Pub Date : 2014-04-11DOI: 10.1109/ISBB.2014.6820894
Chengxiong Wu, Q. Fang
A lightweight imaging method based on electrolyte-insulator-semiconductor (EIS) structure was developed to analyze single cells. Cells were cultured on the EIS structure surface, and the impedance of this cell-based biosensor was measured by two-electrode electrochemical system. For the field-effect and internal photoelectric effect of semiconductor and the electric insulativity of living cell, difference impedance was detected when a scanning laser irradiated at the cell-free and cell-on area respectively. Thus, an image of cell distribution and adhesion could be obtained by calculating impedance for each scanning point. The results of the experiment showed that the spatial resolution of the proposed imaging method could reach to 5 μm, and the sensitivity was high, which indicate that it has great potential to be used in various cell-based assays, such as cytotoxicity detection, drug evaluation and cancer research.
{"title":"A novel live cell imaging method with sub-cellular resolution for cell-based assays","authors":"Chengxiong Wu, Q. Fang","doi":"10.1109/ISBB.2014.6820894","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820894","url":null,"abstract":"A lightweight imaging method based on electrolyte-insulator-semiconductor (EIS) structure was developed to analyze single cells. Cells were cultured on the EIS structure surface, and the impedance of this cell-based biosensor was measured by two-electrode electrochemical system. For the field-effect and internal photoelectric effect of semiconductor and the electric insulativity of living cell, difference impedance was detected when a scanning laser irradiated at the cell-free and cell-on area respectively. Thus, an image of cell distribution and adhesion could be obtained by calculating impedance for each scanning point. The results of the experiment showed that the spatial resolution of the proposed imaging method could reach to 5 μm, and the sensitivity was high, which indicate that it has great potential to be used in various cell-based assays, such as cytotoxicity detection, drug evaluation and cancer research.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134613376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-04-11DOI: 10.1109/ISBB.2014.6820921
Yu-Chieh Lee, Hsin Chen
This paper presents a CMOS chip integrating EGFETs (extended-gate field-effect transistors) with gold microelectrodes for label-free monitoring of the DNA amplification. The accumulation of intrinsic charges of DNAs causes the surface potential of microelectrodes to change gradually, and the potential change is detected by the readout circuit integrated with the microelectrodes. A second-order Bessel low pass filter is further employed to eliminate both high-frequency noise and ground interferences.
{"title":"Gold microelectrode arrays with monolithically-integrated circuits for label-free monitoring of bio-molecule interaction in-situ","authors":"Yu-Chieh Lee, Hsin Chen","doi":"10.1109/ISBB.2014.6820921","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820921","url":null,"abstract":"This paper presents a CMOS chip integrating EGFETs (extended-gate field-effect transistors) with gold microelectrodes for label-free monitoring of the DNA amplification. The accumulation of intrinsic charges of DNAs causes the surface potential of microelectrodes to change gradually, and the potential change is detected by the readout circuit integrated with the microelectrodes. A second-order Bessel low pass filter is further employed to eliminate both high-frequency noise and ground interferences.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133996211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-04-11DOI: 10.1109/ISBB.2014.6820932
Ko-Chi Kuo, Chi-Wei Wu
This paper presents a wide tuning, low phase noise, and fast locking CMOS integer-N frequency synthesizer with 1.8V power supply. The proposed design can be used for the IEEE 802.15.4a unlicensed ultra-wideband healthcare applications such as body sensor network. The operating frequency range of the proposed design is ranged from 4.6 GHz to 5.6 GHz for the local oscillator of the RF front-end circuits. The proposed frequency synthesizer consists of a fast-phase-frequency detector charge pump (Fast-PFDCP), a dual mode low-pass loop filter (Dual_Mode_LPF), a voltage control oscillator, an auto-band selection (ABS), an optimum-band selection (OBS), a lock detector, and a pulse-swallow divider. By adapting the Auto Band Selection (ABS), the proposed design can reduce the calibration time by using the binary search algorithm to select the calibration word. In addition, the Optimal Band Selection (OBS) algorithm is proposed to acquire the optimum band which exhibits the minimum VCOμ gainμ variation which can affect the performance of phase noise of overall frequency synthesizer significantly. Furthermore, the design of the voltage-controlled oscillator with the switch-capacitor technique can achieve the wide tuning range and the low phase noise in order to cover the desired operating frequency bands and to accommodate process, voltage, and temperature (PVT) variations. The frequency synthesizer is designed by using the TSMC 0.18μm CMOS 1P6M technology.
