Pub Date : 2010-12-01DOI: 10.1109/ICSMB.2010.5735403
S. Biswas, P. Pramanik, P. Dasgupta, A. Chanda
Micro-Mechanical properties of bone have been extensively observed in this study. It has also been attempted to correlate it with the microstructural aspects. The load deformation pattern of human cortical bone (both male and female) under uniaxial compressive and tensile loading was studied. The density and porosity of the whole femur as well as different parts of it was also studied. Microstructure of bone, mainly the osteon structure, its distribution and its deformation under different stress fields have been thoroughly studied with the help of Scanning electron microscopy and reported here.
{"title":"A comparative study of microstructure and mechanical properties of human cortical bone","authors":"S. Biswas, P. Pramanik, P. Dasgupta, A. Chanda","doi":"10.1109/ICSMB.2010.5735403","DOIUrl":"https://doi.org/10.1109/ICSMB.2010.5735403","url":null,"abstract":"Micro-Mechanical properties of bone have been extensively observed in this study. It has also been attempted to correlate it with the microstructural aspects. The load deformation pattern of human cortical bone (both male and female) under uniaxial compressive and tensile loading was studied. The density and porosity of the whole femur as well as different parts of it was also studied. Microstructure of bone, mainly the osteon structure, its distribution and its deformation under different stress fields have been thoroughly studied with the help of Scanning electron microscopy and reported here.","PeriodicalId":297136,"journal":{"name":"2010 International Conference on Systems in Medicine and Biology","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116157517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.1109/ICSMB.2010.5735422
Debasish Dewanjee, A. Mitra, J. Chatterjee
Self medication in India is of great concern and need to be addressed appropriately. Many young individuals irrespective of age and sex go for self medicated drugs (over the counter drug) without actual knowledge of the adverse effect of the medication. Our study highlights the dependence of people over self medication. The main aim of this study was to convey and analyze the branded medicines used by college students, awareness, decisions behind self medication, confidence in medicine system, drug information resources, adverse findings if any and knowledge of drug profile. Samples of 1900 young students belonging to different regions of West Bengal were randomly selected from nineteen different colleges of nineteen districts (one college from each district) of West Bengal. An inclusion criterion was 18–25 years (mean age 20.53±2.12). A total of 205 students were excluded in accordance with the exclusion criteria like improper information. The prevalence of self medication among college students was 89%. About 78.05% students had a positive faith in allopathic medicines. 79.17% students learn self medication from doctors who prescribed medicines during their sickness. 17.69% were alcoholic, 24.73% were smokers, 10.69% students with chronic problems, who were considered to be at risk of drug adversity. Only 41.85% students were aware about drug interactions. Generally, the self medication was due to the illness associated with cough & cold, gastrointestinal Infections, headache and fever, mouth ulcer & throat infections. Respondents were using Schedule H drugs/potent drugs for minor illness. The results are based on the answers which were given by respondents asked during the study. The prevalence of self medication among college students in West Bengal is high. The percentage of self medication might change along with locality and region. This survey conveyed that the majority of college students had a poor knowledge about proper self medication and the knowledge of the benefits and risks were not up to mark. A number of students consulted pharmacists and followed advertisements on drug information. This issue needs to be addressed by the responsible authorities of State Pharmacy Council/Ministry of Health.
