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2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings最新文献

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Data-driven selection of motion correction techniques in breast DCE-MRI 数据驱动的乳腺DCE-MRI运动校正技术选择
Gabriele Piantadosi, S. Marrone, R. Fusco, A. Petrillo, M. Sansone, Carlo Sansone
It is well known that some sort of motion correction technique (MCT) should be performed before DCE-MRI data analysis in order to reduce movement artefacts. However, it is not clear if a single MCT can produce optimum results for every single examination, since for example different movements can occur. In this paper we investigated the possibility of choosing the best MCT per each specific patient, before performing further data analysis (e.g. tumour segmentation). In particular, our aim is the proposal of some physiological model-based quality indexes (QIs) for ranking different MCT on a patient basis. Moreover, for practical feasibility, we investigated the performance of our proposal when only a small fraction of the available data was used. We performed tests on a dataset of patients with breast tumour. Specifically, for each patient we compared the “reference ranking” of different MCT obtained by using the results of tumour segmentation with the rankings produced with each QI. Our results indicate that the ranking obtained by using the QI based on the Extended Tofts-Kermode model (with the Parker arterial input function) are in accordance with the “reference ranking”. Moreover, computational load can be significantly reduced without affecting the overall performance by using only 5% of the available data.
众所周知,在DCE-MRI数据分析之前应该进行某种运动校正技术(MCT),以减少运动伪影。然而,目前尚不清楚单一MCT是否可以为每次检查产生最佳结果,因为例如可能发生不同的运动。在本文中,我们研究了在进行进一步的数据分析(例如肿瘤分割)之前,为每个特定患者选择最佳MCT的可能性。特别是,我们的目标是提出一些基于生理模型的质量指标(QIs),以便根据患者对不同的MCT进行排名。此外,为了实际的可行性,我们研究了仅使用一小部分可用数据时我们的建议的性能。我们对乳腺肿瘤患者的数据集进行了测试。具体而言,对于每个患者,我们将使用肿瘤分割结果获得的不同MCT的“参考排名”与每个QI产生的排名进行了比较。我们的研究结果表明,基于扩展Tofts-Kermode模型(带有Parker动脉输入函数)的QI得到的排名符合“参考排名”。此外,只需使用5%的可用数据,就可以在不影响整体性能的情况下显著降低计算负载。
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引用次数: 10
Big data analytics to identify deceleration characteristics of an older driver 大数据分析,识别老司机的减速特征
R. B. Wallace, Akshay Puli, R. Goubran, F. Knoefel, S. Marshall, M. Porter, Andrew Smith
This paper presents the analysis of all driving by a single (female) older diver over a one year period from the Candrive project. Data analytics techniques have been applied to this unique big data set that includes 1 Hz sampled Global Positioning System (GPS) and Geographic Information System (GIS) data and includes the analysis of 1562 trips covering 13,425 km. The driver is known to have stable general, cognitive and physical health through clinical testing at the start and end of the 1 year period. The paper specifically explores the deceleration habits of the driver by locating all deceleration events over the period with a net velocity drop of 4km/hr or more resulting in 24,794 events being identified. The paper finds that the mean and minimum deceleration values for the events, both have two phases where the deceleration values increase with the size of the velocity drop (-0.252 and -0.0593 hr·m/km·s2 respectively) until the drop exceeds 27.5km/hr and then the second phase has a much lower slope (-0.027 and -0.0053 hr·m/km·s2 respectively). Subsets of the deceleration events such as posted speed limit on road and decelerations ending with a stopped vehicle exhibit the same two phase relationship. The two phases and their transition are attributes of the deceleration habits for the driver that may potentially be used to distinguish between drivers of a vehicle.