{"title":"An 802.15.4a wide band frequency synthesizer for 5GHz ISM band health care applications","authors":"Ko-Chi Kuo, Chi-Wei Wu","doi":"10.1109/ISBB.2014.6820932","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820932","url":null,"abstract":"This paper presents a wide tuning, low phase noise, and fast locking CMOS integer-N frequency synthesizer with 1.8V power supply. The proposed design can be used for the IEEE 802.15.4a unlicensed ultra-wideband healthcare applications such as body sensor network. The operating frequency range of the proposed design is ranged from 4.6 GHz to 5.6 GHz for the local oscillator of the RF front-end circuits. The proposed frequency synthesizer consists of a fast-phase-frequency detector charge pump (Fast-PFDCP), a dual mode low-pass loop filter (Dual_Mode_LPF), a voltage control oscillator, an auto-band selection (ABS), an optimum-band selection (OBS), a lock detector, and a pulse-swallow divider. By adapting the Auto Band Selection (ABS), the proposed design can reduce the calibration time by using the binary search algorithm to select the calibration word. In addition, the Optimal Band Selection (OBS) algorithm is proposed to acquire the optimum band which exhibits the minimum VCOμ gainμ variation which can affect the performance of phase noise of overall frequency synthesizer significantly. Furthermore, the design of the voltage-controlled oscillator with the switch-capacitor technique can achieve the wide tuning range and the low phase noise in order to cover the desired operating frequency bands and to accommodate process, voltage, and temperature (PVT) variations. The frequency synthesizer is designed by using the TSMC 0.18μm CMOS 1P6M technology.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132857816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-04-11DOI: 10.1109/ISBB.2014.6820948
Chung-Chih Lin, Jyh-Ying Peng, Y. Tseng, C. Chou, F. Chang, Y. Wu, L. Kao, Chun-Nan Hsu
Studies on the mechanism of toxins are important to reveal the etiology of Parkinson's disease (PD). Complex I inhibitors are a main group of PD toxins, and their chemical features have been intensively studied. However, the chemical structures specific to mitochondrial morphological changes are still unknown. We developed a drug profiling system that combines mitochondrial morphological quantification and chemical substructure computation, which allows us to discover chemical substructures specific to mitochondrial morphological changes. Using this system, we quantified the mitochondrial morphology induced by annonaceous acetogenins, and calculated the maximum common substructure of acetogenins inducing similar cell responses. We discovered that (1) the hydroxyl groups close to γ-lactone in annonacin may result in stronger effects on nuclear size reduction and mitochondrial aggregation; (2) bis-THF acetogenins may have less mitochondria aggregation than those of mono-THF acetogenins; (3) less hydroxyl group at the alkyl chain opposite from γ-lactone end may result in less mitochondrial fission.
{"title":"Profiling mitochondrial complex I inhibitors by combining mitochondrial morphological features and maximum common chemical substructures","authors":"Chung-Chih Lin, Jyh-Ying Peng, Y. Tseng, C. Chou, F. Chang, Y. Wu, L. Kao, Chun-Nan Hsu","doi":"10.1109/ISBB.2014.6820948","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820948","url":null,"abstract":"Studies on the mechanism of toxins are important to reveal the etiology of Parkinson's disease (PD). Complex I inhibitors are a main group of PD toxins, and their chemical features have been intensively studied. However, the chemical structures specific to mitochondrial morphological changes are still unknown. We developed a drug profiling system that combines mitochondrial morphological quantification and chemical substructure computation, which allows us to discover chemical substructures specific to mitochondrial morphological changes. Using this system, we quantified the mitochondrial morphology induced by annonaceous acetogenins, and calculated the maximum common substructure of acetogenins inducing similar cell responses. We discovered that (1) the hydroxyl groups close to γ-lactone in annonacin may result in stronger effects on nuclear size reduction and mitochondrial aggregation; (2) bis-THF acetogenins may have less mitochondria aggregation than those of mono-THF acetogenins; (3) less hydroxyl group at the alkyl chain opposite from γ-lactone end may result in less mitochondrial fission.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121481624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-04-11DOI: 10.1109/ISBB.2014.6820953
Han-Wei Dan, Wan-Chi Hung, Y.‐S. Tsai, Chung-Chih Lin
Mitochondria play an important role in producing energy of cell, aging and cell death. Previous investigations suggest that mitochondrial dysfunctions are associated with neurodegenerative, and the peripheral blood cells of those patients have validation of mitochondrial morphology. This study presents an analysis system of automated 3D mitochondrial morphology of lymphocytes in 3D images to reveal morphological features of mitochondria, and this system is specific for analyzing mice T lymphocyte precursors in thymus and mature lymphocytes in spleen. Mitochondria in original confocal and deconvoluted wild-field micrographs are segmented by Support Vector Machine, and then image features are extracted for morphological subtype clustering. The distribution of subtypes in individual lymphocytes is used to classify precursors and mature lymphocytes by decision tree. There are more short tubules in spleen lymphocyte, and more globules in thymus lymphocyte. The accuracy of cell classified from confocal and wild-field images in this system are both over 96% for training set, and for testing set, the accuracy for confocal and wild-field micrographs are 79% and 71% respectively. In conclusions, this new system can be used for investigations of lymphocyte development and drug discovery for inflammation and immunity.
