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Kardiomiopati Tirotoksikosis 心肌病 甲状腺毒症
Pub Date : 2024-06-03 DOI: 10.55175/cdk.v51i6.1074
Nikolaus Lizu Tallo, Meri Estivo Sihombing
Tirotoksikosis merupakan sindrom klinis akibat berlebihnya produksi hormon tiroid (hipertiroidisme). Perubahan konsentrasi hormon tiroid secara langsung memengaruhi terjadinya perubahan abnormal struktur dan/atau fungsi jantung yang menyebabkan kardiomiopati dan meningkatkan risiko komplikasi seperti gagal jantung dan aritmia yang mengancam jiwa. Data global menunjukkan sekitar 1% pasien tirotoksikosis mengalami kardiomiopati dilatasi yang menyebabkan gangguan berat fungsi ventrikel kiri dan berujung pada syok kardiogenik. Diagnosis dini dan tata laksana yang tepat sangat diperlukan untuk luaran dan prognosis yang lebih baik.
甲亢是甲状腺激素分泌过多(甲状腺功能亢进症)导致的临床综合征。甲状腺激素浓度的变化会直接影响心脏结构和/或功能的异常变化,导致心肌病,并增加心力衰竭和危及生命的心律失常等并发症的风险。全球数据显示,约有1%的甲亢患者会发生扩张型心肌病,导致左心室功能严重受损,引发心源性休克。为了获得更好的治疗效果和预后,早期诊断和适当的治疗是必要的。
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引用次数: 0
Analysis of Risks of Low Energy Availability and Eating Disorders in Female Elite Dancers at X Dance School in Jakarta, Indonesia 印度尼西亚雅加达 X 舞蹈学校女性精英舞者能量不足和饮食失调的风险分析
Pub Date : 2024-06-03 DOI: 10.55175/cdk.v51i6.1045
N. Sudarsono, Ria Lestari, Yose Natasa
Due to their aesthetic demand and high training load, ballet dancers are often at risk of low energy availability (LEA), with or without eating disorders (ED). A prolonged state of LEA may alter physiological function and lead to other major health concerns. This study aims to analyze the risk of LEA and eating disorders in female elite dancers at X dance school in Jakarta. This descriptive cross-sectional design study was followed by 11 dancers. Risk of LEA was assessed using the low energy availability in females questionnaire (LEAF-Q), eating behaviors using the eating attitude test (EAT-26) questionnaire, and body composition using the bioelectrical impedance analysis (BIA) instrument. A total of 18.2% of dancers were at risk of LEA (LEAF-Q score ≥8) and no dancers were at risk of eating disorders. The most common characteristics of LEA are gastrointestinal dysfunction (90.9%), followed by menstrual disturbance (45.5%), and musculoskeletal injury (9.1%). Compared to the first study in Indonesia, this study showed lower proportion of dancers at risk of LEA and ED at X dance school in Jakarta. Despite a lower proportion, most dancers experienced other characteristics of LEA, thus prevention and health management are required to reduce further health issues.
