Pub Date : 2020-10-26DOI: 10.15406/aovs.2020.10.00397
Zemanova M, Macejova I, S. L., V. E
{"title":"Treatment of mild forms of blepharitis using direct plasma discharge","authors":"Zemanova M, Macejova I, S. L., V. E","doi":"10.15406/aovs.2020.10.00397","DOIUrl":"https://doi.org/10.15406/aovs.2020.10.00397","url":null,"abstract":"","PeriodicalId":287670,"journal":{"name":"Advances in Ophthalmology & Visual System","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116001646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-13DOI: 10.15406/aovs.2020.10.00395
H. Khan, Muhammad Aamir Shahzad, M. Awan, A. Marashi
{"title":"Perspective on retinal findings in COVID-19","authors":"H. Khan, Muhammad Aamir Shahzad, M. Awan, A. Marashi","doi":"10.15406/aovs.2020.10.00395","DOIUrl":"https://doi.org/10.15406/aovs.2020.10.00395","url":null,"abstract":"","PeriodicalId":287670,"journal":{"name":"Advances in Ophthalmology & Visual System","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125967157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-18DOI: 10.15406/aovs.2020.10.00393
A. A. Chaudhary, Sidra Iqbal, Shamim Akhtar, M. Aslam, Fatima Iqbal
Purpose: Aim of this study was to correlate head posture, working distance and luminance with Myopia. Methods: 300 myopic aged 7 to 18 years (mean 13.5 years) without spectacles male students were included. The subjects under study were analysed through comprehensive examination (visual acuity, objective and subjective refraction). They were asked to recite Holy Book for ten minutes; a random picture was clicked and posture was measured by drawing neck angle at the picture. Their habitual maximum and minimum working distance was measured when student move backward and forward. Luminance level was recorded of each student at place where he used to study. Results: Results of this study showed a negative correlation between myopia and posture reading ([95% CI] RE r= -0.07, p = 0.228, LE r= -0.079, p = 0.173) that depicts if angle decreases then myopia increases. A downhill and significant correlation was found between luminance level and myopia ([95% CI] RE r= -0.700, p = 0.000, LE -0.693, p = 0.000); as the lux (luminance) gets reduced the spherical equivalent gets increased and vice versa. There is a negative correlation between spherical equivalent and minimum working distance ([95% CI] RE r= -0.612, p = 0.000, LE r= -0.588, p = 0.000). A negative correlation between myopia and maximum working distance was found ([95% CI] RE r= -0.634, p = 0.000, LE r= -0.604, p = 0.000). Conclusion: We concluded that variable working distance, adoption of abnormal head posture and low luminance in Religious Schools has noteworthy association with myopia. Eye care professionals should play their vital role to enlighten the community that while performing near tasks all these risk factors should be avoided to halt the progression of myopia.
