Pub Date : 2015-05-07DOI: 10.1109/MeMeA.2015.7145249
Manuel Schimmack, A. Hand, Paolo Mercorelli, A. Georgiadis
An orthosis embedded with a surface electromyography (sEMG) measurement system, integrated with metal-polymer composite fibers, was used to monitor the electrical activity of the forearm muscles during movement. The comfortable and noninvasive sEMG system was developed for long term monitoring during rehabilitation. Wavelets were used to denoise and compress the raw biosignals. The focus here is a comparison of the usefulness of the Haars and Daubechies wavelets in this process, using the Discrete Wavelet Transform (DWT) version of Wavelet Package Transform (WPT). A denoising algorithm is proposed to detect unavoidable measured noise in the acquired data, which uses a seminorm to define the noise. Using this norm it is possible to rearrange the wavelet basis, which can illuminate the differences between the coherent and incoherent parts of the sequence, where incoherent refers to the part of the signal that has either no information or contradictory information. In effect, the procedure looks for the subspace characterized either by small components or by opposing components in the wavelet domain. The proposed method is general, can be applied to any low frequency signal processing, and was built with wavelet algorithms from the WaveLab 850 library of the Stanford University (USA).
{"title":"Using a seminorm for wavelet denoising of sEMG signals for monitoring during rehabilitation with embedded orthosis system","authors":"Manuel Schimmack, A. Hand, Paolo Mercorelli, A. Georgiadis","doi":"10.1109/MeMeA.2015.7145249","DOIUrl":"https://doi.org/10.1109/MeMeA.2015.7145249","url":null,"abstract":"An orthosis embedded with a surface electromyography (sEMG) measurement system, integrated with metal-polymer composite fibers, was used to monitor the electrical activity of the forearm muscles during movement. The comfortable and noninvasive sEMG system was developed for long term monitoring during rehabilitation. Wavelets were used to denoise and compress the raw biosignals. The focus here is a comparison of the usefulness of the Haars and Daubechies wavelets in this process, using the Discrete Wavelet Transform (DWT) version of Wavelet Package Transform (WPT). A denoising algorithm is proposed to detect unavoidable measured noise in the acquired data, which uses a seminorm to define the noise. Using this norm it is possible to rearrange the wavelet basis, which can illuminate the differences between the coherent and incoherent parts of the sequence, where incoherent refers to the part of the signal that has either no information or contradictory information. In effect, the procedure looks for the subspace characterized either by small components or by opposing components in the wavelet domain. The proposed method is general, can be applied to any low frequency signal processing, and was built with wavelet algorithms from the WaveLab 850 library of the Stanford University (USA).","PeriodicalId":277757,"journal":{"name":"2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125912074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-05-07DOI: 10.1109/MeMeA.2015.7145197
Ting-Ying Wei, C. Young
Past researches showed that neurofeedback training can enhance cognitive function. This study used alpha rhythm (8-12Hz) to conduct brain induced training. It proposed the use of Bluetooth Low Energy to connect the EEG signals to the smartphone. Then, the pattern of the interface will display the induced alpha energy. The result of the experiment indicates that the alpha power showed on the phone has a significant memory increase in the results of the memory of cognitive brain training.
{"title":"A mobile approach for neurofeedback cognitive enhancement","authors":"Ting-Ying Wei, C. Young","doi":"10.1109/MeMeA.2015.7145197","DOIUrl":"https://doi.org/10.1109/MeMeA.2015.7145197","url":null,"abstract":"Past researches showed that neurofeedback training can enhance cognitive function. This study used alpha rhythm (8-12Hz) to conduct brain induced training. It proposed the use of Bluetooth Low Energy to connect the EEG signals to the smartphone. Then, the pattern of the interface will display the induced alpha energy. The result of the experiment indicates that the alpha power showed on the phone has a significant memory increase in the results of the memory of cognitive brain training.","PeriodicalId":277757,"journal":{"name":"2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124050275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-05-07DOI: 10.1109/MEMEA.2015.7145182
F. Palorini, D. Origgi, M. Guernieri, A. Troia, C. Magnetto, G. Durando
A framework for the evaluation of temperature increase in a tissue-mimicking material (TMM) induced by a clinical Ultrasound-guided High Intensity Focused Ultrasound (US-guided HIFU) system was developed. HIFU procedures are minimally invasive treatments that achieve deep tumor ablation, with the sparing of normal tissues, through thermal or mechanical effects induced by a HIFU beam generated with a focused transducer. Temperature evaluation is therefore crucial for the assurance of patient safety and treatment effectiveness. Nevertheless, it is a very difficult task on the US-guided systems, where high-pressure fields are involved. As far as we know, this study is the first attempt of temperature evaluation on a clinical US-guided HIFU system. Temperature evaluation was performed at typical clinical settings (between 80 W and 400 W, for 3s sonications) by the use of needle thermocouples connected to a voltmeter and inserted in a polyacrylamide gel phantom, prepared in-house to reproduce soft tissue behavior. Data sampling was performed with the use of acquisition software developed with LabView, while US-imaging was used to verify the position of the thermocouple. Typical rising curves of temperature were recovered, and rapid decrease was found when the HIFU field turned off. The highest temperature increases were concentrated inside the geometrical focus and were higher than 55 Celsius degrees at all power outputs. Repetition of measurements was not possible after sonications at the highest power outputs (400W). The absolute temperature of 98 Celsius degrees was never exceeded.
