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New approaches in the detection and management of diabetic retinopathy in the near future 近期糖尿病视网膜病变检测与治疗的新方法
Pub Date : 2023-01-20 DOI: 10.15406/aovs.2023.13.00430
L. Balyen
Diabetes mellitus (DM), a group of metabolic diseases characterized by hyperglycemia, is a major public health problem worldwide. In recent years, the incidence and prevalence of DM has been increasing as a global epidemic. Diabetic retinopathy (DR) is the most common complication of DM and remains the major cause of preventable blindness among working-age people in most developed countries and it has a significant socioeconomic impact and source of morbidity. DR, which has long been recognized as a microvascular disease, has been demonstrated by laboratory and clinical evidence that inflammation and retinal neurodegeneration may also contribute to diabetic retinal damage in the early stages of DR. New diagnostic and treatment modalities in DR management is promising. Further elucidation of the underlying molecular mechanisms may provide new medical approaches for the development of novel therapeutic modalities. Nowadays, novel diagnostic devices such as ultrawide field fundus fluorescein angiography, optic coherence tomography angiography and adaptive optics retinal imaging have improved the detection of DR earlier, faster and more accurately. Subthreshold micropulse laser and other laser photocoagulation applications may be an alternative to conventional retinal photocoagulation with lower complications for DR treatment. In recent years, artificial intelligence, machine learning, and deep learning based diagnosis and treatment applications are developing. In addition, in recent years, unmanned automated-based diagnostic and treatment methods and newly developed intravitreal drugs and implants can offer more diagnostic and treatment options with promising results. This review provides an overview of novel diagnostic and treatment approaches for preventing the progression of diabetic retinopathy.
糖尿病(DM)是一组以高血糖为特征的代谢性疾病,是世界范围内的主要公共卫生问题。近年来,糖尿病作为一种全球性流行病的发病率和流行率呈上升趋势。糖尿病视网膜病变(DR)是糖尿病最常见的并发症,在大多数发达国家仍是导致工作年龄人群可预防性失明的主要原因,它具有重大的社会经济影响和发病来源。长期以来,DR一直被认为是一种微血管疾病,实验室和临床证据表明,炎症和视网膜神经变性也可能导致DR早期的糖尿病性视网膜损伤。新的DR诊断和治疗模式很有希望。进一步阐明潜在的分子机制可能为开发新的治疗方式提供新的医学途径。如今,超宽视场眼底荧光素血管造影、光学相干断层血管造影和自适应光学视网膜成像等新型诊断设备使DR的检测更早、更快、更准确。阈下微脉冲激光和其他激光光凝应用可能是传统视网膜光凝治疗的替代方法,并发症较低。近年来,基于人工智能、机器学习和深度学习的诊断和治疗应用正在发展。此外,近年来,基于无人驾驶的自动化诊疗方法和新开发的玻璃体内药物和植入物可以提供更多的诊断和治疗选择,并且效果良好。本文综述了预防糖尿病视网膜病变进展的新诊断和治疗方法。
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引用次数: 0
Recurrent craniopharyngioma 复发颅咽管瘤
Pub Date : 2023-01-20 DOI: 10.15406/aovs.2023.13.00431
L. Martelli
Craniopharyngioma is a rare embryonic malformation tumor in the sellar and parasellar area of low histological grade. Local recurrence is frequent, being of great importance the use of the preoperative visual field as a clinical predictive indicator; and its postoperative outcome. The objective of this report is to recognize a recurrence in the event of small changes in visual acuity or campimetric alterations in patients with a history of this tumor. Clinical case: A 10-year-old girl presents to the clinic with a history of craniopharyngioma operated on a year earlier, with both atrophic optic nerves and decreased visual acuity. Complementary studies and urgent referral to the pediatric neurosurgeon were carried out, who detected intracranial hypertension secondary to recurrence of the craniopharyngioma, leading to its surgical removal. Conclusion: It is important to highlight the requesting of a visual field both for the detection of possible recurrences and for the follow-up of the craniopharyngioma, considering its high recurrence rate.