由于芭蕾舞演员的审美要求和高训练负荷,他们经常面临低能量可用性(LEA)的风险,并伴有或不伴有饮食失调(ED)。长期的低能量状态可能会改变生理功能,并引发其他重大健康问题。本研究旨在分析雅加达 X 舞蹈学校的女性精英舞蹈演员患 LEA 和饮食失调症的风险。这项描述性横断面设计研究对 11 名舞者进行了跟踪调查。使用女性低能量可用性问卷(LEAF-Q)评估 LEA 风险,使用饮食态度测试(EAT-26)问卷评估饮食行为,使用生物电阻抗分析(BIA)仪器评估身体成分。共有 18.2% 的舞者有 LEA 风险(LEAF-Q 分数≥8),没有舞者有饮食失调风险。最常见的 LEA 特征是胃肠功能紊乱(90.9%),其次是月经紊乱(45.5%)和肌肉骨骼损伤(9.1%)。与印尼的第一项研究相比,本研究显示雅加达 X 舞蹈学校的舞者有 LEA 和 ED 风险的比例较低。尽管比例较低,但大多数舞者都有 LEA 的其他特征,因此需要进行预防和健康管理,以减少进一步的健康问题。
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引用次数: 0
Saphenous Vein Graft (SVG) Stenosis Revascularization with Percutaneous Coronary Intervention (PCI) 经皮冠状动脉介入治疗(PCI)的隐静脉移植(SVG)狭窄血管再通术
Pub Date : 2024-06-03 DOI: 10.55175/cdk.v51i6.983
I. M. O. Intervention Lissa Sabrina, I. P. PCI Sidharta Salim Adnyana, Amalia Nurjanah Pradnyandari, 1. Anak, Wynne Putradana Agung Candra, Putu Dyah Djoen Herdianto Wahyuni, Ida Ayu, Cintya, Ayu Saraswati, terutama setelah cedera . The combination of HIV and Sidharta Salim. Sindr, syphilis needs longer dan Osteomalasia otak traumatis, therapy and requires Diinduksi Tenofovir minimal. Gambaran, E. Tedyanto, Eka Widyadharma
Coronary artery bypass grafting (CABG) is the most ideal and frequently performed procedure for multi-vascular coronary artery stenosis, but its long-term prognosis is unfavorable. A 64-year-old male with a history of coronary artery graft surgery seven years ago complained of recurrent chest pain radiating to the jaw, relieved by isosorbide dinitrate. Physical examination, electrocardiography, and echocardiography test results were within normal limits. Laboratory results showed critical blood urea nitrogen (BUN) values requiring hemodialysis, on angiographic examination showed stenosis in all grafted and native coronary arteries. The diagnoses were grade III coronary artery disease and renal failure. Percutaneous coronary intervention using a drug-eluting stent (DES) in the saphenous vein graft conduit of the right coronary artery was performed, along with dual antiplatelet agents, b-blockers, nitrates, and statins.
冠状动脉旁路移植术(CABG)是治疗多血管冠状动脉狭窄最理想、最常用的手术,但其长期预后并不乐观。一名 64 岁的男性患者 7 年前接受过冠状动脉移植手术,主诉胸痛反复发作,并向下颌放射,服用二硝酸异山梨酯后症状缓解。体格检查、心电图和超声心动图检查结果均在正常范围内。化验结果显示血尿素氮(BUN)值达到临界值,需要进行血液透析,血管造影检查显示所有移植冠状动脉和原生冠状动脉均有狭窄。诊断结果为 III 级冠状动脉疾病和肾衰竭。在右冠状动脉的大隐静脉移植导管中使用药物洗脱支架(DES)进行了经皮冠状动脉介入治疗,同时使用了双联抗血小板药物、b受体阻滞剂、硝酸盐和他汀类药物。
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引用次数: 0
Hearing Improvement in Autoinflated Otitis Media Effusion Patients 自动充气中耳炎流脓患者的听力改善
Pub Date : 2024-06-03 DOI: 10.55175/cdk.v51i6.1024
Ugiadam Farhan Firmansyah, Kemal Akbar Suryoadji, Jenny Bashirudin, Brastho Bramantyo, W. Alviandi
Background: Otitis media with effusion (OME) is the presence of middle ear fluid without acute ear infection signs or symptoms. OME is one of the causes of hearing loss. Chronic asymptomatic OME could be managed by careful waiting for 3 months because it is a self-limiting disease. During surveillance, autoinflation is a beneficial intervention with minimal side effects and high adherence. Objective: To evaluate the effectiveness of autoinflation to improve hearing in otitis media with effusion and hearing loss. Methods: Literature searching was conducted through PubMed, Cochrane, ScienceDirect, Scopus, and EBSCOHost with inclusion and exclusion criteria. The articles were selected and underwent critical appraisal using rapid critical appraisal of systematic review and level of evidence by the Oxford Centre for Evidence-based Medicine in 2011. Result: One systematic review and meta-analysis, or RCT, met the criteria. This article revealed a pooled estimate of RR 1.74; 95% CI [1.22-2.50] with a Z-score of 3.02 (p=0.0025). This result showed substantial significant (p=0.01) heterogeneity (I2=69%). Conclusion: OME patients with hearing loss who performed autoinflation >1 month had a 1.74 times greater chance of achieving hearing improvement than controls. Autoinflation with the Politzer method gives significant results in improving hearing loss. Large-scale RCT research is recommended to evaluate the effectiveness of autoinflation with the Politzer method or other available methods in OME patients with hearing loss.
