Journal of Integrative and Complementary Medicine最新文献

Aim: To systematically assess the therapeutic impact of music interventions on hypertensive disorders of pregnancy (HDP). Design: Systematic review and meta-analysis. Methods: A comprehensive search of various databases, such as PubMed, Embase, Cochrane Library, Web of Science, Scopus, CINAHL, EBSCO, Chinese National Knowledge Infrastructure, China Biomedical Literature Database, and Foreign Medical Literature Retrieval Service, was conducted to identify randomized controlled trials (RCTs) investigating the impact of music therapy on HDP from their inception through March 2024. Two independent reviewers performed study selection, data extraction, and risk-of-bias assessment using RoB 2. Statistical analyses were conducted in STATA 17, with evidence certainty graded using Grading of Recommendations Assessment, Development, and Evaluation. The protocol followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and was prospectively registered in PROSPERO. Results: The meta-analysis included 14 RCTs comprising 1,477 participants. Five separate meta-analyses were conducted to compare the efficacy of music therapy versus standard care. Moderate-quality evidence from randomized trials demonstrated significant reductions associated with music therapy in systolic blood pressure (mean difference [MD] = -10.55 mmHg, 95% confidence interval [CI]: -13.86 to -7.24, p < 0.05), diastolic blood pressure (MD = -8.14 mmHg, 95% CI: -10.59 to -5.58, p < 0.05), sleep quality in patients with hypertension (MD = -1.95 points, 95% CI: -2.41 to -1.49, p < 0.05), and depression (MD = -7.80 points, 95% CI: -9.97 to -5.64, p < 0.001). Low-quality evidence suggested a modest improvement in anxiety (MD = -7.24 points, 95% CI: -8.84 to -5.64, p < 0.05). No publication bias was found in the comprehensive analysis results (all p > 0.1). Conclusion: Our systematic review suggests that adjunctive music therapy provides clinically relevant benefits for controlling systolic and diastolic blood pressure and improving psychological outcomes including anxiety, depression, and sleep quality in patients with HDP when compared with standard care alone.

Introduction: Noninvasive, nonablative capacitive and resistive radiofrequency has emerged as a therapeutic tool for managing pelvic pain. However, research on its efficacy in pelvic floor dysfunctions is limited. This study aimed to evaluate the effectiveness of capacitive and resistive radiofrequency therapy for primary dysmenorrhea. Methods: A randomized, single-blind, controlled trial was conducted. Forty-five nulliparous women with a medical diagnosis of primary dysmenorrhea were included. Participants were randomly assigned to one of three groups: transabdominal radiofrequency, intracavitary radiofrequency, or control. The intervention groups received nine 20-min sessions, with 3 sessions per week over 3 weeks between menstrual cycles. Pain intensity, menstrual quality of life, general quality of life, and pain pressure thresholds were assessed at baseline, postintervention, and at 1-month follow-up. Results: Both transabdominal and intracavitary radiofrequency significantly reduced pain intensity compared with the control group (p < 0.001). Intracavitary radiofrequency achieved a greater reduction than transabdominal, although this difference was not statistically significant (p = 0.311). No significant between-group differences were observed in mechanical sensitivity (p > 0.05) across all pressure points. Menstrual quality of life significantly improved in the intracavitary group compared with the control (p = 0.023), whereas the transabdominal group showed no significant improvement (p = 0.176). Changes in general quality of life were not statistically significant in any group (p > 0.05). Conclusion: Both transabdominal and intracavitary radiofrequency therapies produced short-term reduction in pain intensity in women with primary dysmenorrhea. As the efficacy between modalities did not differ significantly, treatment could be tailored to patient preference and tolerability.

