Pub Date : 2015-07-02DOI: 10.1109/MeMeA.2015.7145247
Siyu He, J. Gómez-Tames, Wenwei Yu
Needle EMG (Electromyogram) Exam (NEE) is an important neurological exam, and neurology interns and novice medical need repetitive training to gain the necessary skill to perform the exam. However, until now it has been difficult to reproduce multiple pathological conditions for their training, since in most cases, trainees serve as human subjects for each other. A robotic simulator that could reproduce behavior with various pathological disorders can be of great help for NEE skill training. Needle tip localization is a key component of the robotic simulator, since position-dependent-EMG is the signal source for skilled neurologists to determine the pathological situation. The needle tip localization has been investigated for many medical tests and applications, such as prostate brachytherapy, etc. However, only few studies have been reported on the process of needle operation in muscle based on EMG signals dependent on needle tip position. Our idea is to apply a tissue-like conductive phantom so as to realize both physical sense of insertion, and needle localization for the NEE robotic simulator. A pair of electrodes was designed to generate a near-linear voltage distribution along the depth direction of the tissue-like phantom, by which the inserted needle could be localized. The influence of the shape of phantom and electrodes on detection accuracy were investigated by a set of measurement experiment and a computer simulation. The results showed that, the estimated depth values agreed with that of the computer simulation model, and the curved phantom had a much steeper distribution in the deeper region (better accuracy for needle tip detection).
{"title":"Needle detection by electro-localization for a needle EMG exam robotic simulator","authors":"Siyu He, J. Gómez-Tames, Wenwei Yu","doi":"10.1109/MeMeA.2015.7145247","DOIUrl":"https://doi.org/10.1109/MeMeA.2015.7145247","url":null,"abstract":"Needle EMG (Electromyogram) Exam (NEE) is an important neurological exam, and neurology interns and novice medical need repetitive training to gain the necessary skill to perform the exam. However, until now it has been difficult to reproduce multiple pathological conditions for their training, since in most cases, trainees serve as human subjects for each other. A robotic simulator that could reproduce behavior with various pathological disorders can be of great help for NEE skill training. Needle tip localization is a key component of the robotic simulator, since position-dependent-EMG is the signal source for skilled neurologists to determine the pathological situation. The needle tip localization has been investigated for many medical tests and applications, such as prostate brachytherapy, etc. However, only few studies have been reported on the process of needle operation in muscle based on EMG signals dependent on needle tip position. Our idea is to apply a tissue-like conductive phantom so as to realize both physical sense of insertion, and needle localization for the NEE robotic simulator. A pair of electrodes was designed to generate a near-linear voltage distribution along the depth direction of the tissue-like phantom, by which the inserted needle could be localized. The influence of the shape of phantom and electrodes on detection accuracy were investigated by a set of measurement experiment and a computer simulation. The results showed that, the estimated depth values agreed with that of the computer simulation model, and the curved phantom had a much steeper distribution in the deeper region (better accuracy for needle tip detection).","PeriodicalId":277757,"journal":{"name":"2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings","volume":"1267 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123356008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-07-02DOI: 10.1109/MeMeA.2015.7145187
Nina Rudigkeit, Marion Gebhard, A. Gräser
Head-controlled Human-Machine Interfaces play an important role in restoration of the autonomy of severely disabled people, like tetraplegics. In the literature, different control modes to map head movement onto a single degree of freedom of an object to be controlled have been presented. However, the control modes have not been compared with each other under different conditions. With the work presented in this paper, we close this gap by evaluating two of the most promising control modes, namely position mode and velocity mode. These modes were tested under different conditions in order to highlight their advantages and disadvantages and to make suggestions which mode should be used for a particular application. Head movements were measured using a smart 9-axis motion sensor system. The mouse cursor control was considered as an example application for which control modes were compared subjectively as well as objectively. The objective comparison was carried out using a two-dimensional Fitts' Law Test at two different distances to the computer screen. Then, the modes were evaluated subjectively with an evaluation sheet. Position control mode turned out to be significantly faster than the velocity mode. On the other hand, the error rate for position mode increased significantly with the screen distance while velocity mode was insensitive to screen displacements. This was in line with the significantly higher ratings of accurate pointing for velocity mode. Because of this, the velocity mode is the preferred choice for safety-critical applications, such as robot control, while position mode should be used when speed is more important than accuracy, e.g. for cursor control. Therefore, the usefulness of the control modes depends on the application.
