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2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings最新文献

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Connected vision care for eradication of preventable blindness 联网视力保健根除可预防性失明
Nataraj Kuntagod, Sanjoy Paul, S. Kumaresan, Bharath Balasubramaniam, Imtiaz Ahmed
90% of the visually impaired worldwide live in a low income setting, and 80% of all visual impairment can be prevented or cured provided, a timely care is given. A large portion of at risk population does not avail timely vision care due to low awareness and inability to afford nor access quality vision care. Generating high patient volumes by reaching out into the community is a general approach taken by many hospitals to provide quality and affordable vision care. However, all of them rely on semi-skilled field workers to reach out to the community. A significant challenge to the effectiveness of field workers is the paper-based systems they use to register patients, gather information about them, and analyze the collected data. The lack of online monitoring and access to real-time analytics makes the process inefficient when scaled across large geographies. This paper proposes a connected vision care wireless solution comprising of a mobile decision support system and an analysis and reporting server connected via an existing cellular infrastructure. This solution upgrades every field worker to a knowledge worker, enables automatic compliance and status tracking of patients, and provides real-time analysis for efficient program management. This paper highlights the improved efficiency of the vision care program achieved using the solution in a field trial conducted by Sankara Eye Care hospital in Tamil Nadu, India.
全世界90%的视障者生活在低收入环境中,如果及时提供护理,80%的视障者是可以预防或治愈的。很大一部分高危人群由于意识不高、负担不起或无法获得高质量的视力保健而无法及时获得视力保健。通过接触社区来增加患者数量是许多医院提供高质量和负担得起的视力护理的一般方法。然而,他们都依靠半熟练的现场工作人员来接触社区。现场工作人员的有效性面临的一个重大挑战是他们用来登记患者、收集患者信息和分析收集到的数据的基于纸张的系统。缺乏在线监控和访问实时分析使得该流程在跨大地域扩展时效率低下。本文提出了一种连接的视觉护理无线解决方案,包括移动决策支持系统和通过现有蜂窝基础设施连接的分析和报告服务器。该解决方案将每个现场工作人员升级为知识工作者,实现患者的自动合规和状态跟踪,并为高效的项目管理提供实时分析。本文重点介绍了在印度泰米尔纳德邦的Sankara眼科医院进行的现场试验中,使用该解决方案提高了视力保健计划的效率。
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引用次数: 4
Combining Graph Analysis and Recurrence Plot on fMRI data fMRI数据的图分析与递归图相结合
A. Lombardi, P. Guccione, L. Mascolo, P. Taurisano, L. Fazio, G. Nico
In this work we investigate on the nonlinear properties of the brain networks using Graph Analysis and Cross Recurrence Plot. The nonlinear dynamics of the brain is analyzed using time series coming from fMRI data. Two groups of human subjects, one affected by schizophrenia and the other of healthy controls, are imaged during the completion of a working memory task. To examine the spatio-temporal properties of the BOLD signal, nonlinear recurrence properties are extracted from the time series of the most relevant voxels, using the cross recurrence plots and the corresponding measures. Then, a graph is built using such measures as weights between different brain regions (the nodes). The purpose of the paper is to give a description of the most relevant functional areas activated during the task completion and to capture the differences between the groups. Results are promising, since the methodology is still to be fully developed and explored.
