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Tatoos and Uveitis
Pub Date : 2019-03-12 DOI: 10.15406/aovs.2019.09.00340
B. DeBroff
The association of skin tattoos and the latter occurrence of uveitis were first described in 1952. This article reviews the causation, presenting symptoms, physical examination, and work-up, histology, and treatment options. Ophthalmologists need to consider this etiology when patients present with uveits and the public needs to understand the risks associated with skin tattoos.
皮肤纹身与后一种葡萄膜炎的关系在1952年首次被描述。本文综述了病因、表现症状、体格检查和检查、组织学和治疗方案。当患者出现葡萄膜时,眼科医生需要考虑这种病因,公众需要了解与皮肤纹身相关的风险。
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引用次数: 0
Immunohistochemical characterization of sub retinalmembranes (SRMs) in proliferative vitreoretinopathy 增生性玻璃体视网膜病变视网膜下膜(SRMs)的免疫组织化学特征
Pub Date : 2018-02-21 DOI: 10.15406/aovs.2018.08.00270
H. Alkatan, Mohammed D. Alotaibi, A. Maktabi, D. Edward, I. Kozák
Purpose: To provide immuno histo chemical characterization of sub retinal bands removed during retinal surgery in eyes with proliferative vitreo retinopathy (PVR). Methods: This study included all eyes with the clinical diagnosis of PVR that underwent pars plana vitrectomy surgery during which the subretinal tissue causing retinal detachment was obtained. The subretinal bands were removed “en bloc” through retinotomy using subretinal intraocular forceps. The excised tissue was sent for histopathologic analysis. Immunohistochemistry (IHC) was performed to confirm the cellular nature and components of these subretinal membranes. The IHC stains included, glial fibrillary acidic protein (GFAP), Pancytokeratin, CD3 CD20 CD68 and CD34. Results: Subretinal membranes (SRMs) from 7 eyes were included in the analysis. All cases had successful surgical outcome with reattachment six months after surgery. The microscopic examination of the excised tissue nicely demonstrated the constituents of the SRM as follows: retinal pigmented epithelial (RPE) cells that stained positively with cytokeratin (7/7), avascular plaques of RPE cells showing metaplasia in the form of spindle cells (7/7). Fragments of gliotic GFAP-positive neural retina was adherent to the fibrous plaque (6/7). Bruch’s membrane was identified in one specimen. CD68 positive macrophages were seen in (5/7) being silicon oil- laden macrophages in2/5. Rare CD3 positive cells were also noted in 1 specimen. Conclusion: Subretinal bands in PVR are mainly composed of reactive avascular plaques of RPE metaplasia and macrophage infiltration. The overlying gliotic retina or Bruch’s membrane are likely to be adherent to such plaques and might be inadvertently excised during removal of such membranes. Removal of SRMs is essential for successful reattachment of the retina.
目的:研究增殖性玻璃体视网膜病变(PVR)视网膜手术切除视网膜下带的免疫组化特征。方法:本研究纳入所有临床诊断为PVR并行玻璃体切割手术的眼,手术过程中获得视网膜下组织导致视网膜脱离。视网膜下带通过视网膜下眼内钳视网膜切开术“整体”切除。切除的组织送去做组织病理学分析。免疫组织化学(IHC)证实了这些视网膜下膜的细胞性质和成分。免疫组化染色包括:胶质纤维酸性蛋白(GFAP)、泛细胞角蛋白、CD3、CD20、CD68和CD34。结果:7只眼的视网膜下膜(SRMs)被纳入分析。所有病例术后6个月均成功复位。切除组织的显微镜检查清楚地显示SRM的组成如下:视网膜色素上皮(RPE)细胞被细胞角蛋白染色呈阳性(7/7),RPE细胞的无血管斑块显示梭形细胞的化生(7/7)。胶质细胞gmap阳性的神经视网膜碎片粘附在纤维斑块上(6/7)。在一个标本中发现了布鲁氏膜。CD68阳性巨噬细胞为(5/7),硅油负载巨噬细胞为(2/5)。1例标本中也有罕见的CD3阳性细胞。结论:PVR视网膜下带主要由RPE化生反应性无血管斑块和巨噬细胞浸润组成。上面的胶质视网膜或Bruch膜可能附着在斑块上,在去除这些膜的过程中可能被无意中切除。摘除srm对于成功的视网膜再附着是必不可少的。
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引用次数: 1
An unusual case of pseudo foster kennedy syndrome 伪福斯特·肯尼迪综合症的罕见病例
Pub Date : 2018-02-21 DOI: 10.15406/aovs.2018.08.00269
J. Bhalla, P. Lal
We are hereby presenting a case of Pseudo Foster Kennedy syndrome, which is a rare phenomenon in itself because of normal level of inflammatory markers i.e. ESR and CRP levels with positive temporal artery biopsy.