本文介绍了在Candrive项目的一年中,由一名单身(女性)老年潜水员驾驶的所有分析。数据分析技术已应用于这一独特的大数据集,其中包括1 Hz采样的全球定位系统(GPS)和地理信息系统(GIS)数据,包括对1562次旅行的分析,覆盖13425公里。在1年期间的开始和结束时,通过临床测试,驾驶员的一般、认知和身体健康状况稳定。本文通过定位净速度下降4公里/小时或以上的所有减速事件,从而确定了24,794个事件,专门探讨了驾驶员的减速习惯。研究发现,事件的平均减速值和最小减速值都有两个阶段,减速值随着速度下降的大小而增加(分别为-0.252和-0.0593 hr·m/km·s2),直到速度下降超过27.5km/hr,然后第二个阶段的斜率要小得多(分别为-0.027和-0.0053 hr·m/km·s2)。减速事件的子集,如道路限速和以停车结束的减速,表现出相同的两相关系。这两个阶段及其转换是驾驶员减速习惯的属性,可以潜在地用于区分车辆驾驶员。
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引用次数: 13
A novel approach for design and testing digital m-health applications 设计和测试数字移动医疗应用程序的新方法
G. Andria, A. Lanzolla, G. Cavallo, Giuseppe Russo, F. Marinosci, R. Incalzi, M. Benvenuto
The management of age related diseases is one of the most discussed and controverted topic in Healthcare policy: cost-efficient solutions are needed to reduce the economic impact on welfare systems and to improve the quality of life of the patients. This is particularly true for chronic diseases, in which a simple, but continuous monitoring of suitable functional parameters able to evaluate the patient status would allow a consistent reduction of hospitalizations. In this paper we present the experience derived from a “Living Lab”, a novel model of participated innovation in which the end-user plays a crucial role. We co-designed, implemented and tested a m-health solution for remote monitoring of physiological parameters directly from chronic patients' house according to a clinical protocol defined by healthcare professionals. For this aim set of parameters such as Blood Pressure, Body Weight, Heart Rate, Pulse Oximetry was measured and, if needed, the answers to a questionnaire. The proposed system allows to reduce the hospitalization rate and to increase the empowerment of the patient in the self-management of his chronic health condition.
年龄相关疾病的管理是医疗保健政策中讨论最多和最有争议的话题之一:需要具有成本效益的解决方案来减少对福利系统的经济影响并提高患者的生活质量。对于慢性疾病尤其如此,对能够评估患者状态的适当功能参数进行简单但持续的监测将使住院率持续下降。在本文中,我们介绍了来自“生活实验室”的经验,这是一种参与创新的新模式,最终用户在其中起着至关重要的作用。我们共同设计、实施并测试了一种移动健康解决方案,用于根据医疗保健专业人员定义的临床协议直接从慢性患者家中远程监测生理参数。为此,测量了一系列参数,如血压、体重、心率、脉搏血氧仪,如果需要,还测量了问卷的答案。拟议的系统可以降低住院率,并增加患者自我管理其慢性健康状况的能力。
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引用次数: 6
Measurement issues in probing depth evaluation of periodontal pockets 牙周袋探诊深度评估中的测量问题
G. Genta, G. Barbato, R. Levi, M. Erriu, F. Pili
Measurement of periodontal pocket depth, a key step in detection and analysis of periodontal diseases, is frequently affected by substantial uncertainty. Estimation of distance between gingival margin and connective ligament, an apparently straightforward measurement task routinely performed with simple probes, entails a fairly complex pattern of single and combined effects. Layout of marks on probe affects readings, since, when interpolation is involved, operator's experience comes into the picture. Compliance of tissues at pocket bottom implies dependence of probe penetration from insertion force, whose control again is affected by operator's experience. Hazy definition of gingival margin further contributes to scatter in results, liable to lead to diagnostic mistakes and wrong therapeutic decisions. An investigation on measurement issues, aimed at identification of main factors affecting uncertainty in evaluation of pocket depth, was performed in vitro with an ad hoc device, developed in order to get traceability and evaluate reproducibility of measurements of pockets with different depths. Measurements were performed by operators with different experience and skill, using three types of periodontal probes currently in use. Results showed a different performance of the probes in terms both of bias and scatter. Occurrence of false positives and negatives were found to be strongly dependent upon operator experience.