{"title":"Study of self medication of allopathic medicine among college students in West Bengal","authors":"Debasish Dewanjee, A. Mitra, J. Chatterjee","doi":"10.1109/ICSMB.2010.5735422","DOIUrl":"https://doi.org/10.1109/ICSMB.2010.5735422","url":null,"abstract":"Self medication in India is of great concern and need to be addressed appropriately. Many young individuals irrespective of age and sex go for self medicated drugs (over the counter drug) without actual knowledge of the adverse effect of the medication. Our study highlights the dependence of people over self medication. The main aim of this study was to convey and analyze the branded medicines used by college students, awareness, decisions behind self medication, confidence in medicine system, drug information resources, adverse findings if any and knowledge of drug profile. Samples of 1900 young students belonging to different regions of West Bengal were randomly selected from nineteen different colleges of nineteen districts (one college from each district) of West Bengal. An inclusion criterion was 18–25 years (mean age 20.53±2.12). A total of 205 students were excluded in accordance with the exclusion criteria like improper information. The prevalence of self medication among college students was 89%. About 78.05% students had a positive faith in allopathic medicines. 79.17% students learn self medication from doctors who prescribed medicines during their sickness. 17.69% were alcoholic, 24.73% were smokers, 10.69% students with chronic problems, who were considered to be at risk of drug adversity. Only 41.85% students were aware about drug interactions. Generally, the self medication was due to the illness associated with cough & cold, gastrointestinal Infections, headache and fever, mouth ulcer & throat infections. Respondents were using Schedule H drugs/potent drugs for minor illness. The results are based on the answers which were given by respondents asked during the study. The prevalence of self medication among college students in West Bengal is high. The percentage of self medication might change along with locality and region. This survey conveyed that the majority of college students had a poor knowledge about proper self medication and the knowledge of the benefits and risks were not up to mark. A number of students consulted pharmacists and followed advertisements on drug information. This issue needs to be addressed by the responsible authorities of State Pharmacy Council/Ministry of Health.","PeriodicalId":297136,"journal":{"name":"2010 International Conference on Systems in Medicine and Biology","volume":"141 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132165417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.1109/ICSMB.2010.5735364
H. Begam, A. Chanda, B. Kundu
Nano hydroxyapatite (HAp) more closely mimics the size of HAp crystals in natural bone and teeth. Due to high surface energy, nano-sized HAp powder can result in better sinterability and, therefore improve mechanical properties. In this present work, nano particle hydroxyapatite was prepared using two methods, wet chemical method and ammoniacal method. The as prepared powder and calcined powder was characterized by XRD, FTIR to study the phases of the powders. 50 vol% slurry was prepared using powders calcined at 1000°C for 2 hours and sodium polyacrylate was used as deflocculating agent. After slip casting in Plaster of Paris mould, the green samples were sintered at different temperature 1100, 1200, 1250 and 1300°C for 2 hours to study the sintering behavior. Physical, mechanical and biological characterization was done for the sintered samples.
纳米羟基磷灰石(HAp)更接近于天然骨和牙齿中羟基磷灰石晶体的大小。纳米HAp粉体由于具有较高的表面能，具有较好的烧结性能，从而提高了力学性能。本文采用湿化学法和氨法制备了纳米羟基磷灰石。采用XRD、FTIR对制备的粉末和煅烧后的粉末进行了表征。采用粉末在1000℃下煅烧2小时，以聚丙烯酸钠为防絮凝剂，制备50 vol%浆料。在Plaster of Paris模具中进行滑铸后，分别在1100、1200、1250、1300℃不同温度下烧结2h，研究其烧结行为。对烧结样品进行了物理、力学和生物学表征。
{"title":"Synthesis and characterization of nano-grained hydroxyapatite through slip casting technique","authors":"H. Begam, A. Chanda, B. Kundu","doi":"10.1109/ICSMB.2010.5735364","DOIUrl":"https://doi.org/10.1109/ICSMB.2010.5735364","url":null,"abstract":"Nano hydroxyapatite (HAp) more closely mimics the size of HAp crystals in natural bone and teeth. Due to high surface energy, nano-sized HAp powder can result in better sinterability and, therefore improve mechanical properties. In this present work, nano particle hydroxyapatite was prepared using two methods, wet chemical method and ammoniacal method. The as prepared powder and calcined powder was characterized by XRD, FTIR to study the phases of the powders. 50 vol% slurry was prepared using powders calcined at 1000°C for 2 hours and sodium polyacrylate was used as deflocculating agent. After slip casting in Plaster of Paris mould, the green samples were sintered at different temperature 1100, 1200, 1250 and 1300°C for 2 hours to study the sintering behavior. Physical, mechanical and biological characterization was done for the sintered samples.","PeriodicalId":297136,"journal":{"name":"2010 International Conference on Systems in Medicine and Biology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131265320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.1109/ICSMB.2010.5735416
Subhojit Ghosh, S. Maka
The last four decades have seen the development of several mathematical models describing different aspects of blood glucose regulation, mainly the dynamics of glucose metabolism and the insulin action on glucose production and utilization. One of these models, developed by Ghosh and Maka [1] involves representation of the glucose-insulin dynamics by a (piecewise affine) PWA model. The PWA modeling allows determination of the basal values of physiological variables as well as the point of hopf bifurcation of plasma glucose without carrying out extensive simulations or solving complex transcendental equations. This paper deals with some basic properties regarding the physiological feasibility of the PWA model. Theorems on the positivity and uniqueness of the solution as well as the existence of oscillatory behavior at steady state are proved.
