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2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings最新文献

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A novel automatically initialized level set approach based on region correlation for lumbar vertebrae CT image segmentation 一种基于区域相关的自动初始化水平集方法用于腰椎CT图像分割
Y. Li, Wei Liang, Jindong Tan, Yinlong Zhang
Despite recent advances, robust automatic segmentation for vertebrae computed tomography (CT) image still presents considerable challenges, mainly due to its inherent limitations, such as topological variation, irregular boundaries (double boundary, weak boundary) and image noises, etc. Therefore, this paper proposes a novel automatically initialized level set approach based on region correlation, which is able to deal with these problems in the segmentation. First, an automatically initialized level set function (AILSF) is designed to automatically generate a smooth initial contour. This AILSF comprises hybrid morphological filter (HMF) and Gaussian mixture model (GMM), which can guarantee the initial contour precisely adjacent to the object boundary. Second, we introduce a region correlation based level set formulation, which simultaneously consider the histogram information of inside and outside the level set contour, to overcome the weak boundary leaking and image noises problem. Experimental results on clinical lumbar vertebrae CT images demonstrate that our proposed approach is more accurate in segmenting with irregular boundaries and more robust to different levels of salt-and-pepper noises.
尽管近年来取得了一些进展,但椎骨计算机断层扫描(CT)图像的鲁棒自动分割仍然面临相当大的挑战,主要是由于其固有的局限性,如拓扑变异、不规则边界(双边界、弱边界)和图像噪声等。因此,本文提出了一种基于区域相关性的自动初始化水平集方法,能够很好地解决图像分割中的这些问题。首先,设计了自动初始化水平集函数(AILSF),自动生成平滑的初始轮廓;该AILSF由混合形态滤波(HMF)和高斯混合模型(GMM)组成,可以保证初始轮廓精确地接近目标边界。其次,引入基于区域相关的水平集公式,同时考虑水平集轮廓内外的直方图信息,克服了弱边界泄漏和图像噪声问题;临床腰椎CT图像的实验结果表明,该方法对不规则边界的分割更加准确,对不同程度的椒盐噪声具有更强的鲁棒性。
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引用次数: 11
Thermocouples for temperature monitoring during pancreatic laser ablation: Analysis of the measurement error 用于胰腺激光消融温度监测的热电偶:测量误差分析
E. Schena, P. Saccomandi, C. Massaroni, G. Frauenfelder, F. Giurazza, G. M. Peroglio, S. Silvestri, M. Caponero, A. Polimadei
Laser ablation (LA) is a minimally invasive procedure used to remove cancer by inducing hyperthermia. It is based on the interaction between laser light and tissue: the absorbed light is converted into heat causing a tissue temperature increase. The amount of damaged volume depends on temperature and time exposure of the tissue to the hyperthermia. As a consequence, the monitoring of tissue temperature during LA could be particularly beneficial to optimize treatment outcomes. Thermocouples are one of the most employed transducer for temperature measurement. Their main drawback is related to the strong light absorption of the two metallic wires which constitute a thermocouple. The light absorption causes an overestimation of actual temperature, in literature known as artifact. This work aims at assessing this artifact on ex vivo swine pancreases undergoing LA. The artifacts have been estimated at the three laser powers (1.6 W, 2 W and 5 W) and at two distances from the optical applicator. In particular, the artifact decreases with the distance from the optical applicator and depends on P: at 1.6 W and 2 W it is negligible at 12 mm of distance, on the other hand at 5 W it is significant also at 15 mm (1.7 °C). Summing up: the artifact is strongly influenced by the distance between the thermocouple and the optical applicator, and by the laser power; also at high distance from the applicator it can cause error which are not acceptable for the application of interest (e.g., at 5 W and 10 mm the error is about 4 °C). Although the use of thermocouples entails the concern related to the artifact, it must be considered that proper model can be employed to correct the measurement error.