背景:中耳炎伴积液(OME)是指出现中耳积液而无急性耳部感染症状或体征。中耳积液是导致听力损失的原因之一。由于慢性无症状中耳炎是一种自限性疾病,因此只需小心等待3个月即可治愈。在监测期间,自动充气是一种有益的干预措施,副作用小,依从性高。目的评估自动充气对改善中耳炎伴渗出和听力损失患者的听力的有效性。研究方法:采用多维数据挖掘法进行文献检索:通过 PubMed、Cochrane、ScienceDirect、Scopus 和 EBSCOHost 进行文献检索,并制定纳入和排除标准。筛选出的文章采用牛津循证医学中心 2011 年提出的系统综述和证据水平快速批判性评估方法进行批判性评估。结果:一篇系统综述和荟萃分析或 RCT 符合标准。这篇文章显示的汇总估计值为 RR 1.74;95% CI [1.22-2.50],Z 值为 3.02(p=0.0025)。这一结果显示出极大的异质性(P=0.01)(I2=69%)。结论:听力损失的 OME 患者如果进行了 1 个月以上的自动充气,其听力改善的几率是对照组的 1.74 倍。采用 Politzer 方法进行自动充气对改善听力损失有显著效果。建议进行大规模的 RCT 研究,以评估采用 Politzer 方法或其他可用方法对听力损失的 OME 患者进行自动充气的有效性。
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引用次数: 0
Pain Management in Critical Patients in the ICU 重症监护室危重病人的疼痛管理
Pub Date : 2024-06-03 DOI: 10.55175/cdk.v51i6.1044
Laurencia Ardi
Critically ill patients are patients in life-threatening conditions and will result in significant increment of mortality and morbidity if not given immediate medical intervention. Critically ill patients, especially those using ventilators, often experience pain. Pain can be caused by interventions or procedures in the ICU or by other unknown causes. Pain management in critically ill patients can be non-pharmacological or pharmacological.
危重病人是指生命垂危的病人,如果得不到及时的医疗干预,死亡率和发病率都会大幅上升。危重病人,尤其是使用呼吸机的病人,经常会感到疼痛。疼痛可能由重症监护室的干预措施或程序引起,也可能由其他未知原因引起。危重病人的疼痛治疗可以是非药物治疗,也可以是药物治疗。
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引用次数: 0
Predictive factors of early recurrence of pancreatic adenocarcinoma after curative resection surgery 胰腺腺癌根治性切除手术后早期复发的预测因素
Pub Date : 2024-06-03 DOI: 10.55175/cdk.v51i6.965
M. F. Soelaeman, F. A. Rahmat, A. W. Wardhana
Introduction: Pancreatic adenocarcinoma stands as one of the most devastating forms of cancer, with a survival rate of less than 5% after 5 years. Despite resection surgery being the only curative option, recurrence occurs in up to 85% of cases. It is crucial to identify factors that can accurately predict the probability of recurrence for more effective management strategies. Method: Following the PRISMA guidelines, a systematic review was carried out by extracting relevant studies from the PubMed MEDLINE database. Results: A total of 1,345 studies were initially identified, and 34 studies were analyzed. A total of thirty-five predictive factors were identified and classified into preoperative and postoperative categories. These factors were be further subdivided into patient characteristics, biomarkers, tumor characteristics, and genetics. The most frequently observed factors were lymph node metastasis, serum CA 19-9 level, and tumor size. Conclusion: Preoperative and postoperative patient characteristics, genetics, biomarkers, and tumor characteristics data can be utilized to predict and implement suitable follow-up strategies aimed at enhancing patient survival rates.