{"title":"Evaluation of control modes for head motion-based control with motion sensors","authors":"Nina Rudigkeit, Marion Gebhard, A. Gräser","doi":"10.1109/MeMeA.2015.7145187","DOIUrl":"https://doi.org/10.1109/MeMeA.2015.7145187","url":null,"abstract":"Head-controlled Human-Machine Interfaces play an important role in restoration of the autonomy of severely disabled people, like tetraplegics. In the literature, different control modes to map head movement onto a single degree of freedom of an object to be controlled have been presented. However, the control modes have not been compared with each other under different conditions. With the work presented in this paper, we close this gap by evaluating two of the most promising control modes, namely position mode and velocity mode. These modes were tested under different conditions in order to highlight their advantages and disadvantages and to make suggestions which mode should be used for a particular application. Head movements were measured using a smart 9-axis motion sensor system. The mouse cursor control was considered as an example application for which control modes were compared subjectively as well as objectively. The objective comparison was carried out using a two-dimensional Fitts' Law Test at two different distances to the computer screen. Then, the modes were evaluated subjectively with an evaluation sheet. Position control mode turned out to be significantly faster than the velocity mode. On the other hand, the error rate for position mode increased significantly with the screen distance while velocity mode was insensitive to screen displacements. This was in line with the significantly higher ratings of accurate pointing for velocity mode. Because of this, the velocity mode is the preferred choice for safety-critical applications, such as robot control, while position mode should be used when speed is more important than accuracy, e.g. for cursor control. Therefore, the usefulness of the control modes depends on the application.","PeriodicalId":277757,"journal":{"name":"2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings","volume":"185 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132064702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-05-07DOI: 10.1109/MeMeA.2015.7145231
Maria Kyrarini, Xingchen Wang, A. Gräser
Gait analysis has become recently a popular research field and been widely applied to clinical diagnosis of neurodegenerative diseases. Various low-cost sensor-based and vision-based systems are developed for capturing the hip and knee joint angles. However, the performances of these systems have not been validated and compared between each other. The purpose of this study is to set up an experiment and compare the performances of a sensor-based system with multiple inertial measurement units (IMUs), a vision-based gait analysis system with marker detection, and a markerless vision-based system on capturing the hip and knee joint angles during normal walking. The obtained measurements were validated with the data acquired from goniometers as ground truth measurement. The results indicate that the IMUs-based sensor system gives excellent performance with small errors, while vision systems produce acceptable results with slightly larger errors.
{"title":"Comparison of vision-based and sensor-based systems for joint angle gait analysis","authors":"Maria Kyrarini, Xingchen Wang, A. Gräser","doi":"10.1109/MeMeA.2015.7145231","DOIUrl":"https://doi.org/10.1109/MeMeA.2015.7145231","url":null,"abstract":"Gait analysis has become recently a popular research field and been widely applied to clinical diagnosis of neurodegenerative diseases. Various low-cost sensor-based and vision-based systems are developed for capturing the hip and knee joint angles. However, the performances of these systems have not been validated and compared between each other. The purpose of this study is to set up an experiment and compare the performances of a sensor-based system with multiple inertial measurement units (IMUs), a vision-based gait analysis system with marker detection, and a markerless vision-based system on capturing the hip and knee joint angles during normal walking. The obtained measurements were validated with the data acquired from goniometers as ground truth measurement. The results indicate that the IMUs-based sensor system gives excellent performance with small errors, while vision systems produce acceptable results with slightly larger errors.","PeriodicalId":277757,"journal":{"name":"2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124420553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-05-07DOI: 10.1109/MEMEA.2015.7145177
A. Retico, A. Vitacolonna, A. Galante, Tiziana M. Florio, A. Cimini, R. Stara, G. Tiberi, M. Tosetti, N. Fontana, G. Manara, A. Monorchio, M. Alecci
Ultra-High Field (UHF) (4-9.4T) Magnetic Resonance Imaging (MRI) and Spectroscopy (MRS) are valuable tools in the diagnosis and monitoring of many diseases thanks to the enhanced Signal-to-Noise Ratio (SNR) and spectral/spatial resolution. However, such UHF MR applications require the development and optimization of specially designed Radio Frequency (RF) coils. In this study we report the design, construction, workbench and MR testing of a novel 7T double-tuned (1H/31P) RF surface coil made with microstrip technology. The RF coil is suitable for MRI and MRS human studies of the lower limbs and also of the human head. The double-tuned RF coil was tested at the IMAGO7 Foundation in Pisa (Italy). Ex vivo MR 1H images and 31P spectra obtained with a large size fresh calf veal sample showed an excellent SNR within about 50 mm from the RF surface coil. It is believed that the combined 7T MR 1H/31P will provide benefits in performing clinical follow-up of muscular disorders in young and aging patients. The proposed design can be easily extended to the simultaneous detection of the 1H and other low-gamma nuclei, such as 7Li, 11B, 13C, 17O, 23Na.
