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2013 IEEE Nuclear Science Symposium and Medical Imaging Conference (2013 NSS/MIC)最新文献

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Motion compensated 4D PET-CT-MR image generation for respiratory synchronized multi-modal image display 运动补偿4D PET-CT-MR图像生成呼吸同步多模态图像显示
Pub Date : 2013-11-01 DOI: 10.1109/NSSMIC.2013.6829266
W. H. Nam, Jihye Kim, I. Ahn, Yongjin Chang, J. Ra
Positron emission tomography (PET) image has been widely used for early detection of malignant lesion(s) and its treatment, because it can provide functional information. Since computed tomography (CT) and magnetic resonance (MR) images can provide high resolution anatomical information, their simultaneous display with PET image may improve the clinical value of PET-image-based applications. Meanwhile, temporal information regarding anatomical changes due to respiration may be important in the radiation therapy planning of a thoracic or abdominal region. To provide such important information, we propose a framework for motion compensated 4D PET-CT-MR image generation. To realize the framework, we present a MR-driven motion compensation algorithm for respiratory-gated 4D PET imaging. We then introduce a respiratory-synchronized multi-modal image generation method. We expect that the respiratory-synchronized multi-modal image display can be useful for clinicians to efficiently utilize the temporal information as well as the complementary spatial information in their applications.
正电子发射断层扫描(PET)图像由于能提供功能信息,已广泛应用于恶性病变的早期发现和治疗。由于计算机断层扫描(CT)和磁共振(MR)图像可以提供高分辨率的解剖信息,因此它们与PET图像同时显示可以提高PET图像应用的临床价值。同时,关于呼吸引起的解剖变化的时间信息可能对胸部或腹部区域的放射治疗计划很重要。为了提供这些重要的信息,我们提出了一个运动补偿的4D PET-CT-MR图像生成框架。为了实现该框架,我们提出了一种磁共振驱动的呼吸门控四维PET成像运动补偿算法。然后,我们介绍了一种呼吸同步的多模态图像生成方法。我们期望呼吸同步多模态图像显示可以帮助临床医生在其应用中有效地利用时间信息以及互补的空间信息。
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引用次数: 0
Imaging corn plants with PhytoPET, a modular PET system for plant biology 用植物生物学的模块化PET系统PhytoPET成像玉米植株
Pub Date : 2013-11-01 DOI: 10.1109/NSSMIC.2013.6829796
S. Lee, B. Kross, J. McKisson, J. McKisson, A. Weisenberger, W. Xi, C. Zorn, G. Bonito, C. Howell, C. Reid, A. Crowell, L. Cumberbatch, C. Topp, M. Smith
PhytoPET is a modular positron emission tomography (PET) system designed specifically for plant imaging. The PhytoPET design allows flexible arrangements of PET detectors based on individual standalone detector modules built from single Hamamatsu H8500 position sensitive photomultiplier tubes and pixelated LYSO arrays. We have used the PhytoPET system to perform preliminary corn plant imaging studies at the Duke University Biology Department Phytotron. Initial evaluation of the PhytoPET system to image the biodistribution of the positron emitting tracer 11C in corn plants is presented. 11CO2 is loaded into corn seedlings by a leaf-labeling cuvette and translocation of 11C-sugars is imaged by a flexible arrangement of PhytoPET modules on each side. The PhytoPET system successfully images 11C within corn plants and allows for the dynamic measurement of 11C-sugar translocation from the leaf to the roots.
