Pub Date : 2014-04-11DOI: 10.1109/ISBB.2014.6820892
K. Sasagawa, Yasumi Ohta, Mayumi Motoyama, T. Noda, T. Tokuda, J. Ohta, Sadao Shiosaka
We have developed an implantable micro imaging device that can observe specific molecules such as neuropsin in the deep brain of a freely-moving mouse with minimal invasiveness. A chemical substance, 4-methylcoumaryl-7-amide (MCA), which reacts with neuropsin and changes to fluorophore, 7-amino-4-methyl coumarin (AMC), is injected by a specially designed cannula employed with the device. The implanted sensor can measure spatio-temporal dynamics of neuropisn through fluorescence of AMC, which is accompanied by specific behavior in artificially induced epilepsy. The damage induced by the implantation of the device has been investigated. Four weeks after the implantation, no connective tissues are observed at the implanted locations and imaging was successfully conducted. Immuno-staining of the brain after the implantation reveals that the damage area is limited in less than 100 μm from the sensor surface.
{"title":"An implantable micro imaging device for molecular imaging in a brain of freely-moving mouse","authors":"K. Sasagawa, Yasumi Ohta, Mayumi Motoyama, T. Noda, T. Tokuda, J. Ohta, Sadao Shiosaka","doi":"10.1109/ISBB.2014.6820892","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820892","url":null,"abstract":"We have developed an implantable micro imaging device that can observe specific molecules such as neuropsin in the deep brain of a freely-moving mouse with minimal invasiveness. A chemical substance, 4-methylcoumaryl-7-amide (MCA), which reacts with neuropsin and changes to fluorophore, 7-amino-4-methyl coumarin (AMC), is injected by a specially designed cannula employed with the device. The implanted sensor can measure spatio-temporal dynamics of neuropisn through fluorescence of AMC, which is accompanied by specific behavior in artificially induced epilepsy. The damage induced by the implantation of the device has been investigated. Four weeks after the implantation, no connective tissues are observed at the implanted locations and imaging was successfully conducted. Immuno-staining of the brain after the implantation reveals that the damage area is limited in less than 100 μm from the sensor surface.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126955507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pulmonary edema, i.e. excess of extravascular fluid in lungs, is a common manifestation of various clinical conditions. Although the etiology of the pulmonary edema is deduced with the help of history, physical examination and various biochemical and radiological investigations, computer aided evaluation of pulmonary edema will be helpful for physicians in determining the course of management for the condition. In this study we present texture analysis of chest x-ray, using Gabor filter and one of the machine learning techniques, Support Vector Machine (SVM), to distinguish the normal chest x-ray from the chest x-ray of pulmonary edema. This is an initial step towards computer aided quantitative assessment of the pulmonary edema using chest x-ray.
{"title":"Distinguishing normal and pulmonary edema chest x-ray using Gabor filter and SVM","authors":"Atul Kumar, Yen-Yu Wang, Kai-Che Liu, I-Chen Tsai, Ching-Chun Huang, Nguyen Hung","doi":"10.1109/ISBB.2014.6820918","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820918","url":null,"abstract":"Pulmonary edema, i.e. excess of extravascular fluid in lungs, is a common manifestation of various clinical conditions. Although the etiology of the pulmonary edema is deduced with the help of history, physical examination and various biochemical and radiological investigations, computer aided evaluation of pulmonary edema will be helpful for physicians in determining the course of management for the condition. In this study we present texture analysis of chest x-ray, using Gabor filter and one of the machine learning techniques, Support Vector Machine (SVM), to distinguish the normal chest x-ray from the chest x-ray of pulmonary edema. This is an initial step towards computer aided quantitative assessment of the pulmonary edema using chest x-ray.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116776454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-04-11DOI: 10.1109/ISBB.2014.6820942
Peng Li, Lei Yu, Jiping Wang, Liquan Guo, Qiang Fang
A model-based controller for artificial pancreas requires a model that is able to predict future glucose trends precisely. To quantify the effect of meal intake on the quality of empirical dynamic models (EDM), changing meal conditions (e.g., the meal amounts and times variation, individual differences) were simulated to generate data. Both single-input single-output (SISO) and multi-input single-output (MISO) EDM were identified and evaluated via model identification technology. The prediction accuracy of these models varies significantly within a subject and between subjects due to the different variation of meal amounts, and the additional afternoon snack and meal times shift have the greatest influence on these models. The prediction accuracy of MISO models are worse than that of SISO models under the changing meal condition.