激光消融(LA)是一种通过诱导高温去除癌症的微创手术。它是基于激光和组织之间的相互作用:吸收的光转化为热,导致组织温度升高。受损体积的大小取决于组织在高温下暴露的温度和时间。因此,在LA期间监测组织温度可能特别有利于优化治疗结果。热电偶是最常用的温度测量传感器之一。它们的主要缺点与构成热电偶的两条金属线的强光吸收有关。光的吸收导致了对实际温度的高估,在文献中被称为伪影。这项工作的目的是评估这种伪影在体外猪胰腺进行LA。在三种激光功率(1.6 W, 2w和5w)和距离光学施加器的两个距离下,对伪影进行了估计。特别是,伪影随着与光学涂抹器的距离而减少,并取决于P:在1.6 W和2 W时,它在12 mm的距离下可以忽略不计,另一方面,在5w时,它在15 mm(1.7°C)下也很重要。综上所述:伪影受热电偶与光学施加器之间的距离和激光功率的强烈影响;此外,在距离涂抹器较远的地方,它可能会导致不适合应用的误差(例如,在5w和10mm时,误差约为4°C)。虽然热电偶的使用涉及到与工件相关的问题,但必须考虑到可以采用适当的模型来纠正测量误差。
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引用次数: 3
An Automatic Sensing Test procedure for Implantable Cardioverter Defibrillators 植入式心律转复除颤器的自动感应测试程序
I. Spano, S. Sulis, A. Serpi, I. Marongiu, G. Gatto, V. Nissardi
An Automatic Sensing Test procedure (AST) for evaluating the sensing performances of Implantable Cardioverter Defibrillators (ICDs) is presented in this paper. AST is based on the Sensitivity Test described by the Standard CEI EN 45502-2-1 for pacemakers and consists of determining the ICD sensing thresholds at different heartbeat frequencies. Consequently, an extensive evaluation of ICD sensing performances can be achieved. AST has been implemented by means of virtual instruments developed in the Labview environment and has been validated experimentally through several tests. These have been performed inside an anechoic RF chamber. Such an environment guarantees proper shielding against external electromagnetic interferences, thus ensuring reliability and repeatability of the tests. The discussion of the results highlights the usefulness of the proposed procedure.
本文提出了一种用于评估植入式心律转复除颤器(ICDs)感知性能的自动感知测试程序(AST)。AST是基于标准CEI EN 45502-2-1对起搏器描述的灵敏度测试,包括确定不同心跳频率下的ICD传感阈值。因此,可以实现对ICD传感性能的广泛评估。AST采用Labview环境下开发的虚拟仪器实现,并通过多次实验验证。这些都是在消声射频室中进行的。这样的环境保证了对外部电磁干扰的适当屏蔽,从而确保了测试的可靠性和可重复性。对结果的讨论突出了所建议程序的有效性。
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引用次数: 1
A preliminary study on quality of knee strength measurements by means of Hand Held Dynamometer and Optoelectronic System 手持式测力仪与光电系统膝关节强度测量质量的初步研究
A. Ancillao, S. Rossi, F. Patané, P. Cappa
Strength measurements are popular in the clinical practice to evaluate the health status of patients and quantify the outcome of training programs. Currently a common method to measure strength is based on Hand Held Dynamometers (HHD) which is operator-dependent. Some studies were conducted on repeatability of strength measurements but they were limited to the statistical analysis of repeated measurements of force. In this work, the authors developed a methodology to study the quality of knee flexion/extension strength measurements by measuring the effective HHD position and orientation with respect to the patient. HHD positioning attitude was measured by means of an Optoelectronic System for which a marker protocol was defined ad-hoc. The approach allowed to assess quality of measurements and operator's ability by means of quantitative indices. The protocol permitted the evaluation of: angles of HHD application, angular range of motion of the knee and range of motion of the HHD. RMSE parameters allowed to quantify the inaccuracy associated to the selected indices. Results showed that the operator was not able to keep the subject's limb completely still. The force exerted by the subject was higher in knee extension and the knee range of motion was higher than expected, however the operator had more difficulties in holding the HHD in knee flexion trials. This work showed that HHD positioning should be as accurate as possible, as it plays an important role for the strength evaluation. Moreover, the operator should be properly trained and should be strong enough to counteract the force of the subject.
