Pub Date : 2014-04-11DOI: 10.1109/ISBB.2014.6820945
Jia-Jung Wang, Jia-Fu Yang, Chan-Ting Lin, W. Tseng
Endothelial function has shown to be strongly associated with cardiovascular risk. In the study, postocclusive flow-mediated vasodilatation (FMD) was measured and used to assess the endothelial function in three different vascular beds. Twenty-six healthy volunteers were recruited in the study and asked to undertake a 3-minute occlusion of left brachial arteries. Result analysis showed that FMD of radial arteries with the pneumatic oscillometry was found to be significantly greater than that of small arteries together with microvessels in fingers with the photo-plethysmography (122 ± 61 versus 87 ± 56, p = 0.02). Besides, FMD of skin microcirculation in fingers with the laser Doppler flowmetry was calculated to be 118 ± 68, with no significant level as compared with radial arterial FMD. Due to a smaller coefficient of variations, the oscillometric technique proposed may become an alternative for evaluating endothelial function of peripheral arteries.
{"title":"Simultaneous assessment of postocclusive flow-mediated vasodilatation in three vascular beds","authors":"Jia-Jung Wang, Jia-Fu Yang, Chan-Ting Lin, W. Tseng","doi":"10.1109/ISBB.2014.6820945","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820945","url":null,"abstract":"Endothelial function has shown to be strongly associated with cardiovascular risk. In the study, postocclusive flow-mediated vasodilatation (FMD) was measured and used to assess the endothelial function in three different vascular beds. Twenty-six healthy volunteers were recruited in the study and asked to undertake a 3-minute occlusion of left brachial arteries. Result analysis showed that FMD of radial arteries with the pneumatic oscillometry was found to be significantly greater than that of small arteries together with microvessels in fingers with the photo-plethysmography (122 ± 61 versus 87 ± 56, p = 0.02). Besides, FMD of skin microcirculation in fingers with the laser Doppler flowmetry was calculated to be 118 ± 68, with no significant level as compared with radial arterial FMD. Due to a smaller coefficient of variations, the oscillometric technique proposed may become an alternative for evaluating endothelial function of peripheral arteries.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123063563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-04-11DOI: 10.1109/ISBB.2014.6820919
Po-An Chen, Chin-Lung Yang, S. Tseng, Ming-Wei Li
A 23(cm) × 11(cm) tissue cancer detector based on frequency-domain photon migration (FDPM) technique is studied in this paper. The high cost and bulky network analyzer-based FDPM was implemented on PCB with high phase sensitivity. A Network Analyzer costs over one million NT dollars however the proposed detector costs only about several thousand NT dollars. So the proposed FDPM architecture features on compact, low cost, and portable advantages. A down-converted technique and a zero detector phase error elimination improve both resolution and accuracy of phase measurement. The optical receiver with improvement of both the resolution and the accuracy on amplitude and phase difference measurement are presented in details. The results are compared to a commercial Network Analyzer. Phase and amplitude measured errors compared to commercially Network Analyzer are less than 7 %. It proves that the proposed detector has the capability to replace a commercially Network Analyzer.