在这项工作中,我们使用图分析和交叉递归图来研究大脑网络的非线性特性。利用来自功能磁共振成像数据的时间序列分析了大脑的非线性动力学。两组人类受试者,一组患有精神分裂症,另一组健康对照,在完成工作记忆任务时进行成像。为了检验BOLD信号的时空特性,利用交叉递归图和相应的度量,从最相关体素的时间序列中提取非线性递归特性。然后,使用诸如不同大脑区域(节点)之间的权重之类的度量来构建图。本文的目的是描述在任务完成过程中激活的最相关的功能区域,并捕捉组之间的差异。结果是有希望的,因为该方法仍有待充分发展和探索。
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引用次数: 2
Flow cytometer for reference measurements of blood cell concentrations with low uncertainty 流式细胞仪用于血液细胞浓度的参考测量,不确定度低
M. Kammel, A. Kummrow, M. John, S. Reitz, K. Witt, J. Neukammer
A method is described to determine cell concentrations for erythrocytes and leukocytes with typical uncertainties of 0.8% and 2%, respectively. The unique method is designed in such a way that results are traceable to SI derived units. The sample suspensions are prepared under gravimetric control. The sample volume measured in cell counting is determined by weighing, including separate density measurements. Random coincidences are a significant challenge in particle counting leading to underestimated cell concentrations. In the method described here this challenge is met by recording the integrated dead time in particle counting and applying dilution series. This method is now routinely applied to provide reference measurement values for external quality assurance of German hematology laboratories for the complete blood count.
本文描述了一种测定红细胞和白细胞浓度的方法,其典型不确定度分别为0.8%和2%。独特的方法是这样设计的,结果可追溯到SI派生单位。样品悬浮液是在重量控制下制备的。在细胞计数中测量的样品体积是通过称重确定的,包括单独的密度测量。随机巧合是粒子计数中的一个重大挑战,导致细胞浓度被低估。在这里描述的方法中,通过记录颗粒计数中的积分死区时间和应用稀释级数来满足这一挑战。该方法现已常规应用于德国血液学实验室全血细胞计数的外部质量保证提供参考测量值。
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引用次数: 5
Improving classification of sit, stand, and lie in a smartphone human activity recognition system 改进智能手机人体活动识别系统中坐、站、躺的分类
N. A. Capela, E. Lemaire, N. Baddour
Human Activity Recognition (HAR) allows healthcare specialists to obtain clinically useful information about a person's mobility. When characterizing immobile states with a smartphone, HAR typically relies on phone orientation to differentiate between sit, stand, and lie. While phone orientation is effective for identifying when a person is lying down, sitting and standing can be misclassified since pelvis orientation can be similar. Therefore, training a classifier from this data is difficult. In this paper, a hierarchical classifier that includes the transition phases into and out of a sitting state is proposed to improve sit-stand classification. For evaluation, young (age 26 ± 8.9 yrs) and senior (age 73 ± 5.9yrs) participants wore a Blackberry Z10 smartphone on their right front waist and performed a continuous series of 16 activities of daily living. Z10 accelerometer and gyroscope data were processed with a custom HAR classifier that used previous state awareness and transition identification to classify immobile states. Immobile state classification results were compared with (WT) and without (WOT) transition identification and previous state awareness. The WT classifier had significantly greater sit sensitivity and F-score (p<;0.05) than WOT. Stand specificity and F-score for WT were significantly greater than WOT for seniors. WT sit sensitivity was greater than WOT for the young population, though not significantly. All outcomes improved for the young population. These results indicated that examining the transition period before an immobile state can improve immobile state recognition. Sit-stand classification on a continuous daily activity data set was comparable to the current literature and was achieved without the use of computationally intensive feature spaces or classifiers.