{"title":"On the properties of a piecewise affine model for glucose regulation","authors":"Subhojit Ghosh, S. Maka","doi":"10.1109/ICSMB.2010.5735416","DOIUrl":"https://doi.org/10.1109/ICSMB.2010.5735416","url":null,"abstract":"The last four decades have seen the development of several mathematical models describing different aspects of blood glucose regulation, mainly the dynamics of glucose metabolism and the insulin action on glucose production and utilization. One of these models, developed by Ghosh and Maka [1] involves representation of the glucose-insulin dynamics by a (piecewise affine) PWA model. The PWA modeling allows determination of the basal values of physiological variables as well as the point of hopf bifurcation of plasma glucose without carrying out extensive simulations or solving complex transcendental equations. This paper deals with some basic properties regarding the physiological feasibility of the PWA model. Theorems on the positivity and uniqueness of the solution as well as the existence of oscillatory behavior at steady state are proved.","PeriodicalId":297136,"journal":{"name":"2010 International Conference on Systems in Medicine and Biology","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132641885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.1109/ICSMB.2010.5735354
Gurjeet Singh, D. Joshi, S. Anand, P. Swami
This paper presents the Difference based algorithm for identifying regions in knee joint movement for a gait cycle. Presented regions are different from biological regions like stance and swing. As the regions have different damping characteristics in subsequent regions, this algorithm has its unique application of controlling the damping in prosthetic knee for echo control prosthesis.
{"title":"Sub region identification in gait cycle for real time implementation","authors":"Gurjeet Singh, D. Joshi, S. Anand, P. Swami","doi":"10.1109/ICSMB.2010.5735354","DOIUrl":"https://doi.org/10.1109/ICSMB.2010.5735354","url":null,"abstract":"This paper presents the Difference based algorithm for identifying regions in knee joint movement for a gait cycle. Presented regions are different from biological regions like stance and swing. As the regions have different damping characteristics in subsequent regions, this algorithm has its unique application of controlling the damping in prosthetic knee for echo control prosthesis.","PeriodicalId":297136,"journal":{"name":"2010 International Conference on Systems in Medicine and Biology","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133272903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.1109/ICSMB.2010.5735384
A. Acharya, S. Kar, A. Routray
This paper presents the variation of functional interdependency of electroencephalograph (EEG) signals from different cortical areas during a 36 hour long sleep deprived experiment using phase synchronization. Weighted undirected network structures have been constructed based on the magnitude of Phase Synchronization at various levels of wavelet decomposition. Various network parameters have been computed at each stages of the experiment to study the integration and segregation of different lobes. It has been found that few network parameters exhibit definite patterns in some frequency bands with increasing sleepiness and fatigue at successive stages of the experiment.
{"title":"Phase synchronization based weighted networks for classifying levels of fatigue and sleepiness","authors":"A. Acharya, S. Kar, A. Routray","doi":"10.1109/ICSMB.2010.5735384","DOIUrl":"https://doi.org/10.1109/ICSMB.2010.5735384","url":null,"abstract":"This paper presents the variation of functional interdependency of electroencephalograph (EEG) signals from different cortical areas during a 36 hour long sleep deprived experiment using phase synchronization. Weighted undirected network structures have been constructed based on the magnitude of Phase Synchronization at various levels of wavelet decomposition. Various network parameters have been computed at each stages of the experiment to study the integration and segregation of different lobes. It has been found that few network parameters exhibit definite patterns in some frequency bands with increasing sleepiness and fatigue at successive stages of the experiment.","PeriodicalId":297136,"journal":{"name":"2010 International Conference on Systems in Medicine and Biology","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116495923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.1109/ICSMB.2010.5735391
P. Mondal, J. Mukhopadhyay, S. Sural, A. K. Majumdar, A. Biswas, A. Singh, S. Mukherjee
Ventriculomegaly is one of the most sensitive markers for abnormal development of the fetal central nervous system. So assessment of the size of lateral ventricles has become an important part of routine neurological assessment in neonates. We have proposed a method for measuring the width of lateral ventricles in term and preterm neonates from the coronal view of their brain ultrasound images. Based on the ultrasound image, the following steps are performed. 1) Ultrasound image is preprocessed to reduce the speckle noise. 2) The region of interest is extracted from the original image. 3) The image containing lateral ventricles and cavum septum pellucidum (CSP) is segmented. 4) Lateral ventricles and CSP are labeled. 5) Morphological operations are done to smooth the boundaries of lateral ventricles and to fill the cavities. 6) Lateral ventricle width is measured by means of the proposed image processing method.