Objective: Aiming at evaluating the effectiveness and safety of Guizhi Fuling Wan or Keishibukuryogan (GZFL) on prostate diseases, to provide available synthesized evidence for clinical application. Methods: Randomized controlled trials (RCTs) were identified from English, Chinese, Japanese, and Korean electronic databases, the search date ranged from the inception of databases to July 2024. Rev-Man 5.4.1 software was applied in the analysis of extracted data. Results: 23 studies were included in the meta-analysis, 12 studies on chronic prostatitis(CP) and 11 studies on benign prostatic hyperplasia (BPH). The synthesized results showed that GZFL had a significantly higher effective rate compared to the control group both in BPH (risk difference [RD] = 0.14, 95% confidence interval [CI] [0.10, 0.18], p < 0.00001) and CP (RD = 0.19, 95% CI [0.14, 0.23], p < 0.00001). It reduced the International Prostate Symptom score (mean difference [MD] = -3.19, 95% CI [-5.35, -1.02], p = 0.004) and NIH Chronic Prostatitis Symptom Index score (MD = -4.09, 95% CI [-5.04, -3.15], p < 0.00001), It also had a significant effect on reducing postvoid residual urine (MD = -6.73, 95% CI [-10.12, -3.33], p = 0.0001), prostate volume (MD = -2.59, 95% CI [-4.39, -0.80], p = 0.005), and increasing maximum urinary flow rate (MD = 1.61, 95% CI [1.11, 2.10], P < 0.00001). A few studies have also reported its therapeutic effects on prostate cancer. No severe adverse effects were reported. Conclusion: GZFL is effective and safe for BPH and CP in alleviating symptoms, improving scale scores. Rigorously designed clinical trials are necessary for further clinical application.

Introduction: Xinmailong injection (XMLI) is a common Traditional Chinese Medicine for treating chronic heart failure (CHF) in China. However, strong evidence-based medical evidence for XMLI is lacking. Purpose: To evaluate the efficacy and safety of XMLI in patients with CHF. Methods: PubMed, the Cochrane Library, Web of Science, Embase, China National Knowledge Infrastructure, Wanfang Database, VIP Database for Chinese Technical Periodicals, and Chinese Biomedical Literature Database were searched to identify randomized controlled trials (RCTs) of XMLI for CHF from the inception of the databases to November 2, 2024. The Cochrane risk of bias tool for randomized trials (RoB 2) was used to evaluate the quality of studies, and STATA 17.0 software was used to perform a meta-analysis of left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), brain natriuretic peptide (BNP), N-terminal pro-brain natriuretic peptide (NT-proBNP), 6-min walking distance (6-MWD), and adverse reactions. The quality of evidence was rated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Results: Twenty-three RCTs comprising 2643 patients were included. Meta-analysis showed that compared with those under conventional Western drug treatment (CWT), combined XMLI and CWT effectively increased LVEF (mean difference [MD] = 6.66, 95% confidence interval [CI] [5.23, 8.09], Z = 9.12, p < 0.001) and 6-MWD (MD = 44.01, 95% CI [28.63,59.38], Z = 5.61, p < 0.001) and reduced LVEDD (MD = -4.19, 95% CI [-5.55, -2.83], Z = -6.05, p < 0.001), BNP (MD = -178.84, 95% CI [-230.29, -127.40], Z = -6.81, p < 0.001), and NT-proBNP (MD = -490.95, 95% CI [-729.40, -252.50], Z = -4.04, p < 0.001). There were no statistically significant differences between the two adverse reactions (risk ratio [RR] = 1.47, 95% CI [0.73,2.99], Z = 1.08, p = 0.28). The GRADE assessment rated adverse reactions as moderate-quality evidence, while LVEDD, BNP, NT-proBNP, and 6-MWD were classified as low-quality evidence, and LVEF was categorized as very low-quality evidence. Conclusions: This systematic review demonstrates that combining XMLI with CWT is effective and safe for managing CHF and offers an evidence-based adjunctive therapeutic strategy. Further high-quality clinical trials are required to investigate the prognostic implications and long-term outcomes.

Objective: To assess the effectiveness of acupressure in addressing the symptom cluster of pain, fatigue, sleep disturbances, and depression (P-F-S-D) in patients with cancer through a systematic review. Methods: A comprehensive search was conducted across three English-language medical databases (PubMed, Embase, and the Cochrane Library) and two Chinese databases (China National Knowledge Infrastructure and Wanfang). Only randomized controlled trials (RCTs) examining the impact of acupressure on the P-F-S-D symptom cluster were included. Two reviewers independently screened studies, evaluated the risk of bias, and extracted relevant data in parallel. The risk of bias in eligible RCTs was appraised using the revised Cochrane Risk of Bias tool (RoB 2.0). Meta-analysis was performed using Stata software. Results: A total of 20 studies (reported in 21 articles) met the inclusion criteria and were classified as either having a low risk of bias or some concerns regarding bias. Meta-analysis revealed that acupressure achieved large-effect reductions in the P-F-S-D symptom cluster compared to both sham acupoint (endpoint standardized mean difference [SMD] = -0.84 [-1.05, -0.63], 4-week follow-up SMD = -0.87 [-1.35, -0.39]) and usual care groups (endpoint SMD = -0.68 [-0.83, -0.53], 4-week follow-up SMD = -0.60 [-0.87, -0.33]) (all p = 0.000). Initial high heterogeneity (I² = 65.6%-67.1%) resolved after sensitivity analysis (I² = 19.7%-35.2%), confirming result robustness. Subgroup analysis further revealed that acupressure significantly benefited various symptom combinations, including P-F-S-D, P-F-S, F-S-D, F-S, P-S, and P-F. No serious adverse events were reported. Conclusions: The findings of this study suggest that acupressure should be considered for patients with cancer experiencing the P-F-S-D symptom cluster. However, given the considerable heterogeneity, potential bias, and lack of systematic adverse event reporting in the included studies, further large-scale, multicenter, high-quality RCTs are necessary to better evaluate the effectiveness and safety of acupressure for multisymptom relief.