{"title":"Effect of meal intake on the quality of empirical dynamic models for Type 1 Diabetes","authors":"Peng Li, Lei Yu, Jiping Wang, Liquan Guo, Qiang Fang","doi":"10.1109/ISBB.2014.6820942","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820942","url":null,"abstract":"A model-based controller for artificial pancreas requires a model that is able to predict future glucose trends precisely. To quantify the effect of meal intake on the quality of empirical dynamic models (EDM), changing meal conditions (e.g., the meal amounts and times variation, individual differences) were simulated to generate data. Both single-input single-output (SISO) and multi-input single-output (MISO) EDM were identified and evaluated via model identification technology. The prediction accuracy of these models varies significantly within a subject and between subjects due to the different variation of meal amounts, and the additional afternoon snack and meal times shift have the greatest influence on these models. The prediction accuracy of MISO models are worse than that of SISO models under the changing meal condition.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"114 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116544005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-04-11DOI: 10.1109/ISBB.2014.6820946
Shun-Ren Siao, Chih-Cheng Hsu, Mark Po-Hung Lin, Shuenn-Yuh Lee
This paper presents a novel approach for electrocardiogram (ECG) data compression in a healthcare monitoring system, which helps to reduce power consumption during wireless communication. The proposed ECG data compression approach consists of multilevel vector (MLV) compression, integer-linear-programming (ILP)-based compression, and Huffman coding. The MLV compression provides different compression levels for different parts of ECG signal. The ILP-based compression achieves even higher compression ratio while satisfying tolerable error rate. The Huffman coding encodes compressed ECG data without data loss. Experimental results based on the MIT-BIH arrhythmia database show that our approach result in the best quality and accuracy in terms of compression ratio and error rate compared with the previous works.
{"title":"A novel approach for ECG data compression in healthcare monitoring system","authors":"Shun-Ren Siao, Chih-Cheng Hsu, Mark Po-Hung Lin, Shuenn-Yuh Lee","doi":"10.1109/ISBB.2014.6820946","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820946","url":null,"abstract":"This paper presents a novel approach for electrocardiogram (ECG) data compression in a healthcare monitoring system, which helps to reduce power consumption during wireless communication. The proposed ECG data compression approach consists of multilevel vector (MLV) compression, integer-linear-programming (ILP)-based compression, and Huffman coding. The MLV compression provides different compression levels for different parts of ECG signal. The ILP-based compression achieves even higher compression ratio while satisfying tolerable error rate. The Huffman coding encodes compressed ECG data without data loss. Experimental results based on the MIT-BIH arrhythmia database show that our approach result in the best quality and accuracy in terms of compression ratio and error rate compared with the previous works.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115176524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-04-11DOI: 10.1109/ISBB.2014.6820896
Wen-Ying Chang, Chi-Chun Chen, Chin-Lung Yang
This paper presents a cost-effective sensor system for the applications of large area array sensing. Unlike the traditional pressure sensing methods, projected capacitor technologies are proposed for sensing. The rapid charge time method is utilized to measure the capacitance values of the projected capacitive array electrodes. By constructing the process of projected capacitive array electrode, the required characteristics of the projected capacitor are identified, especially characteristics for large area applications. Three main factors, the area of electrodes, the use of shielding and gap between the guard ring and the electrode, also affect the capacitance primary value especially in the large-size applications. At last, a flexible projected capacitive sensing array with 8 × 10 electrodes was implemented to validate the feasibility of projected capacitive array electrodes.
