Pub Date : 2010-12-01DOI: 10.1109/ICSMB.2010.5735359
A. Bhattacharjee, A. Sutradhar
This paper deals with a frequency domain kernel estimation problem for modeling a nonlinear dynamic system of multivariable glucose-insulin process in an insulin dependent diabetes mellitus (IDDM) patient. For such a process with uncertainties and parameter variations, the nonparametric models are most useful for closed loop model predictive control. The present work proposes a frequency domain kernel estimation of a Hammerstein model using the harmonic excitation input by taking FFT on the input data sequence from the glucose-insulin process of IDDM patient model. For the multivariable system, the first block is a two-input single output nonlinear block followed by a SISO linear filter. The adaptive recursive least square (ARLS) algorithm is used to solve up to second order kernels of Volterra equations with extended input vector consisting of self and cross components. Twice the length of the extended input vector for the MISO system was considered for finding the kernels and the output in frequency domain. The input-output data taken from the first principle model of nonlinear process, have been used to identify the system with a short filter memory length of M=2 and the validation results have shown good fit both in frequency and time domain responses.
{"title":"Frequency domain hammerstein model of glucose-insulin process in IDDM patient","authors":"A. Bhattacharjee, A. Sutradhar","doi":"10.1109/ICSMB.2010.5735359","DOIUrl":"https://doi.org/10.1109/ICSMB.2010.5735359","url":null,"abstract":"This paper deals with a frequency domain kernel estimation problem for modeling a nonlinear dynamic system of multivariable glucose-insulin process in an insulin dependent diabetes mellitus (IDDM) patient. For such a process with uncertainties and parameter variations, the nonparametric models are most useful for closed loop model predictive control. The present work proposes a frequency domain kernel estimation of a Hammerstein model using the harmonic excitation input by taking FFT on the input data sequence from the glucose-insulin process of IDDM patient model. For the multivariable system, the first block is a two-input single output nonlinear block followed by a SISO linear filter. The adaptive recursive least square (ARLS) algorithm is used to solve up to second order kernels of Volterra equations with extended input vector consisting of self and cross components. Twice the length of the extended input vector for the MISO system was considered for finding the kernels and the output in frequency domain. The input-output data taken from the first principle model of nonlinear process, have been used to identify the system with a short filter memory length of M=2 and the validation results have shown good fit both in frequency and time domain responses.","PeriodicalId":297136,"journal":{"name":"2010 International Conference on Systems in Medicine and Biology","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124934810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.1109/ICSMB.2010.5735338
Lisong Ai, Fei Yu, T. Hsiai
Real-time detection of pre-atherosclerotic lesions remains an unmet clinical challenge. We demonstrated the application of microelectromechanical systems (MEMS) sensors in an eccentric stenotic model in which convective heat transfer peaked in the throat of the stenosis, and decreased downstream in the zone of flow reversal. We hereby provided new insights into changes in convective heat transfer in the regions of non-obstructive, albeit inflammatory, atherosclerotic lesions in the New Zealand White rabbits fed on hypercholesterolemic diet (HD, n=3). The instantaneous temperature fluctuations altered the resistance of the MEMS sensing elements from which convective heat transfer was sensed as changes in voltages. The presence of pre-atherosclerotic lesions in the distal aortic arch significantly increased the changes in output voltage (Vave = 0.24 V) compared to that of lesion free rabbit aorta fed on normal standard diet (Vave = 0.0058V) (ND, n=3). The sensors further detected differential Vave in the thoracic aorta (HD: Vave =0.723V versus ND: Vave =:0.131 V), but similar Vave values in the abdominal aortas in the absence of atheromas (HD: Vave =0.144V versus ND: Vave =:0.143V). Vave values were also similar in distal aortic arch, thoracic and abdominal aortas in the rabbits fed on ND. Thus, MEMS thermal sensors provided a new strategy to detect pre-atherosclerotic lesions.