{"title":"3D image processing for mitochondria morphology variation analysis","authors":"Han-Wei Dan, Wan-Chi Hung, Y.‐S. Tsai, Chung-Chih Lin","doi":"10.1109/ISBB.2014.6820953","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820953","url":null,"abstract":"Mitochondria play an important role in producing energy of cell, aging and cell death. Previous investigations suggest that mitochondrial dysfunctions are associated with neurodegenerative, and the peripheral blood cells of those patients have validation of mitochondrial morphology. This study presents an analysis system of automated 3D mitochondrial morphology of lymphocytes in 3D images to reveal morphological features of mitochondria, and this system is specific for analyzing mice T lymphocyte precursors in thymus and mature lymphocytes in spleen. Mitochondria in original confocal and deconvoluted wild-field micrographs are segmented by Support Vector Machine, and then image features are extracted for morphological subtype clustering. The distribution of subtypes in individual lymphocytes is used to classify precursors and mature lymphocytes by decision tree. There are more short tubules in spleen lymphocyte, and more globules in thymus lymphocyte. The accuracy of cell classified from confocal and wild-field images in this system are both over 96% for training set, and for testing set, the accuracy for confocal and wild-field micrographs are 79% and 71% respectively. In conclusions, this new system can be used for investigations of lymphocyte development and drug discovery for inflammation and immunity.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122613414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-04-11DOI: 10.1109/ISBB.2014.6820911
S. Hached, Aref Trigui, Imane El Khalloufi, M. Sawan, Oleg Loutochin, J. Corcos
In this paper, we present a smart battery charging system implementing the recently established Qi wireless power transmission standard. Proposed device offers the possibility of charging batteries with any Qi certified power transmitter. It eliminates the dependency to a special charger making energy supplying possible in public places and foreign countries without special equipment or adapters. It is remotely controlled through Bluetooth Low Energy protocol allowing real-time control and supervision with smartphones. The proposed device can be used with single or multiple implants architecture. Experiments have been conducted with various implants prototypes. Proposed charging system ensured proper operation and supervision. System design and experimental results are reported and discussed.
{"title":"A Bluetooth-based Low-Energy Qi-compliant battery charger for implantable medical devices","authors":"S. Hached, Aref Trigui, Imane El Khalloufi, M. Sawan, Oleg Loutochin, J. Corcos","doi":"10.1109/ISBB.2014.6820911","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820911","url":null,"abstract":"In this paper, we present a smart battery charging system implementing the recently established Qi wireless power transmission standard. Proposed device offers the possibility of charging batteries with any Qi certified power transmitter. It eliminates the dependency to a special charger making energy supplying possible in public places and foreign countries without special equipment or adapters. It is remotely controlled through Bluetooth Low Energy protocol allowing real-time control and supervision with smartphones. The proposed device can be used with single or multiple implants architecture. Experiments have been conducted with various implants prototypes. Proposed charging system ensured proper operation and supervision. System design and experimental results are reported and discussed.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122778518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-04-11DOI: 10.1109/ISBB.2014.6820941
Shih-Yu Chang Chien, Cheng-Han Hsieh, Mark Po-Hung Lin, Q. Fang, Shuenn-Yuh Lee
A real-time ECG beat detection and classification system integrated with a decimation filter is presented in this paper. The decimation filter with a decimation ratio of 128 is utilized with four stages to optimize power. The beat detection algorithm is based on multi-scale Haar wavelet transform. The first step of the beat detection algorithm is to define a region composed of 128 sample points. The next step is to define the beat position. The beat detection algorithm which is verified with data from MIT/BIH Arrhythmia Database achieves a sensitivity of 99.67% and a positive predictability of 99.59%. The used heartbeat classification algorithm is called maximum similarity comparisons. The parameter of the classification is programmable for doctors. This proposed system can realize multiple functions in real time. This chip is fabricated in a 0.18 μm standard CMOS technology with chip area of 4.84 mm2, which achieves low power consumptions and can carry out a long term cardiac monitoring.