颅咽管瘤是一种罕见的胚胎畸形肿瘤,发生于鞍区和鞍旁区,组织学分级低。局部复发频繁,术前视野作为临床预测指标具有重要意义;以及术后的结果。本报告的目的是识别复发的情况下的小变化的视力或运动改变的患者的历史,这种肿瘤。临床病例:一名10岁女童,一年前手术颅咽管瘤病史,视神经萎缩,视力下降。进行了补充研究并紧急转诊给儿科神经外科医生,他发现颅咽管瘤复发继发于颅内高压,导致手术切除。结论:颅咽管瘤复发率高,在复发率高的情况下,重视视野检查对复发率的检测和随访具有重要意义。
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引用次数: 0
Pregnancy induced ocular changes 妊娠引起的眼部变化
Pub Date : 2023-01-09 DOI: 10.15406/aovs.2023.13.00428
P. Garg, Apala Priyadarshi, Swarastra P Singh, Parul Sinha
Pregnancy is often associated with ocular changes which may be more commonly transient but occasionally permanent. The ocular effects of pregnancy may be physiological or pathological or may be modifications of pre-existing conditions. The ophthalmological manifestations occurring during pregnancy may be pre-existing before pregnancy or may be aggravated or induced by pregnancy itself. Irrespective of the visual health status of the pregnant women, regular perinatal eye examination should be scheduled in order to assure continuous surveillance of healthy eyes. Careful surveillance for appropriate and timely diagnosis is imperative for understanding management. The aim of this review is to elaborate the physiological and pathological changes occurring in the eye during pregnancy and the needful management.
妊娠常伴有眼部变化,这种变化通常是短暂的,偶尔也会是永久性的。妊娠对眼部的影响可能是生理性的或病理性的,也可能是对已有疾病的改变。妊娠期间出现的眼科表现可能是妊娠前就存在的,也可能是妊娠本身加重或诱发的。无论孕妇的视力健康状况如何,都应定期进行围产期眼科检查,以确保持续监测健康的眼睛。对适当和及时诊断的仔细监测是了解管理的必要条件。本文综述的目的是阐述妊娠期间眼睛发生的生理和病理变化以及必要的处理。
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引用次数: 0
Refraction and the dissatisfied patient 折射和不满意的病人
Pub Date : 2022-12-28 DOI: 10.15406/aovs.2022.12.00427
Perez Mauricio, Gabarro Jose, Schmidt Anita
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引用次数: 0
Corneal integrity in ahmed valve implantation: pars plana vs ciliary sulcus vs anterior chamber ahmed瓣植入术中的角膜完整性:平面部、睫状沟、前房
Pub Date : 2022-12-09 DOI: 10.15406/aovs.2022.12.00426
Dubay Sareta K, Dwarika Dorian, Bhola Ronnie
Complex and refractory glaucoma cases, non-responsive to maximal management, require surgical intervention. The Ahmed Valve, a Glaucoma Drainage Device, is widely used in these scenarios. It may be implanted into the anterior chamber, ciliary sulcus and pars plana. However, there is no general consensus in the literature on which location is best when corneal protection is considered. This paper aimed to review all these studies, including ours, to determine which may be best, while still not compromising on valve efficacy in intraocular pressure reduction.
复杂和难治性青光眼,无反应的最大管理,需要手术干预。Ahmed阀,一种青光眼引流装置,在这些情况下被广泛使用。可植入前房、睫状沟和睫状肌平滑肌。然而,在考虑角膜保护时,在哪个位置是最好的,在文献中没有普遍的共识。本文旨在回顾所有这些研究,包括我们的研究,以确定哪一个可能是最好的,同时仍然不影响瓣膜在降低眼压方面的疗效。
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引用次数: 0
Krukenberg spindle and its implications Krukenberg纺锤体及其含义
Pub Date : 2022-11-16 DOI: 10.15406/aovs.2022.12.00425
A. Silvina, Soledad Varas, Roque Valerio
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引用次数: 0
The compatibility between optical coherence tomography and fundus fluorescein angiography in the detection of macular edema involving the fovea 光学相干断层扫描和眼底荧光素血管造影在检测累及中央窝的黄斑水肿中的相容性
Pub Date : 2022-10-03 DOI: 10.15406/aovs.2022.12.00422
B. Turgut, Selahattin Semih Aydogan
Objective: To investigate the compatibility between optical coherence tomography (OCT) and fundus fluorescein angiography (FFA) in the detection of macular edema (ME) excluding subretinal fluid (SRF) involving the fovea. Materials and methods: In this retrospective study in the Ophthalmology Department at our university hospital, interpretation of OCT and FFA images was performed for 200 eyes that underwent simultaneous FFA and OCT to rule out ME. The cases having SRF were excluded from the study. Results: Of 200 eyes, 193 eyes (96.5%) had the finding of ME confirmed by both techniques. There were 2 eyes (1%) for which FFA revealed ME involving fovea with hyperfluorescence in the macula while OCT demonstrated no intraretinal edema or subretinal fluid in the macula. For 5 eyes in the study (2.5%), OCT revealed intraretinal edema in the fovea, while these were not detected by FFA. Conclusion: This study suggests that FFA and OCT are highly sensitive techniques for the detection of ME and they correlate with each other. The little discrepancy between OCT and FFA for determining ME may be due to intracellular or extracellular edema and fast or slower development of retinal edema.
