled to SiPMs individually. For signal readout for detector modules, the transmission-line readout with high speed waveform sampling is adopted to fully exploit the fast time response of SiPM with reduced electronics channels. A detector simulation has been developed using Geant4 package to check the performances of the proposed detector. Previously we demonstrated that our signal readout approach is feasible with SiPM. Based on the experience with the proto-type readout board, second generation readout board has been developed to implement the transmission-line signal readout for the proposed detector. In the paper, we present the initial results obtained from the simulation studies and experimental tests using the newly developed strip-line board.","PeriodicalId":246351,"journal":{"name":"2013 IEEE Nuclear Science Symposium and Medical Imaging Conference (2013 NSS/MIC)","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126876297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The transition radiation detector of the alpha magnetic spectrometer(AMS-02) on the International Space Station and the precision measurement of the cosmic ray positron fraction 国际空间站α磁谱仪(AMS-02)的跃迁辐射探测器及宇宙射线正电子分数的精密测量
Pub Date : 2013-10-01 DOI: 10.1109/NSSMIC.2013.6829508
C. Chung
On May 19th 2011, the AMS-02 experiment was successfully deployed on board the Earth-orbiting International Space Station (ISS) and is constantly operating since then without interruption. AMS is a complex particle detector in space and conducts research in astroparticle physics by precisely measuring charged cosmic particles to study acceleration, propagation and contributions from new particle physics and astrophysical sources. This is made possible by the main features of the AMS detector, namely its large acceptance, the long duration mission about 20 years limited by the ISS lifespan and the unique high proton rejection power by combining the electromagnetic calorimeter and the transition radiation detector (TRD). The TRD is designed to separate positrons from the huge proton background with a high efficiency. A precision measurement of the positron fraction in the energy range from 0.5 to 350 GeV is presented. The accurate data show that the positron fraction is steadily increasing from 10 to 250 GeV with a decreasing slope by an order of magnitude between 20 and 250 GeV. The positron fraction spectrum shows no fine structure and no observable anisotropy. These observations show the existence of new physical phenomena whether from a particle physics or an astrophysical origin.
2011年5月19日,AMS-02实验成功部署在绕地球轨道运行的国际空间站(ISS)上,此后一直在持续运行,没有中断。AMS是一个复杂的空间粒子探测器,通过精确测量带电宇宙粒子来研究加速、传播以及新粒子物理和天体物理源的贡献,从而进行天体粒子物理研究。这是由于AMS探测器的主要特点,即其广泛的接受度,国际空间站寿命限制的约20年的长时间任务,以及结合电磁量热计和过渡辐射探测器(TRD)独特的高质子排斥功率。TRD被设计用于以高效率从巨大的质子背景中分离正电子。提出了在0.5 ~ 350 GeV能量范围内精确测量正电子分数的方法。精确数据表明,正电子分数从10 ~ 250 GeV稳步增加,在20 ~ 250 GeV之间以一个数量级的斜率递减。正电子分数谱没有精细结构,也没有观察到各向异性。这些观测表明,不论是粒子物理学还是天体物理学的起源,都存在着新的物理现象。
{"title":"The transition radiation detector of the alpha magnetic spectrometer(AMS-02) on the International Space Station and the precision measurement of the cosmic ray positron fraction","authors":"C. Chung","doi":"10.1109/NSSMIC.2013.6829508","DOIUrl":"https://doi.org/10.1109/NSSMIC.2013.6829508","url":null,"abstract":"On May 19th 2011, the AMS-02 experiment was successfully deployed on board the Earth-orbiting International Space Station (ISS) and is constantly operating since then without interruption. AMS is a complex particle detector in space and conducts research in astroparticle physics by precisely measuring charged cosmic particles to study acceleration, propagation and contributions from new particle physics and astrophysical sources. This is made possible by the main features of the AMS detector, namely its large acceptance, the long duration mission about 20 years limited by the ISS lifespan and the unique high proton rejection power by combining the electromagnetic calorimeter and the transition radiation detector (TRD). The TRD is designed to separate positrons from the huge proton background with a high efficiency. A precision measurement of the positron fraction in the energy range from 0.5 to 350 GeV is presented. The accurate data show that the positron fraction is steadily increasing from 10 to 250 GeV with a decreasing slope by an order of magnitude between 20 and 250 GeV. The positron fraction spectrum shows no fine structure and no observable anisotropy. These observations show the existence of new physical phenomena whether from a particle physics or an astrophysical origin.","PeriodicalId":246351,"journal":{"name":"2013 IEEE Nuclear Science Symposium and Medical Imaging Conference (2013 NSS/MIC)","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126966187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