{"title":"A user interactive method for measuring lateral ventricle width in neonates","authors":"P. Mondal, J. Mukhopadhyay, S. Sural, A. K. Majumdar, A. Biswas, A. Singh, S. Mukherjee","doi":"10.1109/ICSMB.2010.5735391","DOIUrl":"https://doi.org/10.1109/ICSMB.2010.5735391","url":null,"abstract":"Ventriculomegaly is one of the most sensitive markers for abnormal development of the fetal central nervous system. So assessment of the size of lateral ventricles has become an important part of routine neurological assessment in neonates. We have proposed a method for measuring the width of lateral ventricles in term and preterm neonates from the coronal view of their brain ultrasound images. Based on the ultrasound image, the following steps are performed. 1) Ultrasound image is preprocessed to reduce the speckle noise. 2) The region of interest is extracted from the original image. 3) The image containing lateral ventricles and cavum septum pellucidum (CSP) is segmented. 4) Lateral ventricles and CSP are labeled. 5) Morphological operations are done to smooth the boundaries of lateral ventricles and to fill the cavities. 6) Lateral ventricle width is measured by means of the proposed image processing method.","PeriodicalId":297136,"journal":{"name":"2010 International Conference on Systems in Medicine and Biology","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126047737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.1109/ICSMB.2010.5735373
A. Barui, P. Banerjee, R. Das, S. Dhara, J. Chatterjee
Non-invasive visualization of wound bed with depth information is important to understand the tissue repair under therapeutic interventions. In this context, present study performs skin swept source-optical coherence tomography (i.e. optical biopsy/OCT) and correlates findings with histo-pathological observations on different types of traumatic non-healing wounds under honey dressing. Correlation between OCT and microscopic observations were explored especially in respect to progressive growth and maturation of the epithelial and sub-epithelial components. Characteristic transition of uniform hypo-lucid band for de-pigmented zone to wavy highly lucid band for the pigmented zone in the OCT images could be directly correlated with the microscopic findings on transformation of flattened pre-mature epithelium of de-pigmented area to thicker and matured epithelium with rete-pegs in pigmented zone. This correlated evaluation of multimodal images demonstrates the applicability of SS-OCT in wound research and importance of integrated approach in validation of newer technology.
{"title":"Correlating optical biopsy with histopathology of wounds under topical intervention with honey","authors":"A. Barui, P. Banerjee, R. Das, S. Dhara, J. Chatterjee","doi":"10.1109/ICSMB.2010.5735373","DOIUrl":"https://doi.org/10.1109/ICSMB.2010.5735373","url":null,"abstract":"Non-invasive visualization of wound bed with depth information is important to understand the tissue repair under therapeutic interventions. In this context, present study performs skin swept source-optical coherence tomography (i.e. optical biopsy/OCT) and correlates findings with histo-pathological observations on different types of traumatic non-healing wounds under honey dressing. Correlation between OCT and microscopic observations were explored especially in respect to progressive growth and maturation of the epithelial and sub-epithelial components. Characteristic transition of uniform hypo-lucid band for de-pigmented zone to wavy highly lucid band for the pigmented zone in the OCT images could be directly correlated with the microscopic findings on transformation of flattened pre-mature epithelium of de-pigmented area to thicker and matured epithelium with rete-pegs in pigmented zone. This correlated evaluation of multimodal images demonstrates the applicability of SS-OCT in wound research and importance of integrated approach in validation of newer technology.","PeriodicalId":297136,"journal":{"name":"2010 International Conference on Systems in Medicine and Biology","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128441201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.1109/ICSMB.2010.5735408
L. Das, R. Malviya, M. Manjunatha, A. Ray, J. Chatterjee, P. Dutta
This paper is aimed at the development of a cost effective monolayered LBC slide preparation technique for automated nuclear and cellular features segmentation using image processing techniques. The sensitivity of Liquid Based Cytology (LBC) in monolayer preparation is reported to be better than Conventional Pap Smears (CPS) in automated image analysis. In our study a low-cost monolayer preparation by LBC for cervical smear has been developed. The digital images of new LBC method and CPS were processed to segment out primary target features like cervical cells and their nuclei. The target feature segmentation was successfully done and the used nuclear segmentation method was applied for the first time for these images. The sensitivity of the present LBC technique was superior to CPS as the algorithms developed for the segmentation and analysis of nucleus run better on the newly developed monolayer images.