人体活动识别(HAR)允许医疗保健专家获得有关患者活动的临床有用信息。当用智能手机描述静止状态时,HAR通常依赖于手机的方向来区分坐、站和躺。虽然手机的方向可以有效地识别一个人是躺着的,但坐着和站着可能会被错误地分类,因为骨盆的方向可能相似。因此,从这些数据中训练分类器是困难的。本文提出了一种包含坐姿转换阶段和坐姿转换阶段的分层分类器,以改进坐姿-站立分类。为了进行评估,年轻(26±8.9岁)和老年(73±5.9岁)的参与者在右前腰上佩戴黑莓Z10智能手机,并连续进行16项日常生活活动。Z10加速度计和陀螺仪数据使用自定义HAR分类器进行处理,该分类器使用先前状态感知和过渡识别对静止状态进行分类。固定状态分类结果比较了(WT)和(WOT)转移识别和先前状态感知。WT分类器的坐下敏感性和f评分显著高于WOT (p<;0.05)。老年人WT的特异性和f值显著高于WOT。年轻人群的WT敏感性大于WOT,但不显著。年轻人的所有结果都有所改善。这些结果表明,检测静止状态前的过渡时间可以提高静止状态的识别。在连续的日常活动数据集上进行坐姿-站立分类与当前文献相当,并且在不使用计算密集型特征空间或分类器的情况下实现。
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引用次数: 23
Yield-oriented biopotential amplifier design for PCB-based active dry electrodes 基于pcb的有源干电极的产量导向生物电位放大器设计
Carlos E. Teixeira, Luís H. C. Ferreira
In physiological measurement systems, the most critical stages are the transduction and the amplification, mainly when tolerances of components are taken into account. In this case, if there is a small difference between DC input voltages of the biopotential amplifier, its DC output voltage may be saturated, even when DC suppression circuits are used. In this paper, we propose an active biopotential electrode and, based on a yield-oriented analysis, a maximum gain condition that guarantees a constant DC output voltage of the proposed biopotential amplifier without using laser trimming. A DC Monte-Carlo simulation is performed to demonstrate our results and an experimental procedure is also carried out to analyze the proposed system by measuring heartbeat frequency.
在生理测量系统中,最关键的阶段是转导和放大,主要是在考虑组分的公差时。在这种情况下,如果生物电位放大器的直流输入电压相差很小,即使使用直流抑制电路,其直流输出电压也可能饱和。在本文中,我们提出了一种有源生物电位电极,并基于面向产量的分析,最大增益条件,以保证所提出的生物电位放大器的直流输出电压恒定,而无需使用激光修整。通过直流蒙特卡罗模拟来验证我们的结果,并通过测量心跳频率来分析所提出的系统。
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引用次数: 2
A novel approach for features extraction in physiological signals 生理信号特征提取的一种新方法
G. Cosoli, L. Casacanditella, F. Pietroni, Andrea Calvaresi, G. M. Revel, L. Scalise
The authors have investigated a novel processing technique, which allows to measure possibly relevant features in the ECG (Electrocardiogram) signal according to the morphology of its waveform. The aim of this work is to prove its efficacy in the assessment of the subject's Heart Rate (HR) and to broaden its use to signals coming from different biomedical sensors (based on optical, acoustical and mechanical principles) for the computation of HR. The analysis technique proposed for the identification of the main feature (R-peak) in ECG signal provides results that are comparable to those obtained with traditional approaches. The approach has also been applied to other signals related to blood flow, such as PCG (Phonocardiography), PPG (Photoplethysmography) and VCG (Vibrocardiography), where standard algorithms (i.e. Pan & Tompkins) could not be widely applied. HR results from a measurement campaign on 8 healthy subjects have shown, respect to ECG, a deviation (calculated as 2σ) of ±3.3 bpm, ±2.3 bpm and ±1.5 bpm for PCG, PPG and VCG. Future work will involve the extraction of additional features from the previous signals, with the aim of a deeper characterization of them to better describe the subject's health status.
