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2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)最新文献

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Systematic pipeline for the analysis of microRNA-gene interactions in active and latent TB infection 用于分析活动性和潜伏性结核感染中microrna -基因相互作用的系统管道
Julia Tzu-Ya Weng, Kai-Yao Huang, Shih-Wei Lee, L. S. Wu, Yi-Cheng Chen, Tzong-Yi Lee
Tuberculosis (TB) is the second most common cause of death from infectious diseases. About 90% of those infected are asymptomatic-the so-called latent TB infections (LTBI), with a 10% lifetime chance of progressing to active TB. Several gene expression studies have compared healthy controls versus active TB or LTBI patients. The results vary due to diverse genetic background, study designs, and the inherent complexity of the disease process. Thus, developing a sensitive and efficient method for the detection of LTBI is both crucial and challenging. Our objective was to establish an efficient and cost-effective pipeline for gene and microRNA expression profiling in TB and LTBI. We attempted to investigate the interaction between these two types of molecular signatures as biomarkers for a more sensitive and specific differentiation among active TB, LTBI, and healthy individuals. Following our systematic pipeline, we have uncovered novel differences specific to the Taiwanese population. Differentially expressed microRNAs and their interactions with the corresponding target genes will serve as potential molecular signatures to enhance our understanding of the underlying mechanisms of TB and facilitate the development for a more sensitive diagnostic assay for LTBI.
结核病是导致传染病死亡的第二大常见原因。大约90%的感染者是无症状的,即所谓的潜伏性结核感染(LTBI),一生中有10%的机会发展为活动性结核。一些基因表达研究比较了健康对照与活动性结核病或LTBI患者。由于不同的遗传背景、研究设计和疾病过程的内在复杂性,结果有所不同。因此,开发一种灵敏而有效的方法来检测LTBI是至关重要的,也是具有挑战性的。我们的目标是建立一个高效和经济的管道,用于结核病和LTBI的基因和microRNA表达谱分析。我们试图研究这两种类型的分子特征之间的相互作用,作为在活动性结核病、LTBI和健康个体之间更敏感和特异性区分的生物标志物。根据我们的系统管道,我们发现了台湾人口特有的新差异。差异表达的microrna及其与相应靶基因的相互作用将作为潜在的分子特征,增强我们对结核病潜在机制的理解,并促进开发更敏感的LTBI诊断方法。
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引用次数: 0
Smart textiles applied in emergency department patients with chest pain 智能纺织品在急诊科胸痛患者中的应用
Sheng-Chung Tien, Ren-Guey Lee, Yen-Yi Feng, Shih-Feng Huang, Wen-Han Chang, Tsung-Yu Lee
Develop a system with heart-rate detecting function, convenient-moving and effectively to ease the medical staff's working efficiency when facing the patients in clinic is our main goal. Prognosis, which means the results of disease-prediction based on groups of clue's samples in medical, the bigger the samples, the more precise the prognosis. This research uses the conductive silk in the textile design. We adapt the wearing-comfortable conductive vest and chest belt to record hospitalized patients' continuously physiological index. In the end of hospitalization, the system will summarize the original indexes of hospital, HRV and other indexes to evaluate the risk score of hospital-discharging, which provides a better hospital-discharging diagnosis focusing on chest pain patients for ER doctors, and verifies the accuracy of this prognosis by means of the 3 days and 30 days recalling rate of patients.
开发一种具有心率检测功能,移动方便,有效缓解医护人员在门诊面对病人时工作效率的系统是我们的主要目标。预后是指医学上基于线索样本群的疾病预测结果,样本越大,预测越准确。本研究将导电丝应用于纺织品设计中。我们采用穿戴舒适的导电背心和胸带来记录住院病人的连续生理指标。在住院结束时,系统将综合医院原有指标、HRV等指标对出院风险评分进行评估,为急诊医生提供更好的以胸痛患者为重点的出院诊断,并通过患者3天、30天的召回率验证该预后的准确性。
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引用次数: 1
A swept-field multi-channel aspiration condenser for low-ppm level detection 一种用于低ppm水平检测的扫描场多通道吸气冷凝器
Chien-Fu Hsueh, K. Tang
IMS(Ion Mobility Spectrometry) is a technique has been widely used for hazardous compounds detection. IMS can operates in atmospheric condition with low detection limit and fast response time. It became popular in various application, such as detection of chemical warfare agent, toxic industrial compounds and explosives. In this paper, we present a low-cost, easy to assembly device as an ion mobility spectrometry. This device is based on the theory of the first order differential aspiration condenser described by Puumalainen. Unlike the original device proposed by Puumalainen, the electric field is swept in discrete steps and can be control by user for specific application. Tammet transform is introduced to our system for expanding gas recognition ability. The result shows our system is capable for low-ppm level gas detection.
