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Van İlinde Ambalajsız Olarak Satılan Bazı Baharatlarda Aflatoksin ve Ağır Metal Düzeylerinin Belirlenmesi ve Ağır Metallerin Sağlık Risklerinin Değerlendirilmesi
Pub Date : 2022-09-16 DOI: 10.53424/balikesirsbd.1160866
Ufuk Mercan
Aim: This study aimed to determine the aflatoxin and heavy metal levels in the samples of unpackaged red pepper, black pepper and cumin sold in Van and to estimate the health risks of heavy metals. Materials and Methods: In 60 samples (20 of each spice sample) obtained from herbal shops and markets, aflatoxin analysis was done with HPLC device and heavy metal analysis was done with ICP-MS device. Results: Although AFG1 and AFG2 were not detected in all spice samples, AFB1 and AFB2 were not detected in all cumin samples, AFB1 was detected in all red pepper samples and only one black pepper samples, and AFB2 in 18 red pepper samples. As a result of heavy metal analysis, the average concentration of Ni, Cd, Pb and Al were 5.08, 0.35, 2.47, 392.45 ppm in black pepper, 9.12, 0.20, 1.40, 514.4 ppm in cumin and 8.95, 0.06, 0.11, 33.75 ppm in red pepper, respectively. Arsenic was detected only in cumin and its average concentration was 0.06 ppm. Conclusion: In 90% (18 samples) of red pepper samples, AFB1 was detected above the permisisble limit value in Turkish food codex. The Cd level in black pepper samples and Ni levels in all spice samples determined in this study were above the limit values. According to daily intake tolerance limits, although Ni, As, and Cd levels in spices do not pose any risk, Al in all spice samples and Pb levels in black pepper samples are above the daily intake tolerance limits. Spice samples do not pose risk of non-carcinogenic effects, as THQ exposure values are less than 1.
目的:测定在上海销售的未包装红辣椒、黑胡椒和孜然样品中的黄曲霉毒素和重金属含量,并估计重金属对健康的危害。材料与方法:采用高效液相色谱法(HPLC)和ICP-MS法(ICP-MS)分别对60份(每种香料各20份)样品进行黄曲霉毒素分析和重金属分析。结果:虽然没有在所有香料样品中检测到AFG1和AFG2,没有在所有孜然样品中检测到AFB1和AFB2,但在所有红辣椒样品中检测到AFB1,只有一个黑胡椒样品中检测到AFB2, 18个红辣椒样品中检测到AFB2。重金属分析结果表明,黑胡椒中Ni、Cd、Pb、Al的平均浓度分别为5.08、0.35、2.47、392.45 ppm,孜然中为9.12、0.20、1.40、514.4 ppm,红辣椒中为8.95、0.06、0.11、33.75 ppm。砷仅在孜然中检出,其平均浓度为0.06 ppm。结论:90%(18份)的红椒样品中AFB1含量高于土耳其食品法典允许限量。本研究测定的黑胡椒样品中的镉含量和所有香料样品中的镍含量均超过限量值。根据每日摄入耐受限量,虽然香料中的Ni、As和Cd含量不会对人体造成危害,但所有香料样品中的Al和黑胡椒样品中的Pb含量均超过每日摄入耐受限量。香料样品不会造成非致癌作用的风险,因为四氢大麻酚的暴露值小于1。
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引用次数: 0
Evaluation Of One Health Implementations: Current Standardized Frameworks 一个健康实施的评估:当前的标准化框架
Pub Date : 2022-09-16 DOI: 10.53424/balikesirsbd.1145053
P. Şahintürk
Tek Sağlık yaklaşımı, hayvan-insan-ekosistem etkileşiminde halk sağlığı sorunlarının ele alınmasında kritik bir araç olarak önem kazanmaya devam etmektedir. Küresel düzeyde bu kavrama geniş bir destek vardır ve bu durum dünya çapında çeşitli Tek Sağlık girişimlerinin kurulmasına yol açmıştır. Tek Sağlık topluluğu için güncel bir zorluk, Tek Sağlık'ın sürdürülebilirliğini sağlamak için eylem çağrısının ve temel prensiplerin ilerisine nasıl geçileceğidir. Gerçek