目的:探讨头部姿势、工作距离和亮度与近视的关系。方法:选取300名7 ~ 18岁(平均13.5岁)近视不戴眼镜的男学生。通过综合检查(视力、客观、主观屈光)对研究对象进行分析。他们被要求背诵《圣经》十分钟;随机点击一张图片，在图片前画出颈部角度来测量姿态。测量学生前后移动时的习惯最大和最小工作距离。记录每个学生在他曾经学习过的地方的亮度水平。结果:本研究结果显示近视与姿势阅读呈负相关([95% CI] RE r= -0.07, p = 0.228, LE r= -0.079, p = 0.173)，表明角度减小近视加重。亮度水平与近视呈显著下降相关([95% CI] RE r= -0.700, p = 0.000, LE -0.693, p = 0.000);当勒克斯(亮度)降低时，球面等效变大，反之亦然。球形当量与最小工作距离呈负相关([95% CI] RE r= -0.612, p = 0.000, LE r= -0.588, p = 0.000)。近视与最大工作距离呈负相关([95% CI] RE r= -0.634, p = 0.000, LE r= -0.604, p = 0.000)。结论:不同的工作距离、采用不正常的头部姿势和宗教学校的低亮度与近视有显著的关系。眼保健专业人员应该发挥他们的重要作用，使社会认识到，在执行近距离任务时，应避免所有这些危险因素，以阻止近视的发展。
{"title":"Relationship of posture, working distance and luminance with myopia among male population of religious rural schools of Pakistan","authors":"A. A. Chaudhary, Sidra Iqbal, Shamim Akhtar, M. Aslam, Fatima Iqbal","doi":"10.15406/aovs.2020.10.00393","DOIUrl":"https://doi.org/10.15406/aovs.2020.10.00393","url":null,"abstract":"Purpose: Aim of this study was to correlate head posture, working distance and luminance with Myopia. Methods: 300 myopic aged 7 to 18 years (mean 13.5 years) without spectacles male students were included. The subjects under study were analysed through comprehensive examination (visual acuity, objective and subjective refraction). They were asked to recite Holy Book for ten minutes; a random picture was clicked and posture was measured by drawing neck angle at the picture. Their habitual maximum and minimum working distance was measured when student move backward and forward. Luminance level was recorded of each student at place where he used to study. Results: Results of this study showed a negative correlation between myopia and posture reading ([95% CI] RE r= -0.07, p = 0.228, LE r= -0.079, p = 0.173) that depicts if angle decreases then myopia increases. A downhill and significant correlation was found between luminance level and myopia ([95% CI] RE r= -0.700, p = 0.000, LE -0.693, p = 0.000); as the lux (luminance) gets reduced the spherical equivalent gets increased and vice versa. There is a negative correlation between spherical equivalent and minimum working distance ([95% CI] RE r= -0.612, p = 0.000, LE r= -0.588, p = 0.000). A negative correlation between myopia and maximum working distance was found ([95% CI] RE r= -0.634, p = 0.000, LE r= -0.604, p = 0.000). Conclusion: We concluded that variable working distance, adoption of abnormal head posture and low luminance in Religious Schools has noteworthy association with myopia. Eye care professionals should play their vital role to enlighten the community that while performing near tasks all these risk factors should be avoided to halt the progression of myopia.","PeriodicalId":287670,"journal":{"name":"Advances in Ophthalmology & Visual System","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124881561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-28DOI: 10.15406/aovs.2020.10.00391
F. Co, Ajite Ko
Aim: To determine the acceptance rate and barrier to uptake of Trabeculectomy among glaucoma patients in our Hospital. Method: All newly diagnosed cases of primary open angle Glaucoma patients seen from May to October 2018 at the glaucoma clinic of Ekiti State University Teaching Hospital were interviewed for the study using a semi-structured questionnaire designed for it. The data obtained were coded and analyzed using Statistical Package for Social Sciences (SPSS) Version 15. Result: One hundred and thirty-eight primary open angle glaucoma patients with age range 23 to 82years, mean of 58.2 SD+14.6 were analyzed for this study, they comprised of 71males and 67 females, m: f ratio 1.05:1. Twenty four (17.4%) accepted surgery as against 114 (82.6%) that rejected it, fear of going blind was the most common reason for rejection (82.5%), other reasons include seeing well and bad experience of some other patients that had surgery. Conclusion: There is a low level of acceptance for Trabeculectomy in this study due mainly to fear of going blind. There is therefore the need for counselling of glaucoma patients on the benefit and safety of Trabeculectomy in order to reduce the magnitude of blindness from the disease.