{"title":"Efficacy of low cost Liquid Based Cytology for cerivcal smears in automated segmentation of cells and nuclei","authors":"L. Das, R. Malviya, M. Manjunatha, A. Ray, J. Chatterjee, P. Dutta","doi":"10.1109/ICSMB.2010.5735408","DOIUrl":"https://doi.org/10.1109/ICSMB.2010.5735408","url":null,"abstract":"This paper is aimed at the development of a cost effective monolayered LBC slide preparation technique for automated nuclear and cellular features segmentation using image processing techniques. The sensitivity of Liquid Based Cytology (LBC) in monolayer preparation is reported to be better than Conventional Pap Smears (CPS) in automated image analysis. In our study a low-cost monolayer preparation by LBC for cervical smear has been developed. The digital images of new LBC method and CPS were processed to segment out primary target features like cervical cells and their nuclei. The target feature segmentation was successfully done and the used nuclear segmentation method was applied for the first time for these images. The sensitivity of the present LBC technique was superior to CPS as the algorithms developed for the segmentation and analysis of nucleus run better on the newly developed monolayer images.","PeriodicalId":297136,"journal":{"name":"2010 International Conference on Systems in Medicine and Biology","volume":"94 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131095207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.1109/ICSMB.2010.5735378
P. Maity, A. Maity, S. Mukhopadhya, A. Sadhu, D. Moulik, S. Chatterjee, Arindam Ghosh, P. Banerjee, S. Dhara, J. Chatterjee
In pathology, phyllodes and fibroadenoma of breast are two well-known tumors with differential malignant potentialities and aetio-pathology. But diagnostic ambiguity prevails, particularly in the condition of stromal hyper-cellularity. To address such classification problem, current study evaluated fresh breast tumor biopsies in respect to expression of some candidate genes by immunohistochemistry (IHC) and structurally by swept source-optical coherence tomography (SS-OCT). The IHC assessed the expression of p63 and α-SMA in myoepithelial cells (MECs) and collagen I and III in stroma. Through skin SS-OCT, the cross-sectional structural features were noted non-invasively. In phyllodes, expressions of P63 and α-SMA were less in comparison to fibroadenoma and their normal counterpart whereas it was just reverse for collagen I and III. The OCT images demonstrated differential optical features of the biopsies in terms of presence of foaminess in phyllodes in contrast to compactness of fibroadenoma. Thus, the current study identified differential structural and molecular signatures in these tumors, to address the diagnostic ambiguities.
{"title":"Distinguishing phyllodes from fibroadenoma by immunohistochemical and swept source-optical coherence tomography studies","authors":"P. Maity, A. Maity, S. Mukhopadhya, A. Sadhu, D. Moulik, S. Chatterjee, Arindam Ghosh, P. Banerjee, S. Dhara, J. Chatterjee","doi":"10.1109/ICSMB.2010.5735378","DOIUrl":"https://doi.org/10.1109/ICSMB.2010.5735378","url":null,"abstract":"In pathology, phyllodes and fibroadenoma of breast are two well-known tumors with differential malignant potentialities and aetio-pathology. But diagnostic ambiguity prevails, particularly in the condition of stromal hyper-cellularity. To address such classification problem, current study evaluated fresh breast tumor biopsies in respect to expression of some candidate genes by immunohistochemistry (IHC) and structurally by swept source-optical coherence tomography (SS-OCT). The IHC assessed the expression of p63 and α-SMA in myoepithelial cells (MECs) and collagen I and III in stroma. Through skin SS-OCT, the cross-sectional structural features were noted non-invasively. In phyllodes, expressions of P63 and α-SMA were less in comparison to fibroadenoma and their normal counterpart whereas it was just reverse for collagen I and III. The OCT images demonstrated differential optical features of the biopsies in terms of presence of foaminess in phyllodes in contrast to compactness of fibroadenoma. Thus, the current study identified differential structural and molecular signatures in these tumors, to address the diagnostic ambiguities.","PeriodicalId":297136,"journal":{"name":"2010 International Conference on Systems in Medicine and Biology","volume":"48 5 Suppl 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128195749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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