{"title":"A compact and non-invasive tissue cancer detectors based on frequency-domain photon migration","authors":"Po-An Chen, Chin-Lung Yang, S. Tseng, Ming-Wei Li","doi":"10.1109/ISBB.2014.6820919","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820919","url":null,"abstract":"A 23(cm) × 11(cm) tissue cancer detector based on frequency-domain photon migration (FDPM) technique is studied in this paper. The high cost and bulky network analyzer-based FDPM was implemented on PCB with high phase sensitivity. A Network Analyzer costs over one million NT dollars however the proposed detector costs only about several thousand NT dollars. So the proposed FDPM architecture features on compact, low cost, and portable advantages. A down-converted technique and a zero detector phase error elimination improve both resolution and accuracy of phase measurement. The optical receiver with improvement of both the resolution and the accuracy on amplitude and phase difference measurement are presented in details. The results are compared to a commercial Network Analyzer. Phase and amplitude measured errors compared to commercially Network Analyzer are less than 7 %. It proves that the proposed detector has the capability to replace a commercially Network Analyzer.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125986078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-04-11DOI: 10.1109/ISBB.2014.6820931
Eka Adi Prasetyo Joko Prawiro, Chia-Chun Hu, Yi-Sheng Chan, Cheng-Hung Chang, Yuan-Hsiang Lin
Exercise is important for health, however inappropriate exercise would harm our body or get nothing affects. Therefore, a wearable exercise intensity monitoring device can assist user to manage their exercise intensity. Heart rate (HR) is an index to indicate the exercise intensity. In this paper, we proposed a high accuracy HR detection method and implemented it on a wearable and low power device for exercise intensity monitoring. This device consists of a two-electrode ECG amplifier, a MSP430 microprocessor and a Bluetooth Low Energy (BLE) module. Moreover, the device can transmit the HR to a Smart-phone via the BLE. The accuracy of HR detection method is verified in both resting and dynamic conditions. For resting condition, we use a commercial ECG simulator as signal input and the accuracy of HR detection is 100 percents. For dynamic condition, we use treadmill test. Three subjects (2 male, 1 female) walking in six speeds from 1.8 km/h until 6.3 km/h and running in 7.2 km/h. The accuracy of HR detection is 99.7 percents.
{"title":"A heart rate detection method for low power exercise intensity monitoring device","authors":"Eka Adi Prasetyo Joko Prawiro, Chia-Chun Hu, Yi-Sheng Chan, Cheng-Hung Chang, Yuan-Hsiang Lin","doi":"10.1109/ISBB.2014.6820931","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820931","url":null,"abstract":"Exercise is important for health, however inappropriate exercise would harm our body or get nothing affects. Therefore, a wearable exercise intensity monitoring device can assist user to manage their exercise intensity. Heart rate (HR) is an index to indicate the exercise intensity. In this paper, we proposed a high accuracy HR detection method and implemented it on a wearable and low power device for exercise intensity monitoring. This device consists of a two-electrode ECG amplifier, a MSP430 microprocessor and a Bluetooth Low Energy (BLE) module. Moreover, the device can transmit the HR to a Smart-phone via the BLE. The accuracy of HR detection method is verified in both resting and dynamic conditions. For resting condition, we use a commercial ECG simulator as signal input and the accuracy of HR detection is 100 percents. For dynamic condition, we use treadmill test. Three subjects (2 male, 1 female) walking in six speeds from 1.8 km/h until 6.3 km/h and running in 7.2 km/h. The accuracy of HR detection is 99.7 percents.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127382111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-04-11DOI: 10.1109/ISBB.2014.6820897
M. Bouali, Benoit Auclair, M. Sawan, A. Miled
This paper presents a reprogrammable low-voltage power-supply integrated circuit for low resistive load down to 180 Ω. The achieved chip is dedicated for biomedical lab-on-chip (LoC) platforms. The proposed system includes two positive and two negative fully independent output voltage channels. Each positive and negative channel provides a reprogrammable DC output which varies from 14.23 mV to 1.42 V and -1.54 V to 0 V, respectively. Each channel is controlled through a reprogrammable reference voltage circuit with an 8-bit digital to analog converter (DAC). A wireless real-time control of output signals amplitude is performed with LabVIEW and FPGA-based interface. The proposed architecture is implemented with 0.18 μm 3.3 V 1-poly 6-metal CMOS technology. The chip area is 1.5 mm2. Post-layout simulations show that the minimum voltage step is 12.21 mV. The accuracy of output voltage is 5 mV and the measured power consumption is 35 mW.