dünyaya ilişkin verilerin yetersizliği, insan-hayvan-çevre sağlığı eksenindeki eksikliklerin tespit edilmesini engellemekte, bu durum politika ve uygulamaların şekillendirilmesinde Tek Sağlık yaklaşımının uygulanmasını zorlaştırmakta; önleme ve kontrol faaliyetlerinin gecikmesine veya eksik kalmasına yol açmaktadır. Bu nedenle Tek Sağlık'ın hastalıkların önlenmesi ve kontrolü, antimikrobiyal direnç, gıda güvenliği ve çevre sağlığı alanlarındaki ek faydalarını gösteren resmi standart analizler önemlidir ve bunların değerlendirilmesi gerekmektedir. Tek Sağlık Değerlendirme Ağı (NEOH), Küresel Sağlık Güvenliği (GHS) Endeksi, Çevresel Performans Endeksi (EPI) ve Küresel Tek Sağlık Endeksi (GOHI) gibi uygun bir değerlendirme şeması ile birlikte iyi yapılandırılmış kavramsal sistemler, mevcut durumun daha iyi anlaşılmasına ve Tek Sağlık uygulaması için belirli sosyo-ekolojik ortamlara kolayca uyarlanmış hedef ve stratejilerin belirlenmesine yardımcı olabilmektedir. Tek Sağlık değerlendirilmesi standardize edilmiş yöntemlerin geliştirilmesi, Tek Sağlık girişimlerinde daha uzun vadeli yeni kazanımları daha kalıcı hale getirmek için büyük bir fırsat sunmaktadır.
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引用次数: 0
NANOPARTICLE TOXICITY IN AQUACULTURE 水产养殖中的纳米颗粒毒性
Pub Date : 2022-09-16 DOI: 10.53424/balikesirsbd.1158751
Ilker Simsek, Özgür Kuzukıran, A. Filazi
Nanopartiküller (NP’ler) 1 ile 100 nm arasında bulunan partiküllere verilen isimdir. NP’ler normal malzemelerden farklı belirli fiziksel ve kimyasal özelliklerinden dolayı ticari kullanım için yapay olarak sentezlenmekte, endüstriyel üretim esnasında kasıtsız bir yan ürün veya doğal olarak meydana gelmektedir. Her gün gelişmekte olan nanoteknoloji, elektronik, tıp, inşaat, kozmetik, tekstil, otomotiv, çevre, gıda, ev aletleri, yenilebilir enerji, petrol, tarım, matbaacılık, spor ve sağlık gibi alanlarda kullanılmaktadır. En yaygın kullanılan NP’ler ise gümüş (Ag), titanyum (Ti) ve silikon dioksit (SiO2) veya karbon (C) tabanlı olanlardır. Ticari olarak üretilen NP'ler, üretim aşamalarında veya yaşam döngülerinin son aşamasında atık ürünler olarak sucul ortama deşarj edilebilmektedir. Bu NP'ler yüzey veya yeraltı suyu ortamlarına geçebilmektedir. Su kaynaklarına doğrudan, yağış veya topraktan süzülüp gelen NP’ler balık, kabuklular ve hatta tek hücreli organizmalar gibi sucul organizmalara yönelik önemli etkilere neden olabilmektedirler. Sucul organizmalar NP’lere solungaçları, yutma, dermal temas, hücrelere adsorpsiyon gibi yollarla maruz kalmaktadırlar. NP’ler canlılarda lipid peroksidasyonuna, hücre yapısının bozulmasına, mitokondride bozulmaya, protein oksidasyonuna ve DNA hasarı gibi etkilere neden olmaktadırlar. NP’ler çevresel risk değerlendirmeleri çoğunlukla tüm risk faktörlerini dikkate almayan standart laboratuvar koşulları altında gerçekleştirilmektedir. Bu nedenle çevre ve atık su ortamları gibi karmaşık ortamlara salınan NP’lerin bu ortamlardaki davranışları laboratuvar ortamından farklı olabilmektedir.