{"title":"Real-time detection of pre-atherosclerotic lesions in New Zealand White rabbits","authors":"Lisong Ai, Fei Yu, T. Hsiai","doi":"10.1109/ICSMB.2010.5735338","DOIUrl":"https://doi.org/10.1109/ICSMB.2010.5735338","url":null,"abstract":"Real-time detection of pre-atherosclerotic lesions remains an unmet clinical challenge. We demonstrated the application of microelectromechanical systems (MEMS) sensors in an eccentric stenotic model in which convective heat transfer peaked in the throat of the stenosis, and decreased downstream in the zone of flow reversal. We hereby provided new insights into changes in convective heat transfer in the regions of non-obstructive, albeit inflammatory, atherosclerotic lesions in the New Zealand White rabbits fed on hypercholesterolemic diet (HD, n=3). The instantaneous temperature fluctuations altered the resistance of the MEMS sensing elements from which convective heat transfer was sensed as changes in voltages. The presence of pre-atherosclerotic lesions in the distal aortic arch significantly increased the changes in output voltage (Vave = 0.24 V) compared to that of lesion free rabbit aorta fed on normal standard diet (Vave = 0.0058V) (ND, n=3). The sensors further detected differential Vave in the thoracic aorta (HD: Vave =0.723V versus ND: Vave =:0.131 V), but similar Vave values in the abdominal aortas in the absence of atheromas (HD: Vave =0.144V versus ND: Vave =:0.143V). Vave values were also similar in distal aortic arch, thoracic and abdominal aortas in the rabbits fed on ND. Thus, MEMS thermal sensors provided a new strategy to detect pre-atherosclerotic lesions.","PeriodicalId":297136,"journal":{"name":"2010 International Conference on Systems in Medicine and Biology","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125394021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.1109/ICSMB.2010.5735342
R. Pradhan, A. Mitra, Soumen Das
This paper presents the standardization of three electrode device for bioimpedance study. The COMSOL Multiphysics is used as the simulation tool for the characterization of the microdevice. In the last decades, the bioimpedance methodology has been extensively used to study the different aspects of biomedical practices. The Micro Electro Mechanical system (MEMS) helps to fabricate miniature devices for the bioimpedance study. In this work a MEMS based three electrode device is simulated using COMSOL Multiphysics to find out the impedance of Phosphate Buffered Solution (PBS) which is the physiological medium for most biological studies and used to stabilize the microelectrodes under testing. The impedance obtained from COMSOL environment is processed with an equivalent circuits simulator named as ZsimpWin by taking into account the equivalent circuit of the PBS.
{"title":"Simulation of three electrode device for bioimpedance study using COMSOL Multiphysics","authors":"R. Pradhan, A. Mitra, Soumen Das","doi":"10.1109/ICSMB.2010.5735342","DOIUrl":"https://doi.org/10.1109/ICSMB.2010.5735342","url":null,"abstract":"This paper presents the standardization of three electrode device for bioimpedance study. The COMSOL Multiphysics is used as the simulation tool for the characterization of the microdevice. In the last decades, the bioimpedance methodology has been extensively used to study the different aspects of biomedical practices. The Micro Electro Mechanical system (MEMS) helps to fabricate miniature devices for the bioimpedance study. In this work a MEMS based three electrode device is simulated using COMSOL Multiphysics to find out the impedance of Phosphate Buffered Solution (PBS) which is the physiological medium for most biological studies and used to stabilize the microelectrodes under testing. The impedance obtained from COMSOL environment is processed with an equivalent circuits simulator named as ZsimpWin by taking into account the equivalent circuit of the PBS.","PeriodicalId":297136,"journal":{"name":"2010 International Conference on Systems in Medicine and Biology","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126164478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.1109/ICSMB.2010.5735372
Swarupa Ghosh, S. Sarkar, N. Das
Mitochondria are the most important source of Reactive Oxygen species. Superoxide anion produced by mitochondria leads to damage to membranes impairing the ability of mitochondria to synthesize ATP and to carry out their wide range of metabolic functions. Thus mitochondria are both the source as well as the target for ROS. Oxidative stress generated in ischemia-reperfusion and other neurodegenerative disorders, distorts the homeostasis between ROS generation in mitochondria and its antioxidant defense for ROS detoxification. The weakened cellular antioxidant level in ageing accelerates mitochondrial oxidative damage also and this contributes to the decrease in efficiency of oxidative phosphorylation associated with ageing. Quercetin (QC), the naturally occurring flavonoid has immense free radical scavenging properties but its clinical application is restricted mostly due to its insoluble nature and inability to circumvent the Blood Brain Barrier like most of the common therapeutics. Nanocapsulated QC (NQC) is an effective approach in combating ischemia- reperfusion induced neurodegeneration. Cerebral ischemia subsequent reperfusion causes a massive damage in rat brain, both for young and aged. NQC treatment exerted a substantial protection against cerebral ischemia reperfusion induced mitochondrial damage. Higher conjugated diene and ROS level in neuronal mitochondria accompanied with a lower GSH were found in aged, compared to sham control young rats. Further loss of those parameters was observed in aged rat brain by cerebral ischemia and reperfusion. NQC treatment resulted a significant protection both in young and old rats, where as, no significant protection was noticed when aged rats were treated with QC. The marked damage in neuronal mitochondrial respiratory enzymes due to ischemia-reperfusion in all age grouped rats was prevented by NQC and protected mitochondria to restore its normal functions.