{"title":"A 7T double-tuned (1H/31P) microstrip surface RF coil for the IMAGO7 MR scanner","authors":"A. Retico, A. Vitacolonna, A. Galante, Tiziana M. Florio, A. Cimini, R. Stara, G. Tiberi, M. Tosetti, N. Fontana, G. Manara, A. Monorchio, M. Alecci","doi":"10.1109/MEMEA.2015.7145177","DOIUrl":"https://doi.org/10.1109/MEMEA.2015.7145177","url":null,"abstract":"Ultra-High Field (UHF) (4-9.4T) Magnetic Resonance Imaging (MRI) and Spectroscopy (MRS) are valuable tools in the diagnosis and monitoring of many diseases thanks to the enhanced Signal-to-Noise Ratio (SNR) and spectral/spatial resolution. However, such UHF MR applications require the development and optimization of specially designed Radio Frequency (RF) coils. In this study we report the design, construction, workbench and MR testing of a novel 7T double-tuned (<sup>1</sup>H/<sup>31</sup>P) RF surface coil made with microstrip technology. The RF coil is suitable for MRI and MRS human studies of the lower limbs and also of the human head. The double-tuned RF coil was tested at the IMAGO7 Foundation in Pisa (Italy). Ex vivo MR <sup>1</sup>H images and <sup>31</sup>P spectra obtained with a large size fresh calf veal sample showed an excellent SNR within about 50 mm from the RF surface coil. It is believed that the combined 7T MR <sup>1</sup>H/<sup>31</sup>P will provide benefits in performing clinical follow-up of muscular disorders in young and aging patients. The proposed design can be easily extended to the simultaneous detection of the <sup>1</sup>H and other low-gamma nuclei, such as <sup>7</sup>Li, <sup>11</sup>B, <sup>13</sup>C, <sup>17</sup>O, <sup>23</sup>Na.","PeriodicalId":277757,"journal":{"name":"2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117180444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-05-07DOI: 10.1109/MeMeA.2015.7145245
R. Vallascas, M. Usai
The aim of the work is focused on the generation of a FEM 3D model, by using Ansys code, able to arm-cuff interface simulation during deflation. For this purpose it was measured the circumferential distribution of the pressure produced by the cuff on the arm during the inflation and the deflation. The parameters of the arm have been identified by searching vessel-occluded conditions at the systolic blood pressure of the subject for the bladder/arm ratio equal to 80%. The model was validated preliminarily checking its ability to correctly simulate the phenomenon of miscuffing by comparison with the data derived from the consolidated bibliography of the sector. The code has been then applied using as external load an experimental circumferential distribution of the pressure. The model has allowed to simulate the shape of the lumen of the arterial vessel during the deflation, properly highlighting the moments in which the pressure of deflation equals the systolic and diastolic pressures of the patient.