{"title":"An on-chip programmable multichannel power supply for a lab-on-chip platform","authors":"M. Bouali, Benoit Auclair, M. Sawan, A. Miled","doi":"10.1109/ISBB.2014.6820897","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820897","url":null,"abstract":"This paper presents a reprogrammable low-voltage power-supply integrated circuit for low resistive load down to 180 Ω. The achieved chip is dedicated for biomedical lab-on-chip (LoC) platforms. The proposed system includes two positive and two negative fully independent output voltage channels. Each positive and negative channel provides a reprogrammable DC output which varies from 14.23 mV to 1.42 V and -1.54 V to 0 V, respectively. Each channel is controlled through a reprogrammable reference voltage circuit with an 8-bit digital to analog converter (DAC). A wireless real-time control of output signals amplitude is performed with LabVIEW and FPGA-based interface. The proposed architecture is implemented with 0.18 μm 3.3 V 1-poly 6-metal CMOS technology. The chip area is 1.5 mm2. Post-layout simulations show that the minimum voltage step is 12.21 mV. The accuracy of output voltage is 5 mV and the measured power consumption is 35 mW.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134646682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-04-11DOI: 10.1109/ISBB.2014.6820901
P. Huang, Cheng-I Chen, P. Lin, Ping Chen, Lipin Hsu
In this paper, we present a PET and MR brain image fusion method based on wavelet transform for low- and high-activity brain image regions, respectively. Our method can generate very good fusion result by adjusting the anatomical structural information in the gray matter (GM) area, and then patching the spectral information in the white matter (WM) area after the wavelet decomposition and gray-level fusion. We used normal axial, normal coronal, and Alzheimer's disease brain images as the three datasets for testing and comparison. Experimental results showed that the performance of our fusion method is better than that of IHS+RIM fusion method in terms of spectral discrepancy (SD) and average gradient (AG). In fact, our method is superior to IHS+RIM method both visually and quantitatively.
{"title":"PET and MRI brain image fusion using wavelet transform with structural information adjustment and spectral information patching","authors":"P. Huang, Cheng-I Chen, P. Lin, Ping Chen, Lipin Hsu","doi":"10.1109/ISBB.2014.6820901","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820901","url":null,"abstract":"In this paper, we present a PET and MR brain image fusion method based on wavelet transform for low- and high-activity brain image regions, respectively. Our method can generate very good fusion result by adjusting the anatomical structural information in the gray matter (GM) area, and then patching the spectral information in the white matter (WM) area after the wavelet decomposition and gray-level fusion. We used normal axial, normal coronal, and Alzheimer's disease brain images as the three datasets for testing and comparison. Experimental results showed that the performance of our fusion method is better than that of IHS+RIM fusion method in terms of spectral discrepancy (SD) and average gradient (AG). In fact, our method is superior to IHS+RIM method both visually and quantitatively.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133361407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-04-11DOI: 10.1109/ISBB.2014.6820909
C. Chou, Jiann-Der Lee, Carol T. Liu, M. Tsai
This paper describes a novel region segmentation method created to enhance spatial relationships in 3-D optical coherence tomography (OCT) images. To reduce the noise and distortion problems in low-resolution OCT images, previous work used the mean value and an enhanced-fuzzy-c-mean algorithm to cluster pixels in 2-D OCT images and find the edge between different clustered regions. To utilize more spatial relationships and to reduce computation time, the proposed method uses the mean value and a 3-D filter-based-fuzzy-c-mean algorithm to cluster pixels in 3-D OCT images and find the edge between different clustered regions. The OCT images of an artificial object used to simulate vessels are tested in the experiment, and the segmented regions of interest are reconstructed via AVIZO for 3-D display purposes.
{"title":"Region segmentation in 3-D optical coherence tomography images","authors":"C. Chou, Jiann-Der Lee, Carol T. Liu, M. Tsai","doi":"10.1109/ISBB.2014.6820909","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820909","url":null,"abstract":"This paper describes a novel region segmentation method created to enhance spatial relationships in 3-D optical coherence tomography (OCT) images. To reduce the noise and distortion problems in low-resolution OCT images, previous work used the mean value and an enhanced-fuzzy-c-mean algorithm to cluster pixels in 2-D OCT images and find the edge between different clustered regions. To utilize more spatial relationships and to reduce computation time, the proposed method uses the mean value and a 3-D filter-based-fuzzy-c-mean algorithm to cluster pixels in 3-D OCT images and find the edge between different clustered regions. The OCT images of an artificial object used to simulate vessels are tested in the experiment, and the segmented regions of interest are reconstructed via AVIZO for 3-D display purposes.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133840713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-04-11DOI: 10.1109/ISBB.2014.6820954
T. Lin, J. L. Shen, C. A. Lin, W. H. Chang, C. Yuan
Single-molecule spectroscopy (SMS) is a powerful and versatile technique that can be utilized to unravel the bio-molecule dynamics and to sense specific bio-molecules with extremely high sensitivity. A key requirement for successfully performing SMS is to incorporate suitable reporters/sensors. When the target molecules interact with them, the signals (such as fluorescence intensity/lifetime) can be changed accordingly. These reporters should be small enough, bio-compatible, non-toxic, and optically stable. Newly emerged fluorescent gold nanoclusters (Au NCs) have been demonstrated to be promising reporters in terms of aforementioned factors. In this work, we will explore their fluorescence properties from the single-molecule viewpoints by using novel fluorescence lifetime correlation spectroscopy. By which, the triplet state dynamics and diffusion process can be observed and the relevant time constant was derived. This work paves a way to use their single-particle fluorescence properties, such as fluorescence lifetime or triplet state dynamics for high-sensitivity bio-sensing in the future.