{"title":"Measurements of temperature increase induced on a tissue-mimicking material by a clinical US-guided HIFU system","authors":"F. Palorini, D. Origgi, M. Guernieri, A. Troia, C. Magnetto, G. Durando","doi":"10.1109/MEMEA.2015.7145182","DOIUrl":"https://doi.org/10.1109/MEMEA.2015.7145182","url":null,"abstract":"A framework for the evaluation of temperature increase in a tissue-mimicking material (TMM) induced by a clinical Ultrasound-guided High Intensity Focused Ultrasound (US-guided HIFU) system was developed. HIFU procedures are minimally invasive treatments that achieve deep tumor ablation, with the sparing of normal tissues, through thermal or mechanical effects induced by a HIFU beam generated with a focused transducer. Temperature evaluation is therefore crucial for the assurance of patient safety and treatment effectiveness. Nevertheless, it is a very difficult task on the US-guided systems, where high-pressure fields are involved. As far as we know, this study is the first attempt of temperature evaluation on a clinical US-guided HIFU system. Temperature evaluation was performed at typical clinical settings (between 80 W and 400 W, for 3s sonications) by the use of needle thermocouples connected to a voltmeter and inserted in a polyacrylamide gel phantom, prepared in-house to reproduce soft tissue behavior. Data sampling was performed with the use of acquisition software developed with LabView, while US-imaging was used to verify the position of the thermocouple. Typical rising curves of temperature were recovered, and rapid decrease was found when the HIFU field turned off. The highest temperature increases were concentrated inside the geometrical focus and were higher than 55 Celsius degrees at all power outputs. Repetition of measurements was not possible after sonications at the highest power outputs (400W). The absolute temperature of 98 Celsius degrees was never exceeded.","PeriodicalId":277757,"journal":{"name":"2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings","volume":"103 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124781569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-05-07DOI: 10.1109/MeMeA.2015.7145254
Aydin Saribudak, S. Gundry, Jianmin Zou, M. U. Uyar
Personalized approach to anti-cancer therapy necessitates the adaptation of standardized guidelines for chemotherapy schedules to individual cancer patients. We introduce a methodology, namely Personalized Relevance Parameterization (PReP-G), based on the genomic data of breast cancer patients to compute time course of drug efficacy on tumor progression. The pharmacodynamic (PD) parameters of transit compartmental systems are computed to quantify the drug efficacy and kinetics of cell death. We integrate the genetic information of 74 breast cancer related genes for 78 patients with clinical t-stage of 3 from the I-SPY 1 TRIAL with the tumor volume measurements from NBIA database into our PReP-G model to compute tumor growth and shrinkage parameters. The performance of the method is evaluated for the breast cancer cell lines of BT-474, MDA-MB-435 and MDA-MB-231 for a given chemotherapy, where the anti-cancer agents Doxorubicin and Cyclophosphamide are administered to animal models and the change of tumor size is measured in time. We compare our results from PReP-G model with the experimental measurements. The consistency between computed results and the volume measurements is encouraging to develop personalized tumor growth models and decision support systems based on genetic data.