我们在此报告一例伪福斯特肯尼迪综合征,这是一种罕见的现象,因为炎症标志物,即ESR和CRP水平正常,颞动脉活检呈阳性。
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引用次数: 0
Unilateral Multiple Serous Retinal Detachments in Polycythemia Vera Patient 真性红细胞增多症患者单侧多发性浆液性视网膜脱离
Pub Date : 2018-02-16 DOI: 10.15406/aovs.2018.08.00267
Oudeh M, Marashi A
Purpose: To report a case with new signs that could be caused by polycythemia vera itself or just a coincidence and managing it with systemic steroids. Methods: This was interventional case report, of a 59-year-old patient with polycythemia vera, presented with acute unilateral vision loss. Ophthalmological investigation revealed multiple serous retinal detachments with mild anterior chamber reaction these signs look similar to ocular signs of Vogt-Koyanagi-Harada disease, but in one eye and without systematic involvement of VKH. Polycythemia vera is a haematological disease that causes an increase number of red blood cells. The patient red blood cells were normal and he was compliance with Polycythemia vera treatment. All infectious tests were negative as well as autoimmune disease markers. Unilateral probable VKH disease was our diagnosis, patient was managed. Results: Polycythemia vera is a haematological disease that have a few ocular symptoms. These signs include multiple serous retinal detachments with uveitis that respond well to corticosteroids. Conclusion: Systematic corticosteroids which show a remarkable improvement in ocular signs and symptoms of Polycythemia vera that mimic VKH.
目的:报告一个可能由真性红细胞增多症本身或巧合引起的新症状,并使用全身性类固醇治疗。方法:这是一个59岁真性红细胞增多症患者的介入病例报告,表现为急性单侧视力丧失。眼科检查显示多发性浆液性视网膜脱离,伴有轻度前房反应,这些体征与Vogt-Koyanagi-Harada病的眼部体征相似,但在一只眼睛中,没有VKH的系统性累及。真性红细胞增多症是一种引起红细胞增多的血液病。患者红细胞正常,符合真性红细胞增多症治疗。所有的感染性检查和自身免疫性疾病标志物均为阴性。我们诊断单侧疑似VKH病,对患者进行治疗。结果:真性红细胞增多症是一种具有少量眼部症状的血液病。这些征象包括多发性浆液性视网膜脱离伴葡萄膜炎,对皮质类固醇反应良好。结论:系统使用皮质类固醇可显著改善真性红细胞增多症的眼部体征和症状。
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引用次数: 0
Acanthamoeba Keratitis - A Diagnostic Dilemma: A Case Report 棘阿米巴角膜炎-诊断困境:一个病例报告
Pub Date : 2018-02-16 DOI: 10.15406/aovs.2018.08.00268
Praveen Panwar, K. Sharma
Acanthi amoeba keratitis presents as diagnostic dilemma as it mimics herpes simpex viral keratitis. It is also a diagnostic challenge due to lack of awareness, difficulty in diagnosis which requires strong clinical suspicion and lack of effective treatment further complicates its management. We report a case of 47years old female with pain, redness and watering having deep stoma ring infiltrates. The strong suspicion based on clinical findings and failure to respond to antiviral therapy prompted us to investigate her further and the diagnosis of acanthi amoeba keratitis was made although there was no history of contact lens wear. Inspite of full diagnostic work up for bacterial, fungal and viral corneal pathogen, the diagnosis of Acanthi amoeba can be easily missed, therefore one must keep the possibility of this rare entity.