{"title":"New FEM 3D model for arm-cuff interface simulation","authors":"R. Vallascas, M. Usai","doi":"10.1109/MeMeA.2015.7145245","DOIUrl":"https://doi.org/10.1109/MeMeA.2015.7145245","url":null,"abstract":"The aim of the work is focused on the generation of a FEM 3D model, by using Ansys code, able to arm-cuff interface simulation during deflation. For this purpose it was measured the circumferential distribution of the pressure produced by the cuff on the arm during the inflation and the deflation. The parameters of the arm have been identified by searching vessel-occluded conditions at the systolic blood pressure of the subject for the bladder/arm ratio equal to 80%. The model was validated preliminarily checking its ability to correctly simulate the phenomenon of miscuffing by comparison with the data derived from the consolidated bibliography of the sector. The code has been then applied using as external load an experimental circumferential distribution of the pressure. The model has allowed to simulate the shape of the lumen of the arterial vessel during the deflation, properly highlighting the moments in which the pressure of deflation equals the systolic and diastolic pressures of the patient.","PeriodicalId":277757,"journal":{"name":"2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114238418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-05-07DOI: 10.1109/MeMeA.2015.7145259
C. Divieto, M. Sassi
Human mesenchymal stem cells are a good candidate to repair and to regenerate tissues for regenerative medicine applications. Their use in combination with 3D scaffolds has been largely studied in vitro to characterize their properties and differentiation potential prior to apply them in vivo. One of the most important clues in vitro is given by their proliferation trend, leading to information about their viability, their wellness, their interaction with scaffolds, etc. In order to measure the proliferation of hMSCs on scaffolds for regenerative medicine, it is important to adopt accurate counting methods in both research and diagnostic studies. This work aims to develop a reproducible method for hMSCs proliferation measurement in 3D cell cultures on coralline scaffolds (Biocoral®). Results demonstrated that: proliferation curves obtained in this work are reproducible at different initial cell densities on several scaffolds cultured with hMSC in long term experiments (3 weeks).
{"title":"Reproducible measurements of human mesenchymal stem cells counting and proliferation in 3D scaffolds for regenerative medicine","authors":"C. Divieto, M. Sassi","doi":"10.1109/MeMeA.2015.7145259","DOIUrl":"https://doi.org/10.1109/MeMeA.2015.7145259","url":null,"abstract":"Human mesenchymal stem cells are a good candidate to repair and to regenerate tissues for regenerative medicine applications. Their use in combination with 3D scaffolds has been largely studied in vitro to characterize their properties and differentiation potential prior to apply them in vivo. One of the most important clues in vitro is given by their proliferation trend, leading to information about their viability, their wellness, their interaction with scaffolds, etc. In order to measure the proliferation of hMSCs on scaffolds for regenerative medicine, it is important to adopt accurate counting methods in both research and diagnostic studies. This work aims to develop a reproducible method for hMSCs proliferation measurement in 3D cell cultures on coralline scaffolds (Biocoral®). Results demonstrated that: proliferation curves obtained in this work are reproducible at different initial cell densities on several scaffolds cultured with hMSC in long term experiments (3 weeks).","PeriodicalId":277757,"journal":{"name":"2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124088564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-05-07DOI: 10.1109/MeMeA.2015.7145223
Qing Zhu, Xiaogang Sun, Xingsong Wang, Qingcong Wu, B. Liang
Fracture reduction is a critical step in minimally invasive surgery of displaced femoral fracture treatment. Skeletal traction and alignment for fracture reduction can be performed individually in the operation, which is a standard procedure for the surgeons in practice. The intraoperative counteracting soft tissue forces during the fracture reduction should be measured precisely for improvement of the operation. In this paper, a set of measurement system was developed to obtain the value of the forces. Forces of skeletal traction and alignment were measured by three individual sensors, and the corresponding results can be recorded instantaneously during the fracture reduction process. According to an experimental test, the maximum alignment force in X-axis and Y-axis direction were 48.4N and 240.1N, respectively. The maximum traction force was 379.7N, occurred because of the slight valgus positioning of the leg to be convenient to insert the intramedullary nail. The highest forces were mostly observed along the shaft axis for skeletal traction. The experimental results show the effectiveness of the proposed measurement system, and indicate the potential application in developing new instruments for the fracture reduction operation.