{"title":"Genomic based personalized chemotherapy analysis to support decision systems for breast cancer","authors":"Aydin Saribudak, S. Gundry, Jianmin Zou, M. U. Uyar","doi":"10.1109/MeMeA.2015.7145254","DOIUrl":"https://doi.org/10.1109/MeMeA.2015.7145254","url":null,"abstract":"Personalized approach to anti-cancer therapy necessitates the adaptation of standardized guidelines for chemotherapy schedules to individual cancer patients. We introduce a methodology, namely Personalized Relevance Parameterization (PReP-G), based on the genomic data of breast cancer patients to compute time course of drug efficacy on tumor progression. The pharmacodynamic (PD) parameters of transit compartmental systems are computed to quantify the drug efficacy and kinetics of cell death. We integrate the genetic information of 74 breast cancer related genes for 78 patients with clinical t-stage of 3 from the I-SPY 1 TRIAL with the tumor volume measurements from NBIA database into our PReP-G model to compute tumor growth and shrinkage parameters. The performance of the method is evaluated for the breast cancer cell lines of BT-474, MDA-MB-435 and MDA-MB-231 for a given chemotherapy, where the anti-cancer agents Doxorubicin and Cyclophosphamide are administered to animal models and the change of tumor size is measured in time. We compare our results from PReP-G model with the experimental measurements. The consistency between computed results and the volume measurements is encouraging to develop personalized tumor growth models and decision support systems based on genetic data.","PeriodicalId":277757,"journal":{"name":"2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124478244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-05-07DOI: 10.1109/MeMeA.2015.7145205
F. Montecchia, S. Luciani, R. Cicchetti, Rosanna Grossi, F. Midulla, C. Moretti, P. Papoff
High-flow humidified nasal cannula (HFNC) is often used to relieve respiratory distress in children with acute pulmonary disease, although its effects on respiratory mechanics have not been objectively studied. The purpose of this study was to test the feasibility of measuring pharyngeal (PP) and esophageal (Pes) pressures of young children on HFNC oxygen therapy through a specifically designed new monitoring, acquisition, and elaboration system (MAES). Through MAES we recorded and elaborated Pes and PP tracings obtained through esophageal and pharyngeal catheters in a group of young children hospitalized in a Pediatric Intensive Care Unit because of respiratory distress. All traces were recorded during spontaneous breathing and on HFNC 1 and 2 L/kg/min. To determine the onset and the end of inspiration, the Pes and PP signals were synchronized with the inspiratory flow obtained by a flow transducer placed in the HFNC circuit. Direct measurement of inspiratory flow by a face mask pneumotachograph also allowed for inspiratory tidal volume (TV) measurement which was used together with Pes curve to build Campbell's diagram as well as the static lung and chest wall recoil curves required for pressure time product (PTP) evaluation. Using MAES we were able to obtain: time interval between the beginning of inspiratory effort and inspiration (Tdelay), TV, intrinsic positive end expiratory pressure (PEEPi), total inspiratory Pes variation (ΔPes), transpulmonary pressure at end of inspiration (Ptpei), dynamic lung compliance (CLdyn), total lung resistance (RLtot) along with all the relevant components of the inspiratory work of breathing (WOB) and PTP. We believe that this new system will allow clinicians for a bedside monitoring of respiratory distress in infants treated with HFNC and to modify flow rates accordingly.
{"title":"Pharyngeal and esophageal pressure measurements to evaluate respiratory mechanics in infants on high flow nasal cannula: A feasibility study","authors":"F. Montecchia, S. Luciani, R. Cicchetti, Rosanna Grossi, F. Midulla, C. Moretti, P. Papoff","doi":"10.1109/MeMeA.2015.7145205","DOIUrl":"https://doi.org/10.1109/MeMeA.2015.7145205","url":null,"abstract":"High-flow humidified nasal cannula (HFNC) is often used to relieve respiratory distress in children with acute pulmonary disease, although its effects on respiratory mechanics have not been objectively studied. The purpose of this study was to test the feasibility of measuring pharyngeal (PP) and esophageal (Pes) pressures of young children on HFNC oxygen therapy through a specifically designed new monitoring, acquisition, and elaboration system (MAES). Through MAES we recorded and elaborated Pes and PP tracings obtained through esophageal and pharyngeal catheters in a group of young children hospitalized in a Pediatric Intensive Care Unit because of respiratory distress. All traces were recorded during spontaneous breathing and on HFNC 1 and 2 L/kg/min. To determine the onset and the end of inspiration, the Pes and PP signals were synchronized with the inspiratory flow obtained by a flow transducer placed in the HFNC circuit. Direct measurement of inspiratory flow by a face mask pneumotachograph also allowed for inspiratory tidal volume (TV) measurement which was used together with Pes curve to build Campbell's diagram as well as the static lung and chest wall recoil curves required for pressure time product (PTP) evaluation. Using MAES we were able to obtain: time interval between the beginning of inspiratory effort and inspiration (Tdelay), TV, intrinsic positive end expiratory pressure (PEEPi), total inspiratory Pes variation (ΔPes), transpulmonary pressure at end of inspiration (Ptpei), dynamic lung compliance (CLdyn), total lung resistance (RLtot) along with all the relevant components of the inspiratory work of breathing (WOB) and PTP. We believe that this new system will allow clinicians for a bedside monitoring of respiratory distress in infants treated with HFNC and to modify flow rates accordingly.","PeriodicalId":277757,"journal":{"name":"2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133517523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-05-07DOI: 10.1109/MeMeA.2015.7145220