PhytoPET是一种模块化正电子发射断层扫描(PET)系统,专为植物成像而设计。PhytoPET设计允许灵活安排PET探测器,基于单个独立探测器模块,由单个Hamamatsu H8500位置敏感光电倍增管和像素化LYSO阵列构建。我们已经使用PhytoPET系统在杜克大学生物系Phytotron进行了初步的玉米植物成像研究。本文介绍了利用PhytoPET系统对正电子发射示踪剂11C在玉米植株中的生物分布进行成像的初步评价。通过叶片标记试管将11c - co2装载到玉米幼苗中,并通过每侧灵活排列的PhytoPET模块对11c -糖的易位进行成像。PhytoPET系统成功地对玉米植株内的11C进行了成像,并允许动态测量11C-糖从叶片到根的转运。
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引用次数: 5
LOR-based reconstruction for super-resolved 3D PET image 基于lr的超分辨三维PET图像重建
Pub Date : 2013-11-01 DOI: 10.1109/NSSMIC.2013.6829239
I. Ahn, Jihye Kim, W. H. Nam, Yongjin Chang, J. Ra
PET images usually suffer from low spatial resolution due to positron range, photon non-collinearity, scatters inside scintillating crystals, finite dimension of crystals, and so on. To improve the spatial resolution based on wobble scanning, we previously proposed a sinogram-based super-resolution (SR) algorithm based on a space-variant blur matrix. However, the algorithm may cause unwanted resolution loss due to an inevitable interpolation process for preparing even-spaced sinograms. In this paper, we propose a novel and efficient one-step line of response (LOR) based SR framework for 3D PET images. In the framework, we efficiently determine a large number of space-variant PSFs in an image space by using the scanner symmetries and the proposed PSF interpolation scheme based on non-rigid registration. We then obtain a HR image via one-step super-resolved 3D PET image reconstruction with the determined PSFs. Furthermore, we reduce the computational time of GPU-based reconstruction by introducing a parallel-friendly cone-beam based LOR system matrix. The proposed framework provides noticeable improvement on the spatial resolution of PET images with a considerable reduction of computational time.
由于正电子范围、光子非共线性、闪烁晶体内部散射、晶体尺寸有限等原因,PET图像通常存在空间分辨率低的问题。为了提高基于摆动扫描的空间分辨率,我们提出了一种基于空间变模糊矩阵的图像超分辨率(SR)算法。然而,该算法可能会造成不必要的分辨率损失,由于一个不可避免的插值过程,以准备均匀间隔的正弦图。在本文中,我们提出了一种新颖高效的基于一步响应线(LOR)的三维PET图像SR框架。在该框架中,我们利用扫描器对称性和提出的基于非刚性配准的PSF插值方案,有效地确定了图像空间中的大量空间变PSF。然后,我们通过一步超分辨3D PET图像重建获得HR图像。此外,我们还引入了一种并行友好的锥束LOR系统矩阵,从而减少了基于gpu的重构的计算时间。该框架显著提高了PET图像的空间分辨率,大大减少了计算时间。
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引用次数: 1
Characterization results and first applications of KLauS - an ASIC for SiPM charge and fast discrimination readout 用于SiPM电荷和快速鉴别读出的专用集成电路KLauS的表征结果和首次应用
Pub Date : 2013-10-31 DOI: 10.1109/NSSMIC.2013.6829778
K. Briggl, W. Shen, T. Harion, R. Hagdorn, P. Eckert, T. Klapdor-Kleingrothaus, M. Dorn, H. Schultz-Coulon
KLauS is an ASIC produced in the AMS 0.35μm SiGe technology to read out the charge signals from silicon photomultipliers. Developed as an analog front end for future calorimeters with high granularity as pursued by the AHCAL concept in the CALICE collaboration, the ASIC is supposed to measure the charge signal of the sensors in a large dynamic range and with a high precision. In order to compensate bias and temperature fluctuations of each sensor individually, an 8-bit DAC to tune the voltage at the input terminal is implemented. Using an integrated fast comparator with low jitter, the time information can be measured with sub-nanosecond resolution. The low power consumption of the ASIC can be further decreased using power gating techniques. Future versions of KLauS are under development and will incorporate an ADC with a resolution of up to 12 bit together with blocks for digital data transmission. Most recent characterization results for the KLauS chip are presented as well as results from a KLauS-based test setup developed for mass characterization of scintillator tiles used in the AHCAL test beam program.