力量测量在临床实践中很流行,用于评估患者的健康状况和量化训练计划的结果。目前测量强度的常用方法是基于手持测力计(HHD),这是依赖于操作人员的。对强度测量的可重复性进行了一些研究,但仅限于对反复测量的力进行统计分析。在这项工作中,作者开发了一种方法,通过测量HHD相对于患者的有效位置和方向来研究膝关节屈伸强度测量的质量。HHD定位姿态是通过一个光电系统来测量的,该系统的标记协议是自定义的。该方法可以通过定量指标来评估测量质量和操作人员的能力。该方案允许评估:HHD应用的角度,膝关节的角度运动范围和HHD的运动范围。RMSE参数允许量化与所选指数相关的不准确性。结果表明,操作者无法使受试者的肢体完全静止。受试者在膝关节伸展时施加的力比预期的要大,膝关节活动范围比预期的要大,然而在膝关节屈曲试验中,操作者在握住HHD时遇到了更多的困难。研究表明,HHD定位在强度评价中起着重要作用,应尽可能准确。此外,操作者应该经过适当的训练,并且应该有足够的力量来抵消主体的力量。
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引用次数: 2
Sensors in LTCC-technology with embedded microfluidic features, for medical applications 传感器在ltcc技术与嵌入式微流控功能,用于医疗应用
R. Ciobanu, C. Schreiner, V. Drug, T. Schreiner, Dorin Antal
The lab-on-chip testing units based on microfluidics technology are booming nowadays, due to robustness, simplicity of use and reliability. Multilayer ceramics, functionalized with nano-scaled sensing materials, and further integrated within microfluidic test elements, are of great challenge and represent the purpose of the paper. The LTCC technology versatility allows the 3D integration of electrochemical sensors with microfluidic features, and further with advanced signal processing and wireless communication.
基于微流控技术的实验室片上测试装置具有鲁棒性好、使用简单、可靠性好等优点,目前正蓬勃发展。多层陶瓷,功能化的纳米级传感材料,并进一步集成到微流控测试元件,是一个很大的挑战,代表了本文的目的。LTCC技术的多功能性允许具有微流体特征的电化学传感器的3D集成,并进一步具有先进的信号处理和无线通信。
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引用次数: 4
Towards a Probabilistic Model Checking-based approach for Medical Device Risk Assessment 基于概率模型检验的医疗器械风险评估方法研究
Giuseppe Cicotti, A. Coronato
Medical Devices (MDs) are subject to a Risk Management process to guarantee their safety with respect to risks patients and healthcare operators may experience. Well known classical Probabilistic Risk Assessment (PRA) techniques widely used in the MD sector, such as Failure Model and Effective Critical Analysis (FMEA) and Fault-Tree/Event-Tree do not allow to model the dynamics of hazardous situations which involves interactions among system components, human actions, process operations and the environment. This lack is overcome by using a dynamic PRA (DPRA) approach which aids in specifying risk scenarios. DPRA is extensively used in the nuclear, avionics, and space industries to identify possible accident scenarios, but to the best of our knowledge it is not so in the MD field. In this paper we propose a DPRA approach for MD Risk Assessment which relies on the use of a Probabilistic Model Checking (PMC) technique to perform quantitative analysis of risk scenarios. Particularly, our approach combines the ease of Event Sequence Diagram (ESD) to capture the dynamics of risk scenarios and the Markov Decision Processes formalism used as a stochastic model by which to encode ESD. By using a PMC technique to evaluate the MDP-based risk scenarios, we achieve two main benefits. Firstly, hundreds of different scenario realisations can be analysed in seconds due to the computational effectiveness of current PMC algorithms. Secondly, since such technique is based on a state-transition representation, we take advantage of the reachability analysis of states within the risk scenario state space to also quantify the effectiveness of control mechanisms or mitigation actions used to prevent and/or reduce the MD exposition to risk factors. Our ultimate objective is to derive an intuitive, easy, and computationally efficient formal method to perform quantitative risk scenario analysis oriented towards increasing the MD safety. We have applied our approach to an actual MD taken as a case study to demonstrate the features of our DPRA solution.