R. Marco, S. Rossi, Benedetta Bachetti, C. Mazzà, P. Cappa
Optoelectronic systems are largely employed for human movement analysis, where marker trajectories are used to estimate the articular joint kinematics. From a literature analysis it emerged that the error associated to the joint kinematics can be reduced performing the data collection in the center of the system calibration volume. According to human movement analysis literature, the foot-ankle complex appears to be the anatomical joint most affected by instrument inaccuracy, as it moves in the lower bound of the calibration volume during the gait cycle. A multi-segment marker-based model of the lower limb - including the pelvis, thigh, tibia, hindfoot, forefoot and hallux - was investigated in this paper. One healthy subject was asked to walk on the central and on two boundary areas of the capture volume calibrated for the experiments. The calibration procedure was focused on the exploitation of the effects on the joint angles of: (i) calibration volumes (i.e. the global one and two of its sub-volumes) and (ii) number of frames acquired for the calibration procedure (refinement frames). In order to quantify the precision of estimating the joint kinematics when changing the calibration procedure, the RMSE among different refinement frames using both the global volume and the two sub-volumes was computed as an index of the joint angles variation estimated on the sagittal plane. Two two-way ANOVAs were performed to evaluate whether the calibration volumes or the walking areas affect the kinematics. The statistical analysis highlighted a good robustness of the reconstruction algorithm implemented by the optoelectronic system manufacturer. Few variables showed significant differences for the RMSEs, with p-values lower than 0.05. No clear dependence on the body segments here analyzed emerged from the analysis. The coefficient of Multiple Correlations was computed in order to enlighten the similarities among the joint angles time patterns. We conclude that reconstructed trajectories can be affected by the same magnitude errors, regardless to the calibrated volume or the considered walking area. This finding allows conducting the gait analysis without paying attention when calibrating the system and without having to impose excessive restrictions to the tested subjects, allowing to keep their movement as natural as possible.
{"title":"Effect of the calibration procedure of an optoelectronic system on the joint kinematics","authors":"R. Marco, S. Rossi, Benedetta Bachetti, C. Mazzà, P. Cappa","doi":"10.1109/MeMeA.2015.7145220","DOIUrl":"https://doi.org/10.1109/MeMeA.2015.7145220","url":null,"abstract":"Optoelectronic systems are largely employed for human movement analysis, where marker trajectories are used to estimate the articular joint kinematics. From a literature analysis it emerged that the error associated to the joint kinematics can be reduced performing the data collection in the center of the system calibration volume. According to human movement analysis literature, the foot-ankle complex appears to be the anatomical joint most affected by instrument inaccuracy, as it moves in the lower bound of the calibration volume during the gait cycle. A multi-segment marker-based model of the lower limb - including the pelvis, thigh, tibia, hindfoot, forefoot and hallux - was investigated in this paper. One healthy subject was asked to walk on the central and on two boundary areas of the capture volume calibrated for the experiments. The calibration procedure was focused on the exploitation of the effects on the joint angles of: (i) calibration volumes (i.e. the global one and two of its sub-volumes) and (ii) number of frames acquired for the calibration procedure (refinement frames). In order to quantify the precision of estimating the joint kinematics when changing the calibration procedure, the RMSE among different refinement frames using both the global volume and the two sub-volumes was computed as an index of the joint angles variation estimated on the sagittal plane. Two two-way ANOVAs were performed to evaluate whether the calibration volumes or the walking areas affect the kinematics. The statistical analysis highlighted a good robustness of the reconstruction algorithm implemented by the optoelectronic system manufacturer. Few variables showed significant differences for the RMSEs, with p-values lower than 0.05. No clear dependence on the body segments here analyzed emerged from the analysis. The coefficient of Multiple Correlations was computed in order to enlighten the similarities among the joint angles time patterns. We conclude that reconstructed trajectories can be affected by the same magnitude errors, regardless to the calibrated volume or the considered walking area. This finding allows conducting the gait analysis without paying attention when calibrating the system and without having to impose excessive restrictions to the tested subjects, allowing to keep their movement as natural as possible.","PeriodicalId":277757,"journal":{"name":"2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131298149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-05-07DOI: 10.1109/MeMeA.2015.7145186
B. Karaboce
The temperature distribution produced by a HIFU (High Intensity Focused Ultrasound) transducer has been investigated by a set up using T type thermocouple temperature sensors in the automated scanning system. The temperature change and the temperature distribution due to applied ultrasound power have been characterized. The temperature measurements were carried out in a tissue-mimicking material (TMM) that has characteristics very similar to human tissue and in ex vivo tissue. A temperature measurement set up in a tissue phantom has been constructed at TÜBİTAK UME (The Scientific and Technological Research Council of Turkey, the National Metrology Institute) Ultrasound laboratory. Burning and removing the tissue by high power ultrasound have been showed.