离子迁移谱法是一种广泛应用于有害化合物检测的技术。IMS可以在大气条件下工作,检测限低,响应时间快。它在化学战剂,有毒工业化合物和爆炸物的检测等各种应用中受到欢迎。在本文中,我们提出了一种低成本、易于组装的离子迁移谱仪。该装置是根据普玛莱宁所描述的一阶微分吸气冷凝器的理论设计的。与Puumalainen提出的原始设备不同,该设备的电场扫描是离散的步骤,可以由用户控制特定应用。为了提高气体识别能力,在系统中引入了Tammet变换。结果表明,该系统能够进行低ppm水平的气体检测。
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引用次数: 0
Analysis of the multiple ultrasound echoes for measurement of cortical bone thickness 多层超声回波测量皮质骨厚度的分析
Muhamad Khairul Ali Hassan, K. Nagamune
Ultrasound is one of the low cost, and accurate techniques used in clinical practice to diagnose bone characteristics such as bone mineral, bone thickness etc. Many researchers had done experiment using ultrasound transducer in many applications. In determination of bone thickness, some researchers successfully implemented pulse echo technique using a pair of transducers (i.e. transmitter and receiver). However, this study focused on the analysis of the multiple echoes in the cortical bone and determined the correct echoes about the cortical bone using pulse echo method. Based on determined echoes, the flight time of echo from surface of the bone to other surface of the bone was determined for measuring the bone thickness. These measurements are carried out using one transducer that reacts as transmitter and receiver at the same time. Then, bone thickness value was compared with manual thickness measurement using vernier caliper for validation of the process. The results showed that ultrasound pulse echo method provided small errors in the cortical bone thickness measurement, 5.31% which is corresponding to 0.05 mm different. The 90% confidential interval for the bone thickness measurement was 0.024 to 0.124.
超声是一种低成本、准确的诊断骨矿物、骨厚度等骨特征的技术。许多研究者对超声换能器在许多方面的应用做了实验。在测定骨厚度方面,一些研究人员成功地利用一对换能器(即发射器和接收器)实现了脉冲回波技术。然而,本研究重点分析了皮质骨的多重回波,并利用脉冲回波法确定了皮质骨的正确回波。根据确定的回波,确定回波从骨表面到骨其他表面的飞行时间,用于测量骨厚度。这些测量是使用一个传感器同时作为发送器和接收器进行的。然后,将骨厚度值与手工测量的游标卡尺厚度值进行比较,验证工艺。结果表明,超声脉冲回波法测量皮质骨厚度误差较小,误差为5.31%,误差为0.05 mm。骨厚度测量的90%保密区间为0.024 ~ 0.124。
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引用次数: 2
High-fidelity data transmission of multi vital signs for distributed e-health applications 分布式电子医疗应用中多生命体征的高保真数据传输
Jia-Li Ma, Mubo Chen, M. Dong
Developing a portable e-health system based on mobile devices such as smart phone or iPad etc. to monitor and diagnose cardiovascular diseases (CVDs) easily, timely and flexibly is attractive and flourishing with the benefit of vigorous development of embedded-link technology and e-health. Yet, confronting the numerous CVDs, complicated medical diagnosis and users' increasing requirements, these source-limited portable devices are rather restricted to handle such emerging issues. Thus, a remote backyard on-line support and assistance center in such a distributed e-health system is necessitated to perform instant feedback upon users' help requests. To ensure prompt and reliable communication between thousands mobile devices and support center, fast and accurate multi vital signs transmission using high efficient compression/decompression technique becomes the kernel of success or failure. This paper tackles such a bottleneck problem, presents a versatile and high-fidelity multi vital signs compression method using adaptive Fourier decomposition to decompose signal beat into weighted orthogonal components. An intelligent signal type detection and automatic parameter adjustment scheme is designed and implemented, thus compress different bio-signals with compression ratio (CR) > 5.6 and normalized percentage relative difference (PRDN) <; 7.3%. Validated by transmitting various vital signs, such as electrocardiography (ECG), sphygmography (SPG) and heart sound (HS) signals, the proposed method exhibits universal and robust applicability for multi vital signs and achieves competitive performance compared with prior works, making distributed e-health applications be realistic.