纳米粒子(NPs)是指 1 到 100 纳米之间的颗粒。由于某些物理和化学性质不同于普通材料,纳米粒子是人工合成的商业用途,是工业生产过程中无意产生的副产品或自然产生的物质。纳米技术的发展日新月异,其应用领域包括电子、医药、建筑、化妆品、纺织品、汽车、环境、食品、家用电器、可再生能源、石油、农业、印刷、体育和健康等。使用最广泛的纳米粒子是基于银(Ag)、钛(Ti)和二氧化硅(SiO2)或碳(C)的粒子。商业生产的纳米粒子在生产阶段或生命周期结束时会作为废品排入水生环境。这些氮氧化物可进入地表水或地下水环境。直接进入水体、通过降水进入水体或从土壤中沥滤进入水体的氮磷态污染物会对鱼类、甲壳类甚至原生动物等水生生物造成严重影响。水生生物通过鳃、摄食、皮肤接触和细胞吸附等途径接触氮氧化物。氮氧化物会导致脂质过氧化、细胞结构破坏、线粒体破坏、蛋白质氧化和 DNA 损伤。对 NPs 的环境风险评估大多是在标准实验室条件下进行的,没有考虑到所有风险因素。因此,释放到环境和废水环境等复杂环境中的氮氧化物的行为可能与实验室环境不同。
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引用次数: 0
Protective Effect of Lycopene against Genotoxicity of Nickel Sulfate in Rats 番茄红素对大鼠硫酸镍遗传毒性的保护作用
Pub Date : 2022-09-16 DOI: 10.53424/balikesirsbd.1144724
Zozan Gari̇p, F. Temamoğulları, Pinar Aksu Kilicle
Aim: Nickel, which has a wide usage area in industries, has teratogenic, carcinogenic, immunotoxic, and genotoxic effects. In this study, the protective effects of lycopene, which has antioxidant properties, were investigated against genotoxicity caused by nickel sulfate. Materials and Methods: In the study, a total of 24 rats (Wistar albino) were divided into four groups: Group I (control) daily by saline intraperitoneal (i.p.) and corn oil oral gavage (0.5 ml); Group II nickel sulfate (20 mg/kg, i.p.) was dissolved in physiological saline; Group III lycopene corn oil (0.5 ml) was suspended by oral gavage at 20 mg/kg doses; Group IV lycopene was suspended in corn oil (0.5 ml) and given by oral gavage at 20 mg/kg doses, 2 hours later, nickel sulfate (20 mg/kg, i.p.) was administered for 21 days. Micronucleated polychromatic erythrocytes (MNPCE) and polychromatic erythrocytes (PCE) were examined by bone marrow micronucleus test, which is one of the genotoxicity tests. Results: It was determined that the administration of lycopene for preventive purposes decreased the MNPCE levels significantly (p
目的:镍具有致畸、致癌性、免疫毒性和遗传毒性,在工业上有着广泛的应用。研究了具有抗氧化作用的番茄红素对硫酸镍致遗传毒性的保护作用。材料与方法:将24只Wistar白化大鼠分为4组:ⅰ组(对照组)每日腹腔注射生理盐水(i.p)和玉米油灌胃(0.5 ml);第二组硫酸镍(20 mg/kg, i.p)溶解于生理盐水中;III组番茄红素玉米油(0.5 ml)以20 mg/kg剂量灌胃悬浮;IV组番茄红素悬浮于玉米油(0.5 ml)中,以20 mg/kg的剂量灌胃,2 h后,给予硫酸镍(20 mg/kg, ig) 21 d。骨髓微核试验是遗传毒性试验之一,采用骨髓微核试验检测微核多染红细胞(MNPCE)和多染红细胞(PCE)。结果:确定番茄红素用于预防目的可显著降低MNPCE水平(p
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引用次数: 0
Studies on Drug and Metal Residues Detected in Bee Products in Turkey 土耳其蜂产品中药物和金属残留的研究
Pub Date : 2022-09-16 DOI: 10.53424/balikesirsbd.1153667
Mehmet Özüiçli
This study was carried out in order to compile the information obtained from current studies in Turkey on the use of pesticides and antibiotics and metal residue in other bee products, especially honey, offered for human consumption. The beekeeping sector has been rapidly advancing towards industrialization both in our country and around the world. It is rapidly progressing towards becoming an additional income especially for families located in rural areas. Honey should be clean and healthy by nature. As in other living things including humans, various pesticides and antibiotics are used against viral, bacterial, fungal and ectoparasites in honeybees, although their use is prohibited. Therefore, there is a drug residue problem in bee products, especially honey, in our country and in the world. At this point, both bee health and human health are adversely affected. In order to prevent this situation, people working in the health sector, especially veterinarians, have great duties. First of all, beekeeper should be made aware, and researchers should accelerate their efforts to find the most appropriate treatment methods against honey bee diseases by researching natural treatment methods instead of pesticides and antibiotics. These studies should be supported by both the state and the private sector.