{"title":"Development of intraoperative noninvasive force measuring system during femoral fracture reduction","authors":"Qing Zhu, Xiaogang Sun, Xingsong Wang, Qingcong Wu, B. Liang","doi":"10.1109/MeMeA.2015.7145223","DOIUrl":"https://doi.org/10.1109/MeMeA.2015.7145223","url":null,"abstract":"Fracture reduction is a critical step in minimally invasive surgery of displaced femoral fracture treatment. Skeletal traction and alignment for fracture reduction can be performed individually in the operation, which is a standard procedure for the surgeons in practice. The intraoperative counteracting soft tissue forces during the fracture reduction should be measured precisely for improvement of the operation. In this paper, a set of measurement system was developed to obtain the value of the forces. Forces of skeletal traction and alignment were measured by three individual sensors, and the corresponding results can be recorded instantaneously during the fracture reduction process. According to an experimental test, the maximum alignment force in X-axis and Y-axis direction were 48.4N and 240.1N, respectively. The maximum traction force was 379.7N, occurred because of the slight valgus positioning of the leg to be convenient to insert the intramedullary nail. The highest forces were mostly observed along the shaft axis for skeletal traction. The experimental results show the effectiveness of the proposed measurement system, and indicate the potential application in developing new instruments for the fracture reduction operation.","PeriodicalId":277757,"journal":{"name":"2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131062726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-05-07DOI: 10.1109/MEMEA.2015.7145175
M. Fantacci, C. Sottocornola, A. Retico, G. Astrea, R. Battini, M. Tosetti
This work reports a study of Neuromuscular Diseases (NMD) by Magnetic Resonance Imaging as reliable and non invasive instrument for NMD diagnosis and follow up. The evaluation of the images is now only visual, while standardization procedures and quantitative methods could be very useful instruments to optimize the diagnostic performances. We propose a new method to evaluate the fat infiltration in tissues developed and retrospectively applied to images of the human leg. Through a muscle segmentation algorithm on structural T1-weighted magnetic resonance images (MRIs), the estimated non-muscle percentage (eNMP) in the segmented muscle area has been evaluated in healthy subjects as a reference value. A semi-automated procedure allows extending the algorithm to MRIs of NMD patients. A strong correlation has been demonstrated between this index and the disease severity. The final aim is to obtain a quantitative evaluation of fat infiltration percentage and to relate it to the grade of muscle impairment in subjects affected by Neuromuscular Diseases.
{"title":"A non-invasive method for a quantitative evaluation of muscle involvement in MRI of Neuromuscular Diseases","authors":"M. Fantacci, C. Sottocornola, A. Retico, G. Astrea, R. Battini, M. Tosetti","doi":"10.1109/MEMEA.2015.7145175","DOIUrl":"https://doi.org/10.1109/MEMEA.2015.7145175","url":null,"abstract":"This work reports a study of Neuromuscular Diseases (NMD) by Magnetic Resonance Imaging as reliable and non invasive instrument for NMD diagnosis and follow up. The evaluation of the images is now only visual, while standardization procedures and quantitative methods could be very useful instruments to optimize the diagnostic performances. We propose a new method to evaluate the fat infiltration in tissues developed and retrospectively applied to images of the human leg. Through a muscle segmentation algorithm on structural T1-weighted magnetic resonance images (MRIs), the estimated non-muscle percentage (eNMP) in the segmented muscle area has been evaluated in healthy subjects as a reference value. A semi-automated procedure allows extending the algorithm to MRIs of NMD patients. A strong correlation has been demonstrated between this index and the disease severity. The final aim is to obtain a quantitative evaluation of fat infiltration percentage and to relate it to the grade of muscle impairment in subjects affected by Neuromuscular Diseases.","PeriodicalId":277757,"journal":{"name":"2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132683394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-05-07DOI: 10.1109/MEMEA.2015.7145174
A. Retico, R. Stara, M. Fantacci, A. Toncelli, A. Galante, Tiziana M. Florio, M. Alecci, M. Cosottini, G. Astrea, R. Battini, G. Tiberi, M. Costagli, M. Tosetti
Magnetic Resonance (MR) Imaging and Spectroscopy of the muscle is a valuable tool in the diagnosis and monitoring of Neuromuscular Disorders (NMD). New Ultra-High Field (UHF) 7 T MRI systems, with their enhanced Signal-to-Noise Ratio, may offer increased image quality in terms of spatial resolution and/or shorter scanning time compared to lower field systems. In the study of NMD the new features provided by UHF MR may allow the use of functional techniques to improve biochemical and physiological information of skeletal muscle correlated to the pathogenesis and progression of the muscle involvement. This study reports the recent achievements in muscle imaging and spectroscopy obtained at the first Italian 7 T MR scanner available at the IMAGO7 Foundation (Pisa, Italy). Dedicated radio-frequency coils for proton imaging and phosphorous spectroscopy have been designed, developed and validated in vivo, and are now ready for clinical research studies.