{"title":"Focused ultrasound temperature effect in tissue-mimicking material and sheep liver","authors":"B. Karaboce","doi":"10.1109/MeMeA.2015.7145186","DOIUrl":"https://doi.org/10.1109/MeMeA.2015.7145186","url":null,"abstract":"The temperature distribution produced by a HIFU (High Intensity Focused Ultrasound) transducer has been investigated by a set up using T type thermocouple temperature sensors in the automated scanning system. The temperature change and the temperature distribution due to applied ultrasound power have been characterized. The temperature measurements were carried out in a tissue-mimicking material (TMM) that has characteristics very similar to human tissue and in ex vivo tissue. A temperature measurement set up in a tissue phantom has been constructed at TÜBİTAK UME (The Scientific and Technological Research Council of Turkey, the National Metrology Institute) Ultrasound laboratory. Burning and removing the tissue by high power ultrasound have been showed.","PeriodicalId":277757,"journal":{"name":"2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131889798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-05-07DOI: 10.1109/MeMeA.2015.7145185
A. Troia, R. Cuccaro, A. Schiavi
In this paper a novel formulation for the realization of homogenous transparent and tunable attenuating tissue-mimicking materials (TMMs) has been reported. Although many hydrogel based materials have been proposed for high intensity ultrasonic field characterization, no one fully satisfies the requested acoustic and optical properties. Using concentrated salts solutions and different polysaccharide molecules, a simple preparation method has been developed to obtain this new class of TMMs. Physical properties of these TMMs have been investigated by an accurate mechanical and acoustic characterization. Furthermore, a short discussion about the mechanism of ultrasonic attenuation given by salts solutions embedded in polymeric matrix has been conducted. Finally, by means of an experiment on protein denaturation induced by HIFU, the different mechanism underlying lesions formation occurring in a transparent TMM with and without salt has been revealed. Shown results supply a new starting point for the production of TMMs suitable for HIFU characterization.
{"title":"New formulations for realization and characterization of homogeneous tissue mimicking materials for HIFU exposures","authors":"A. Troia, R. Cuccaro, A. Schiavi","doi":"10.1109/MeMeA.2015.7145185","DOIUrl":"https://doi.org/10.1109/MeMeA.2015.7145185","url":null,"abstract":"In this paper a novel formulation for the realization of homogenous transparent and tunable attenuating tissue-mimicking materials (TMMs) has been reported. Although many hydrogel based materials have been proposed for high intensity ultrasonic field characterization, no one fully satisfies the requested acoustic and optical properties. Using concentrated salts solutions and different polysaccharide molecules, a simple preparation method has been developed to obtain this new class of TMMs. Physical properties of these TMMs have been investigated by an accurate mechanical and acoustic characterization. Furthermore, a short discussion about the mechanism of ultrasonic attenuation given by salts solutions embedded in polymeric matrix has been conducted. Finally, by means of an experiment on protein denaturation induced by HIFU, the different mechanism underlying lesions formation occurring in a transparent TMM with and without salt has been revealed. Shown results supply a new starting point for the production of TMMs suitable for HIFU characterization.","PeriodicalId":277757,"journal":{"name":"2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125736967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-05-07DOI: 10.1109/MeMeA.2015.7145258
M. Kammel, A. Kummrow, M. John, S. Reitz, K. Witt, J. Neukammer
A method is described to determine cell concentrations for erythrocytes and leukocytes with typical uncertainties of 0.8% and 2%, respectively. The unique method is designed in such a way that results are traceable to SI derived units. The sample suspensions are prepared under gravimetric control. The sample volume measured in cell counting is determined by weighing, including separate density measurements. Random coincidences are a significant challenge in particle counting leading to underestimated cell concentrations. In the method described here this challenge is met by recording the integrated dead time in particle counting and applying dilution series. This method is now routinely applied to provide reference measurement values for external quality assurance of German hematology laboratories for the complete blood count.