棘阿米巴角膜炎表现为诊断困境,因为它模仿单纯疱疹病毒性角膜炎。由于缺乏认识,诊断困难,需要强烈的临床怀疑和缺乏有效的治疗,这也是一个诊断挑战,进一步复杂化了其管理。我们报告一位47岁女性病患,因深口环浸润而出现疼痛、红肿及流泪。基于临床表现和抗病毒治疗无效的强烈怀疑促使我们对她进行进一步调查,尽管没有佩戴隐形眼镜的历史,但仍诊断为棘阿米巴角膜炎。尽管对细菌性、真菌性和病毒性角膜病原体进行了全面的诊断,但棘阿米巴的诊断很容易被遗漏,因此必须保持这种罕见实体的可能性。
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引用次数: 2
Incidence and Management of Retinoblastoma 视网膜母细胞瘤的发病率和治疗
Pub Date : 2018-02-09 DOI: 10.15406/aovs.2018.08.00266
N. Khan, S. Khan, A. Khan, Aisha Khan, Atiqa Khan, Sobia Khan
This was a retrospective as well as prospective study of fifty (50) cases of retinoblastoma in series during the study period from January 2005 to December 2015, conducted at Liaquat Medical College Eye hospital and Indus Medical College Hospital, Pakistan. The average incidence of retinoblastoma in cases presented in our department was 4.5 cases per year with 0.8 cases per year bilateral and 3.7 cases per year with unilateral involvement respectively. The minimum age in this series was 15 days and maximum age was 8 years, mean age being 3.46 years. Out of these 50 cases, 27(54%) were male and 23(46%) were females. In most of the cases diagnosis was made on clinical grounds and histopathological reports of the biopsy specimens. Other measures like plain X-ray orbit, CT scan, ultrasonography (A and B Scan) and studies of blood chemistry were used where ever needed. Majority of our cases were found to be in a fairly advanced stage (an aplasia grade severe) that is extending beyond the sclera in the orbital tissues. In 4 cases cat’s eye reflex noted. Out of these cases 3 were having involvement of the other eye extensively while in 4th case the other eye was not involved at all. Of the remaining cases 11(22%) were having vitreous seeding, 16(32%) showed extension up to the sclera and 22(44%) extended to involve the orbit. Only one case presented with the involvement of regional lymph nodes. All those cases that underwent modified exonerations were sent to radio isotope center for further management with radiation and/or chemotherapy depending upon the nature of spread. One patient who had the regional lymph nodes involvement, though did not show extra ocular spread in the orbit, underwent chemotherapy following enucleations.2 cases which were diagnosed in very early stage involving the posterior retina behind equator were managed by 60 Cobalt radioactive plaques insertion over the sclera at the site of lesion, left in place till such time as advised by the oncologist of the radio isotope center. A total of 28 enucleations and 19 modified exentrations were carried out. Recurrences were noted in 13 cases, no surgery was done in these cases and they were referred to radio isotope center at Jamshoro, Pakistan for further management with radiation or chemotherapy. In this series no case was found to have distant metastasis anywhere including long bones and other viscera of the body. 12 cases were lost to follow up at different stages of management and 6 of the cases died of unknown cause.