目的:探讨光学相干断层扫描(OCT)和眼底荧光素血管造影(FFA)检测黄斑水肿(ME)的相容性,不包括视网膜下积液(SRF)累及中央窝。材料与方法:本研究在我校附属医院眼科进行回顾性研究,对同时行FFA和OCT的200只眼的OCT和FFA图像进行解读,以排除ME。有SRF的病例被排除在研究之外。结果:200只眼中,193只眼(96.5%)两种方法均证实了ME的发现。有2只眼(1%)FFA显示ME累及黄斑中央凹,伴有高荧光,而OCT未显示黄斑视网膜内水肿或视网膜下积液。研究中有5只眼(2.5%)OCT显示视网膜中央凹水肿,而FFA未检测到。结论:本研究提示FFA和OCT是检测ME的高灵敏度技术,且两者具有相关性。OCT和FFA测定ME差异小可能是由于细胞内或细胞外水肿以及视网膜水肿发展快或慢。
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引用次数: 0
An approach to music therapy and its impact on the management of schizophrenia 音乐治疗方法及其对精神分裂症治疗的影响
Pub Date : 2022-09-22 DOI: 10.15406/aovs.2022.12.00421
Lianne Dilú, Fidel Vázquez
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引用次数: 0
Diagnosis and management of serpiginous choroiditis 蛇形脉络膜炎的诊断与治疗
Pub Date : 2022-09-21 DOI: 10.15406/aovs.2022.12.00420
Jeanie C Lucy
Purpose: Serpiginous choroiditis (SC) is a rare, bilateral, idiopathic inflammatory disorder that causes geographic destruction of the retina and choroid often in healthy middle-aged patients. Symptoms include blurred vision, central and paracentral scotomas. SC is part of a group termed white dot syndromes which involves inflammation of the retina and choroid with the appearance of white dots in the fundus. SC requires a thorough workup prior to treatment to rule out other inflammatory autoimmune or infectious etiologies. Early stages are challenging to diagnose. Treatment includes corticosteroids and immunosuppressive therapy. The exact cause of Serpiginous Choroiditis is not known, yet HLA-B7 is typically positive indicating an autoimmune response in these patients. Choroidal neovascularization and cystoid macula edema are side effects, so close monitoring is important. This case presents a holistic clinical picture of SC to aid in better clinical diagnosis and understanding of this condition for the primary care eye clinician. Results: Presentation of a young otherwise healthy 37-year-old male patient to our clinical service revealed a serpentine shaped retina presentation absent of anterior chamber or vitreous inflammation. Fundus photos, fluorescein angiography, and ocular coherence tomography revealed serpiginous choroiditis. Primary care workup to rule out systemic conditions was unremarkable. Initial treatment with monitoring included intravitreal triamcinolone 2 mg/0.05 mL OU with oral chlorambucil therapy immediately afterwards. Active lesions resolved over the next 3 weeks, yet visual acuity showed no improvement as the foveal was already involved. The goal of chlorambucil therapy for 3 months was to induce sustained remission. Conclusion: Prognosis of SC is less favorable when the macula is involved (macular SC). Upon clinical presentation of serpiginous choroiditis, it is important to establish etiology of non-infectious autoimmune disorders or infectious disorders before classification of idiopathic SC and aggressive treatment to address underlying systemic conditions.