{"title":"Exploration of fluorescence properties of gold nanoclusters at the single-molecule levels","authors":"T. Lin, J. L. Shen, C. A. Lin, W. H. Chang, C. Yuan","doi":"10.1109/ISBB.2014.6820954","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820954","url":null,"abstract":"Single-molecule spectroscopy (SMS) is a powerful and versatile technique that can be utilized to unravel the bio-molecule dynamics and to sense specific bio-molecules with extremely high sensitivity. A key requirement for successfully performing SMS is to incorporate suitable reporters/sensors. When the target molecules interact with them, the signals (such as fluorescence intensity/lifetime) can be changed accordingly. These reporters should be small enough, bio-compatible, non-toxic, and optically stable. Newly emerged fluorescent gold nanoclusters (Au NCs) have been demonstrated to be promising reporters in terms of aforementioned factors. In this work, we will explore their fluorescence properties from the single-molecule viewpoints by using novel fluorescence lifetime correlation spectroscopy. By which, the triplet state dynamics and diffusion process can be observed and the relevant time constant was derived. This work paves a way to use their single-particle fluorescence properties, such as fluorescence lifetime or triplet state dynamics for high-sensitivity bio-sensing in the future.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"124 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126060267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-04-11DOI: 10.1109/ISBB.2014.6820939
Jhin-Fang Huang, W. Lai, Wang-Tyng Lay
A 1-V 5.8 GHz CMOS front-end applying in dedicated biomedical systems has been successfully implemented by TSMC 0.18 μm CMOS process. This system has built in near-infrared laser-driven (NIRLD) might be a promising wireless electrical power source and phase in wake up receiver technology using direct active RF detection for biomedical nanodevices power saving. This proposed prototype includes an input matching low noise amplifier (LNA), a passive balun, a down-conversion Gilbert mixer, a gm-boosting Colpitts VCO, followed by an intermediate frequency (IF) Gm-C bandpass filter. The measured results achieve an input return loss of 27 dB, a conversion gain (CG) of 29 dB, a double-side band (DSB) noise figure (NF) of 4.95 dB, and a third-order intercept point (IIP3) of -24.4 dBm, a tuning range of 5.17-5.98 GHz, a phase noise of -118.5 dBc/Hz at 1 MHz offset from 5.8 GHz and a power consumption of 27.6 mW from 1.0 V supply. The overall chip area including pads is 2.1 (1.75 × 1.2) mm2. This paper also has external connect with a broadband loop-type chip antenna to support biomedical nanodevices healthcare application.