{"title":"The applications of projected capacitive array sensing in healthcare","authors":"Wen-Ying Chang, Chi-Chun Chen, Chin-Lung Yang","doi":"10.1109/ISBB.2014.6820896","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820896","url":null,"abstract":"This paper presents a cost-effective sensor system for the applications of large area array sensing. Unlike the traditional pressure sensing methods, projected capacitor technologies are proposed for sensing. The rapid charge time method is utilized to measure the capacitance values of the projected capacitive array electrodes. By constructing the process of projected capacitive array electrode, the required characteristics of the projected capacitor are identified, especially characteristics for large area applications. Three main factors, the area of electrodes, the use of shielding and gap between the guard ring and the electrode, also affect the capacitance primary value especially in the large-size applications. At last, a flexible projected capacitive sensing array with 8 × 10 electrodes was implemented to validate the feasibility of projected capacitive array electrodes.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131073832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-04-11DOI: 10.1109/ISBB.2014.6820906
M. Lin, Chi-Wan Lin, Ya-Hui Hsieh, Hung-chien Wu, Yong-Sheng Shih, Chuan-Tsung Su, I-Ting Chiu, Jih-Huah Wu
Low level laser therapy (LLLT) is effective in a lot of clinical treatments, but the photobiological basis of this therapy is not well understood. From our previous study, the effectiveness of laser acupuncture (LA) and cupping applied on low back pain (LBP) has been proved. However, the variation of the plasma cortisol level is unknown. Thus, this study aims to evaluate the effectiveness of LA and cupping on LBP by checking the plasma cortisol level. Fifty patients of either sex over 60 years old with LBP were recruited into a single blinded trial. Active group (LA plus soft cupping) and placebo group (sham LA plus soft cupping) were treated for five days. Laser, 40mW, wavelength 808nm, pulse rate 20Hz, was used to irradiate Weizhong (BL40) and Ashi acupoints for 10 minutes. The variation of VAS was recorded and blood samples were taken for the measurement of plasma cortisol levels. There was a significant fall in plasma cortisol in active group (p = 0.013) and placebo group (p = 0.039) after five days' treatment. This result showed that for the people with chronic LBP there is a beneficial effect if they continuously receive the treatment for five days. However, the combination of LA and cupping seems to quickly reduce the inflammation situation than placebo group did.
{"title":"Evaluating the effectiveness of low level laser and cupping on low back pain by checking the plasma cortisol level","authors":"M. Lin, Chi-Wan Lin, Ya-Hui Hsieh, Hung-chien Wu, Yong-Sheng Shih, Chuan-Tsung Su, I-Ting Chiu, Jih-Huah Wu","doi":"10.1109/ISBB.2014.6820906","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820906","url":null,"abstract":"Low level laser therapy (LLLT) is effective in a lot of clinical treatments, but the photobiological basis of this therapy is not well understood. From our previous study, the effectiveness of laser acupuncture (LA) and cupping applied on low back pain (LBP) has been proved. However, the variation of the plasma cortisol level is unknown. Thus, this study aims to evaluate the effectiveness of LA and cupping on LBP by checking the plasma cortisol level. Fifty patients of either sex over 60 years old with LBP were recruited into a single blinded trial. Active group (LA plus soft cupping) and placebo group (sham LA plus soft cupping) were treated for five days. Laser, 40mW, wavelength 808nm, pulse rate 20Hz, was used to irradiate Weizhong (BL40) and Ashi acupoints for 10 minutes. The variation of VAS was recorded and blood samples were taken for the measurement of plasma cortisol levels. There was a significant fall in plasma cortisol in active group (p = 0.013) and placebo group (p = 0.039) after five days' treatment. This result showed that for the people with chronic LBP there is a beneficial effect if they continuously receive the treatment for five days. However, the combination of LA and cupping seems to quickly reduce the inflammation situation than placebo group did.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128818120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-04-11DOI: 10.1109/ISBB.2014.6820908
S. Bao, Huimin Ma, Wenyu Li
Traditional evaluations of human psychological status usually have a great dependence on the experience of the operator, and it is still a challenge to automate the evaluation process. In this study, a new image system ThuPIS (the Tsinghua Psychological Image System) is designed based on Minnesota Multiphasic Personality Inventory (MMPI), a classical personality inventory in clinical mental health diagnose. The goal of ThuPIS is to build an ontology of affective images, which can active difference of physiological reactions among people with different psychological status. Specific image contents were chosen according to the items of MMPI, and organized by a hierarchy structure. Images were rated according to an overall impression, and those with affective ambiguous were eliminated. An experiment was conducted based on ThuPIS, and the results provide evidence that images in this image system could lead to difference in response time of positive facial expression when participants hold different attitudes towards the background images. This new image system could also supplies materials for other studies on human cognition. It is a brand new work and more practical assessments on the new image system are expected along the way.