KLauS是采用AMS 0.35μm SiGe技术生产的ASIC,用于读取来自硅光电倍增管的电荷信号。根据CALICE合作中AHCAL概念所追求的未来高粒度量热计的模拟前端,ASIC应该在大动态范围内以高精度测量传感器的电荷信号。为了单独补偿每个传感器的偏置和温度波动,实现了一个8位DAC来调节输入端的电压。利用集成的低抖动快速比较器,可以以亚纳秒的分辨率测量时间信息。使用功率门控技术可以进一步降低ASIC的低功耗。未来版本的KLauS正在开发中,它将包含一个分辨率高达12位的ADC以及用于数字数据传输的模块。介绍了克劳斯芯片的最新表征结果,以及基于克劳斯的测试装置的结果,该测试装置用于AHCAL测试束程序中使用的闪烁体瓦片的质量表征。
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引用次数: 1
The LHCb trigger system: Performance and outlook LHCb触发系统:性能和前景
Pub Date : 2013-10-31 DOI: 10.1109/NSSMIC.2013.6829553
A. Navarro
The trigger of the LHCb experiment consists of two stages: an initial hardware trigger, and a high-level trigger implemented in a farm of CPUs. It reduces the event rate from an input of 15 MHz to around 5 kHz. To maximize efficiencies and minimize biases, the trigger is designed around inclusive selection algorithms, culminating in a novel boosted decision tree which enables the efficient selection of beauty hadron decays based on a robust partial reconstruction of their decay products. The design and performance of these selection algorithms will be discussed in the context of the 2012 data taking. In order to improve performance, the LHCb upgrade aims to significantly increase the rate at which the detector will be read out, and hence shift more of the workload onto the high-level trigger. It is demonstrated that the current high-level trigger architecture will be able to meet this challenge, and the expected efficiencies in several key channels are discussed in context of the LHCb upgrade.
LHCb实验的触发器包括两个阶段:初始硬件触发器和在cpu群中实现的高级触发器。它将事件速率从15mhz的输入降低到5khz左右。为了最大限度地提高效率和减少偏差,触发器围绕包容性选择算法进行设计,最终形成一种新颖的增强决策树,该决策树能够基于其衰变产物的鲁棒部分重建来有效地选择美丽强子衰变。这些选择算法的设计和性能将在2012年数据采集的背景下进行讨论。为了提高性能,LHCb升级旨在显著提高检测器的读出速率,从而将更多的工作负载转移到高级触发器上。结果表明,当前的高级触发器架构将能够应对这一挑战,并在LHCb升级的背景下讨论了几个关键通道的预期效率。
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引用次数: 0
ATLAS trigger menu and performance in Run 1 and prospects for Run 2 ATLAS触发器菜单和运行1中的性能以及运行2的前景
Pub Date : 2013-10-29 DOI: 10.1109/NSSMIC.2013.6829554
O. Igonkina
The ATLAS trigger system plays a key role in the collection of data for a wide range of physics analyses. The 2012 proton run had significantly larger luminosities and pile-up than the 2011 run. To address these challenges while maintaining or even improving performance, new algorithms have been commissioned. The trigger strategy and the main algorithms and their performance are described. For the 2015 run, the combination of a luminosity increase and an energy increase will put even larger demands on the trigger system. We describe here modifications to the trigger system to address these demands both at the hardware and software levels.
ATLAS触发系统在为广泛的物理分析收集数据方面起着关键作用。2012年的质子运行比2011年的运行有更大的亮度和堆积。为了应对这些挑战,同时保持甚至提高性能,新的算法已经开始使用。介绍了触发策略和主要算法及其性能。对于2015年的运行,亮度增加和能量增加的结合将对触发系统提出更大的要求。我们在这里描述了对触发系统的修改,以满足硬件和软件级别的这些需求。
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引用次数: 2
Development of a 3D imaging calorimeter in lanthanum bromide for gamma-ray space astronomy 伽玛射线空间天文学用溴化镧三维成像量热计的研制
Pub Date : 2013-10-29 DOI: 10.1109/NSSMIC.2013.6829593
A. Gostojić, V. Tatischeff, J. Kiener, C. Hamadache, N. Karkour, D. Linget, G. Sedes, S. Blin, P. Barrillon
The new generation of high light-output inorganic scintillators i.e. cerium-doped lanthanum(III) bromide (LaBr3:Ce) show a promising future in application as a space-based γ-ray calorimeter. Its internal qualities such as good energy resolution or radiation tolerance are well suited for detection of γ-rays in the MeV range, thus providing access to, so far, understudied questions in physics of nucleosynthesis, the active Sun or astrophysical compact objects. For this purpose, under the project of creating a new Compton telescope prototype, we have studied the response of a detection module comprising a 5×5 cm2 area and 1 cm thick LaBr3:Ce crystal scintillator coupled to a 64 channel multi-anode photomultiplier read out by the ASIC MAROC. Measurements with various radioactive sources have been compared with detailed GEANT4 simulations that include the tracking of the near-UV photons produced in the scintillation crystal. The localization of the first interaction point of incident γ-rays have been studied from the measured charge distributions using an artificial neural network. Together with the other measured properties, the position resolution that we obtain makes this detector module very interesting for the next generation of space telescopes operating in the medium-energy γ-ray domain.