{"title":"Acceptability and barrier to consideration for trabeculectomy among glaucoma patients in a tertiary hospital in South-Western Nigeria","authors":"F. Co, Ajite Ko","doi":"10.15406/aovs.2020.10.00391","DOIUrl":"https://doi.org/10.15406/aovs.2020.10.00391","url":null,"abstract":"Aim: To determine the acceptance rate and barrier to uptake of Trabeculectomy among glaucoma patients in our Hospital. Method: All newly diagnosed cases of primary open angle Glaucoma patients seen from May to October 2018 at the glaucoma clinic of Ekiti State University Teaching Hospital were interviewed for the study using a semi-structured questionnaire designed for it. The data obtained were coded and analyzed using Statistical Package for Social Sciences (SPSS) Version 15. Result: One hundred and thirty-eight primary open angle glaucoma patients with age range 23 to 82years, mean of 58.2 SD+14.6 were analyzed for this study, they comprised of 71males and 67 females, m: f ratio 1.05:1. Twenty four (17.4%) accepted surgery as against 114 (82.6%) that rejected it, fear of going blind was the most common reason for rejection (82.5%), other reasons include seeing well and bad experience of some other patients that had surgery. Conclusion: There is a low level of acceptance for Trabeculectomy in this study due mainly to fear of going blind. There is therefore the need for counselling of glaucoma patients on the benefit and safety of Trabeculectomy in order to reduce the magnitude of blindness from the disease.","PeriodicalId":287670,"journal":{"name":"Advances in Ophthalmology & Visual System","volume":"369 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126956671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-23DOI: 10.15406/aovs.2020.10.00389
Jeanie C Lucy
Purpose: Secondary glaucoma refers to any form of glaucoma in which there is an identifiable cause of increased eye pressure, resulting in optic nerve damage and vision loss. Presumed ocular histoplasmosis syndrome (POHS) is an infection caused by the fungus Histoplasma capsulatum. There are diverse ocular and systemic manifestations of POHS, ranging from influenza-like illness, cavitary lung disease to life threatening dissemination affecting multiple major organ systems. Once considered to be a public health threat mainly to Ohio, Mississippi River valley areas of the United States and South America, this case represents a new epidemiological report. Results: Initial presentation of a young patient to our clinical service revealed several punched-out-chorioretinal lesions evident in the left eye. Secondary glaucoma was diagnosed in the left eye after Avastin injection to treat a choroidal neovascular membrane secondary to histoplasmosis. The patient was treated successfully with a topical simbrinza for the glaucoma. Conclusion: The clinical presentation of histo-spots, peripapillary atrophy, and choroidal neovascularization represents a confirmed triad for POHS. Choroidal neovascular membranes can be a complication of POHS and anti-VEGF is a standard treatment. Certain anti-VEGF injections have been linked to sustained elevated intraocular pressure. From a public health perspective, we can look for POHS in other areas of the world where it is not usually and customarily found as well as monitor patients for prolonged increase in eye pressure after Avastin injection.
{"title":"Secondary open-angle glaucoma in presumed ocular histoplasmosis syndrome","authors":"Jeanie C Lucy","doi":"10.15406/aovs.2020.10.00389","DOIUrl":"https://doi.org/10.15406/aovs.2020.10.00389","url":null,"abstract":"Purpose: Secondary glaucoma refers to any form of glaucoma in which there is an identifiable cause of increased eye pressure, resulting in optic nerve damage and vision loss. Presumed ocular histoplasmosis syndrome (POHS) is an infection caused by the fungus Histoplasma capsulatum. There are diverse ocular and systemic manifestations of POHS, ranging from influenza-like illness, cavitary lung disease to life threatening dissemination affecting multiple major organ systems. Once considered to be a public health threat mainly to Ohio, Mississippi River valley areas of the United States and South America, this case represents a new epidemiological report. Results: Initial presentation of a young patient to our clinical service revealed several punched-out-chorioretinal lesions evident in the left eye. Secondary glaucoma was diagnosed in the left eye after Avastin injection to treat a choroidal neovascular membrane secondary to histoplasmosis. The patient was treated successfully with a topical simbrinza for the glaucoma. Conclusion: The clinical presentation of histo-spots, peripapillary atrophy, and choroidal neovascularization represents a confirmed triad for POHS. Choroidal neovascular membranes can be a complication of POHS and anti-VEGF is a standard treatment. Certain anti-VEGF injections have been linked to sustained elevated intraocular pressure. From a public health perspective, we can look for POHS in other areas of the world where it is not usually and customarily found as well as monitor patients for prolonged increase in eye pressure after Avastin injection.","PeriodicalId":287670,"journal":{"name":"Advances in Ophthalmology & Visual System","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131872817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-22DOI: 10.15406/aovs.2020.10.00388