作者研究了一种新的处理技术,可以根据其波形的形态来测量心电图信号中可能相关的特征。这项工作的目的是证明其在评估受试者心率(HR)方面的功效,并将其应用范围扩大到来自不同生物医学传感器(基于光学、声学和机械原理)的信号中,以计算HR。所提出的心电信号主要特征(r -峰)识别分析技术提供了与传统方法相当的结果。该方法也被应用于与血流相关的其他信号,如PCG(心音图)、PPG(光电容积脉搏图)和VCG(心脏振动图),其中标准算法(即Pan & Tompkins)不能广泛应用。8名健康受试者的HR测量结果显示,相对于ECG, PCG、PPG和VCG的偏差(以2σ计算)为±3.3 bpm、±2.3 bpm和±1.5 bpm。未来的工作将涉及从先前的信号中提取额外的特征,目的是更深入地表征它们,以更好地描述受试者的健康状况。
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引用次数: 28
A Digital Image Correlation based technique to control the development of a skeletal muscle engineered tissue by measuring its surface strain field 基于数字图像相关技术,通过测量骨骼肌工程组织的表面应变场来控制其发育
E. Rizzuto, S. Carosio, A. Musarò, Z. Prete
X-MET (Ex-vivo Muscle Engineered Tissue) is a promising 3-dimensional model of skeletal muscle for in vitro tests and in vivo transplant. X-MET is an in vitro cultured tissue and has several properties in common with adult skeletal muscle, from biological and morphological to functional ones. To monitor the X-MET's growing improvements, we developed an experimental system based on Digital Image Correlation (DIC) to precisely measure the tissue's contractile capability, thus trying to prevent the formation of any anisotropic or inhomogeneous parts. We employed a high speed camera mounted on a stereomicroscope, and synchronized the image acquisition with the electrical stimulation and the force response measurement. The capability of measuring the 2-dimensional surface strain field in any desired Region Of Interest (ROI) allowed to obtain a comprehensive monitoring of the tissue's formation, both at a global and a local level. Preliminary results confirmed the adequacy of the system to measure tissue's strain field in complete accordance with the force measurement. Moreover, an in-depth analysis allowed to precisely pinpoint the sub-zones where discontinuities arise during tissue formation, returning essential information to improve X-MET generation process.
X-MET(离体肌肉工程组织)是一种很有前途的骨骼肌三维模型,可用于体外试验和体内移植。X-MET是一种体外培养组织,具有与成人骨骼肌在生物学、形态学和功能上的一些共同特性。为了监测X-MET的不断改进,我们开发了一个基于数字图像相关(DIC)的实验系统,以精确测量组织的收缩能力,从而试图防止任何各向异性或不均匀部分的形成。采用安装在立体显微镜上的高速摄像机,将图像采集与电刺激和力响应测量同步进行。在任何期望的感兴趣区域(ROI)测量二维表面应变场的能力允许在全球和局部水平上获得对组织形成的全面监测。初步结果证实了系统测量组织应变场的充分性,完全符合力的测量。此外,深入分析可以精确定位组织形成过程中出现不连续性的子区域,返回重要信息,以改善X-MET的生成过程。
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引用次数: 4
A smartphone-enhanced pill-dispenser providing patient identification and in-take recognition 智能手机增强的药丸分配器,提供患者身份识别和服药识别
C. Crema, A. Depari, A. Flammini, Mirko Lavarini, E. Sisinni, A. Vezzoli
The wider and wider availability of powerful, low-cost mobile devices (e.g., smartphones or tablets) is deeply changing healthcare, so that the mHealth term has been coined. The announcement of healthcare projects by market big players as Apple and Samsung confirms this trend. In particular, the opportunity to collect reliable patient data automatically allows to enhance patient/user self-management and helps in better delivering therapies. In this paper, authors propose an innovative architecture for a smart pill-dispenser enhanced by a smartdevice that furnishes the capability of automatically identifying the user, other than logging medicine in-take activities. A real-world prototype, based on an emulated pill-dispenser connected via an NFC link to different smartdevices, has been purposely realized. Experimental tests confirm the architecture feasibility. Low-cost requirements are satisfied and a user-friendly interface has been implemented.