{"title":"Implementation of a real-time ECG signal processor","authors":"Shih-Yu Chang Chien, Cheng-Han Hsieh, Mark Po-Hung Lin, Q. Fang, Shuenn-Yuh Lee","doi":"10.1109/ISBB.2014.6820941","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820941","url":null,"abstract":"A real-time ECG beat detection and classification system integrated with a decimation filter is presented in this paper. The decimation filter with a decimation ratio of 128 is utilized with four stages to optimize power. The beat detection algorithm is based on multi-scale Haar wavelet transform. The first step of the beat detection algorithm is to define a region composed of 128 sample points. The next step is to define the beat position. The beat detection algorithm which is verified with data from MIT/BIH Arrhythmia Database achieves a sensitivity of 99.67% and a positive predictability of 99.59%. The used heartbeat classification algorithm is called maximum similarity comparisons. The parameter of the classification is programmable for doctors. This proposed system can realize multiple functions in real time. This chip is fabricated in a 0.18 μm standard CMOS technology with chip area of 4.84 mm2, which achieves low power consumptions and can carry out a long term cardiac monitoring.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131524931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-04-11DOI: 10.1109/ISBB.2014.6820926
H. Kuo, Ning-Huei Peng, T. Kao, Weichih Hu
Sudden infant death syndrome (SIDS) is the common cause of death in infants. Apnea is known to be associated with increased incidence of the SIDS. A cessation of breathing, longer than 15 seconds, or accompanied by hypoxia or bradycardia, is called apnea of prematurity and has been found in more than 50% of premature infants. We have designed and constructed an apnea detector for infant monitoring in a clinical environment. The device uses a breath processor module with a surface ECG for detecting apnea. When the infant's breathing counts and heart rates are abnormal, an alarm will sound. This device has shown good performance and feasibility.
{"title":"Using ECG surface electrodes in measurement of respiration rate for preterm infants","authors":"H. Kuo, Ning-Huei Peng, T. Kao, Weichih Hu","doi":"10.1109/ISBB.2014.6820926","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820926","url":null,"abstract":"Sudden infant death syndrome (SIDS) is the common cause of death in infants. Apnea is known to be associated with increased incidence of the SIDS. A cessation of breathing, longer than 15 seconds, or accompanied by hypoxia or bradycardia, is called apnea of prematurity and has been found in more than 50% of premature infants. We have designed and constructed an apnea detector for infant monitoring in a clinical environment. The device uses a breath processor module with a surface ECG for detecting apnea. When the infant's breathing counts and heart rates are abnormal, an alarm will sound. This device has shown good performance and feasibility.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128434857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-04-11DOI: 10.1109/ISBB.2014.6820938
Chih-Chan Tu, Tsung-Hsien Lin
This paper performs the detailed analysis and measurement of a pseudo-resistor based CCIA used for bio-potential signal acquisition. The pseudo-resistor is implemented with MOS transistors operating in deep sub-threshold region, whose characteristic is not well-modeled in simulation. The resistor value versus control voltage and the effect of leakage current at OPAMP input node are discussed and characterized in this paper. The tested chip consumes 1.3μA from a 1-V supply, and the total integrated noise from 0.5 to 100 Hz is 3.26μVrms. It achieves a noise efficiency factor of 14.6.
{"title":"Measurement and parameter characterization of pseudo-resistor based CCIA for biomedical applications","authors":"Chih-Chan Tu, Tsung-Hsien Lin","doi":"10.1109/ISBB.2014.6820938","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820938","url":null,"abstract":"This paper performs the detailed analysis and measurement of a pseudo-resistor based CCIA used for bio-potential signal acquisition. The pseudo-resistor is implemented with MOS transistors operating in deep sub-threshold region, whose characteristic is not well-modeled in simulation. The resistor value versus control voltage and the effect of leakage current at OPAMP input node are discussed and characterized in this paper. The tested chip consumes 1.3μA from a 1-V supply, and the total integrated noise from 0.5 to 100 Hz is 3.26μVrms. It achieves a noise efficiency factor of 14.6.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131140957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-04-11DOI: 10.1109/ISBB.2014.6820940
L. Septiana, Kang-Ping Lin
This study presents a novel X-ray image enhancement method. The method proposed in this study is an improved method from Perona-Malik anisotropic diffusion to enhance the quality of X-ray image. This improvement is implemented by combining histogram equalization, Perona-Malik anisotropic diffusion, and a weighted K-means clustering. The result from the real X-ray image shows that the proposed algorithm can improve the image quality of the original low dose x-ray image and make it become more reliable.
{"title":"X-ray image enhancement using a modified anisotropic diffusion","authors":"L. Septiana, Kang-Ping Lin","doi":"10.1109/ISBB.2014.6820940","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820940","url":null,"abstract":"This study presents a novel X-ray image enhancement method. The method proposed in this study is an improved method from Perona-Malik anisotropic diffusion to enhance the quality of X-ray image. This improvement is implemented by combining histogram equalization, Perona-Malik anisotropic diffusion, and a weighted K-means clustering. The result from the real X-ray image shows that the proposed algorithm can improve the image quality of the original low dose x-ray image and make it become more reliable.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116973730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：