本研究是一项回顾性和前瞻性研究,对2005年1月至2015年12月期间在巴基斯坦Liaquat医学院眼科医院和印度河医学院医院进行的50例视网膜母细胞瘤进行了系列研究。我科视网膜母细胞瘤平均发病率为4.5例/年,其中双侧0.8例/年,单侧3.7例/年。最小年龄15天,最大年龄8岁,平均年龄3.46岁。其中男性27例(54%),女性23例(46%)。在大多数情况下,诊断是根据临床依据和活检标本的组织病理学报告。其他措施,如普通x射线轨道、CT扫描、超声检查(A和B扫描)和血液化学研究,在需要的时候也会用到。我们的大多数病例被发现处于相当晚期(发育不全严重程度),并延伸到眼眶组织的巩膜以外。4例观察到猫眼反射。在这些病例中,有3例另一只眼睛大面积受累,而第4例另一只眼睛完全没有受累。其余11例(22%)为玻璃体植入,16例(32%)延伸至巩膜,22例(44%)延伸至眼眶。仅一例表现为局部淋巴结受累。所有经过修正的免责的病例被送往放射性同位素中心,根据扩散的性质进行放射和/或化疗的进一步治疗。一名局部淋巴结受累的患者,虽然没有显示眼眶外扩散,但在眼球摘除术后接受了化疗。2例早期诊断为赤道后视网膜病变的患者,在病变部位的巩膜上植入60个钴放射性斑块,直至放射性同位素中心肿瘤学家建议的时间。共进行了28例去核和19例改良去核。13例复发,这些病例未做手术,他们被转诊到巴基斯坦Jamshoro的放射性同位素中心接受放射或化疗的进一步治疗。在这一系列病例中,没有发现远处转移,包括长骨和身体其他脏器。12例在不同治疗阶段失访,6例死亡原因不明。
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引用次数: 0
Goldenhar Syndrome Goldenhar综合症
Pub Date : 2018-02-08 DOI: 10.15406/aovs.2018.08.00265
A. Chauhan, S. Chauhan
Goldenhar syndrome is a hereditary condition which is characterized by preauricular appendages, epibulbar dermoids, along with anomalies of the heart, kidney, and vertebral, central nervous and gastrointestinal system. We report a case of Goldenhar syndrome in a 7-years-old male patient who presented with limbal dermoid, pre auricular tag, microtia and mandibular hypoplasia. We AIM to report this case, given the rarity of this syndrome, and classical signs seen in our patient.
Goldenhar综合征是一种遗传性疾病,其特征是耳前附属物、球外皮样,以及心脏、肾脏、脊椎、中枢神经和胃肠道系统的异常。我们报告一个7岁男性患者的高登哈综合征,他表现为角膜缘皮样,耳前标签,小畸形和下颌发育不全。我们的目的是报告这个病例,考虑到这种综合征的罕见性,并在我们的病人看到经典的迹象。
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引用次数: 0
Neurodegenerative diseases oculomotor manifestations. clinical cases  神经退行性疾病。临床病例
Pub Date : 1900-01-01 DOI: 10.15406/aovs.2022.12.00411
N. Moyseyenko
Oculomotor manifestations (nystagmus and diplopia) do not lead to blindness. But the loss of cognitive properties in the background, such as ability recognition and reading, leads to irreparable social consequences. Therefore, improved methods of diagnostic oculomotor disorders will help reveal neurodegenerative disease in earlier stages. Moreover, their correction will prevent undesirable outcomes. Clinical case 1- Partial Parinaue's syndrome, confirmed by MRI revealed multiple small degenerations in the area of the brain bridge (according to the localization indicated by Parinaue's syndrome - in the dorsal - medial part). Clinical case 2- Pronounced vertical-rotational nystagmus of both eyes with greater amplitude in the lead positions. Viral encephalomyelitis. In their form and nature, oculomotor disorders are a good indicator of the topic of damage to deep brain structures such as the trunk and bridge. Therefore, a more thorough study will help diagnose neurodegenerative injury in the early stages, treatment and prevent unwanted social consequences.