{"title":"Chip design of WuRx front-end and IF Gm-C bandpass filter with antenna to near infrared charging for biomedical application","authors":"Jhin-Fang Huang, W. Lai, Wang-Tyng Lay","doi":"10.1109/ISBB.2014.6820939","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820939","url":null,"abstract":"A 1-V 5.8 GHz CMOS front-end applying in dedicated biomedical systems has been successfully implemented by TSMC 0.18 μm CMOS process. This system has built in near-infrared laser-driven (NIRLD) might be a promising wireless electrical power source and phase in wake up receiver technology using direct active RF detection for biomedical nanodevices power saving. This proposed prototype includes an input matching low noise amplifier (LNA), a passive balun, a down-conversion Gilbert mixer, a gm-boosting Colpitts VCO, followed by an intermediate frequency (IF) Gm-C bandpass filter. The measured results achieve an input return loss of 27 dB, a conversion gain (CG) of 29 dB, a double-side band (DSB) noise figure (NF) of 4.95 dB, and a third-order intercept point (IIP3) of -24.4 dBm, a tuning range of 5.17-5.98 GHz, a phase noise of -118.5 dBc/Hz at 1 MHz offset from 5.8 GHz and a power consumption of 27.6 mW from 1.0 V supply. The overall chip area including pads is 2.1 (1.75 × 1.2) mm2. This paper also has external connect with a broadband loop-type chip antenna to support biomedical nanodevices healthcare application.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129565876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-04-11DOI: 10.1109/ISBB.2014.6820917
Jun-Hong Weng, Di-Yu Lin
This paper proposes the class of the translinear (TL) circuits implementing a wide range of static nonlinear relationships in the current signal domain to computational such as generating products, quotients, vector magnitude and rational functions, which are implemented in a standard 0.35-μm SiGe technology. A shunt-feedback buffer principle is used in order to regulate its emitter voltage of translinear to generate sinusoidal wave. The resolution can be fine tune by adjusting the output current source. The circuits use no any capacitances and filters. The circuits are based on exploit the exponential current-voltage characteristic of bipolar transistors. The analysis of input, and output resistance and current-gain are depicted. The SFDR of sin wave resolution measurement is 55.23 dB at a 1-MHz and the power consumption is 102mW with the die areas 0.66×0.62 μm2.
{"title":"Sine function generator","authors":"Jun-Hong Weng, Di-Yu Lin","doi":"10.1109/ISBB.2014.6820917","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820917","url":null,"abstract":"This paper proposes the class of the translinear (TL) circuits implementing a wide range of static nonlinear relationships in the current signal domain to computational such as generating products, quotients, vector magnitude and rational functions, which are implemented in a standard 0.35-μm SiGe technology. A shunt-feedback buffer principle is used in order to regulate its emitter voltage of translinear to generate sinusoidal wave. The resolution can be fine tune by adjusting the output current source. The circuits use no any capacitances and filters. The circuits are based on exploit the exponential current-voltage characteristic of bipolar transistors. The analysis of input, and output resistance and current-gain are depicted. The SFDR of sin wave resolution measurement is 55.23 dB at a 1-MHz and the power consumption is 102mW with the die areas 0.66×0.62 μm2.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130191528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-04-11DOI: 10.1109/ISBB.2014.6820890
H. Cruz, Ting-Chia Yeh, Hong-Yi Huang, Shueen-Yu Lee, C. Luo
Positron emission tomography architectures have been traditionally dependent on zero crossing discriminators, external voltage references, or fixed voltage references with restricted voltage steps. This paper presents a digital-to-analog converter (DAC) utilized to set the threshold voltages of Time-of-Flight Positron Emission Tomography (TOF-PET) comparators. The DAC circuit uses a charge redistribution architecture, and all the required building blocks have been fully integrated in a 90 nm CMOS process with an area of 170 × 65 μm2. The power consumption is 324 μW with 1.2-V supply voltage. Using a 10-MHz clock, this DAC achieves an effective number of bits (ENOB) of 8.2.
{"title":"DAC for positron emission tomography front-end","authors":"H. Cruz, Ting-Chia Yeh, Hong-Yi Huang, Shueen-Yu Lee, C. Luo","doi":"10.1109/ISBB.2014.6820890","DOIUrl":"https://doi.org/10.1109/ISBB.2014.6820890","url":null,"abstract":"Positron emission tomography architectures have been traditionally dependent on zero crossing discriminators, external voltage references, or fixed voltage references with restricted voltage steps. This paper presents a digital-to-analog converter (DAC) utilized to set the threshold voltages of Time-of-Flight Positron Emission Tomography (TOF-PET) comparators. The DAC circuit uses a charge redistribution architecture, and all the required building blocks have been fully integrated in a 90 nm CMOS process with an area of 170 × 65 μm2. The power consumption is 324 μW with 1.2-V supply voltage. Using a 10-MHz clock, this DAC achieves an effective number of bits (ENOB) of 8.2.","PeriodicalId":265886,"journal":{"name":"2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)","volume":"58 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134411722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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