目的:蛇形脉络膜炎(SC)是一种罕见的,双侧,特发性炎症性疾病,导致视网膜和脉络膜的地理破坏,通常发生在健康的中年患者。症状包括视力模糊,中央和中央旁暗斑。SC是一组称为白点综合征的一部分,涉及视网膜和脉络膜的炎症,眼底出现白点。SC需要在治疗前进行彻底的检查,以排除其他炎症性自身免疫或感染性病因。早期阶段很难诊断。治疗包括皮质类固醇和免疫抑制疗法。蛇形脉络膜炎的确切病因尚不清楚,但HLA-B7通常呈阳性,表明这些患者存在自身免疫反应。脉络膜新生血管和囊样黄斑水肿是副作用,因此密切监测是重要的。本病例提供了SC的整体临床图像,以帮助初级保健眼科临床医生更好地进行临床诊断和了解这种情况。结果:一位年轻健康的37岁男性患者在我们的临床服务中表现为蛇形视网膜,没有前房或玻璃体炎症。眼底照片、荧光素血管造影和眼相干断层扫描显示丝状脉络膜炎。排除系统性疾病的初级保健检查不显著。初始监测治疗包括玻璃体注射曲安奈德2 mg/0.05 mL OU,随后立即口服氯霉素治疗。活动性病变在接下来的3周内消退,但由于中央凹已经受累,视力没有改善。chlorambucil治疗3个月的目标是诱导持续缓解。结论:累及黄斑的SC预后较差。根据蛇形脉络膜炎的临床表现,在对特发性SC进行分类和积极治疗以解决潜在的全身疾病之前,确定非感染性自身免疫性疾病或感染性疾病的病因是很重要的。
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引用次数: 0
Integration of optometry at the national health system: the case of the first optometrists in Mozambique 国家卫生系统验光的整合:莫桑比克第一批验光师的案例
Pub Date : 2022-09-13 DOI: 10.15406/aovs.2022.12.00419
Joel Bambamba, Ramos Antonio, S. Latorre, Isaura Brito, Anselmo Vilanculos, Kajal Shah, D. González
Introduction: In the last two decades an increasing number of African countries have established Optometry training to tackle the largely unmet eye health needs of the population. However not sufficient evidence exist on how the profession is integrated and contributing to national health systems. In Mozambique, the optometry program started under the Faculty of Health Sciences in the public Lúrio University in 2009. From 2012 to 2016, 23 graduates were employed by the National Health System (NHS). Objective: The aim of this research is to document the integration of Optometrists at the National Health System in Mozambique. Methods: This is a descriptive, quantitative and cross-sectional study. Questionnaires and structured interviews were administered to all participants. Results: The response rate was 100% and the Optometrists were found practicing in 10 of the 11 provinces of the country distributed among primary, secondary and tertiary health facilities, providing refraction and managing common ocular pathologies along with the Ophthalmic Technicians, resolving the majority of patient needs and needing to refer 28% of cases to other professionals. The lack of equipment was the main expressed barrier to the provision of effective eye care services. According to them, the optometry curriculum responds well (91%) to the competencies required at the workplace. Areas for improvement training and provision of services were identified and presented in the study Conclusion: Optometrists are providing effective services needing to work closely and in coordination with other professionals. This research revealed the need for equipment provision and continuing education.
导言:在过去二十年中,越来越多的非洲国家建立了验光培训,以解决人口中大部分未满足的眼保健需求。然而,没有足够的证据表明该职业如何整合并为国家卫生系统做出贡献。在莫桑比克,公立Lúrio大学卫生科学学院于2009年启动了验光方案。从2012年到2016年,有23名毕业生受雇于国家卫生系统(NHS)。目的:本研究的目的是记录莫桑比克国家卫生系统验光师的整合情况。方法:采用描述性、定量、横断面研究。对所有参与者进行问卷调查和结构化访谈。结果:回复率为100%,验光师在全国11个省中的10个省执业,分布在初级、二级和三级卫生机构,与眼科技术人员一起提供验光和处理常见的眼部病变,解决了大多数患者的需求,需要将28%的病例转诊给其他专业人员。缺乏设备是提供有效眼科保健服务的主要障碍。根据他们的说法,验光课程很好地反映了工作场所所需的能力(91%)。结论:验光师提供的有效服务需要与其他专业人员密切合作和协调。这项研究揭示了设备供应和继续教育的必要性。
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Advances in Ophthalmology & Visual System
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