简介胰腺腺癌是最具破坏性的癌症之一,5 年后的存活率不到 5%。尽管切除手术是唯一的治愈选择,但高达 85% 的病例会复发。找出能准确预测复发概率的因素,以制定更有效的治疗策略至关重要。方法:按照 PRISMA 指南,从 PubMed MEDLINE 数据库中提取相关研究,进行系统性综述。结果初步确定了 1,345 项研究,并对 34 项研究进行了分析。共确定了 35 个预测因素,并将其分为术前和术后两类。这些因素又进一步细分为患者特征、生物标志物、肿瘤特征和遗传学。最常见的因素是淋巴结转移、血清 CA 19-9 水平和肿瘤大小。结论术前和术后患者特征、遗传学、生物标志物和肿瘤特征数据可用于预测和实施适当的随访策略,从而提高患者的生存率。
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引用次数: 0
Use of Low Level Laser in Cosmetic Dermatology 低水平激光在皮肤美容中的应用
Pub Date : 2024-06-03 DOI: 10.55175/cdk.v51i6.991
Mutia Fadhila Sy, N. Jusuf
Low level laser therapy (LLLT) is used in almost all areas of modern medicine, including cosmetic dermatology. LLLT has been beneficial for the treatment of wrinkles, acne vulgaris, hypertrophic scars, hair loss, cellulite, and burns. LLLT can reduce UV damage both as a treatment and as a prophylaxis. In pigmentation disorders such as vitiligo, LLLT can increase pigmentation by stimulating melanocyte proliferation and reducing depigmentation. The non-invasive nature and near absence of side effects of LLLT encourage further research in cosmetic dermatology.
低强度激光疗法(LLLT)几乎应用于现代医学的所有领域,包括美容皮肤科。LLLT 对治疗皱纹、寻常痤疮、增生性疤痕、脱发、橘皮组织和烧伤很有帮助。作为一种治疗和预防手段,激光可减少紫外线的伤害。对于白癜风等色素沉着疾病,激光可刺激黑色素细胞增殖,减少色素脱失,从而增加色素沉着。LLLT 的非侵入性和几乎无副作用的特点鼓励人们在美容皮肤科领域开展进一步的研究。
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引用次数: 0
Management of Acute Coronary Syndrome with ST Segment Elevation aVR Leads in Hospitals with Limited Facilities 在设施有限的医院处理 ST 段抬高的急性冠状动脉综合征 aVR 导联
Pub Date : 2024-06-03 DOI: 10.55175/cdk.v51i6.934
David Kristianus, Yuliana Rias Mayasari, Leona Friyanti Ngadiah
Analysis of aVR leads on electrocardiography (ECG) is often given less attention, when in fact ST-segment elevation in aVR leads and diffuse ST-segment depression in other leads indicates circumferential subendocardial ischemia, which can be caused by left main coronary artery occlusion (LMCA) or three-vessel coronary artery disease (3VD) and is associated with a poor prognosis. An 83-year-old male came to the emergency room with chest pain for 18 hours. The ECG showed ST-segment elevation in the aVR with diffuse ST-segment depression in the anteroinferolateral leads. He was diagnosed with acute coronary syndrome (ACS), suspected occlusion of the left main coronary artery (LMCA), and a differential diagnosis of three-vessel coronary artery disease (3VD). Examination of cardiac markers and cardiac catheterization facilities were not available. A loading dose of aspirin and clopidogrel was given. During in-hospital treatment, ECG evaluation showed improvement of aVR ST-segment elevation. Early recognition of ACS with aVR ST-segment elevation and prompt early management are important.