{"title":"Nanocapsulated flavonoid: Effect on cerebral ischemia-reperfusion induced mitochondrial oxidative damage in rat brain","authors":"Swarupa Ghosh, S. Sarkar, N. Das","doi":"10.1109/ICSMB.2010.5735372","DOIUrl":"https://doi.org/10.1109/ICSMB.2010.5735372","url":null,"abstract":"Mitochondria are the most important source of Reactive Oxygen species. Superoxide anion produced by mitochondria leads to damage to membranes impairing the ability of mitochondria to synthesize ATP and to carry out their wide range of metabolic functions. Thus mitochondria are both the source as well as the target for ROS. Oxidative stress generated in ischemia-reperfusion and other neurodegenerative disorders, distorts the homeostasis between ROS generation in mitochondria and its antioxidant defense for ROS detoxification. The weakened cellular antioxidant level in ageing accelerates mitochondrial oxidative damage also and this contributes to the decrease in efficiency of oxidative phosphorylation associated with ageing. Quercetin (QC), the naturally occurring flavonoid has immense free radical scavenging properties but its clinical application is restricted mostly due to its insoluble nature and inability to circumvent the Blood Brain Barrier like most of the common therapeutics. Nanocapsulated QC (NQC) is an effective approach in combating ischemia- reperfusion induced neurodegeneration. Cerebral ischemia subsequent reperfusion causes a massive damage in rat brain, both for young and aged. NQC treatment exerted a substantial protection against cerebral ischemia reperfusion induced mitochondrial damage. Higher conjugated diene and ROS level in neuronal mitochondria accompanied with a lower GSH were found in aged, compared to sham control young rats. Further loss of those parameters was observed in aged rat brain by cerebral ischemia and reperfusion. NQC treatment resulted a significant protection both in young and old rats, where as, no significant protection was noticed when aged rats were treated with QC. The marked damage in neuronal mitochondrial respiratory enzymes due to ischemia-reperfusion in all age grouped rats was prevented by NQC and protected mitochondria to restore its normal functions.","PeriodicalId":297136,"journal":{"name":"2010 International Conference on Systems in Medicine and Biology","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130604782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.1109/ICSMB.2010.5735393
S. Pal, Chandana Mitra, D. Bakshi
Introduction: Moxibustion means application of heat directly or indirectly on the skin at certain points (called Acupuncture points) with a certain technique by igniting dried Moxa leaves. It is a method of treatment complementary and enhancing to Acupuncture therapy, in certain conditions alone can be more effective. Oriental belief is that Moxa leaves take away dampness from the body. Botanical name of the plant is Artemesia Vulgaris known as Indian wormwood. This Plant is also known as Mugwort which is considered to have special properties that protects weary travelers against exhaustion. This herb has a long history of folk tradition and use.