A PET detector module using FPGA-only MVT digitizers 一个PET检测器模块,使用仅fpga的MVT数字转换器
Pub Date : 2013-10-01 DOI: 10.1109/NSSMIC.2013.6829063
D. Xi, Chen Zeng, W. Liu, Xiang Liu, L. Wan, Heejong Kim, Luyao Wang, C. Kao, Q. Xie
Multi-voltage threshold (MVT) is an amplitude-based sampling method. It takes timing samples when the event pulse crosses the user-defined thresholds. Only a few comparators and TDCs are required when implementing such digitizer. Previously, we have demonstrated an FPGA-only MVT digitizer based on this method. The FPGA-only MVT digitizer employs the differential I/Os in an FPGA as the required comparators and FPGA based TDCs. The implementation of this digitizer is entirely based on the FPGA. We have demonstrated that it is possible to implement a significant number of MVT digitizers by using a single FPGA. It is also flexible, as it allows us to readily modify, or add functions to, the implementation without requiring costly hardware changes. Currently, we are developing a PET detector module using the FPGA-only MVT digitizer. In this paper we describe the design and implementation of the detector module and report its performance properties. The detector module has a total detection sensitive area of 50mm × 50mm, an overall energy resolution of 15.1% FWHM at 511keV, and a module-level coincidence timing resolution of 684ps FWHM. In addition, our preliminary imaging with such detector module successfully resolves 1.6mm-diameter rods separated by 3.2mm.
多电压阈值(MVT)是一种基于幅值的采样方法。当事件脉冲超过用户定义的阈值时,它会进行定时采样。在实现这种数字化时,只需要几个比较器和tdc。在此之前,我们已经演示了基于该方法的仅fpga的MVT数字化仪。仅FPGA的MVT数字化仪采用FPGA中的差分I/ o作为所需的比较器和基于FPGA的tdc。该数字化仪的实现完全基于FPGA。我们已经证明,使用单个FPGA可以实现大量的MVT数字化仪。它也很灵活,因为它允许我们随时修改或向实现添加功能,而不需要昂贵的硬件更改。目前,我们正在使用仅fpga的MVT数字化仪开发PET检测器模块。本文描述了该检测器模块的设计与实现,并报告了其性能特性。检测器模块的总探测敏感面积为50mm × 50mm, 511keV时的总能量分辨率为15.1% FWHM,模块级符合定时分辨率为684ps FWHM。此外,我们使用该探测器模块进行初步成像,成功地分辨出直径1.6mm、间隔3.2mm的棒。
{"title":"A PET detector module using FPGA-only MVT digitizers","authors":"D. Xi, Chen Zeng, W. Liu, Xiang Liu, L. Wan, Heejong Kim, Luyao Wang, C. Kao, Q. Xie","doi":"10.1109/NSSMIC.2013.6829063","DOIUrl":"https://doi.org/10.1109/NSSMIC.2013.6829063","url":null,"abstract":"Multi-voltage threshold (MVT) is an amplitude-based sampling method. It takes timing samples when the event pulse crosses the user-defined thresholds. Only a few comparators and TDCs are required when implementing such digitizer. Previously, we have demonstrated an FPGA-only MVT digitizer based on this method. The FPGA-only MVT digitizer employs the differential I/Os in an FPGA as the required comparators and FPGA based TDCs. The implementation of this digitizer is entirely based on the FPGA. We have demonstrated that it is possible to implement a significant number of MVT digitizers by using a single FPGA. It is also flexible, as it allows us to readily modify, or add functions to, the implementation without requiring costly hardware changes. Currently, we are developing a PET detector module using the FPGA-only MVT digitizer. In this paper we describe the design and implementation of the detector module and report its performance properties. The detector module has a total detection sensitive area of 50mm × 50mm, an overall energy resolution of 15.1% FWHM at 511keV, and a module-level coincidence timing resolution of 684ps FWHM. In addition, our preliminary imaging with such detector module successfully resolves 1.6mm-diameter rods separated by 3.2mm.","PeriodicalId":246351,"journal":{"name":"2013 IEEE Nuclear Science Symposium and Medical Imaging Conference (2013 NSS/MIC)","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114955408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
期刊
2013 IEEE Nuclear Science Symposium and Medical Imaging Conference (2013 NSS/MIC)
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1