{"title":"Flow cytometer for reference measurements of blood cell concentrations with low uncertainty","authors":"M. Kammel, A. Kummrow, M. John, S. Reitz, K. Witt, J. Neukammer","doi":"10.1109/MeMeA.2015.7145258","DOIUrl":"https://doi.org/10.1109/MeMeA.2015.7145258","url":null,"abstract":"A method is described to determine cell concentrations for erythrocytes and leukocytes with typical uncertainties of 0.8% and 2%, respectively. The unique method is designed in such a way that results are traceable to SI derived units. The sample suspensions are prepared under gravimetric control. The sample volume measured in cell counting is determined by weighing, including separate density measurements. Random coincidences are a significant challenge in particle counting leading to underestimated cell concentrations. In the method described here this challenge is met by recording the integrated dead time in particle counting and applying dilution series. This method is now routinely applied to provide reference measurement values for external quality assurance of German hematology laboratories for the complete blood count.","PeriodicalId":277757,"journal":{"name":"2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116497809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-05-07DOI: 10.1109/MeMeA.2015.7145232
G. Cosoli, L. Casacanditella, F. Pietroni, Andrea Calvaresi, G. M. Revel, L. Scalise
The authors have investigated a novel processing technique, which allows to measure possibly relevant features in the ECG (Electrocardiogram) signal according to the morphology of its waveform. The aim of this work is to prove its efficacy in the assessment of the subject's Heart Rate (HR) and to broaden its use to signals coming from different biomedical sensors (based on optical, acoustical and mechanical principles) for the computation of HR. The analysis technique proposed for the identification of the main feature (R-peak) in ECG signal provides results that are comparable to those obtained with traditional approaches. The approach has also been applied to other signals related to blood flow, such as PCG (Phonocardiography), PPG (Photoplethysmography) and VCG (Vibrocardiography), where standard algorithms (i.e. Pan & Tompkins) could not be widely applied. HR results from a measurement campaign on 8 healthy subjects have shown, respect to ECG, a deviation (calculated as 2σ) of ±3.3 bpm, ±2.3 bpm and ±1.5 bpm for PCG, PPG and VCG. Future work will involve the extraction of additional features from the previous signals, with the aim of a deeper characterization of them to better describe the subject's health status.
{"title":"A novel approach for features extraction in physiological signals","authors":"G. Cosoli, L. Casacanditella, F. Pietroni, Andrea Calvaresi, G. M. Revel, L. Scalise","doi":"10.1109/MeMeA.2015.7145232","DOIUrl":"https://doi.org/10.1109/MeMeA.2015.7145232","url":null,"abstract":"The authors have investigated a novel processing technique, which allows to measure possibly relevant features in the ECG (Electrocardiogram) signal according to the morphology of its waveform. The aim of this work is to prove its efficacy in the assessment of the subject's Heart Rate (HR) and to broaden its use to signals coming from different biomedical sensors (based on optical, acoustical and mechanical principles) for the computation of HR. The analysis technique proposed for the identification of the main feature (R-peak) in ECG signal provides results that are comparable to those obtained with traditional approaches. The approach has also been applied to other signals related to blood flow, such as PCG (Phonocardiography), PPG (Photoplethysmography) and VCG (Vibrocardiography), where standard algorithms (i.e. Pan & Tompkins) could not be widely applied. HR results from a measurement campaign on 8 healthy subjects have shown, respect to ECG, a deviation (calculated as 2σ) of ±3.3 bpm, ±2.3 bpm and ±1.5 bpm for PCG, PPG and VCG. Future work will involve the extraction of additional features from the previous signals, with the aim of a deeper characterization of them to better describe the subject's health status.","PeriodicalId":277757,"journal":{"name":"2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124053027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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