{"title":"Development of Moxibustion based novel technique using Himalayan herbs for fast relief as well as prevention of certain human ailments","authors":"S. Pal, Chandana Mitra, D. Bakshi","doi":"10.1109/ICSMB.2010.5735393","DOIUrl":"https://doi.org/10.1109/ICSMB.2010.5735393","url":null,"abstract":"Introduction: Moxibustion means application of heat directly or indirectly on the skin at certain points (called Acupuncture points) with a certain technique by igniting dried Moxa leaves. It is a method of treatment complementary and enhancing to Acupuncture therapy, in certain conditions alone can be more effective. Oriental belief is that Moxa leaves take away dampness from the body. Botanical name of the plant is Artemesia Vulgaris known as Indian wormwood. This Plant is also known as Mugwort which is considered to have special properties that protects weary travelers against exhaustion. This herb has a long history of folk tradition and use.","PeriodicalId":297136,"journal":{"name":"2010 International Conference on Systems in Medicine and Biology","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131629547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.1109/ICSMB.2010.5735411
Rashmi Mukherjee, C. D. Ray, C. Chakraborty, Swagata Dasgupta, K. Chaudhury
Maternal dyslipidemia in preeclampsia is well established. Serum lipid levels as potential predictors of preeclampsia are yet to be investigated. Discriminant analysis and k-means clustering were used to predict preeclampsia (PE) based on the contribution of lipid parameters. Serum total cholesterol (TC), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C) and triglycerides (TG) were measured in venous blood samples of women with PE (Group A; n=62) and normotensive pregnant women (Group B; n=54). Very low density lipoprotein (VLDL) was calculated as 1/5 of TG. Discriminant analysis was used to identify the clinical markers amongst these parameters. k-means clustering was used to validate the parameters identified. TC, LDL-C, TG and VLDL levels were significantly higher and HDL-C significantly lower in Group A when compared with Group B. Amongst these, TG, VLDL and TC emerged as the ideal set of clinical markers in discriminating Group A and Group B with an overall classification accuracy of 87.9%, 87.9% and 86.1%, respectively. The clusters centers indicating mean values of TG, TC and VLDL were significantly higher in Group A as compared to Group B. Discriminant analysis was used to identify the most useful set of clinical markers amongst all the lipid parameters. Serum TG, VLDL and TC levels predicted PE with maximum accuracy, which was further verified by k-means clustering.
{"title":"Clinical biomarker for predicting preeclampsia in women with abnormal lipid profile: Statistical pattern classification approach","authors":"Rashmi Mukherjee, C. D. Ray, C. Chakraborty, Swagata Dasgupta, K. Chaudhury","doi":"10.1109/ICSMB.2010.5735411","DOIUrl":"https://doi.org/10.1109/ICSMB.2010.5735411","url":null,"abstract":"Maternal dyslipidemia in preeclampsia is well established. Serum lipid levels as potential predictors of preeclampsia are yet to be investigated. Discriminant analysis and k-means clustering were used to predict preeclampsia (PE) based on the contribution of lipid parameters. Serum total cholesterol (TC), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C) and triglycerides (TG) were measured in venous blood samples of women with PE (Group A; n=62) and normotensive pregnant women (Group B; n=54). Very low density lipoprotein (VLDL) was calculated as 1/5 of TG. Discriminant analysis was used to identify the clinical markers amongst these parameters. k-means clustering was used to validate the parameters identified. TC, LDL-C, TG and VLDL levels were significantly higher and HDL-C significantly lower in Group A when compared with Group B. Amongst these, TG, VLDL and TC emerged as the ideal set of clinical markers in discriminating Group A and Group B with an overall classification accuracy of 87.9%, 87.9% and 86.1%, respectively. The clusters centers indicating mean values of TG, TC and VLDL were significantly higher in Group A as compared to Group B. Discriminant analysis was used to identify the most useful set of clinical markers amongst all the lipid parameters. Serum TG, VLDL and TC levels predicted PE with maximum accuracy, which was further verified by k-means clustering.","PeriodicalId":297136,"journal":{"name":"2010 International Conference on Systems in Medicine and Biology","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134107802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.1109/ICSMB.2010.5735332
A. Fernandis, M. Wenk
Lipids play an important role in signaling mechanisms, regulation of protein function and control of a wide variety of cellular responses. As these lipids are important regulators their levels are tightly controlled and fine tuned both spatially as well as temporally. An imbalance in these lipids, in particular those involved in cell signaling, could lead to various pathological disorders. Thus these lipids and their effectors can serve as biomarkers. Indeed, cardiovascular diseases, obesity, neurological disorders, as well as infectious diseases have been directly implicated with aberrant lipid metabolism. This indicates that careful inspection of lipid level using metabolic profiling could help in clinical diagnostics of these pathologies.