{"title":"ThuPIS: A new affective image system for psychological analysis","authors":"S. Bao, Huimin Ma, Wenyu Li","doi":"10.1109/ISBB.2014.6820908","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820908","url":null,"abstract":"Traditional evaluations of human psychological status usually have a great dependence on the experience of the operator, and it is still a challenge to automate the evaluation process. In this study, a new image system ThuPIS (the Tsinghua Psychological Image System) is designed based on Minnesota Multiphasic Personality Inventory (MMPI), a classical personality inventory in clinical mental health diagnose. The goal of ThuPIS is to build an ontology of affective images, which can active difference of physiological reactions among people with different psychological status. Specific image contents were chosen according to the items of MMPI, and organized by a hierarchy structure. Images were rated according to an overall impression, and those with affective ambiguous were eliminated. An experiment was conducted based on ThuPIS, and the results provide evidence that images in this image system could lead to difference in response time of positive facial expression when participants hold different attitudes towards the background images. This new image system could also supplies materials for other studies on human cognition. It is a brand new work and more practical assessments on the new image system are expected along the way.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131883347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Classification of leukemia samples based on gene expression profiles has been proved an efficient way. Large numbers of intelligence algorithms have been exploited based on this purpose. However, few of them display stable and accurate performance for both low and high gene dimensionalities. Still none of them could keep the history information of optimization. Here, a classification algorithm based on the novel multivariant optimization algorithm (MOA) is proposed. Leukemia gene expression profiles with different dimensionalities are used for validation. The particle swarm optimization (PSO) and the two-layer particle swarm optimization (TLPSO) algorithm are used for comparison. The MOA shows stable and relatively accurate classification performance and could be used as an effective classification algorithm for gene expression profiles.
{"title":"Classification of leukemia gene expression profiles based on multivariant optimization algorithm","authors":"Yajie Liu, Xinling Shi, Changxing Gou, Baolei Li, Qinhu Zhang, Lv Danjv, Yunchao Huang","doi":"10.1109/ISBB.2014.6820912","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820912","url":null,"abstract":"Classification of leukemia samples based on gene expression profiles has been proved an efficient way. Large numbers of intelligence algorithms have been exploited based on this purpose. However, few of them display stable and accurate performance for both low and high gene dimensionalities. Still none of them could keep the history information of optimization. Here, a classification algorithm based on the novel multivariant optimization algorithm (MOA) is proposed. Leukemia gene expression profiles with different dimensionalities are used for validation. The particle swarm optimization (PSO) and the two-layer particle swarm optimization (TLPSO) algorithm are used for comparison. The MOA shows stable and relatively accurate classification performance and could be used as an effective classification algorithm for gene expression profiles.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131381567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-04-11DOI: 10.1109/ISBB.2014.6820935
Yen-Jen Chen, Marc D. Green, Sarah A Sabatinos, S. Forsburg, Chun-Nan Hsu, Jyh-Ying Peng
Schizosaccharomyces pombe shares many genes and proteins with humans and is a good model for chromosome behavior and DNA dynamics, which can be analyzed by visualizing the behavior of fluorescently tagged proteins in vivo. However, performing a genome-wide screen for changes in such proteins requires developing methods that automate analysis of multiple images. We developed a high content analysis system to robustly segment transmitted illumination images, extract cell and nucleus boundaries, and quantitatively characterize the fluorescence within each compartment. A support vector machine (SVM) is trained to automatically judge if a cell is undergoing septation, and another two SVMs are trained to classify pombe cells into various phenotypes according to its cell shape and fluorescence signal profile. We applied this system to automatically calculate the percentages of cells of different phenotypes for 4000 S. pombe mutants.