医疗仪器(MDs)须遵守风险管理流程,以确保患者和医疗保健操作员可能遇到的风险安全。广为人知的经典概率风险评估(PRA)技术,如失效模型和有效关键分析(FMEA)以及故障树/事件树,广泛应用于MD领域,不允许对涉及系统组件、人类行为、过程操作和环境之间相互作用的危险情况进行动态建模。通过使用动态PRA (DPRA)方法克服了这一不足,该方法有助于指定风险情景。dpa广泛用于核、航空电子和航天工业,以识别可能的事故情景,但据我们所知,它在MD领域并非如此。在本文中,我们提出了一种dpa方法用于MD风险评估,该方法依赖于使用概率模型检查(PMC)技术对风险情景进行定量分析。特别是,我们的方法结合了事件序列图(ESD)的易用性来捕捉风险情景的动态,并将马尔可夫决策过程形式化用作编码ESD的随机模型。通过使用PMC技术来评估基于mdp的风险情景,我们获得了两个主要好处。首先,由于当前PMC算法的计算效率,可以在几秒钟内分析数百种不同的场景实现。其次,由于这种技术基于状态转换表示,我们利用风险情景状态空间内状态的可达性分析来量化用于预防和/或减少MD暴露于风险因素的控制机制或缓解行动的有效性。我们的最终目标是推导出一种直观、简单、计算效率高的形式化方法来进行定量的风险情景分析,以提高MD安全性。我们已经将我们的方法应用于一个实际的MD,作为一个案例研究来演示我们的dpa解决方案的特性。
{"title":"Towards a Probabilistic Model Checking-based approach for Medical Device Risk Assessment","authors":"Giuseppe Cicotti, A. Coronato","doi":"10.1109/MeMeA.2015.7145195","DOIUrl":"https://doi.org/10.1109/MeMeA.2015.7145195","url":null,"abstract":"Medical Devices (MDs) are subject to a Risk Management process to guarantee their safety with respect to risks patients and healthcare operators may experience. Well known classical Probabilistic Risk Assessment (PRA) techniques widely used in the MD sector, such as Failure Model and Effective Critical Analysis (FMEA) and Fault-Tree/Event-Tree do not allow to model the dynamics of hazardous situations which involves interactions among system components, human actions, process operations and the environment. This lack is overcome by using a dynamic PRA (DPRA) approach which aids in specifying risk scenarios. DPRA is extensively used in the nuclear, avionics, and space industries to identify possible accident scenarios, but to the best of our knowledge it is not so in the MD field. In this paper we propose a DPRA approach for MD Risk Assessment which relies on the use of a Probabilistic Model Checking (PMC) technique to perform quantitative analysis of risk scenarios. Particularly, our approach combines the ease of Event Sequence Diagram (ESD) to capture the dynamics of risk scenarios and the Markov Decision Processes formalism used as a stochastic model by which to encode ESD. By using a PMC technique to evaluate the MDP-based risk scenarios, we achieve two main benefits. Firstly, hundreds of different scenario realisations can be analysed in seconds due to the computational effectiveness of current PMC algorithms. Secondly, since such technique is based on a state-transition representation, we take advantage of the reachability analysis of states within the risk scenario state space to also quantify the effectiveness of control mechanisms or mitigation actions used to prevent and/or reduce the MD exposition to risk factors. Our ultimate objective is to derive an intuitive, easy, and computationally efficient formal method to perform quantitative risk scenario analysis oriented towards increasing the MD safety. We have applied our approach to an actual MD taken as a case study to demonstrate the features of our DPRA solution.","PeriodicalId":277757,"journal":{"name":"2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116199864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Submovements composition and quality assessment of reaching movements in subjects with Parkinson's Disease 帕金森病患者伸手动作的亚动作组成及质量评估