牙周袋深度的测量是牙周疾病检测和分析的关键步骤,但往往存在很大的不确定性。估计牙龈缘与结缔组织韧带之间的距离,是一项简单的测量任务,通常用简单的探针进行,需要相当复杂的单一和联合效应模式。探针上标记的布局会影响读数,因为当涉及到插值时,操作员的经验就会进入画面。口袋底部组织的顺应性意味着探针的穿透依赖于插入力,而插入力的控制又受到操作者经验的影响。龈缘的模糊定义进一步导致结果的分散,容易导致诊断错误和错误的治疗决策。为了获得不同深度口袋测量结果的可追溯性并评价测量结果的可重复性,采用自制装置对测量问题进行了研究,旨在确定影响口袋深度评估不确定度的主要因素。测量由具有不同经验和技能的操作人员进行,使用目前使用的三种牙周探针。结果表明,探针在偏置和散射方面表现出不同的性能。发现假阳性和阴性的发生强烈依赖于操作人员的经验。
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引用次数: 1
Compensating magnetic disturbances on MARG units by means of a low complexity data fusion algorithm 利用低复杂度数据融合算法补偿MARG单元上的磁扰动
P. Daponte, L. D. Vito, S. Rapuano, M. Riccio, F. Picariello
The paper proposes a new algorithm for the estimation of orientation of MARG (Magnetic, Angular Rate and Gravity) units, capable of compensating the influence of short-duration magnetic disturbances on the magnetometer, with application in motion tracking for rehabilitation. The proposed algorithm has been designed starting from a widely used low-complexity orientation estimation algorithm, based on the gradient descent minimization. The proposed algorithm has been validated by means of laboratory experiments, aimed at verifying its capability of correctly estimating orientation, by compensating the magnetic disturbances both in static and in dynamic conditions. The results of such experimental phase are presented and discussed in the paper.
本文提出了一种新的磁、角率和重力(MARG)单元方位估计算法,能够补偿短时间磁扰动对磁强计的影响,并应用于运动跟踪康复。该算法是在一种基于梯度下降最小化的低复杂度方向估计算法的基础上设计的。通过实验室实验验证了该算法在静态和动态条件下通过补偿磁干扰来正确估计方向的能力。本文对该实验阶段的结果进行了介绍和讨论。
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引用次数: 9
Integration of outcome estimations with a clinical decision support system: Application in the neonatal intensive care unit (NICU) 结果评估与临床决策支持系统的整合:在新生儿重症监护病房(NICU)的应用
M. Frize, Jeff Gilchrist, Hasmik Martirosyan, E. Bariciak
Our previous research led to the development of mortality risk estimations for infants in the neonatal intensive care unit (NICU) using quality archived databases. A decision support system was created with a clinician module containing relevant patient information and a variety of outcome estimations; the PPADS (Physician-Parent Decision Support) tool also contains a module for parents with the aim to help them make joint decisions with physicians on the direction of care for their infant. New work developed the ANN-Builder which uses an open-source artificial neural network library that would enable handling real-time data streaming and automate the process of providing risk estimations of mortality. Additionally, the patient data and risk estimations were successfully integrated into the PPADS tool. The mortality estimations surpass the clinical expectations. The next and final step will be to replace missing values in the data and add alarms for major changes in the risk estimations provided by the system.