Shubhangi Dubey
Cataract surgery today has become more of a refractive surgery with high patient expectations and demand of independence from glasses. Modern cataract surgery is characterized by obtaining precise postoperative target refraction with the premium intraocular lenses (IOLs) available today. The multifocal IOLs are designed to reduce the spectacle dependence after cataract surgery. Previously a variety of studies were performed that confirmed a significant improvement in uncorrected visual acuity after implantation of multifocal IOLs as compared to monofocal IOLs.1‒5 Initially multifocal IOLs that were designed were having a bifocal design which allowed the patient to have a good distance and near visual acuity post operatively, but near vision came at the expense of reduced contrast sensitivity.6‒8 Nowadays, due to increased use of computers the preference of spectacles has changed from near to intermediate distance. In this sense achieving an intermediate vision with an IOL is a good option. The IOL technologies in the latest times help in rehabilitating the distance and near visual acuities and also by incorporating a component of intermediate vision (ie, trifocal IOLs) to ensure spectacle independence.9‒11 The present study aims at assessing the performance of AT LISA tri 839MP trifocal diffractive IOL in terms of visual acuity and independence from spectacles. The other objectives are to assess changes in the distance, near and intermediate visual acuities, contrast sensitivity postoperatively and plotting the defocus curves.
{"title":"Visual outcomes after bilateral implantation of a new generation diffractive trifocal intraocular lens","authors":"Shubhangi Dubey","doi":"10.15406/aovs.2020.10.00388","DOIUrl":"https://doi.org/10.15406/aovs.2020.10.00388","url":null,"abstract":"Cataract surgery today has become more of a refractive surgery with high patient expectations and demand of independence from glasses. Modern cataract surgery is characterized by obtaining precise postoperative target refraction with the premium intraocular lenses (IOLs) available today. The multifocal IOLs are designed to reduce the spectacle dependence after cataract surgery. Previously a variety of studies were performed that confirmed a significant improvement in uncorrected visual acuity after implantation of multifocal IOLs as compared to monofocal IOLs.1‒5 Initially multifocal IOLs that were designed were having a bifocal design which allowed the patient to have a good distance and near visual acuity post operatively, but near vision came at the expense of reduced contrast sensitivity.6‒8 Nowadays, due to increased use of computers the preference of spectacles has changed from near to intermediate distance. In this sense achieving an intermediate vision with an IOL is a good option. The IOL technologies in the latest times help in rehabilitating the distance and near visual acuities and also by incorporating a component of intermediate vision (ie, trifocal IOLs) to ensure spectacle independence.9‒11 The present study aims at assessing the performance of AT LISA tri 839MP trifocal diffractive IOL in terms of visual acuity and independence from spectacles. The other objectives are to assess changes in the distance, near and intermediate visual acuities, contrast sensitivity postoperatively and plotting the defocus curves.","PeriodicalId":287670,"journal":{"name":"Advances in Ophthalmology & Visual System","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126827352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-30DOI: 10.15406/aovs.2020.10.00387
Arantrinita Evelyn Komaratih
Optical Coherence Tomography (OCT) is new technique that produces images of biological tissue by measuring the reflection of light from the structure being examined. OCT can greatly assist clinicians in diagnosing and managing glaucoma, especially early disease, when used in conjunction with serial clinical exams and visual field testing. Identification of structural damage to the optic nerve and retinal nerve fiber layer (RNFL) is an important component in the diagnosis of glaucoma. Spectral Domain OCT (SD-OCT), allows an earlier examination of these structures and is equipped with an analysis of the macula area to detect ganglion cell damage.