L. Iuppariello, P. Bifulco, M. Romano, M. Cesarelli, G. D'Addio
The segmentation of seemingly continuous movements into segments has been theorized for many years. These segments may be considered as “primitive” movements, or building blocks of more complex movements. The existence of these fragments, or sub-movements as they are called, has been supported by a wide range of studies over the past 100 years. Evidence for the existence of discrete sub-movements underlying continuous human movement has motivated many attempts to “extract” them. Recently, the sub-movement theory gained a great appeal in the rehabilitation field. In fact, understanding movement deficits following CNS lesions, and the relationships between these deficits and functional ability, is fundamental to the development of successful rehabilitation therapies. So, here a novel sub-movements decomposition method is proposed; it is based on a constrained-Expectation-Maximization. This representation allowed us to explore whether the movements are built up of elementary kinematic units by decomposing each signal into a weighted combination of 2D Gaussian functions. These can be used to assess the quality of reaching movements in subjects with Parkinson's Disease.
将看似连续的运动分割成片段的理论已经存在了很多年。这些片段可以被认为是“原始”运动,或者是更复杂运动的组成部分。这些碎片的存在,或者称之为次级运动,在过去的100年里得到了广泛研究的支持。在人类连续运动的基础上存在着离散子运动的证据,这促使许多人试图“提取”它们。近年来,次运动理论在康复领域引起了极大的关注。事实上,了解中枢神经系统损伤后的运动缺陷,以及这些缺陷与功能能力之间的关系,是成功康复治疗发展的基础。为此,本文提出了一种新的子运动分解方法;它基于约束-期望-最大化。这种表示允许我们通过将每个信号分解为二维高斯函数的加权组合来探索运动是否由基本运动学单元组成。这些可以用来评估帕金森病患者的伸手动作质量。
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引用次数: 19
Efficient techniques to enhance nearfield imaging of human head for anomaly detection 增强人类头部近场成像的有效技术用于异常检测
Muhammad Naveed Tabassum, I. Elshafiey, Mubashir Alam
This paper proposes efficient algorithms to enhance the nearfield electromagnetic imaging of human head. Forward problem is modeled using SAM head phantom with brain tumor anomalies, surrounded by a circular applicator antenna array. Scattered signals are compressively sensed (CS) at a limited number of sensing positions, and the sensed signals are preprocessed efficiently using a proposed novel technique to maximize information extraction. A dictionary is formed and then implemented in CS based inverse problem analysis. Reconstructed images are enhanced using new post-processing techniques to improve the spatial resolution. Image quality is analyzed using the quality metric in terms of peak signal-to-noise ratio (PSNR). The quality of the reconstructed images and the corresponding PSNR values reveals the validity of the imaging techniques.