我们之前的研究导致了使用高质量存档数据库对新生儿重症监护病房(NICU)婴儿死亡率风险估计的发展。创建了一个决策支持系统,其中包含临床医生模块,其中包含相关患者信息和各种结果估计;PPADS(医生-父母决策支持)工具还包含一个供父母使用的模块,目的是帮助他们与医生就婴儿护理方向共同做出决定。新的工作开发了ANN-Builder,它使用一个开源的人工神经网络库,可以处理实时数据流,并自动提供死亡率风险估计的过程。此外,患者数据和风险评估成功地整合到PPADS工具中。死亡率估计超出了临床预期。下一步也是最后一步是替换数据中的缺失值,并为系统提供的风险估计中的重大变化添加警报。
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引用次数: 9
Measurements of change in thermal images due to applied pressure 由于施加压力而引起的热像变化的测量
Stephanie L. Bennett, R. Goubran, F. Knoefel
Thermal imaging is of value to medical professionals because of its low risk and non-invasive properties. While thermal imaging has been explored in the area of pressure ulcers, many relevant papers address existing pressure ulcers and few address the prevention of pressure ulcers. This paper aims to examine the potential of thermal imaging in the prevention of pressure ulcers by extracting temperature-based and region-based measurements from thermal images and quantifying thermal patterns. A subject was asked to press on a pressure sensor mat at two specified intensities, and a series of thermal images were taken before and after to track thermal behaviour. These images were subjected to standard image processing techniques before temperature specific contour and area measurements were extracted as well as region specific intensity and weighted centroid measurements. Results indicated that the contour and area measurements were able to capture the temperature pattern of the whole hand, while the intensity measurements were able to indicate region specific thermal patterns. These results suggest that the extraction of measurements from a series of thermal images can capture and quantify visually identifiable thermal patterns of the hand over time. These findings will be expanded upon in future work by further examining different measurements, sharper images, different equipment and the involvement of elderly patients. While future collection of patient data is expected to yield different thermal patterns, this paper has demonstrated recognition and quantification of a pattern, regardless of the pattern itself.
热成像因其低风险和非侵入性而对医学专业人员有价值。虽然热成像已经在压疮领域进行了探索,但许多相关的论文都是针对现有的压疮,而很少涉及压疮的预防。本文旨在通过从热图像中提取基于温度和基于区域的测量并量化热模式来研究热成像在预防压疮方面的潜力。受试者被要求在两个指定强度下按压压力传感器垫,并在前后拍摄一系列热图像以跟踪热行为。这些图像经过标准的图像处理技术,然后提取温度比轮廓和面积测量,以及区域比强度和加权质心测量。结果表明,轮廓和面积测量能够捕获整个手的温度模式,而强度测量能够显示特定区域的热模式。这些结果表明,从一系列热图像中提取测量值可以捕获和量化手部随时间变化的视觉可识别的热模式。这些发现将在未来的工作中进一步扩展,通过进一步研究不同的测量方法,更清晰的图像,不同的设备和老年患者的参与。虽然未来收集的患者数据预计会产生不同的热模式,但本文已经证明了一种模式的识别和量化,而不考虑模式本身。
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引用次数: 4
Development and characterization of porous magnesium bioresorbable implants 多孔镁生物可吸收植入物的研制与表征
E. Angelini, B. Benedetti, D. Fulginiti, S. Grassini, F. Ferraris, M. Parvis
The use of temporary implants, which is widely diffused in orthopedic surgery requires surgical procedures to remove the implants after bone healing. A bioresorbable implant, which does not need to be surgically removed, would reduce both patient morbidity and risks of future diseases. Thanks to their biocompatibility, magnesium and its alloys have been proposed for self-degrading implants; moreover, Mg-based implants with a porous structure can stimulate the bone growth. This paper describes the preliminary results obtained by employing Spark Plasma Sintering (SPS) to produce a magnesium foam with a porosity able to stimulate the bone growth.