进行这项研究是为了汇编目前在土耳其进行的关于在供人类食用的其他蜂产品,特别是蜂蜜中使用杀虫剂和抗生素以及金属残留物的研究所获得的资料。无论是在我国还是在世界范围内,养蜂业都在迅速向工业化迈进。它正迅速发展成为一项额外收入,特别是对农村地区的家庭而言。蜂蜜本质上应该是干净健康的。与包括人类在内的其他生物一样,蜜蜂也被用于对付病毒、细菌、真菌和体外寄生虫,尽管它们的使用是被禁止的。因此,国内外蜂产品特别是蜂蜜中存在药物残留问题。在这一点上,蜜蜂的健康和人类的健康都受到不利影响。为了防止这种情况,在卫生部门工作的人,特别是兽医,负有重大责任。首先,应该提高养蜂人的意识,研究人员应该加快努力,通过研究代替杀虫剂和抗生素的自然治疗方法,找到最合适的治疗蜜蜂疾病的方法。这些研究应得到国家和私营部门的支持。
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引用次数: 0
Gerilim Tipi Baş Ağrısında Akupunktur Tedavisinin Etkinliğinde Cinsiyetlerin Karşılaştırılması
Pub Date : 2022-09-15 DOI: 10.53424/balikesirsbd.1137670
Burak Gülcen, Nermin Tepe
Objective: Tension-type headache (TTH) with an average lifetime prevalence of 46% (12-78%) in adults is the most common primary headache type. Acupuncture treatment is one of the adjunctive therapy in tension type headache so we wanted to evaluate the response difference of acupuncture between genders. Material and Methods: In this retrospective study, the medical records of TTH patients, aged between 18 and 60, who did not receive conventional medical treatment (patient refusing medical treatment or intolerance due to drug side effects) and completed pre-determined sessions of acupuncture therapy in the outpatient clinics between 2017 and 2019 were evaluated. The monthly attack frequency, attack severity (Visual Analogue Scale), and the duration of attacks before and after acupuncture treatment between genders were documented. Results: A total of 17 patients meeting the study criteria were included in the study. No statistically significant difference in the frequency, the duration, and the severity of monthly attacks before and after the treatment were found between the genders. The monthly attack frequency and Visual Analogue Scale (VAS) score were found to be significantly decreased in women themselves before and after treatment in themselves. There was no statistically significant difference in the frequency, duration and severity of monthly attacks before and after the treatment among the men. Conclusion: Acupuncture should be considered as an alternative treatment option, especially in women with chronic TTH who do not want to use drugs or who have tolerability problems due to side effects or combination with medical therapy.