{"title":"Early diagnosis glaucoma using spectral domain OCT","authors":"Arantrinita Evelyn Komaratih","doi":"10.15406/aovs.2020.10.00387","DOIUrl":"https://doi.org/10.15406/aovs.2020.10.00387","url":null,"abstract":"Optical Coherence Tomography (OCT) is new technique that produces images of biological tissue by measuring the reflection of light from the structure being examined. OCT can greatly assist clinicians in diagnosing and managing glaucoma, especially early disease, when used in conjunction with serial clinical exams and visual field testing. Identification of structural damage to the optic nerve and retinal nerve fiber layer (RNFL) is an important component in the diagnosis of glaucoma. Spectral Domain OCT (SD-OCT), allows an earlier examination of these structures and is equipped with an analysis of the macula area to detect ganglion cell damage.","PeriodicalId":287670,"journal":{"name":"Advances in Ophthalmology & Visual System","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129838178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-26DOI: 10.15406/aovs.2020.10.00386
Hafiza Humaira Yasmeen, Iqra Khalil
Objective: To compare astigmatism after phacoemulsification and extracapsular cataract extraction technique. Method: It was a hospital-based cross-sectional study conducted at Zainab Medicare hospital Haroonabad from September 2018 to May 2019. A sample size of 80 patients having cataract, age 41 to 70 years was included in this study. Slit lamp examination was performed for anterior segment evaluation and astigmatism was determined with autorefraction and keratometry. Result: Phaco technique was more reliable. The means and the standard deviation of phaco post op astigmatism was 0.7860 ±.48880 and ECCE post op astigmatism was 3.6310±1.96236 which indicated that the degree of astigmatism increases after extra capsular cataract extraction technique. The significant level was 0.00 which showed that the phaco technique is highly significant. Conclusion: Corneal astigmatism was almost similar in two groups prior to surgery but after the cataract surgery the astigmatism significantly decreased after phacoemulsification group at 2 weeks follow-up, the results indicated that phaco may be considered superior to ECCE. No suturing is required in phaco and hence lesser chances of post op astigmatism.
{"title":"Comparison of astigmatism after phacoemulsification and extracapsular cataract extraction","authors":"Hafiza Humaira Yasmeen, Iqra Khalil","doi":"10.15406/aovs.2020.10.00386","DOIUrl":"https://doi.org/10.15406/aovs.2020.10.00386","url":null,"abstract":"Objective: To compare astigmatism after phacoemulsification and extracapsular cataract extraction technique. Method: It was a hospital-based cross-sectional study conducted at Zainab Medicare hospital Haroonabad from September 2018 to May 2019. A sample size of 80 patients having cataract, age 41 to 70 years was included in this study. Slit lamp examination was performed for anterior segment evaluation and astigmatism was determined with autorefraction and keratometry. Result: Phaco technique was more reliable. The means and the standard deviation of phaco post op astigmatism was 0.7860 ±.48880 and ECCE post op astigmatism was 3.6310±1.96236 which indicated that the degree of astigmatism increases after extra capsular cataract extraction technique. The significant level was 0.00 which showed that the phaco technique is highly significant. Conclusion: Corneal astigmatism was almost similar in two groups prior to surgery but after the cataract surgery the astigmatism significantly decreased after phacoemulsification group at 2 weeks follow-up, the results indicated that phaco may be considered superior to ECCE. No suturing is required in phaco and hence lesser chances of post op astigmatism.","PeriodicalId":287670,"journal":{"name":"Advances in Ophthalmology & Visual System","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114881483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-22DOI: 10.15406/aovs.2020.10.00385
M. Khamaily, Joumany Brahim Salem, I. Tarib, T. Abdellaoui, Y. Mouzari, F. Asri, K. Reda, A. Oubaaz