在骨科手术中广泛使用的临时植入物需要在骨愈合后进行外科手术以移除植入物。一个生物可吸收的植入物,不需要手术移除,将降低病人的发病率和未来疾病的风险。由于其生物相容性,镁及其合金已被提出用于自降解植入物;此外,具有多孔结构的镁基植入物可以促进骨生长。本文介绍了用火花等离子烧结(SPS)制备泡沫镁的初步结果,该泡沫镁具有孔隙度,能够刺激骨骼生长。
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引用次数: 2
A new arterial blood pressure Holter based on the oscillometric method 一种基于示波法的动脉血压动态记录仪
R. Vallascas
From the comparison of the data available in the field literature, it follows that the range of oscillometric ratios is quite extensive, with an interval of 20% for systolic and around 30% for diastolic blood pressure. For example Geddes [8] states that these may range from 0.45 to 0.57 for systolic and from 0.75 to 0.86 for diastolic. Current commercial devices were not designed to perform the task of calculating these oscillometric ratios, and they utilize average values set for all measurements regardless of the physiological characteristics of the individual user and the yielding of the cuff used. While, as noted, oscillometric ratios are unique to each user as they contain much individual and operational information, such as cuff pulsatility, physiology of the measurement site, environmental conditions and the clinician's ability in performing the measurement. Hence, the need to revise current standards by making more restrictive rules is clear. In the author's opinion, this innovative solution has the special features providing greater accuracy in the measurement of systolic and diastolic pressures, and simulations and preliminary clinical trials have confirmed this. The work is devoted to both the presentation of the pressure Holter prototype and to the communication of results obtained during the characterization of the methodology and the algorithms used. Validation involved 33 subjects (22 men and 11 women) aged between 23 and 82 years, with arm circumferences from 21 to 41 cm, with systolic blood pressure (PSYS) in the 94 ÷ 204 mmHg range and diastolic (PDIA) 49÷106 mmHg. The results largely satisfy the requirements of the Protocol AAMI SP-10.
从现场文献中现有数据的比较可以看出,振荡比的范围相当广泛,收缩压的间隔为20%,舒张压的间隔约为30%。例如,Geddes[8]指出,收缩压的范围从0.45到0.57,舒张压的范围从0.75到0.86。目前的商业设备并没有设计来执行计算这些振荡比的任务,它们使用所有测量的平均值,而不考虑个人用户的生理特征和所使用的袖带的屈服。然而,如前所述,振荡比对每个用户来说都是独一无二的,因为它们包含了许多个人和操作信息,如袖带脉搏、测量部位的生理、环境条件和临床医生执行测量的能力。因此,通过制定更严格的规则来修订现行标准的必要性是显而易见的。在作者看来,这种创新的解决方案具有特殊的特点,在测量收缩压和舒张压时提供更高的准确性,模拟和初步临床试验已经证实了这一点。这项工作致力于压力霍尔特原型的展示,以及在方法和所用算法的表征过程中获得的结果的交流。验证涉及33名受试者(22名男性和11名女性),年龄在23至82岁之间,手臂周长21至41厘米,收缩压(PSYS)在94 ÷ 204 mmHg范围内,舒张压(PDIA) 49÷106 mmHg。结果基本满足AAMI SP-10协议的要求。
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引用次数: 0
Development of a reliable method for orbit segmentation & measuring 研制一种可靠的轨道分割与测量方法
Matthias Becker, K. Friese, Franz-Erich Wolter, N. Gellrich, H. Essig
Injuries of the bony orbit, which contains the eye, not only have aesthetic implications but also impair stereoscopic vision. Different techniques are used for surgical treatment. In this work we will present a tool that allows the reliable segmentation of the reconstructed and the unaffected orbit. For this we present a novel anterior closing that follows the clinical understanding of anatomy. To assist in the post-surgical evaluation, we suggest parameters with respect to clinically relevant regions (orbital floor, medial wall) and demonstrate a method to automatically determine them. We evaluate our methods on three clinical cases.
眼眶骨的损伤不仅具有美学意义,而且会损害立体视觉。手术治疗采用了不同的技术。在这项工作中,我们将提出一个工具,允许可靠的分割重建和未受影响的轨道。为此,我们提出了一种新的前闭合,遵循临床对解剖学的理解。为了协助术后评估,我们提出了有关临床相关区域(眶底、内侧壁)的参数,并演示了一种自动确定它们的方法。我们通过三个临床病例来评价我们的方法。
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引用次数: 4
期刊
2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings
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