目的:紧张性头痛(TTH)是成年人最常见的原发性头痛类型,平均终生患病率为46%(12-78%)。针刺治疗是紧张性头痛的辅助治疗方法之一,因此我们想要评价针刺在性别间的反应差异。材料与方法:回顾性分析2017 - 2019年门诊未接受常规治疗(因药物副作用拒绝治疗或不耐受)、完成预定疗程针灸治疗的18 - 60岁TTH患者的病历。记录不同性别患者针刺前后每月发作频率、发作严重程度(视觉模拟量表)及发作持续时间。结果:符合研究标准的患者共17例纳入研究。治疗前后每月发作的频率、持续时间和严重程度在性别间无统计学差异。治疗前后,患者每月发作频率和视觉模拟量表(VAS)评分均明显下降。治疗前后男性每月发作的频率、持续时间和严重程度无统计学差异。结论:针灸治疗应作为一种替代治疗方案,特别是对于不愿使用药物或因副作用或联合药物治疗而存在耐受性问题的慢性TTH妇女。
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引用次数: 0
The Relationship between Smartphone Addiction and Parenting of Mothers 智能手机成瘾与母亲教养的关系
Pub Date : 2022-09-14 DOI: 10.53424/balikesirsbd.1096725
Selin Demi̇rbağ, Dilek Ergin, Duygu Karaarslan, Nesrin Şen Celasin
Aim: The aim of this study is to determine the relationship between smartphone addiction and parenting levels of mothers whose 18-48-month-old with chronic diseases. Materials and Methods: The research is analytical-cross-sectional type. The research was conducted by face-to-face interview with 140 mothers were accompanying 18-48 months-old-children with chronic diseases in a university hospital in western Turkey between February 2021 and March 2022 and agreed to participate in the study. Data collection tools are Sociodemographic Form, Parenting Scale, Smartphone Addiction Scale-Short Form. Results: It was found that the mothers' smartphone addiction scale mean scores were low. It was found that the mean scores of the parenting scale were low, but they showed positive parenting. It was determined that there was a significant relationship between the smartphone addiction scale and the gender of the child, the age of the mother, the time spent by the mother on the phone, and the state of using the phone to prevent responsibilities (p
目的:本研究的目的是确定18-48个月患有慢性疾病的母亲的智能手机成瘾与育儿水平之间的关系。材料与方法:本研究为分析横断面型。该研究是通过面对面访谈对140名母亲进行的,这些母亲在2021年2月至2022年3月期间在土耳其西部的一家大学医院陪伴18-48个月大的慢性病儿童,并同意参与该研究。数据收集工具有社会人口统计表、养育量表、智能手机成瘾量表-简短表格。结果:发现母亲智能手机成瘾量表平均得分较低。结果发现,父母教养量表的平均得分较低,但他们表现出积极的教养。研究确定,智能手机成瘾量表与孩子的性别、母亲的年龄、母亲使用手机的时间以及使用手机防止责任的状态之间存在显著的关系(p
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引用次数: 0
Koruyucu Sağlıkta Fiziksel Aktivite Danışmanlığı: Derleme
Pub Date : 2022-09-13 DOI: 10.53424/balikesirsbd.1089892
Gulfidan Tokgöz
Physiotherapy approaches appeal to all individuals in society, including healthy individuals. Physical Activity Counseling (PAC), one of these applications, can be defined as providing verbal and written advice or guidance to encourage increased physical activity and can be applied face-to-face or with technology-based methods. PAC, one of the preventive health services, is recommended by many public health organizations, including the World Health Organization. The aim of this review is to research the literature about the role and applications of PAC in preventive health and to provide current evidence-based information to clinicians and academics working in this field.
物理治疗方法对社会上所有人都有吸引力,包括健康的人。体育活动咨询(PAC)是其中一种应用,可以定义为提供口头和书面的建议或指导,以鼓励增加体育活动,可以面对面或采用基于技术的方法。PAC是预防性保健服务之一,得到包括世界卫生组织在内的许多公共卫生组织的推荐。本综述的目的是研究PAC在预防健康中的作用和应用的文献,并为在该领域工作的临床医生和学者提供最新的循证信息。
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引用次数: 0
Biological Activity and Chemical Composition of Jujuba (Ziziphus jujuba) Fruit 枣果实的生物活性和化学成分研究
Pub Date : 2022-09-13 DOI: 10.53424/balikesirsbd.1159940
Serkan Korkut
Jujuba (Ziziphus jujuba) has a long history of usage as a fruit and remedy. The main biologically active components are vitamin C, phenolics, flavonoids, triterpenic acids, and polysaccharides. Many phytochemical studies of jujuba fruits indicate that Z. jujuba has important biological effects, such as the anticancer, anti-inflammatory, antiobesity, immunostimulant, antioxidant, hepatoprotective, neuroprotective and gastrointestinal protective activities. This review aims to explain bioactive characteristics of Z. jujuba by several examples of studies.