{"title":"Lipidomics as a diagnostic and research tool","authors":"A. Fernandis, M. Wenk","doi":"10.1109/ICSMB.2010.5735332","DOIUrl":"https://doi.org/10.1109/ICSMB.2010.5735332","url":null,"abstract":"Lipids play an important role in signaling mechanisms, regulation of protein function and control of a wide variety of cellular responses. As these lipids are important regulators their levels are tightly controlled and fine tuned both spatially as well as temporally. An imbalance in these lipids, in particular those involved in cell signaling, could lead to various pathological disorders. Thus these lipids and their effectors can serve as biomarkers. Indeed, cardiovascular diseases, obesity, neurological disorders, as well as infectious diseases have been directly implicated with aberrant lipid metabolism. This indicates that careful inspection of lipid level using metabolic profiling could help in clinical diagnostics of these pathologies.","PeriodicalId":297136,"journal":{"name":"2010 International Conference on Systems in Medicine and Biology","volume":"30 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133091125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.1109/ICSMB.2010.5735420
S. RoyChoudhury, Rashmi Mukherjee, K. Chaudhury
Glutathione peroxidase (GPx) and other selenoproteins (SeP) are involved in the detoxification of reactive oxygen species (ROS). ROS is implicated in preeclampsia (PE). Generation of ROS and antioxidant effect of total GPx in women with PE was estimated. Since we found a significant decrease in total GPx level of women with PE, we were motivated to characterize at a molecular level SeP present in GPx (GPx 1–4, 6). Other SeP including selenoprotein P (SEPP), selenoprotein S (SELS) and thioredoxin reductase (TXNRD) were also analyzed since literature suggests that they also play a critical role in down regulation of oxidative stress (OS) in PE. Non SeP GPx were also analyzed for comparison purposes. Serum GPx was measured in venous blood samples of women with PE (Group A; n=25) and normotensive pregnant women (Group B; n=32) spectrophotometrically. Intracellular ROS generated by peripheral blood mononuclear cells was measured using flow cytometry. Molecular characterization of the SeP was done by sequence analysis at nucleotide, codon and amino acid levels. Intracellular ROS level was significantly increased in Group A as compared to Group B. ROS and GPx were significantly negatively correlated in both Group A and Group B. SePs involved in PE, primarily belonged to two nucleotide biasing groups, AT and GC. Dinucleotide usage and codon preferences in these two groups were found to be in accordance with their respective compositional bias. Such nucleotide compositional bias seemed to be major factor driving their selective codon choices. These SePs differ within themselves with respect to their relative amino acid abundance.
{"title":"Molecular characterization of selenoproteins based on decreased glutathione peroxidase activity in preeclampsia","authors":"S. RoyChoudhury, Rashmi Mukherjee, K. Chaudhury","doi":"10.1109/ICSMB.2010.5735420","DOIUrl":"https://doi.org/10.1109/ICSMB.2010.5735420","url":null,"abstract":"Glutathione peroxidase (GPx) and other selenoproteins (SeP) are involved in the detoxification of reactive oxygen species (ROS). ROS is implicated in preeclampsia (PE). Generation of ROS and antioxidant effect of total GPx in women with PE was estimated. Since we found a significant decrease in total GPx level of women with PE, we were motivated to characterize at a molecular level SeP present in GPx (GPx 1–4, 6). Other SeP including selenoprotein P (SEPP), selenoprotein S (SELS) and thioredoxin reductase (TXNRD) were also analyzed since literature suggests that they also play a critical role in down regulation of oxidative stress (OS) in PE. Non SeP GPx were also analyzed for comparison purposes. Serum GPx was measured in venous blood samples of women with PE (Group A; n=25) and normotensive pregnant women (Group B; n=32) spectrophotometrically. Intracellular ROS generated by peripheral blood mononuclear cells was measured using flow cytometry. Molecular characterization of the SeP was done by sequence analysis at nucleotide, codon and amino acid levels. Intracellular ROS level was significantly increased in Group A as compared to Group B. ROS and GPx were significantly negatively correlated in both Group A and Group B. SePs involved in PE, primarily belonged to two nucleotide biasing groups, AT and GC. Dinucleotide usage and codon preferences in these two groups were found to be in accordance with their respective compositional bias. Such nucleotide compositional bias seemed to be major factor driving their selective codon choices. These SePs differ within themselves with respect to their relative amino acid abundance.","PeriodicalId":297136,"journal":{"name":"2010 International Conference on Systems in Medicine and Biology","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127803576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.1109/ICSMB.2010.5735368