Introduction: Among rural communities, there is a growing occurrence of persons with multiple chronic conditions (MCC) who have many unmet health care needs. Innovative interventions are needed to help address these needs. The purpose of this article is to describe the feasibility and uptake of a Whole Health System (WHS) health coaching support for rural-residing Veterans with MCC. Methods: This was a prospective qualitative case study of the development and early implementation of two types of health coaching support conducted at the VA Portland Health Care System. The two types of support offered were a health coach alone or a health coach plus remote patient monitoring-home telehealth (RPM-HT). Two clinical teams collaborated on the planning and implementation of the interventions using a collaborative learning process. The observations from this process were then used to conduct a formative evaluation using the Mobilizing Integrated Promoting Action on Research Implementation in Health Services (Mi-PARIHS) toolkit. Results: Of the 56 Veterans offered health coaching support, 6 (10.7%) engaged with the health coach. Among the 32 Veterans offered health coach plus RPM-HT support, 12 (37.5%) participated. Many factors contributed to the limited engagement of Veterans in the WHS coaching interventions including system-, clinician-, and patient-level concerns. Discussion: Our study examining the feasibility and uptake of providing WHS health coaching support highlights the complex care needs and numerous challenges of providing this type of support. Moreover, the formative evaluation using the Mi-PARIHS toolkit reinforced specific barriers that need to be addressed in future implementation efforts of providing person-centered care supported by health coaches. Finally, there is an urgent need for effective solutions given the health disparity gaps in rural communities, shortage of health care professionals, limited access to specialty care and closure of rural hospitals, and the estimated doubling prevalence of MCC over the next 25 years.

Background: A contributing factor to male pattern hair loss (MPHL) is a compromised microcirculation and increased vasoconstriction in the scalp. Since endothelial nitric oxide (NO) was found to act as a vasodilator, our study looked at the efficacy of an amaranthus hair cream in delivering absorbable nitrates to the scalp that would convert to NO resulting in vasodilation and also deliver the nutrients to the scalp. Methods: This was a randomized, double-blinded, placebo-controlled parallel arm study of 50 males of 25-45 years. The study included clinically diagnosed MPHL having Norwood classification III vertex, IV, V, and hair density >100 as measured with Trichoscan. Individuals having a history of active hair loss due to alopecia areata, scarring alopecia, diffuse telogen effluvium or dermatological conditions other than androgenic alopecia were excluded from the study. Amaranthus or placebo cream ∼2 g was applied to the targeted area once daily at night for 90 days. The primary outcome was the mean change in terminal hair density and hair-shaft diameter of terminal hair. The secondary outcome was a mean change in the density of vellus, anagen, and telogen hairs, pilary index, terminal to vellus ratio, and anagen to telogen ratio. Results: The terminal hair density increased significantly (p < 0.0001) by 28% from baseline while placebo had 15% change. Anagen hair count and density increased significantly (p < 0.0001) by 54% from baseline while placebo had a 17.5% change. The pilary index was significantly increased (p < 0.0001) by 25% from baseline while placebo had 7.3% change. The anagen by telogen ratio showed significant increase (p < 0.0001) of 1.5 times whereas placebo showed only 21% change. Conclusion: Amaranthus extract cream significantly improved anagen hair density and follicular health. No adverse effects recorded from this suggest that the Amaranthus extract cream is potential as a safe, and effective supportive therapy for MPHL.