眼球运动表现(眼球震颤和复视)不会导致失明。但在后台认知能力的丧失,如识别和阅读能力,会导致无法弥补的社会后果。因此,改进的眼动疾病诊断方法将有助于在早期阶段发现神经退行性疾病。此外,他们的纠正将防止不良后果。临床病例1-部分Parinaue综合征,MRI证实脑桥区多发小变性(根据Parinaue综合征定位-在背-内侧)。临床病例2-双眼明显垂直旋转性眼球震颤,前导位置振幅较大。病毒性脑脊髓炎。就其形式和性质而言,动眼病是脑深部结构(如躯干和脑桥)损伤的一个很好的指标。因此,更深入的研究将有助于早期诊断神经退行性损伤,治疗和防止不必要的社会后果。
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引用次数: 0
Awareness about retinopathy of prematurity among nurses working at neonatal intensive care unit of nampula central hospital in mozambique, 2021 2021年,莫桑比克楠普拉中心医院新生儿重症监护室护士对早产儿视网膜病变的认识
Pub Date : 1900-01-01 DOI: 10.15406/aovs.2022.12.00410
Joel Bambamba, ​Carlos Fresno, ​Angela Bambamba, ​Sancho Chivinde, ​Momade Fumo, ​Hermenegildo Tomo, ​Alcino Muaprato, ​Suale Puchar
Introduction: Retinopathy of prematurity is a bilateral dysfunction of abnormal retinal vascularization in preterm infants, especially those with very low birth weight. The consequences range from normal vision to blindness. In recent years, the survival rate for the extreme group of patients with prematurity has increased from 8% to 35% in middle-income countries, as well as its early identification of retinal damage and institution of appropriate treatment to prevent blindness and provide children with better overall development. The natural evolution of the disease generates a high social and financial cost for the entire community, since in its more advanced stages it causes severe and irreversible damage to vision, also impairing the entire cognitive and psychomotor development of the affected child. Objective: The aim of the study was to document the awareness about Retinopathy of Prematurity among nurses working at neonatal intensive care unit of Nampula Central Hospital in Mozambique. Methods: A questionnaire was designed on awareness pattern. The questionnaire included questions about nurses education and experience, knowledge of screening guidelines, risk factors for Retinopathy of Prematurity, diagnose and treatment and it was applied to16 nurses working at neonatal intensive care unit of Nampula Central Hospital in Mozambique. It was a self-administered questionnaire, collected in October 2021. Results: The total number of the sample was 16 nurses, 87.5% were female and 12.5% were male. The mean age of study participants was 35.9 ± 7.3 years old. It was observed that the age of respondents shows predominance towards 40 years and above. Regarding the working experience at the neonatal intensive care, 43.75% of participants ranged from 1-4 years. Among the most cited risk factors; indicated professional to perform the eye exam; timing to perform the eye exam and the indicated treatment for Retinopathy of Prematurity, the following stand out: Low gestational age (56.25%);Retina Specialist(75.0%); Depends of Gestational Age (56.25%) and Cryotherapy alongside with Laser Photocoagulation and surgery (31.25%). Conclusion: The results of the study suggest that most nurses working in the neonatal Intensive care unit services of Nampula Central Hospital were aware about the prevention, diagnose and treatment of Retinopathy of Prematurity. The findings indicate the need for dissemination of information through seminars, workshops and internal educational activities to improve nurses' awareness about the clinical condition.