随着嵌入式链接技术和电子医疗的蓬勃发展,开发基于智能手机、iPad等移动设备的便携式电子医疗系统,方便、及时、灵活地监测和诊断心血管疾病,是一种极具吸引力和蓬勃发展的系统。然而,面对数量众多的cvd、复杂的医疗诊断和用户日益增长的需求,这些源受限的便携式设备在处理这些新出现的问题时相当有限。因此,在这种分布式电子卫生系统中,需要一个远程后院在线支持和援助中心来对用户的帮助请求进行即时反馈。为了确保数千台移动设备与支持中心之间的及时可靠通信,采用高效的压缩/解压技术快速准确地传输多生命体征成为成败的核心。本文针对这一瓶颈问题,提出了一种通用的高保真多生命体征压缩方法,利用自适应傅立叶分解将信号节拍分解为加权正交分量。设计并实现了一种智能信号类型检测和参数自动调整方案,实现了对不同生物信号的压缩,压缩比(CR) > 5.6,归一化百分比相对差(PRDN) <;7.3%。通过传输各种生命体征,如心电图(ECG)、血液学(SPG)和心音(HS)信号进行验证,该方法具有多生命体征的通用性和鲁棒性,与先前的工作相比,具有竞争力的性能,使分布式电子健康应用成为现实。
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引用次数: 5
Event-related spectral perturbations and phase synchronization of EEG during natural auditory memory retrieval task 自然听觉记忆提取任务中脑电图的事件相关谱摄动与相位同步
Y. Tseng, C. Kuo, M. Liou
Brain oscillations and connectivity have received considerable attention in cognitive neuroscience. In this study, we recorded the electroencephlography (EEG) signals of thirteen subjects recruited for the natural auditory memory retrieval task. EEGs were recorded using an electrode cap with event-related potentials (ERPs) and event-related spectral perturbations (ERSPs) computed. For evaluating the interaction between distinct brain regions, phase-locking value (PLV) was calculated to determine the functional connectivity for distinct frequency bands. The results of ERSPs show that there is larger delta (1-4 Hz) and theta (5-8 Hz) synchronization in the left- and midline-frontal areas for subjects when they attend to the music segments with main theme. For the desynchronization of the alpha oscillation (8-12 Hz) in the midline-occipital and parietal region, the local suppression may indicate the engagement of specific cortical areas in sensory or cognitive functions. There is also strong beta synchronization when the subjects were attending to melody similar to the main theme which may indicate the active inhibition of motor cortices. The functional connectivity is shown by calculating the phase synchronization. Since the task is mainly related to the retrieval of working memory, the phase-locking value for the theta band is significantly larger when the subjects heard the melody similar to the main theme than the condition without main-theme recognition. However, the difference of phase synchronization between main-theme condition and other sound segments is not significant. The phase synchronization is significantly larger for the condition of similar melody in the frontal-parietal, frontal-temporal, and temporal-parietal regions which may indicate the processing of memory information.
脑振荡和连通性在认知神经科学中受到了相当大的关注。在这项研究中,我们记录了13名被试的脑电图信号。使用电极帽记录脑电图,并计算事件相关电位(ERPs)和事件相关谱摄动(ERSPs)。为了评估不同脑区之间的相互作用,计算锁相值(PLV)来确定不同频段的功能连通性。ersp结果显示,当受试者听主旋律音乐片段时,左额叶和中线额叶区域的δ (1-4 Hz)和θ (5-8 Hz)同步更大。对于枕中线和顶叶区α振荡(8-12 Hz)的不同步,局部抑制可能表明特定皮质区域参与感觉或认知功能。当受试者聆听与主旋律相似的旋律时,也存在较强的β同步,这可能表明运动皮质受到积极抑制。通过对相位同步的计算,证明了系统的功能连通性。由于该任务主要涉及工作记忆的提取,当被试听到与主旋律相似的旋律时,其theta波段的锁相值明显大于没有主旋律识别的情况。而主旋律状态与其他声段的相位同步差异不显著。在旋律相似的情况下,大脑额顶叶区、额颞叶区和颞顶叶区的相位同步明显增大,这可能表明记忆信息的加工过程。
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引用次数: 0
Detection of RBC agglutination in blood typing test using integrated Light-Eye-Technology (iLeyeT) 集成光眼技术(iLeyeT)检测血型试验中红细胞凝集
Yaw-Jen Chang, Walter H. Chang, Yu-Te Lin
Blood typing is a critical test in many medical procedures, especially for blood transfusion. Incompatible red blood cells (RBCs) in transfusion might result in intravascular hemolysis and even cause recipient's death. The test result of blood typing can be determined by observing the agglutination of RBCs. In this study, a novel method for determining the extent of RBC agglutination using the integrated Light-Eye Technology (iLeyeT) system is presented. Blood typing tests based on manual polybrene technique were carried out in microchambers. If RBC agglutination occurs, the laser beam provided by the iLeyeT system is blocked and a reduced laser power is measured. The experimental results show that green laser beam had better performance and successful determinations of RBC agglutinations in blood typing tests were achieved by means of iLeyeT system.