心电图(ECG)上 aVR 导联的分析往往不太受重视,而实际上 aVR 导联 ST 段抬高和其他导联弥漫性 ST 段压低表明心内膜下缺血,这种缺血可能由左冠状动脉主干闭塞(LMCA)或三血管冠状动脉疾病(3VD)引起,预后不良。一名 83 岁的男性因胸痛 18 小时来到急诊室。心电图显示 aVR 段 ST 段抬高,前铁侧导联弥漫性 ST 段压低。他被诊断为急性冠状动脉综合征(ACS),怀疑左冠状动脉主干(LMCA)闭塞,并被鉴别诊断为三血管冠状动脉疾病(3VD)。检查心脏标志物和心导管设施均不具备。给予了负荷剂量的阿司匹林和氯吡格雷。在院内治疗期间,心电图评估显示aVR ST段抬高有所改善。早期识别伴有 aVR ST 段抬高的 ACS 并及时进行早期治疗非常重要。
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引用次数: 0
Diagnosis dan Tata Laksana Eritroderma 红斑痤疮的诊断和治疗
Pub Date : 2024-06-03 DOI: 10.55175/cdk.v51i6.1086
Nurrul Izza Misturiansyah, Umi Miranti, Ayu Lilyana Nuridah, Muhammad Irsyad Amien, R. Yoga
Eritroderma atau dermatitis eksfoliatif merupakan kelainan kulit berupa inflamasi difus dengan karakteristik kemerahan dan skuama kulit yang mengenai lebih dari 90% luas permukaan tubuh. Angka kejadian eritroderma berkisar 1 per 100.000 orang dewasa dengan kematian 16% setiap tahun, terutama pada pasien dengan imunodefisiensi. Beberapa penyebab utama di antaranya psoriasis (23%), dermatitis atopik (16%), reaksi hipersensitivitas obat (15%), dan cutaneous T-cell lymphoma (CTCL) atau sindroma Sezary (5%). Eritroderma adalah kondisi yang berpotensi mengancam jiwa yang memerlukan diagnosis, identifikasi etiologi, dan penatalaksanaan yang tepat.
红斑性皮炎或剥脱性皮炎是一种弥漫性炎症性皮肤病,皮肤会出现特征性的发红和脱屑,影响 90% 以上的体表面积。红皮病的发病率约为成人的十万分之一,每年的死亡率为 16%,尤其是在免疫缺陷患者中。主要病因包括银屑病(23%)、特应性皮炎(16%)、药物超敏反应(15%)、皮肤 T 细胞淋巴瘤(CTCL)或塞扎里综合征(5%)。红斑痤疮有可能危及生命,需要进行正确的诊断、病因鉴定和治疗。
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引用次数: 0
Lethal Complication in a Very Preterm Infant with Congenital Syphilis 一名患有先天性梅毒的早产儿的致命并发症
Pub Date : 2024-05-02 DOI: 10.55175/cdk.v51i5.1093
F. S. Gozali, Claudia Natasha Liman, Putu Siska Suryaningsih
Introduction: Congenital syphilis is a multi-organ infection caused by Treponema pallidum and transmitted from mother to fetus through uteroplacental circulation. Congenital syphilis is one of the main contributors to neonatal deaths in the United States. Case: A male infant was born by cesarean delivery from a G1P0 mother at 28 weeks of gestational age because of premature rupture of the membrane and anhydramnion. The mother had an untreated latent syphilis infection. The birthweight was 1,400 grams, the head circumference was 25 cm, and the body length was 35 cm. His APGAR score was 3-3-5 with severe asphyxia and respiratory distress syndrome. Multiple abnormalities were found, and the VDRL titre was 1/128. Cardiac-pulmonary resuscitation started immediately with 0.15 mg epinephrine through an intraendotracheal tube and continued with 0.02 mg epinephrine through intravenous access every 3 minutes. The baby was declared dead after 30 minutes of resuscitation. Conclusion: Congenital syphilis can cause lethal complications due to untreated latent syphilis suffered by his mother. The mother should undergo antenatal screening to prevent congenital syphilis.
导言:先天性梅毒是由苍白螺旋体引起的多器官感染,通过子宫胎盘循环从母亲传染给胎儿。先天性梅毒是美国新生儿死亡的主要原因之一。病例:一名 G1P0 母亲在孕龄 28 周时因胎膜早破和无羊水剖宫产下一名男婴。母亲患有未经治疗的潜伏梅毒感染。出生体重为 1 400 克,头围为 25 厘米,身长为 35 厘米。他的 APGAR 评分为 3-3-5,伴有严重窒息和呼吸窘迫综合征。发现多处异常,VDRL滴度为1/128。立即开始心肺复苏,通过气管插管输入 0.15 毫克肾上腺素,然后每 3 分钟通过静脉输入 0.02 毫克肾上腺素。抢救 30 分钟后,婴儿被宣布死亡。结论先天性梅毒可导致致命的并发症,这是因为婴儿的母亲患有潜伏梅毒而未得到治疗。母亲应接受产前筛查,以预防先天性梅毒。
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引用次数: 0
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