提出了增强头部近场电磁成像的有效算法。正演问题采用带有脑肿瘤异常的SAM头部幻象,由圆形应用器天线阵列包围。在有限数量的传感位置上压缩感知散射信号,并利用所提出的新技术对感知信号进行有效的预处理,以最大限度地提取信息。在基于CS的反问题分析中,构造了一个字典并实现了该字典。重建图像使用新的后处理技术增强,以提高空间分辨率。用峰值信噪比(PSNR)作为质量度量来分析图像质量。重建图像的质量和相应的PSNR值显示了成像技术的有效性。
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引用次数: 8
Preliminary study for a water-paraffin based phantom in MRI quality assurance test 水-石蜡基假体在MRI质量保证测试中的初步研究
G. Lupi, A. Scorza, Maria Livia Rugiano, S. Sciuto, F. Bini
Magnetic Resonance Imaging (MRI) scanners are widely used both for diagnostic purpose and in studies on material properties. As a consequence they play an important role in diagnosis of diseases and in materials investigations. MRI Quality assurance tests are mandatory to obtain and maintain optimal images during time, some institutional organizations have proposed requirements on MRI image quality even if there are no worldwide standardization procedures .The purpose of this study is to design a novel MRI phantom useful to evaluate basic image quality requirements: our phantom is designed, realized and tested in order to define specific image assurance protocols and tests. Moreover the developed device is low cost, reusable and can be filled with different MRI-compatible materials. In our application the phantom is filled with water and paraffin to compare contrast resolution and signal-to-noise ratio measurements for a same scanner. Tests have been performed on a 3T scanner with 7 different scansion settings. First experimental results are encouraging and confirm a previous theoretical investigation on the employed material characteristics. Therefore other tests and data are going to be collected for the future development and performance improvement of the device.
磁共振成像(MRI)扫描仪广泛用于诊断目的和材料性质的研究。因此,它们在疾病诊断和材料调查中发挥着重要作用。MRI质量保证测试是在一段时间内获得和保持最佳图像的强制性要求,一些机构组织提出了对MRI图像质量的要求,即使没有世界性的标准化程序。本研究的目的是设计一种新的MRI模型,用于评估基本的图像质量要求:我们的模型是为了定义特定的图像保证协议和测试而设计、实现和测试的。此外,开发的设备成本低,可重复使用,可以填充不同的mri兼容材料。在我们的应用中,用水和石蜡填充模体来比较同一台扫描仪的对比度分辨率和信噪比测量值。在3T扫描仪上进行了7种不同扫描设置的测试。第一个实验结果令人鼓舞,并证实了先前对所用材料特性的理论研究。因此,将收集其他测试和数据,以供设备的未来开发和性能改进。
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引用次数: 0
An efficient home-based risk of falling assessment test based on Smartphone and instrumented insole 基于智能手机和仪表鞋垫的家庭跌倒风险评估测试
Johannes C. Ayena, Landry Delphin Chapwouo Tchakouté, M. Otis, B. Ménélas
The aim of this study is to improve and facilitate the methods used to assess risk of falling among older people at home. We propose an automatic version of One-Leg Standing (OLS) test for risk of falling assessment by using a Smartphone and an instrumented insole. For better clinical assessment tests, this study focuses on exploring methods to combine the most important parameters of risk of falling into a single score. Twenty-three volunteers participated in this study for evaluating the effectiveness of the proposed system which includes eleven elderly participants: seven healthy elderly (67.16 ± 4.24 years), four Parkinson disease (PD) subjects (70 ± 12.73 years); and twelve healthy young adults (28.27 ± 3.74 years). Our work suggests that there is an inverse relationship between OLS score proposed and risk of falling. Proposed instrumented insole and application running on Android could be useful at home as a diagnostic aid tool for analyzing the performance of elderly people in OLS test.
本研究的目的是改进和促进用于评估家中老年人跌倒风险的方法。我们提出了一种自动版本的单腿站立(OLS)测试,通过使用智能手机和仪器鞋垫来评估跌倒风险。为了更好的临床评估测试,本研究的重点是探索将最重要的风险参数合并为单一评分的方法。本研究共有23名志愿者参与评估该系统的有效性,其中11名老年人:7名健康老年人(67.16±4.24岁),4名帕金森病(PD)受试者(70±12.73岁);健康青壮年12例(28.27±3.74岁)。我们的工作表明,OLS评分与跌倒风险之间存在反比关系。所提出的仪器鞋垫和Android上运行的应用程序可以作为诊断辅助工具用于分析老年人在OLS测试中的表现。
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引用次数: 25
期刊
2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings
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