前言:早产儿视网膜病变是一种双侧视网膜血管化异常的功能障碍,发生在早产儿,尤其是出生体重过低的早产儿。其后果从正常视力到失明不等。近年来,中等收入国家极端早产儿患者群体的存活率从8%提高到35%,以及早期发现视网膜损伤并采取适当治疗以预防失明和为儿童提供更好的全面发展。这种疾病的自然演变给整个社区造成了高昂的社会和经济代价,因为在其较晚期阶段,它会对视力造成严重和不可逆转的损害,还会损害受影响儿童的整个认知和精神运动发育。目的:本研究的目的是记录在莫桑比克南普拉中心医院新生儿重症监护病房工作的护士对早产儿视网膜病变的认识。方法:采用认知模式设计问卷。问卷包括护士的教育和经验、筛查指南知识、早产儿视网膜病变的危险因素、诊断和治疗等问题,并应用于莫桑比克南普拉中心医院新生儿重症监护病房的16名护士。这是一份自我管理的问卷,于2021年10月收集。结果:共16名护士,其中女性占87.5%,男性占12.5%。研究参与者的平均年龄为35.9±7.3岁。据观察,受访者的年龄以40岁及以上为主。在新生儿重症监护工作经验方面,43.75%的参与者在1-4年之间。在被引用最多的风险因素中;指定专业人员进行眼科检查;早产儿视网膜病变的视力检查时机和指征治疗,以下方面突出:低胎龄(56.25%);视网膜专科医生(75.0%);取决于胎龄(56.25%)和冷冻治疗联合激光光凝和手术(31.25%)。结论:南普拉中心医院新生儿重症监护病房的护士对早产儿视网膜病变的预防、诊断和治疗有一定的了解。研究结果表明,需要通过研讨会、讲习班和内部教育活动来传播信息,以提高护士对临床状况的认识。
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引用次数: 0
Effect of vision therapy on fusional vergences in intermittent exotropia 视力治疗对间歇性外斜视融合性斜视的影响
Pub Date : 1900-01-01 DOI: 10.15406/aovs.2022.12.00408
Priyanka Kumari, Shua Azam, S. Abbas, Nusrat Waheed, Abdul Hameed Talpur, S. Bukhari
Significance: Intermittent exotropia is intermittently manifest squint at distance and latent exophoria at near. Most of the time, the eyes seems to be aligned with normal binocular single vision is maintained because its exodeviation is intermittently controlled by fusional mechanisms. Purpose: To evaluate the effect of vision therapy on fusional vergences in intermittent exotropia. Methods: This hospital-based, Quasi-Experimental study was carried out at the Orthoptics clinic of Al-Ibrahim Eye Hospital from August 2020 to July 2021. Non- probability, purposive sampling was used. This study involved the 40 subjects who were diagnosed with Intermittent Exotropia of age ranges 10 to 25 years, of both genders. A detailed history was evaluated. Orthoptics assessment included visual acuity, cover test, near the point of accommodation and convergence at a distance, and near and fusional vergences of positive and negative with prisms were measured. All subjects underwent vision therapies for 2 months. SPSS version 20.0 was used to analyze the data. Results: A total of 40 subjects with a mean age of 16.53±2.96 were included in this study. Out of 40 subjects, 22 subjects were females and 18 subjects were males. Subjects who received dot card therapy and executives bifocals therapy showed a significant change in the angle of deviation at distance and near (P=.001), followed by reduced the near point of convergence (P=.001), and increased the positive fusional vergences at distance and near (P=.001). There was no significant improvement seen in near point of accommodation (P=.16) with both therapies. Negative fusional vergences showed non-significant as (near: P=.14, distance: P=.05) with executives bifocals and (P=.26) with dot cards. Conclusions: This study showed that vision therapies with dot card and executive bifocals therapy have significantly improved the angle of deviation, positive fusional vergences, and near point of convergence in intermittent exotropia subjects.
意义:间断性外斜视是指远处间歇性地出现斜视,近处潜伏性外斜视。大多数情况下,双眼似乎与正常双目对齐,单视力得以维持,是因为它的外偏移是由融合机制间歇性地控制的。目的:评价视力治疗对间歇性外斜视融合性会聚的影响。方法:本以医院为基础的准实验研究于2020年8月至2021年7月在Al-Ibrahim眼科医院矫视门诊进行。采用非概率、有目的抽样。这项研究涉及40名年龄在10到25岁之间被诊断为间歇性外斜视的受试者,男女皆有。详细的病史评估。正视光学评估包括视力、覆盖测试、近距离调节点和会聚点,以及正、负与棱镜的近距和会聚。所有受试者均接受视力治疗2个月。采用SPSS 20.0版本对数据进行分析。结果:共纳入受试者40例,平均年龄16.53±2.96岁。在40名受试者中,22名为女性,18名为男性。接受点卡治疗和双焦点治疗的受试者在远、近角度偏差发生显著变化(P= 0.001),近会聚点减少(P= 0.001),远、近正向会聚点增加(P= 0.001)。两种治疗方法在近调节点均无显著改善(P= 0.16)。负的融合收敛在(接近:P=)时显示不显著。14,距离:P= 0.05)与高管双光眼镜和(P=.26)点卡。结论:本研究表明,点卡视觉治疗和执行双光治疗可显著改善间歇性外斜视患者的偏斜角、正融合点和近会聚点。
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引用次数: 0
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