枣(Ziziphus Jujuba)作为一种水果和药物有着悠久的使用历史。其主要生物活性成分为维生素C、酚类物质、类黄酮、三萜酸和多糖。许多对枣果实的植物化学研究表明,枣具有抗癌、抗炎、抗肥胖、免疫增强、抗氧化、保肝、保神经、保胃肠等重要的生物学作用。本文通过几个研究实例来说明枣的生物活性特性。
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引用次数: 0
Çocuklarda B12 Vitamini Eksikliği Ve İlişkili Bulguların Sıklığı
Pub Date : 2022-09-03 DOI: 10.53424/balikesirsbd.1142063
Hilâl Aydın, Oğuzhan Korkut, Ezgi Özden, Demet Can
Objective: The purpose of this study was to determine clinical findings associated with vitamin B12 deficiency in patients presenting to the pediatric neurology department with various different symptoms and to discuss these in the light of the current literature. Materials and Methods: Children aged between one month and 18 years presenting to the Balikesir University Medical Faculty pediatric neurology clinic, Turkey, between 01.08.2019-01.08.2021 and with vitamin B12 levels lower than 250 ng/mL were included in this retrospective, cross-sectional study. Results: One hundred sixty-one cases were included in the study 63 (39.1%) female and 98 (60.9%) male. The patients’ mean age was 7.43±5.77 (0-17) years. The majority of patients of both genders were in the 0-6 age group. Neurological findings were present in 81.98% of patients with Vitamin B12 deficiency, and non-neurological findings in 18.01%. The most frequent neurological finding was neuromotor retardation (N=73, 45.34%), followed by seizures (N=33, 20.50%).The most frequent reason for presentation was neuromotor retardation in both boys and girls with vitamin B12 deficiency (N=55, 56.1% and N=18, 28.57%). The mean Vitamin B12 level among all the patients was 167.70±45.17 (58-250) pg/ml. No statistically significant difference was determined between boys and girls in terms of Vitamin B12 and ferritin levels or complete blood count parameters [Hb, Htc, and MCV] (respectively p = 0,428, p = 0,646, p = 0,110, p = 0,128, p = 0,864). Conclusions: This study provides a general evaluation for health professionals regarding clinical presentations encountered by us in association with the disease
目的:本研究的目的是确定在小儿神经科出现各种不同症状的患者中与维生素B12缺乏症相关的临床表现,并结合目前的文献对这些症状进行讨论。材料和方法:这项回顾性横断面研究纳入了2019年8月1日至2021年8月1日期间在土耳其Balikesir大学医学院儿科神经病学诊所就诊的年龄在1个月至18岁之间、维生素B12水平低于250 ng/mL的儿童。结果:共纳入161例患者,女性63例(39.1%),男性98例(60.9%)。患者平均年龄为7.43±5.77(0 ~ 17)岁。男女患者以0-6岁年龄组居多。81.98%的维生素B12缺乏症患者出现神经系统症状,18.01%的患者出现非神经系统症状。最常见的神经学表现为神经运动迟缓(N=73, 45.34%),其次是癫痫发作(N=33, 20.50%)。在缺乏维生素B12的男孩和女孩中,最常见的表现是神经运动迟缓(N=55, 56.1%和N=18, 28.57%)。所有患者的平均维生素B12水平为167.70±45.17 (58-250)pg/ml。在维生素B12和铁蛋白水平或全血细胞计数参数[Hb, Htc和MCV]方面,男孩和女孩之间没有统计学上的显著差异(分别p = 0,428, p = 0,646, p = 0,110, p = 0,128, p = 0,864)。结论:本研究为卫生专业人员提供了一个关于我们遇到的与疾病相关的临床表现的一般评估
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引用次数: 0
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Balıkesır Health Sciences Journal
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