功能强大、成本低廉的移动设备(如智能手机或平板电脑)越来越普及,正在深刻地改变医疗保健,因此移动医疗(mHealth)一词应运而生。苹果和三星等市场巨头宣布的医疗保健项目证实了这一趋势。特别是,自动收集可靠的患者数据的机会可以增强患者/用户的自我管理,并有助于更好地提供治疗。在本文中,作者提出了一种创新的智能分配器架构,该架构由智能设备增强,该智能设备提供了自动识别用户的能力,而不是记录服药活动。一个真实世界的原型,基于一个模拟的药丸分配器,通过NFC连接到不同的智能设备,已经有意实现。实验验证了该架构的可行性。满足了低成本的要求,并且实现了用户友好的界面。
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引用次数: 22
Microsensors and energy harvesting for thermotherapy: Design and characterization 用于热疗的微传感器和能量收集:设计和表征
A. Lay-Ekuakille, G. Pagliara, P. Vergallo, M. Z. U. Rahman, D. K. Reddy, S. Casciaro, F. Conversano
Thermotherapy is often used for diverse biomedical applications. One of them is treating human body area under pain, for example, lumbar pain. Thermotherapy can be used for such purpose by means of, for instance, metal-based bands that produce heat on the area under treatment. The heat delivered by such bands end after a specific time. This is a thermotherapy system based on a contact between dedicated bands and human body area under pain. The bands generally contain materials as polyester, iron or copper, salt, cellulose, active carbons, etc... The paper presents an energy harvesting system based on Seebeck's effect using micro-thermogenerators (TEGs) that convert heat from neck to electrical energy to be used on lumbar area with a further conversion from electrical to heat. This approach, even apparently complicated, allows to use a system that can be utilized every time and for a long period. It is useful because the heat produced by human body is displaced from neck to another area of the same body.
热疗法通常用于各种生物医学应用。其中之一是治疗人体疼痛部位,例如腰痛。热疗法可用于这种目的,例如,通过在治疗区域产生热量的金属基带。这种波段传递的热量在特定时间后结束。这是一种热疗系统,它的基础是在疼痛的情况下,专用带与人体部位接触。带通常含有聚酯、铁或铜、盐、纤维素、活性炭等材料。本文介绍了一种基于塞贝克效应的能量收集系统,该系统使用微型热发生器(TEGs)将颈部的热量转化为电能,再将电能转化为热能,用于腰部。这种方法,即使看起来很复杂,也允许使用一个每次都可以长期使用的系统。这是有用的,因为人体产生的热量从颈部转移到同一身体的其他部位。
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引用次数: 1
New formulations for realization and characterization of homogeneous tissue mimicking materials for HIFU exposures 用于HIFU暴露的均匀组织模拟材料的实现和表征的新配方
A. Troia, R. Cuccaro, A. Schiavi
In this paper a novel formulation for the realization of homogenous transparent and tunable attenuating tissue-mimicking materials (TMMs) has been reported. Although many hydrogel based materials have been proposed for high intensity ultrasonic field characterization, no one fully satisfies the requested acoustic and optical properties. Using concentrated salts solutions and different polysaccharide molecules, a simple preparation method has been developed to obtain this new class of TMMs. Physical properties of these TMMs have been investigated by an accurate mechanical and acoustic characterization. Furthermore, a short discussion about the mechanism of ultrasonic attenuation given by salts solutions embedded in polymeric matrix has been conducted. Finally, by means of an experiment on protein denaturation induced by HIFU, the different mechanism underlying lesions formation occurring in a transparent TMM with and without salt has been revealed. Shown results supply a new starting point for the production of TMMs suitable for HIFU characterization.
本文报道了一种实现均匀透明可调谐衰减组织模拟材料(TMMs)的新配方。虽然许多水凝胶基材料已被提出用于高强度超声场表征,但没有一种材料完全满足所要求的声学和光学性能。利用浓缩盐溶液和不同的多糖分子,开发了一种简单的制备方法,得到了这类新型的TMMs。通过精确的力学和声学表征研究了这些TMMs的物理性质。此外,还对盐溶液包埋在聚合物基体中的超声波衰减机理进行了初步探讨。最后,通过HIFU诱导的蛋白变性实验,揭示了含盐和不含盐透明TMM病变形成的不同机制。所显示的结果为生产适合HIFU表征的TMMs提供了新的起点。
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引用次数: 4
期刊
2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings
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