在许多医疗程序中,尤其是输血过程中,血型是一项至关重要的测试。输血中不相容的红细胞可能导致血管内溶血,甚至导致受者死亡。通过观察红细胞凝集情况,可以确定血型的检测结果。在这项研究中,提出了一种利用集成光眼技术(iLeyeT)系统确定红细胞凝集程度的新方法。在微室中进行了基于人工聚苯乙烯技术的血型检测。如果发生红细胞凝集,则iLeyeT系统提供的激光束被阻挡,并测量降低的激光功率。实验结果表明,绿色激光束具有较好的性能,利用iLeyeT系统可以成功地测定血型试验中的红细胞凝集。
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引用次数: 2
Integrated tracking control circuit for smart vehicle 智能车辆集成跟踪控制电路
Hou-Ming Chen, Guan-Min Chen, Wei-Chih Chen, Ci-Hua Siao, Kuang-Hao Lin
This paper presents a tracking control circuit designed with a standard TSMC 5V 0.35-μm CMOS technology for smart vehicle. The infrared rays are used to detect the distance between the traffic lanes and the vehicle position. The proposed tracking control circuit can correct the vehicle position when the vehicle represents a departure from its traffic lane. Moreover, because the external relays are replaced by integrating the MOS transistors in the control circuit, the response time and board area are effectively reduced.
提出了一种采用TSMC标准5V 0.35 μm CMOS技术设计的智能汽车跟踪控制电路。红外线用于检测车道与车辆位置之间的距离。所提出的跟踪控制电路可以在车辆偏离车道时纠正车辆位置。此外,由于在控制电路中集成MOS晶体管取代了外部继电器,有效地缩短了响应时间和电路板面积。
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引用次数: 0
Brain-robot control interface: Development and application 脑-机器人控制接口:开发与应用
Narendra Prataksita, Yi-Tseng Lin, Hung-Chyun Chou, C. Kuo
Recent advances in brain computer interface (BCI) offers its capabilities to provide a way of communication with non-muscular activity to control computers, robots, and other assistive technologies. This paper exploits the possibility towards a semiautonomous, humanoid robot personal assistant for handicapped subjects. The motor imagery (MI) utilizes the event-related desynchronization (ERD) signal to detect user intentions. The detected user intention is further used to manipulate a small-size humanoid robot. In addition, the robot may avoid collision in terms of a vision-based obstacle avoidance approach so that it can walk in an unstructured environment safely.
脑机接口(BCI)的最新进展提供了一种与非肌肉活动交流的方式,以控制计算机,机器人和其他辅助技术。本文探讨了半自主的类人机器人个人助理的可能性。运动想象(MI)利用事件相关去同步(ERD)信号来检测用户意图。将检测到的用户意图进一步用于操作小型人形机器人。此外,机器人可以通过基于视觉的避障方法避免碰撞,使其能够在非结构化环境中安全行走。
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引用次数: 6
Using wireless measuring devices and Tablet PC to improve the efficiency of vital signs data collection in hospital 利用无线测量设备和平板电脑提高医院生命体征数据采集效率
Yi-Sheng Chan, Hsin-Ju Liang, Yuan-Hsiang Lin
In order to improve the way of data collection and workflow of vital signs measurement in hospital, this paper proposed a Tablet PC based vital signs data collection and information system. This system comprises a database server, Tablet PC, and wireless devices such as blood pressure monitor, infrared thermometer and barcode scanner. The Tablet PC and wireless devices are put on a cart to serve as a mobile nursing information system unit. All of the devices have Bluetooth interface, therefore they can communicate with the Tablet PC via Bluetooth. Moreover, the designed user interface on Tablet PC can inspect patients' information and upload the collected vital signs data to a database server via wireless local area network (WLAN). The system has a pilot trial in hospital, and the results show the system can reduce the time of data transcription. Besides, the benefits of this system are also including: (1) eliminating the error rate caused by hand written, (2) providing real-time vital signs data recording and access, (3) speeding up the overall process of nursing documentation.
为了改进医院生命体征测量的数据采集方式和工作流程,本文提出了一种基于平板电脑的生命体征数据采集与信息系统。该系统由数据库服务器、平板电脑、血压计、红外体温计、条码扫描器等无线设备组成。平板电脑和无线设备放在推车上,作为移动护理信息系统单元。所有的设备都有蓝牙接口,因此它们可以通过蓝牙与平板电脑通信。此外,设计的用户界面可以在平板电脑上查看患者信息,并通过无线局域网(WLAN)将采集到的生命体征数据上传到数据库服务器。该系统已在医院进行了试运行,结果表明,该系统可以减少数据转录的时间。此外,该系统的好处还包括:(1)消除了手工书写造成的错误率;(2)提供了实时的生命体征数据记录和访问;(3)加快了护理文件的整体流程。
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引用次数: 7
期刊
2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014)
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