S. Atreya, U. Singh, R. Ribeiro, S. Anand, A. Jaryal, Sakti Srivastava
Backpack or school bag weight carried by children has raised concerns in worldwide countries over recent decades. School going children face a major problem because of the heavy weight they carry to school everyday as it leads to many problems such as a bent posture and decreased work efficiency. The prescribed weight to be carried by children has been determined to be 10–15% of their body weight; however literature shows that the majority of them carry up to 30% of their body weight. Design changes were introduced in a standard backpack to see how it would facilitate load distribution over the upper torso such that the load is not concentrated on the trunk alone. Subjects were asked to carry out trials with 0% body weight, 15% body weight with a standard backpack and 15% body weight with the modified backpack with arm straps. ECG data using Biopac MP150 was collected and the results between the three trials were compared. The results show loads of 15% of body weight or above significantly increased the amplitude of the R wave which was lower in case of carrying 15% of body weight with the arm strap. Thus the modified backpack has a potential for efficient load carriage.
{"title":"Effect of load distribution of the backpack- a design study","authors":"S. Atreya, U. Singh, R. Ribeiro, S. Anand, A. Jaryal, Sakti Srivastava","doi":"10.1109/ICSMB.2010.5735368","DOIUrl":"https://doi.org/10.1109/ICSMB.2010.5735368","url":null,"abstract":"Backpack or school bag weight carried by children has raised concerns in worldwide countries over recent decades. School going children face a major problem because of the heavy weight they carry to school everyday as it leads to many problems such as a bent posture and decreased work efficiency. The prescribed weight to be carried by children has been determined to be 10–15% of their body weight; however literature shows that the majority of them carry up to 30% of their body weight. Design changes were introduced in a standard backpack to see how it would facilitate load distribution over the upper torso such that the load is not concentrated on the trunk alone. Subjects were asked to carry out trials with 0% body weight, 15% body weight with a standard backpack and 15% body weight with the modified backpack with arm straps. ECG data using Biopac MP150 was collected and the results between the three trials were compared. The results show loads of 15% of body weight or above significantly increased the amplitude of the R wave which was lower in case of carrying 15% of body weight with the arm strap. Thus the modified backpack has a potential for efficient load carriage.","PeriodicalId":297136,"journal":{"name":"2010 International Conference on Systems in Medicine and Biology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128753880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.1109/ICSMB.2010.5735331
R. R. Galigekere
Color is that attribute of light-energy which is related to the wavelength. It is well known that color carries a very important part of information regarding objects of interest in an image. This talk introduces the audience to the representation of color (color-models) and color-based segmentation of images, with several illustrative examples from the speaker's research-experience in this area over the past few years. Application-examples considered in this talk include (i) wound-image processing, (ii) TB-screening, and (iii) Segmentation of Fascia.
{"title":"Color-image processing: An introduction with some medical application-examples","authors":"R. R. Galigekere","doi":"10.1109/ICSMB.2010.5735331","DOIUrl":"https://doi.org/10.1109/ICSMB.2010.5735331","url":null,"abstract":"Color is that attribute of light-energy which is related to the wavelength. It is well known that color carries a very important part of information regarding objects of interest in an image. This talk introduces the audience to the representation of color (color-models) and color-based segmentation of images, with several illustrative examples from the speaker's research-experience in this area over the past few years. Application-examples considered in this talk include (i) wound-image processing, (ii) TB-screening, and (iii) Segmentation of Fascia.","PeriodicalId":297136,"journal":{"name":"2010 International Conference on Systems in Medicine and Biology","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114695450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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