{"title":"Large colloid drusen in young patient instead","authors":"M. Khamaily, Joumany Brahim Salem, I. Tarib, T. Abdellaoui, Y. Mouzari, F. Asri, K. Reda, A. Oubaaz","doi":"10.15406/aovs.2020.10.00385","DOIUrl":"https://doi.org/10.15406/aovs.2020.10.00385","url":null,"abstract":"","PeriodicalId":287670,"journal":{"name":"Advances in Ophthalmology & Visual System","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128062205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-01DOI: 10.15406/aovs.2020.10.00384
Abel Ramón Concepción, Efraín Romo García, Jesús R Álvarez Félix, Silvia Paz Camacho, Elmer López Meza, Itzel Vega Pujalte, Ilse Ochoa Mellado, M. L. Barraza, Carla Angulo Rojo
Introduction: Neurodegenerative diseases affect the central nervous system and cause progressive dysfunction. These debilitating and incurable conditions are characterized by loss of neuronal cell function and are often associated with atrophy of the affected nervous system structures. The retina and the optic nerve are considered an extension of the central nervous system due to their embryonic origin and myelination by oligodendrocytes. Thereby, common physiopathological mechanism may be implicated in the neurodegeneration progress, regulated by key molecules as microRNAs. Aim: To determine the expression profile of microRNAs in peripheral blood in patients with neurodegenerative eye diseases such Glaucoma and Alzheimer´s disease. Methods: Observational, multicentric, comparative study. 50 patients distributed into four groups were included for this study: 10 (20%) with Alzheimer's disease, 20 (40%) with Glaucoma and 20 (40%) healthy control individuals. Results: miR-155 was found to be with tendency to overexpression in the Glaucoma group. miR-483 was found to be significatively overexpressed by five times in the Glaucoma group compared to control individuals. No significant changes were observed for Alzheimer’s disease group in both microRNAs. Conclusion: The preliminary results observed in this study, may suggest that the miR155 and miR483 microRNAs show peripheral blood levels that can be measured in a repeatable and reliable way, this opens the way to a new route of early diagnosis and possible treatment for neurodegenerative eye disease like glaucoma.
{"title":"MicroRNAs in neurodegenerative eye disease","authors":"Abel Ramón Concepción, Efraín Romo García, Jesús R Álvarez Félix, Silvia Paz Camacho, Elmer López Meza, Itzel Vega Pujalte, Ilse Ochoa Mellado, M. L. Barraza, Carla Angulo Rojo","doi":"10.15406/aovs.2020.10.00384","DOIUrl":"https://doi.org/10.15406/aovs.2020.10.00384","url":null,"abstract":"Introduction: Neurodegenerative diseases affect the central nervous system and cause progressive dysfunction. These debilitating and incurable conditions are characterized by loss of neuronal cell function and are often associated with atrophy of the affected nervous system structures. The retina and the optic nerve are considered an extension of the central nervous system due to their embryonic origin and myelination by oligodendrocytes. Thereby, common physiopathological mechanism may be implicated in the neurodegeneration progress, regulated by key molecules as microRNAs. Aim: To determine the expression profile of microRNAs in peripheral blood in patients with neurodegenerative eye diseases such Glaucoma and Alzheimer´s disease. Methods: Observational, multicentric, comparative study. 50 patients distributed into four groups were included for this study: 10 (20%) with Alzheimer's disease, 20 (40%) with Glaucoma and 20 (40%) healthy control individuals. Results: miR-155 was found to be with tendency to overexpression in the Glaucoma group. miR-483 was found to be significatively overexpressed by five times in the Glaucoma group compared to control individuals. No significant changes were observed for Alzheimer’s disease group in both microRNAs. Conclusion: The preliminary results observed in this study, may suggest that the miR155 and miR483 microRNAs show peripheral blood levels that can be measured in a repeatable and reliable way, this opens the way to a new route of early diagnosis and possible treatment for neurodegenerative eye disease like glaucoma.","PeriodicalId":287670,"journal":{"name":"Advances in Ophthalmology & Visual System","volume":"49 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132502530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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