{"title":"Automatic phenotyping of multi-channel Schizosaccharomyces pombe images","authors":"Yen-Jen Chen, Marc D. Green, Sarah A Sabatinos, S. Forsburg, Chun-Nan Hsu, Jyh-Ying Peng","doi":"10.1109/ISBB.2014.6820935","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820935","url":null,"abstract":"Schizosaccharomyces pombe shares many genes and proteins with humans and is a good model for chromosome behavior and DNA dynamics, which can be analyzed by visualizing the behavior of fluorescently tagged proteins in vivo. However, performing a genome-wide screen for changes in such proteins requires developing methods that automate analysis of multiple images. We developed a high content analysis system to robustly segment transmitted illumination images, extract cell and nucleus boundaries, and quantitatively characterize the fluorescence within each compartment. A support vector machine (SVM) is trained to automatically judge if a cell is undergoing septation, and another two SVMs are trained to classify pombe cells into various phenotypes according to its cell shape and fluorescence signal profile. We applied this system to automatically calculate the percentages of cells of different phenotypes for 4000 S. pombe mutants.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"110 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115830405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-04-11DOI: 10.1109/ISBB.2014.6820891
Chien-Chi Lu, W. Tseng, Y. Tseng, Shi-Hang Lin, Kun-Ying Yeh, Shey-Shi Lu, C. Yen, M. Lin, Hung-Wei Chiu
In this work, an in vivo animal experiment was conducted to show that the pulsed radiofrequency (PRF) stimulation in relieving pain is effective for trigeminal neuralgia. The experiment also reveals that the 10-V stimulation is more effective than 5-V stimulation. Hence, in order to generate a high PRF voltage in a brain stimulator, a low-Q class-E amplifier is proposed to be a high voltage electrical stimulation (ES) driver by controlling the input duty cycle. The steady states of the circuit waveform are represented in two PDEs' and are numerically solved in math tool to achieve circuit parameters. When the driver was operated under the condition of Q = 1 and D = 0.8, the output peak voltage was measured up to 10 V, which is 3 times of VDD. The conversion efficiency of the PRF driver was measured 90% that measured load from 300Ω to 1.8kΩ. The efficiency of the low-Q operation is found to be better under mismatched load than in high-Q operation.
本研究通过动物体内实验，验证了脉冲射频(PRF)刺激对三叉神经痛的镇痛效果。实验还表明，10v刺激比5v刺激更有效。因此，为了在脑刺激器中产生高PRF电压，提出了一种低q的e类放大器，通过控制输入占空比作为高压电刺激(ES)驱动器。电路波形的稳态用两个偏微分方程表示，并用数学工具进行数值求解，得到电路参数。当驱动器在Q = 1, D = 0.8的条件下工作时，测得输出峰值电压高达10 V，是VDD的3倍。PRF驱动器的转换效率为90%，测量负载从300Ω到1.8kΩ。结果表明，在负载不匹配情况下，低q操作的效率优于高q操作。
{"title":"A high voltage stimulator using a low-Q class-E pulsed radiofrequency driver for animal study of relieving trigeminal neuralgia pain","authors":"Chien-Chi Lu, W. Tseng, Y. Tseng, Shi-Hang Lin, Kun-Ying Yeh, Shey-Shi Lu, C. Yen, M. Lin, Hung-Wei Chiu","doi":"10.1109/ISBB.2014.6820891","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820891","url":null,"abstract":"In this work, an in vivo animal experiment was conducted to show that the pulsed radiofrequency (PRF) stimulation in relieving pain is effective for trigeminal neuralgia. The experiment also reveals that the 10-V stimulation is more effective than 5-V stimulation. Hence, in order to generate a high PRF voltage in a brain stimulator, a low-Q class-E amplifier is proposed to be a high voltage electrical stimulation (ES) driver by controlling the input duty cycle. The steady states of the circuit waveform are represented in two PDEs' and are numerically solved in math tool to achieve circuit parameters. When the driver was operated under the condition of Q = 1 and D = 0.8, the output peak voltage was measured up to 10 V, which is 3 times of VDD. The conversion efficiency of the PRF driver was measured 90% that measured load from 300Ω to 1.8kΩ. The efficiency of the low-Q operation is found to be better under mismatched load than in high-Q operation.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123991380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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