新一代高光输出无机闪烁体即掺铈溴化镧(LaBr3:Ce)作为天基γ射线量热计具有广阔的应用前景。它的内部特性,如良好的能量分辨率或辐射耐受性,非常适合探测MeV范围内的γ射线,从而提供了迄今为止在核合成、活跃太阳或天体物理致密物体等物理学中尚未得到充分研究的问题。为此,在创建新型康普顿望远镜原型的项目下,我们研究了由5×5 cm2面积和1 cm厚的LaBr3:Ce晶体闪烁体耦合到ASIC MAROC读出的64通道多阳极光电倍增管的探测模块的响应。各种放射源的测量结果已经与详细的GEANT4模拟进行了比较,其中包括对闪烁晶体中产生的近紫外光子的跟踪。利用人工神经网络研究了γ射线入射第一相互作用点的定位。与其他测量特性一起,我们获得的位置分辨率使这个探测器模块对在中能量γ射线域中工作的下一代太空望远镜非常有趣。
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引用次数: 4
A penalized weighted least-squares image reconstruction based on scatter correction methods for X-ray CT 基于散射校正方法的x射线CT惩罚加权最小二乘图像重建
Pub Date : 2013-10-27 DOI: 10.1109/NSSMIC.2013.6829246
Long Chen, T. Rodet, N. Gac
For metal artifact reduction (MAR) in X-ray cone-beam computed tomography (CBCT), we propose a penalized weighted least-squares (PWLS) image reconstruction method [1] based on scatter correction (SC) method. Our main contribution is to incorporate the inaccuracy of the scatter correction data in PWLS method, and to accelerate the PWLS image reconstruction with a preconditioned conjugate gradient (PCG) method [2]. The reconstruction results of both the simulation and experimental data show that our proposed method effectively reduces the metal artifacts (MA). Compared to the state of art, normalized metal artifact reduction (NMAR) method [3], our method prevents the introduction of some new artifacts due to an inappropriate interpolation possible used in NMAR.
为了减少x射线锥束计算机断层扫描(CBCT)中的金属伪影(MAR),我们提出了一种基于散射校正(SC)方法的惩罚加权最小二乘(PWLS)图像重建方法[1]。我们的主要贡献是将散射校正数据的不准确性纳入PWLS方法,并使用预条件共轭梯度(PCG)方法加速PWLS图像重建[2]。仿真和实验数据的重建结果表明,该方法有效地降低了金属伪影(MA)。与目前最先进的归一化金属伪影减少(NMAR)方法[3]相比,我们的方法防止了由于NMAR中可能使用的不适当的插值而引入一些新的伪影。
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引用次数: 2
Incorporation of time-of-flight information in PET list-mode reconstruction using a projector with accurate detector PSF modeling 结合飞行时间信息的PET表模重建利用投影仪与精确的探测器PSF建模
Pub Date : 2013-10-27 DOI: 10.1109/NSSMIC.2013.6829242
A. Autret, J. Bert, O. Strauss, D. Visvikis
In list-mode PET reconstruction the projector is an operator that computes on-the-fly the spatial detector response related to a specific line-of-response (LOR). In the literature, many projectors with PSF modeling have been proposed with different levels of accuracy. A recently proposed projector based on the random sampling of the intrinsic detector response function was shown to accurately model all detector effects including geometry and crystal scatter. Recent PET scanners have the capability to measure the difference in the time arrival of the annihilation gamma photon pairs, also called time-of-flight (TOF). Many studies have shown the benefits, in terms of image quality, from the use of the TOF within the reconstruction process. In this study we evaluate the impact of including TOF information within a projector that includes a full modeling of the detector response. A comparative study with non-TOF image reconstruction using a projector with no (Siddon) and a less accurate (Gaussian) detector PSF modeling was also included in this study. All reconstruction algorithms were implemented on multi-GPUs. Results have shown that combining both TOF and PSF allows a double benefit on the reconstructed images. Contrast recovery was improved by nearly a factor of two, and overall execution times including TOF information were reduced by half compared to corresponding non-TOF reconstructions.