肌肉的磁共振成像和光谱是诊断和监测神经肌肉疾病(NMD)的宝贵工具。新型超高场(UHF) 7 T MRI系统具有增强的信噪比，与低场系统相比，可以在空间分辨率和/或更短的扫描时间方面提供更高的图像质量。在NMD的研究中，UHF MR提供的新特征可能允许使用功能技术来改善骨骼肌的生化和生理信息，这些信息与肌肉受损伤的发病和进展有关。本研究报告了在IMAGO7基金会(比萨，意大利)获得的第一台意大利7t磁共振扫描仪在肌肉成像和光谱方面取得的最新成就。用于质子成像和磷光谱的专用射频线圈已经设计、开发和体内验证，现已准备用于临床研究。
{"title":"Non-invasive assessment of Neuromuscular Disorders by 7 tesla Magnetic Resonance Imaging and Spectroscopy: Dedicated radio-frequency coil development","authors":"A. Retico, R. Stara, M. Fantacci, A. Toncelli, A. Galante, Tiziana M. Florio, M. Alecci, M. Cosottini, G. Astrea, R. Battini, G. Tiberi, M. Costagli, M. Tosetti","doi":"10.1109/MEMEA.2015.7145174","DOIUrl":"https://doi.org/10.1109/MEMEA.2015.7145174","url":null,"abstract":"Magnetic Resonance (MR) Imaging and Spectroscopy of the muscle is a valuable tool in the diagnosis and monitoring of Neuromuscular Disorders (NMD). New Ultra-High Field (UHF) 7 T MRI systems, with their enhanced Signal-to-Noise Ratio, may offer increased image quality in terms of spatial resolution and/or shorter scanning time compared to lower field systems. In the study of NMD the new features provided by UHF MR may allow the use of functional techniques to improve biochemical and physiological information of skeletal muscle correlated to the pathogenesis and progression of the muscle involvement. This study reports the recent achievements in muscle imaging and spectroscopy obtained at the first Italian 7 T MR scanner available at the IMAGO7 Foundation (Pisa, Italy). Dedicated radio-frequency coils for proton imaging and phosphorous spectroscopy have been designed, developed and validated in vivo, and are now ready for clinical research studies.","PeriodicalId":277757,"journal":{"name":"2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133247114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-05-07DOI: 10.1109/MeMeA.2015.7145171
Defne Us, Amalia Moreno-Galera, S. Nazari-Farsani, K. Palovuori, Heikki Kosola, Tiziana Zedda, U. Ruotsalainen
In AvanTomography project, a compact, high performance module was developed for axial positron emission mammography, which can be integrated with X-ray mammography. With its axial crystal orientation, AvanTomography can achieve a uniform spatial resolution and eliminate the parallax error by unambiguously detecting the location of the positron annihilation. Compact design of the module enables a cost and space efficient system for breast screening. Various configurations, plate or full ring, can be obtained by using multiple modules, allowing the screening of axillary and mammary regions with a single scanner position. In this project, a 6-module system was constructed and tested with a 22Na point source. Energy calibration was performed and initial measurements for energy resolution were conducted.
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