在列表模式PET重建中,投影仪是一个操作员,它可以实时计算与特定响应线(LOR)相关的空间探测器响应。在文献中,已经提出了许多具有PSF建模的投影仪,具有不同的精度水平。最近提出了一种基于探测器响应函数随机抽样的投影器,可以准确地模拟所有探测器的几何效应和晶体散射。最近的PET扫描仪有能力测量湮灭伽马光子对到达时间的差异,也称为飞行时间(TOF)。许多研究表明,在图像质量方面,在重建过程中使用TOF的好处。在这项研究中,我们评估了在投影仪中包括TOF信息的影响,其中包括探测器响应的完整建模。本研究还包括使用无(Siddon)和较不精确(高斯)检测器PSF建模的投影仪进行非tof图像重建的比较研究。所有重建算法都在多gpu上实现。结果表明,结合TOF和PSF可以在重建图像上获得双重好处。对比恢复提高了近两倍,与相应的非TOF重建相比,包含TOF信息的总体执行时间减少了一半。
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引用次数: 0
Evaluation of dosimetry characteristics of a Silicon Photo-Multiplier with a plastic scintillator by Cs-137 用Cs-137评价带有塑料闪烁体的硅光倍增器的剂量学特性
Pub Date : 2013-10-27 DOI: 10.1109/NSSMIC.2013.6829622
H. Yoo, C. Kim, Y. Kim, J. Kim, M. Kim, D. Lee, M. Cho, H. Kim, K. Park, D. Kang, S. Park, G. Cho
A Silicon Photo Multiplier (SiPM) is states of arts radiation detector, it is alternative to PM-Tube. But, availability research of SiPM is not entirely satisfactory. In this study, we suggest the radiation detector module coupled with the SiPM and the plastic scintillator, and then, evaluate the availability of detector module for Cs-137 dosimetry. To confirm the dosimetry characteristics, we experimented count difference depends on equivalent dose rate and equivalent dose comparing with MCNP calculation, and, calculating the conversion coefficient depends on count rate and total count that finding the region keeps the linearity of calculating the dose. These experiment results means the SiPM with the plastic scintillator is able to use the dosimetry application for Cs-137. New detector module has the advantages that smaller volume than GM Tube and ion chamber and the lower price than indirect detector module using inorganic scintillator as CsI(TI). So, it will helpful to relieving the public anxiety about radiation exposure by popularizing the dosimetry device.
硅光倍增器(SiPM)是目前最先进的辐射探测器,是pm管的替代品。但是,SiPM的有效性研究并不完全令人满意。在这项研究中,我们提出了与SiPM和塑料闪烁体耦合的辐射探测器模块,然后评估了探测器模块用于Cs-137剂量测定的有效性。为了确定剂量学特性,我们实验了计数差取决于等效剂量率和等效剂量与MCNP计算的比较,计算转换系数取决于计数率和总计数,找到的区域保持了计算剂量的线性。这些实验结果表明,带有塑料闪烁体的SiPM能够用于铯-137的剂量测定应用。新型探测器模块具有体积小于GM管和离子室、价格低于采用无机闪烁体作为CsI(TI)的间接探测器模块的优点。因此,推广剂量仪将有助于缓解公众对辐射暴露的焦虑。
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引用次数: 0
期刊
2013 IEEE Nuclear Science Symposium and Medical Imaging Conference (2013 NSS/MIC)
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